| Type |
Details |
Score |
| Publication |
| First Author: |
Cardoso I |
| Year: |
2006 |
| Journal: |
FASEB J |
| Title: |
Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
234-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meera Khan P |
| Year: |
1988 |
| Journal: |
Hum Genet |
| Title: |
Close linkage of a highly polymorphic marker (D5S37) to familial adenomatous polyposis (FAP) and confirmation of FAP localization on chromosome 5q21-q22. |
| Volume: |
79 |
| Issue: |
2 |
| Pages: |
183-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kraman M |
| Year: |
2010 |
| Journal: |
Science |
| Title: |
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. |
| Volume: |
330 |
| Issue: |
6005 |
| Pages: |
827-30 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
596
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
39 |
| Description: |
Cleavage; by prolyl endopeptidase FAP, antiplasmin-cleaving enzyme FAP soluble form |
| Type: |
site |
| End: |
40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai F |
| Year: |
2013 |
| Journal: |
BMB Rep |
| Title: |
Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model. |
| Volume: |
46 |
| Issue: |
5 |
| Pages: |
252-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Keane FM |
| Year: |
2013 |
| Journal: |
FEBS Open Bio |
| Title: |
Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. |
| Volume: |
4 |
|
| Pages: |
43-54 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation. |
|
•
•
•
•
•
|
| Allele |
| Name: |
fibroblast activation protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanida I |
| Year: |
2012 |
| Journal: |
Autophagy |
| Title: |
The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
88-97 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
736
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
fibroblast activation protein; endonuclease-mediated mutation 1, Nadia Rosenthal |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Douglas T Fearon |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Douglas T Fearon |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion M, Raghu Kalluri |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, transgenic, congenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Raghu Kalluri |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fujita Y |
| Year: |
2007 |
| Journal: |
Mol Microbiol |
| Title: |
Regulation of fatty acid metabolism in bacteria. |
| Volume: |
66 |
| Issue: |
4 |
| Pages: |
829-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schujman GE |
| Year: |
2003 |
| Journal: |
Dev Cell |
| Title: |
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis. |
| Volume: |
4 |
| Issue: |
5 |
| Pages: |
663-72 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the transcription factor FapR, which is involved in the regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism []. FapR controls the expression of many genes involved in fatty acid and phospholipid metabolism (the fap regulon)[]. |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pratt CP |
| Year: |
2017 |
| Journal: |
Front Cell Neurosci |
| Title: |
Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum. |
| Volume: |
11 |
|
| Pages: |
337 |
|
•
•
•
•
•
|
| Allele |
| Name: |
potassium large conductance calcium-activated channel, subfamily M, alpha member 1; endonuclease-mediated mutation 1, Gregg E Homanics |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Epitope tag, Humanized sequence |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Su LK |
| Year: |
1992 |
| Journal: |
Science |
| Title: |
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. |
| Volume: |
256 |
| Issue: |
5057 |
| Pages: |
668-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang K |
| Year: |
1998 |
| Journal: |
Cancer Res |
| Title: |
Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. |
| Volume: |
58 |
| Issue: |
24 |
| Pages: |
5713-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feig C |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. |
| Volume: |
110 |
| Issue: |
50 |
| Pages: |
20212-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai J |
| Year: |
2015 |
| Journal: |
Genes Dev |
| Title: |
β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. |
| Volume: |
29 |
| Issue: |
14 |
| Pages: |
1493-506 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
López-Arribillaga E |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
2992 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li B |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. |
| Volume: |
9 |
| Issue: |
7 |
| Pages: |
e101969 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dang DT |
| Year: |
2000 |
| Journal: |
FEBS Lett |
| Title: |
Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. |
| Volume: |
476 |
| Issue: |
3 |
| Pages: |
203-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kopinke D |
| Year: |
2017 |
| Journal: |
Cell |
| Title: |
Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis. |
| Volume: |
170 |
| Issue: |
2 |
| Pages: |
340-351.e12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Biferali B |
| Year: |
2021 |
| Journal: |
Sci Adv |
| Title: |
Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair. |
| Volume: |
7 |
| Issue: |
23 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marinkovic M |
| Year: |
2019 |
| Journal: |
Life Sci Alliance |
| Title: |
Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis. |
| Volume: |
2 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uapinyoying P |
| Year: |
2023 |
| Journal: |
iScience |
| Title: |
Single-cell transcriptomic analysis of the identity and function of fibro/adipogenic progenitors in healthy and dystrophic muscle. |
| Volume: |
26 |
| Issue: |
8 |
| Pages: |
107479 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang X |
| Year: |
2023 |
| Journal: |
iScience |
| Title: |
Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy. |
| Volume: |
26 |
| Issue: |
1 |
| Pages: |
105775 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shibata H |
| Year: |
1997 |
| Journal: |
Science |
| Title: |
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. |
| Volume: |
278 |
| Issue: |
5335 |
| Pages: |
120-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stumm J |
| Year: |
2018 |
| Journal: |
Stem Cell Res |
| Title: |
Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury. |
| Volume: |
32 |
|
| Pages: |
8-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saito Y |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
889 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang X |
| Year: |
2024 |
| Journal: |
Cell Stem Cell |
| Title: |
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis. |
| Volume: |
31 |
| Issue: |
2 |
| Pages: |
212-226.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hogarth MW |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
2430 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wosczyna MN |
| Year: |
2021 |
| Journal: |
Cell Stem Cell |
| Title: |
Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells. |
| Volume: |
28 |
| Issue: |
7 |
| Pages: |
1323-1334.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang K |
| Year: |
2024 |
| Journal: |
Stem Cell Reports |
| Title: |
MST1/2 regulates fibro/adipogenic progenitor fate decisions in skeletal muscle regeneration. |
| Volume: |
19 |
| Issue: |
4 |
| Pages: |
501-514 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sasaki H |
| Year: |
1986 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Generation of transgenic mice producing a human transthyretin variant: a possible mouse model for familial amyloidotic polyneuropathy. |
| Volume: |
139 |
| Issue: |
2 |
| Pages: |
794-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gui J |
| Year: |
2020 |
| Journal: |
Nat Cancer |
| Title: |
Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs. |
| Volume: |
1 |
| Issue: |
6 |
| Pages: |
603-619 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cho JM |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
21280 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shelton DN |
| Year: |
2006 |
| Journal: |
Cancer Res |
| Title: |
Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. |
| Volume: |
66 |
| Issue: |
15 |
| Pages: |
7571-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lang M |
| Year: |
2017 |
| Journal: |
Cancer Res |
| Title: |
HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis. |
| Volume: |
77 |
| Issue: |
9 |
| Pages: |
2424-2438 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Sodir NM |
| Year: |
2006 |
| Journal: |
Cancer Res |
| Title: |
Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. |
| Volume: |
66 |
| Issue: |
17 |
| Pages: |
8430-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerner EW |
| Year: |
2007 |
| Journal: |
Biochem Soc Trans |
| Title: |
Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. |
| Volume: |
35 |
| Issue: |
Pt 2 |
| Pages: |
322-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smits R |
| Year: |
1998 |
| Journal: |
Gastroenterology |
| Title: |
Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. |
| Volume: |
114 |
| Issue: |
2 |
| Pages: |
275-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Z |
| Year: |
2016 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
Extensive metabolic disorders are present in APC(min) tumorigenesis mice. |
| Volume: |
427 |
|
| Pages: |
57-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paulsen JE |
| Year: |
2000 |
| Journal: |
Scand J Gastroenterol |
| Title: |
Identification and quantification of aberrant crypt foci in the colon of Min mice--a murine model of familial adenomatous polyposis. |
| Volume: |
35 |
| Issue: |
5 |
| Pages: |
534-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Knutsen HK |
| Year: |
2005 |
| Journal: |
Anticancer Res |
| Title: |
Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice. |
| Volume: |
25 |
| Issue: |
6B |
| Pages: |
3781-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pattison AM |
| Year: |
2020 |
| Journal: |
Cancer Biol Ther |
| Title: |
Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity. |
| Volume: |
21 |
| Issue: |
9 |
| Pages: |
799-805 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Husøy T |
| Year: |
2005 |
| Journal: |
Int J Cancer |
| Title: |
Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts. |
| Volume: |
116 |
| Issue: |
3 |
| Pages: |
351-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Erdman SH |
| Year: |
1999 |
| Journal: |
Carcinogenesis |
| Title: |
APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse. |
| Volume: |
20 |
| Issue: |
9 |
| Pages: |
1709-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang K |
| Year: |
2003 |
| Journal: |
Carcinogenesis |
| Title: |
Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. |
| Volume: |
24 |
| Issue: |
3 |
| Pages: |
605-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reggio A |
| Year: |
2020 |
| Journal: |
Life Sci Alliance |
| Title: |
Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration. |
| Volume: |
3 |
| Issue: |
3 |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mázala DA |
| Year: |
2020 |
| Journal: |
JCI Insight |
| Title: |
TGF-β-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model. |
| Volume: |
5 |
| Issue: |
6 |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Reggio A |
| Year: |
2020 |
| Journal: |
Cell Death Differ |
| Title: |
Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/β-catenin axis. |
| Volume: |
27 |
| Issue: |
10 |
| Pages: |
2921-2941 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saccone V |
| Year: |
2014 |
| Journal: |
Genes Dev |
| Title: |
HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. |
| Volume: |
28 |
| Issue: |
8 |
| Pages: |
841-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cordani N |
| Year: |
2014 |
| Journal: |
Stem Cells |
| Title: |
Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation. |
| Volume: |
32 |
| Issue: |
4 |
| Pages: |
874-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Santos SD |
| Year: |
2007 |
| Journal: |
J Pathol |
| Title: |
Impairment of the ubiquitin-proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy. |
| Volume: |
213 |
| Issue: |
2 |
| Pages: |
200-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hiraishi Y |
| Year: |
2018 |
| Journal: |
Sci Rep |
| Title: |
IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
18052 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cho C |
| Year: |
2020 |
| Journal: |
Oncogene |
| Title: |
Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis. |
| Volume: |
39 |
| Issue: |
38 |
| Pages: |
6129-6137 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mazur A |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion. |
| Volume: |
11 |
| Issue: |
3 |
| Pages: |
e0150287 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gonçalves NP |
| Year: |
2016 |
| Journal: |
Neurobiol Aging |
| Title: |
Tissue remodeling after interference RNA mediated knockdown of transthyretin in a familial amyloidotic polyneuropathy mouse model. |
| Volume: |
47 |
|
| Pages: |
91-101 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lees-Shepard JB |
| Year: |
2022 |
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