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Search results 401 to 500 out of 530 for Cpe

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Type Details Score
Publication
27128821 | J:253810
First Author: Ubags ND
Year: 2016
Journal: Am J Respir Cell Mol Biol
Title: A Comparative Study of Lung Host Defense in Murine Obesity Models. Insights into Neutrophil Function.
Volume: 55
Issue: 2
Pages: 188-200
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Publication
10497230 | J:57965
First Author: Berk PD
Year: 1999
Journal: J Biol Chem
Title: Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.
Volume: 274
Issue: 40
Pages: 28626-31
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Publication
15289464 | J:91840
First Author: Chiu CH
Year: 2004
Journal: Genes Dev
Title: Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.
Volume: 18
Issue: 16
Pages: 1970-5
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Publication
8621612 | J:33332
First Author: Collins S
Year: 1996
Journal: J Biol Chem
Title: Pharmacologic manipulation of ob expression in a dietary model of obesity.
Volume: 271
Issue: 16
Pages: 9437-40
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Publication
23736543 | J:203210
First Author: Nakahara K
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia.
Volume: 305
Issue: 3
Pages: E451-63
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Publication
19745193 | J:177975
First Author: Shore SA
Year: 2009
Journal: J Appl Physiol (1985)
Title: Pulmonary responses to subacute ozone exposure in obese vs. lean mice.
Volume: 107
Issue: 5
Pages: 1445-52
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Publication
9405382 | J:44740
First Author: Leibel RL
Year: 1997
Journal: J Biol Chem
Title: The molecular genetics of rodent single gene obesities.
Volume: 272
Issue: 51
Pages: 31937-40
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Publication
10218993 | J:54849
First Author: Wilson BD
Year: 1999
Journal: Endocrinology
Title: Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.
Volume: 140
Issue: 5
Pages: 2387-97
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Publication
9207125 | J:41751
First Author: Dong ZM
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: A new class of obesity genes encodes leukocyte adhesion receptors.
Volume: 94
Issue: 14
Pages: 7526-30
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Publication
14701919 | J:88732
First Author: Lyons MA
Year: 2004
Journal: Physiol Genomics
Title: Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice.
Volume: 17
Issue: 1
Pages: 60-8
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Publication
9885188 | J:51538
 
First Author: Keightley PD
Year: 1998
Journal: Heredity (Edinb)
Title: Test of candidate gene--quantitative trait locus association applied to fatness in mice.
Volume: 81 ( Pt 6)
Pages: 630-7
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Publication
18463231 | J:138523
First Author: Wang F
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation.
Volume: 295
Issue: 1
Pages: C213-20
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Publication
8177042 | J:18161
First Author: Nishina PM
Year: 1994
Journal: Metabolism
Title: Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
Volume: 43
Issue: 5
Pages: 549-53
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Publication
8177043 | J:19043
First Author: Nishina PM
Year: 1994
Journal: Metabolism
Title: Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
Volume: 43
Issue: 5
Pages: 554-8
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Publication
27709799 | J:237213
First Author: Selvaraj P
Year: 2017
Journal: Stem Cells
Title: Neurotrophic Factor-α1: A Key Wnt-β-Catenin Dependent Anti-Proliferation Factor and ERK-Sox9 Activated Inducer of Embryonic Neural Stem Cell Differentiation to Astrocytes in Neurodevelopment.
Volume: 35
Issue: 3
Pages: 557-571
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Publication
10395190 | J:56197
First Author: Schalling M
Year: 1999
Journal: J Intern Med
Title: Genes involved in animal models of obesity and anorexia.
Volume: 245
Issue: 6
Pages: 613-9
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Publication
10395195 | J:56198
First Author: Echwald SM
Year: 1999
Journal: J Intern Med
Title: Genetics of human obesity: lessons from mouse models and candidate genes.
Volume: 245
Issue: 6
Pages: 653-66
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Publication
15917267 | J:99793
First Author: Mazón Peláez I
Year: 2005
Journal: Hum Mol Genet
Title: Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.
Volume: 14
Issue: 14
Pages: 1977-89
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Publication
14974682 | J:87328
First Author: Suto J
Year: 2003
Journal: Biochem Genet
Title: Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 mice.
Volume: 41
Issue: 9-10
Pages: 325-41
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Publication
15210844 | J:93243
First Author: Ishimori N
Year: 2004
Journal: J Lipid Res
Title: Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice.
Volume: 45
Issue: 9
Pages: 1624-32
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Publication
8009369 | J:18405
First Author: Milatovich A
Year: 1994
Journal: Somat Cell Mol Genet
Title: Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.
Volume: 20
Issue: 2
Pages: 75-86
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Publication
9229117 | J:41474
First Author: Naggert J
Year: 1997
Journal: Curr Opin Genet Dev
Title: The genetics of obesity.
Volume: 7
Issue: 3
Pages: 398-404
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Publication
16163737 | J:104961
First Author: St Germain C
Year: 2005
Journal: Mol Reprod Dev
Title: Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
Volume: 72
Issue: 4
Pages: 483-93
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Publication
9680377 | J:48971
First Author: Grewal PK
Year: 1998
Journal: Mamm Genome
Title: High-resolution mapping of mouse chromosome 8 identifies an evolutionary chromosomal breakpoint.
Volume: 9
Issue: 8
Pages: 603-7
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Publication
18256137 | J:133509
First Author: Stratigopoulos G
Year: 2008
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Regulation of Fto/Ftm gene expression in mice and humans.
Volume: 294
Issue: 4
Pages: R1185-96
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Publication
8973143 | J:36583
First Author: Chagnon YC
Year: 1996
Journal: Trends Genet
Title: Genetics of obesity: advances from rodent studies.
Volume: 12
Issue: 11
Pages: 441-4
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Publication
37689751 | J:340404
First Author: Bohuslavova R
Year: 2023
Journal: Nat Commun
Title: NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development.
Volume: 14
Issue: 1
Pages: 5554
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Publication
16247769 | J:102850
First Author: Singh U
Year: 2005
Journal: Dev Dyn
Title: Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1.
Volume: 234
Issue: 4
Pages: 1034-45
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Publication
32694784 | J:310126
First Author: Quarta C
Year: 2019
Journal: Nat Metab
Title: Functional identity of hypothalamic melanocortin neurons depends on Tbx3.
Volume: 1
Issue: 2
Pages: 222-235
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Publication
12652657 | J:106181
First Author: Chiellini C
Year: 2003
Journal: J Cell Physiol
Title: Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Volume: 195
Issue: 2
Pages: 309-21
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Publication
9403069 | J:36973
First Author: Taketo MM
Year: 1997
Journal: Genomics
Title: Mapping of eight testis-specific genes to mouse chromosomes.
Volume: 46
Issue: 1
Pages: 138-42
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Publication
37168577 | J:335566
First Author: Lu C
Year: 2023
Journal: iScience
Title: Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression.
Volume: 26
Issue: 5
Pages: 106670
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Publication
14651920 | J:86843
First Author: Easterday MC
Year: 2003
Journal: Dev Biol
Title: Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Volume: 264
Issue: 2
Pages: 309-22
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Publication
11172053 | J:67552
First Author: Jiang CH
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The effects of aging on gene expression in the hypothalamus and cortex of mice.
Volume: 98
Issue: 4
Pages: 1930-4
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
24006456 | J:221550
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Allele
Cpe<tm1Yplo> | MGI:3527901
Name: carboxypeptidase E; targeted mutation 1, Y Peng Loh
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
9878248 | J:52002
First Author: Paperna T
Year: 1998
Journal: Genomics
Title: Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion.
Volume: 54
Issue: 3
Pages: 453-9
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Protein
Q00493
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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GO Term
GO:0017131 | uridine-rich cytoplasmic polyadenylylation element binding
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Allele
Cpe<em2Smoc> | MGI:7289118
Name: carboxypeptidase E; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GXD Expression
GXD Expression
Probe: MGI:2136809
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136855
Age: embryonic day 12.5
Image: 1D
Note: Expression marks the cortical hem; abuts the CPe dorsally.
Specimen Label: 1D
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:2136809
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136855
Age: embryonic day 12.5
Image: 1F
Note: Expression marks the cortical hem; abuts the CPe caudally.
Specimen Label: 1F
Detected: true
Specimen Num: 11
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Strain
MGI:6428479 | C57BL/6J-Cpe<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein
Q9DA37
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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HT Experiment
E-GEOD-49973 | Gene expression of the mouse choroid plexus epithelium (CPE)
Series Id: GSE49973
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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GXD Expression
GXD Expression
 
Probe: MGI:512808
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136862
Age: embryonic day 12.5
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:512808
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136862
Age: embryonic day 12.5
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2136852
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136863
Age: embryonic day 12.5
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: not shown
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2136852
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136863
Age: embryonic day 12.5
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: not shown
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1275942
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136864
Age: embryonic day 12.5
Image: 3G
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: 3G
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1275942
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136864
Age: embryonic day 12.5
Image: 3G
Note: Expression in the choroid plexus epithelium (CPe) itself, and in head mesenchyme that invades the CPe to form the choroid plexus stroma (CPm).
Specimen Label: 3G
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2136809
Assay Type: RNA in situ
Annotation Date: 2001-07-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2136855
Age: embryonic day 12.5
Image: 1E
Note: Expression marks the cortical hem; no expression in the junctional epithelium between the hem and CPe; abuts the CPe dorsally and caudoventrally.
Specimen Label: 1E
Detected: true
Specimen Num: 10
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Publication
10966857 | -
First Author: Goodge KA
Year: 2000
Journal: Semin Cell Dev Biol
Title: Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.
Volume: 11
Issue: 4
Pages: 235-42
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Protein Domain
IPR034232 | M14_CPE_CPD
Type: Domain
Description: This entry represents the carboxypeptidase domain found in carboxypeptidase (CP) E (CPE, also known as carboxypeptidase H, and enkephalin convertase;(); MEROPS identifier M14.005). CPE belongs to subfamily M14B (N/E subfamily) of the M14 family of metallocarboxypeptidases (MCPs) []. It is an important enzyme responsible for the proteolytic processing of prohormone intermediates (such as pro-insulin, pro-opiomelanocortin, or pro-gonadotropin-releasing hormone) by specifically removing C-terminal basic residues []. In addition, it has been proposed that the regulated secretory pathway (RSP) of the nervous and endocrine systems utilizes membrane-bound CPE as a sorting receptor. A naturally occurring point mutation in CPE reduces the stability of the enzyme and causes its degradation, leading to an accumulation of numerous neuroendocrine peptides that result in obesity and hyperglycemia [, ]. Reduced CPE enzyme and receptor activity could underlie abnormal placental phenotypes from the observation that CPE is down-regulated in enlarged placentas of interspecific hybrid (interspecies hybrid placental dysplasia, IHPD) and cloned mice [].The carboxypeptidase A family can be divided into four subfamilies: M14A(carboxypeptidase A or digestive), M14B (carboxypeptidase H or regulatory), M14C (gamma-D-glutamyl-L-diamino acid peptidase I) and M14D (AGTPBP-1/Nna1-like proteins) [, ]. Members of subfamily M14B have longer C-termini than those of subfamily M14A [], and carboxypeptidase M (a member of the H family) is bound to the membrane by a glycosylphosphatidylinositol anchor, unlike the majority of the M14 family, which are soluble []. The zinc ligands have been determined as two histidines and a glutamate,and the catalytic residue has been identified as a C-terminal glutamate,but these do not form the characteristic metalloprotease HEXXH motif [, ]. Members of the carboxypeptidase A family are synthesised as inactive molecules with propeptides that must be cleaved to activate the enzyme. Structural studies of carboxypeptidases A and B reveal the propeptide to exist as a globular domain, followed by an extended α-helix; this shields the catalytic site, without specifically binding to it, while the substrate-binding site is blocked by making specific contacts [, ].
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Publication
9334247 | J:43620
First Author: Katahira J
Year: 1997
Journal: J Biol Chem
Title: Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.
Volume: 272
Issue: 42
Pages: 26652-8
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Publication
26120850 | J:233788
First Author: Alsters SI
Year: 2015
Journal: PLoS One
Title: Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism.
Volume: 10
Issue: 6
Pages: e0131417
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Protein
Q543R4
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Publication
10635326 | J:59157
First Author: Stebbins-Boaz B
Year: 1999
Journal: Mol Cell
Title: Maskin is a CPEB-associated factor that transiently interacts with elF-4E.
Volume: 4
Issue: 6
Pages: 1017-27
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Publication
28699639 | J:250382
 
First Author: Blandino-Rosano M
Year: 2017
Journal: Nat Commun
Title: Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Volume: 8
Pages: 16014
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Publication
20219456 | J:159995
First Author: Murai S
Year: 2010
Journal: Dev Biol
Title: Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos.
Volume: 341
Issue: 1
Pages: 205-12
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Publication
8335373 | -
First Author: Czeczulin JR
Year: 1993
Journal: Infect Immun
Title: Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli.
Volume: 61
Issue: 8
Pages: 3429-39
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Publication
9087440 | -
First Author: Katahira J
Year: 1997
Journal: J Cell Biol
Title: Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin.
Volume: 136
Issue: 6
Pages: 1239-47
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Publication
17581814 | -
First Author: Hasegawa K
Year: 2007
Journal: J Biol Chem
Title: A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms.
Volume: 282
Issue: 34
Pages: 24777-83
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Protein Domain
IPR003897 | Clenterotox
Type: Family
Description: Clostridial species are one of the major causes of food poisoning/gastro-intestinal illnesses. They are Gram-positive, spore-forming rods that occur naturally in the soil []. Among the family are: Clostridium botulinum, which produces one of the most potent toxins in existence; Clostridium tetani, causative agent of tetanus; and Clostridium perfringens, commonly found in wound infections and diarrhoea cases. The use of toxins to damage the host is a method deployed by many bacterial pathogens.The major virulence factor of C. perfringens is the CPE enterotoxin, which is secreted upon invasion of the host gut, and contributes to food poisoning and other gastrointestinal illnesses []. It has a molecular weight of 35.3kDa, and is responsible for the disintegration of tight junctions between endothelial cells in the gut []. This mechanism is mediated by host claudins-3 and -4, situated at the tight junctions.Two more host receptors have been characterised and expressed in vivo[]. Named CPE-R and RVP1, these may be utilised in the passage of Clostridial species through the gut wall, although the regulatory mechanisms have not been elucidated.This entry also includes HA-70 from Clostridium botulinum C phage. The hemagglutinin (HA) components of the progenitor toxin protects the structural integrity of botulinum neurotoxin. The structure of HA70 from type C and D toxin (HA70/C/D) has been revealed [, ].
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