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Search results 401 to 500 out of 510 for Cd2ap

0.04s
Type Details Score
GXD Expression    
Probe: MGI:6287803
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2838725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6515611
Age: embryonic day 17.0
Specimen Label: not shown
Detected: true
Specimen Num: 33
GXD Expression    
Probe: MGI:6287803
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2807725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:6515611
Age: embryonic day 17.0
Specimen Label: not shown
Detected: true
Specimen Num: 33
GXD Expression  
Probe: MGI:6287803
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3578028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6515611
Age: postnatal adult
Note: Expressed in the crypts and in the basal and middle region of the villi. The signal was less pronounced in the mature cells close to the tips of the villi.
Specimen Label: not shown
Detected: true
Specimen Num: 34
GXD Expression  
Probe: MGI:6287803
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3552223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6515611
Age: embryonic day 15.0
Note: Somewhat weaker expression in the parencymal cells.
Specimen Label: not shown
Detected: true
Specimen Num: 32
GXD Expression  
Probe: MGI:6287803
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6515611
Age: postnatal adult
Note: Expressed in the parietal cells as a weaker signal compared with that of chief cells and mucous neck cells.
Specimen Label: 5G
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:6287803
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3581728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6515611
Age: postnatal adult
Note: Expressed in the mucous neck cells and chief cells.
Specimen Label: 5G
Detected: true
Specimen Num: 20
GXD Expression    
Probe: MGI:6287803
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-06
Strength: Moderate
Sex: Male
Emaps: EMAPS:2965528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6515611
Age: postnatal adult
Specimen Label: 3F
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6287803
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-06
Strength: Moderate
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6515611
Age: postnatal adult
Specimen Label: 3F
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:7576930
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7576953
Age: postnatal adult
Specimen Label: S7C control
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7576930
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7576953
Age: postnatal adult
Note: Expression levels normal compared to wild type.
Specimen Label: S7C Magi2 ko
Detected: true
Specimen Num: 2
Publication
First Author: Dustin ML
Year: 1998
Journal: Cell
Title: A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
Volume: 94
Issue: 5
Pages: 667-77
Publication
First Author: Casalena G
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro.
Volume: 306
Issue: 11
Pages: F1372-80
Publication
First Author: Teng B
Year: 2016
Journal: Diabetes
Title: CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.
Volume: 65
Issue: 12
Pages: 3667-3679
Publication
First Author: Jansson S
Year: 1997
Journal: J Cell Physiol
Title: Mouse metanephric kidney as a model system for identifying developmentally regulated genes.
Volume: 173
Issue: 2
Pages: 147-51
Publication
First Author: Tarttelin EE
Year: 2003
Journal: FEBS Lett
Title: Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue.
Volume: 554
Issue: 3
Pages: 410-6
Publication  
First Author: Kong MS
Year: 2019
Journal: Sci Signal
Title: Inhibition of T cell activation and function by the adaptor protein CIN85.
Volume: 12
Issue: 567
Publication
First Author: Potter AS
Year: 2019
Journal: PLoS One
Title: A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells.
Volume: 14
Issue: 8
Pages: e0216261
Publication
First Author: Yu H
Year: 2016
Journal: J Clin Invest
Title: A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
Volume: 126
Issue: 3
Pages: 1067-78
Publication
First Author: Tsuji K
Year: 2017
Journal: Sci Rep
Title: Ultrastructural Characterization of the Glomerulopathy in Alport Mice by Helium Ion Scanning Microscopy (HIM).
Volume: 7
Issue: 1
Pages: 11696
Publication
First Author: Gaidos G
Year: 2007
Journal: J Cell Sci
Title: Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation.
Volume: 120
Issue: Pt 14
Pages: 2366-77
Publication
First Author: Cormont M
Year: 2003
Journal: Traffic
Title: CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.
Volume: 4
Issue: 2
Pages: 97-112
Publication
First Author: Liu G
Year: 2006
Journal: J Biol Chem
Title: ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.
Volume: 281
Issue: 51
Pages: 39681-92
Publication
First Author: Pozzi A
Year: 2008
Journal: Dev Biol
Title: Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity.
Volume: 316
Issue: 2
Pages: 288-301
Publication
First Author: Kim EH
Year: 2005
Journal: Mamm Genome
Title: Quantitative trait loci for proteinuria in the focal glomerulosclerosis mouse model.
Volume: 16
Issue: 4
Pages: 242-50
Publication
First Author: Schiffer M
Year: 2002
Journal: J Am Soc Nephrol
Title: Inhibitory smads and tgf-Beta signaling in glomerular cells.
Volume: 13
Issue: 11
Pages: 2657-66
Publication
First Author: Jarad G
Year: 2006
Journal: J Clin Invest
Title: Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier.
Volume: 116
Issue: 8
Pages: 2272-9
Publication
First Author: Xiao Z
Year: 2013
Journal: PLoS One
Title: Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.
Volume: 8
Issue: 12
Pages: e83133
Publication
First Author: Fukusumi Y
Year: 2015
Journal: Lab Invest
Title: SV2B is essential for the integrity of the glomerular filtration barrier.
Volume: 95
Issue: 5
Pages: 534-45
Publication
First Author: Voisinne G
Year: 2016
Journal: Mol Syst Biol
Title: Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.
Volume: 12
Issue: 7
Pages: 876
Publication
First Author: Wu F
Year: 2010
Journal: J Am Soc Nephrol
Title: Anion exchanger 1 interacts with nephrin in podocytes.
Volume: 21
Issue: 9
Pages: 1456-67
Publication
First Author: Schiffer M
Year: 2015
Journal: Nat Med
Title: Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.
Volume: 21
Issue: 6
Pages: 601-9
Publication
First Author: Pandey RS
Year: 2019
Journal: Mol Neurodegener
Title: Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer's disease.
Volume: 14
Issue: 1
Pages: 50
Publication
First Author: Schell C
Year: 2015
Journal: PLoS One
Title: Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.
Volume: 10
Issue: 6
Pages: e0129424
Publication
First Author: Lefebvre J
Year: 2015
Journal: Kidney Int
Title: Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.
Volume: 88
Issue: 2
Pages: 321-31
Publication
First Author: Reiser J
Year: 2005
Journal: Nat Genet
Title: TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Volume: 37
Issue: 7
Pages: 739-44
Publication
First Author: Cullen SP
Year: 2007
Journal: J Cell Biol
Title: Human and murine granzyme B exhibit divergent substrate preferences.
Volume: 176
Issue: 4
Pages: 435-44
Publication
First Author: Sadl V
Year: 2002
Journal: Dev Biol
Title: The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells.
Volume: 249
Issue: 1
Pages: 16-29
Publication
First Author: Doné SC
Year: 2008
Journal: Kidney Int
Title: Nephrin is involved in podocyte maturation but not survival during glomerular development.
Volume: 73
Issue: 6
Pages: 697-704
Publication
First Author: Saarikangas J
Year: 2011
Journal: J Cell Sci
Title: Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Volume: 124
Issue: Pt 8
Pages: 1245-55
Publication
First Author: Vasilopoulou E
Year: 2016
Journal: Kidney Int
Title: Loss of endogenous thymosin β4 accelerates glomerular disease.
Volume: 90
Issue: 5
Pages: 1056-1070
Publication
First Author: Wang X
Year: 2024
Journal: BMC Genomics
Title: Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.
Volume: 25
Issue: 1
Pages: 139
Publication
First Author: Dietrich JE
Year: 2015
Journal: EMBO Rep
Title: Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.
Volume: 16
Issue: 8
Pages: 1005-21
Publication
First Author: Nilsson D
Year: 2019
Journal: Physiol Rep
Title: Foxc2 is essential for podocyte function.
Volume: 7
Issue: 9
Pages: e14083
Publication
First Author: Takemoto M
Year: 2006
Journal: EMBO J
Title: Large-scale identification of genes implicated in kidney glomerulus development and function.
Volume: 25
Issue: 5
Pages: 1160-74
Publication
First Author: Osafune K
Year: 2006
Journal: Development
Title: Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.
Volume: 133
Issue: 1
Pages: 151-61
Publication
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication
First Author: Combes AN
Year: 2009
Journal: Dev Dyn
Title: Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
Volume: 238
Issue: 5
Pages: 1033-41
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication
First Author: Ortega-Roldan JL
Year: 2009
Journal: Nucleic Acids Res
Title: Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings: application to the CD2AP SH3-C:ubiquitin complex.
Volume: 37
Issue: 9
Pages: e70
Allele
Name: CD2-associated protein; endonuclease-mediated mutation 1, MODEL-AD Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
DO Term
Allele
Name: CD2-associated protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Hollingworth P
Year: 2011
Journal: Nat Genet
Title: Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Volume: 43
Issue: 5
Pages: 429-35
Protein Domain
Type: Domain
Description: CD2AP is a multifunctional adaptor protein involved in membrane trafficking, dynamic actin remodelling and endocytosis [, ]. CD2AP contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. Different biological processes regulated by CD2AP require specific binding partners [].This entry represents the third SH3 domain (SH3C) of CD2AP. SH3C has been shown to bind ubiquitin [].
Allele
Name: CD2-associated protein; endonuclease-mediated mutation 1, Indra R Gupta
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
Publication
First Author: Moncalián G
Year: 2006
Journal: J Biol Chem
Title: Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.
Volume: 281
Issue: 50
Pages: 38845-53
Protein Domain
Type: Domain
Description: CD2AP is a multifunctional adaptor protein involved in membrane trafficking, dynamic actin remodelling and endocytosis [, ]. CD2AP contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. Different biological processes regulated by CD2AP require specific binding partners [].This entry represents the first SH3 domain (SH3A). It binds to the PXXXPR motif present in c-Cbl and the cytoplasmic domain of cell adhesion protein CD2 [].
Protein Domain
Type: Domain
Description: CD2AP is a multifunctional adaptor protein involved in membrane trafficking, dynamic actin remodelling and endocytosis [, ]. CD2AP contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. Different biological processes regulated by CD2AP require specific binding partners [].This entry represents the second SH3 domain (SH3B) of CD2AP. SH3B binds to c-Cbl in a site (TPSSRPLR is the core binding motif) distinct from the c-Cbl/SH3A binding site [].
Publication
First Author: Rouka E
Year: 2015
Journal: J Biol Chem
Title: Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
Volume: 290
Issue: 42
Pages: 25275-92
Publication
First Author: Badour K
Year: 2003
Journal: Immunity
Title: The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse.
Volume: 18
Issue: 1
Pages: 141-54
Genotype
Symbol: Cd2ap/Cd2ap
Background: C57BL/6-Cd2ap
Zygosity: hm
Has Mutant Allele: true
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain