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Search results 401 to 500 out of 507 for Grm7

0.018s
Type Details Score
Publication
First Author: Van Meerbeke JP
Year: 2013
Journal: Hum Mol Genet
Title: The DcpS inhibitor RG3039 improves motor function in SMA mice.
Volume: 22
Issue: 20
Pages: 4074-83
Publication
First Author: Taylor AS
Year: 2013
Journal: Transgenic Res
Title: Restoration of SMN to Emx-1 expressing cortical neurons is not sufficient to provide benefit to a severe mouse model of Spinal Muscular Atrophy.
Volume: 22
Issue: 5
Pages: 1029-36
Publication
First Author: Stachniak TJ
Year: 2019
Journal: J Neurosci
Title: Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons.
Volume: 39
Issue: 23
Pages: 4461-4474
Publication  
First Author: Summa M
Year: 2013
Journal: Neuropharmacology
Title: Presynaptic mGlu7 receptors control GABA release in mouse hippocampus.
Volume: 66
Pages: 215-24
Publication
First Author: Sanchez G
Year: 2013
Journal: Hum Mol Genet
Title: A novel function for the survival motoneuron protein as a translational regulator.
Volume: 22
Issue: 4
Pages: 668-84
Publication
First Author: Khayrullina G
Year: 2022
Journal: Glia
Title: Survival motor neuron protein deficiency alters microglia reactivity.
Volume: 70
Issue: 7
Pages: 1337-1358
Publication
First Author: Bosch-Marcé M
Year: 2011
Journal: Hum Mol Genet
Title: Increased IGF-1 in muscle modulates the phenotype of severe SMA mice.
Volume: 20
Issue: 9
Pages: 1844-53
Publication  
First Author: Kong L
Year: 2021
Journal: Sci Transl Med
Title: Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA.
Volume: 13
Issue: 578
Publication
First Author: Tejero R
Year: 2020
Journal: iScience
Title: R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy.
Volume: 23
Issue: 2
Pages: 100826
Publication
First Author: Kim JK
Year: 2020
Journal: J Clin Invest
Title: Muscle-specific SMN reduction reveals motor neuron-independent disease in spinal muscular atrophy models.
Volume: 130
Issue: 3
Pages: 1271-1287
Publication
First Author: Iyer CC
Year: 2015
Journal: Hum Mol Genet
Title: Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA.
Volume: 24
Issue: 21
Pages: 6160-73
Publication  
First Author: Poppe L
Year: 2019
Journal: Front Neurosci
Title: Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy.
Volume: 13
Pages: 1233
Publication
First Author: Simon CM
Year: 2017
Journal: Cell Rep
Title: Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy.
Volume: 21
Issue: 13
Pages: 3767-3780
Publication  
First Author: Malacarne C
Year: 2021
Journal: Int J Mol Sci
Title: Dysregulation of Muscle-Specific MicroRNAs as Common Pathogenic Feature Associated with Muscle Atrophy in ALS, SMA and SBMA: Evidence from Animal Models and Human Patients.
Volume: 22
Issue: 11
Publication
First Author: Haramati S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: miRNA malfunction causes spinal motor neuron disease.
Volume: 107
Issue: 29
Pages: 13111-6
Publication
First Author: Van Alstyne M
Year: 2018
Journal: Genes Dev
Title: Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy.
Volume: 32
Issue: 15-16
Pages: 1045-1059
Publication
First Author: Subramanian N
Year: 2012
Journal: Hum Mol Genet
Title: Role of Na(v)1.9 in activity-dependent axon growth in motoneurons.
Volume: 21
Issue: 16
Pages: 3655-67
Publication
First Author: Tejero R
Year: 2016
Journal: Hum Mol Genet
Title: Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy.
Volume: 25
Issue: 21
Pages: 4703-4716
Publication
First Author: Little D
Year: 2015
Journal: Mol Ther
Title: PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy.
Volume: 23
Issue: 2
Pages: 270-7
Publication  
First Author: Feng Z
Year: 2021
Journal: Int J Mol Sci
Title: Activation of Muscle-Specific Kinase (MuSK) Reduces Neuromuscular Defects in the Delta7 Mouse Model of Spinal Muscular Atrophy (SMA).
Volume: 22
Issue: 15
Publication  
First Author: Buettner JM
Year: 2022
Journal: Front Cell Neurosci
Title: p53-dependent c-Fos expression is a marker but not executor for motor neuron death in spinal muscular atrophy mouse models.
Volume: 16
Pages: 1038276
Publication  
First Author: Tseng YT
Year: 2016
Journal: Pharmacol Res
Title: Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy.
Volume: 111
Pages: 58-75
Publication
First Author: Farooq F
Year: 2011
Journal: J Clin Invest
Title: Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway.
Volume: 121
Issue: 8
Pages: 3042-50
Publication
First Author: Kannan A
Year: 2018
Journal: Nucleic Acids Res
Title: Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy.
Volume: 46
Issue: 16
Pages: 8326-8346
Publication
First Author: Ning K
Year: 2010
Journal: Hum Mol Genet
Title: PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons.
Volume: 19
Issue: 16
Pages: 3159-68
Publication  
First Author: Hennlein L
Year: 2023
Journal: J Cell Biol
Title: Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy.
Volume: 222
Issue: 3
Publication
First Author: Fletcher EV
Year: 2017
Journal: Nat Neurosci
Title: Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.
Volume: 20
Issue: 7
Pages: 905-916
Publication
First Author: Simon CM
Year: 2019
Journal: Cell Rep
Title: Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
Volume: 29
Issue: 12
Pages: 3885-3901.e5
Publication
First Author: Kim JK
Year: 2017
Journal: Hum Mol Genet
Title: Motor neuronal repletion of the NMJ organizer, Agrin, modulates the severity of the spinal muscular atrophy disease phenotype in model mice.
Volume: 26
Issue: 13
Pages: 2377-2385
Publication
First Author: Miller N
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy.
Volume: 120
Issue: 47
Pages: e2300308120
Publication
First Author: Wishart TM
Year: 2014
Journal: J Clin Invest
Title: Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy.
Volume: 124
Issue: 4
Pages: 1821-34
Publication  
First Author: Reedich EJ
Year: 2021
Journal: Exp Neurol
Title: Spinal motor neuron loss occurs through a p53-and-p21-independent mechanism in the Smn2B/- mouse model of spinal muscular atrophy.
Volume: 337
Pages: 113587
Publication
First Author: Masugi M
Year: 1999
Journal: J Neurosci
Title: Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.
Volume: 19
Issue: 3
Pages: 955-63
Publication
First Author: Vukojicic A
Year: 2019
Journal: Cell Rep
Title: The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.
Volume: 29
Issue: 10
Pages: 3087-3100.e7
Publication
First Author: Madaro L
Year: 2018
Journal: Nat Cell Biol
Title: Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis.
Volume: 20
Issue: 8
Pages: 917-927
Publication
First Author: Miller N
Year: 2015
Journal: J Neurosci
Title: Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.
Volume: 35
Issue: 15
Pages: 6038-50
Publication  
First Author: Foran E
Year: 2016
Journal: Neurobiol Dis
Title: CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy.
Volume: 88
Pages: 118-24
Publication
First Author: d'Ydewalle C
Year: 2017
Journal: Neuron
Title: The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy.
Volume: 93
Issue: 1
Pages: 66-79
Publication
First Author: Kariya S
Year: 2008
Journal: Hum Mol Genet
Title: Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy.
Volume: 17
Issue: 16
Pages: 2552-69
Publication
First Author: Bäumer D
Year: 2009
Journal: PLoS Genet
Title: Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
Volume: 5
Issue: 12
Pages: e1000773
Publication
First Author: Kaupmann K
Year: 1997
Journal: Nature
Title: Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Volume: 386
Issue: 6622
Pages: 239-46
Publication  
First Author: Tomioka NH
Year: 2014
Journal: Nat Commun
Title: Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.
Volume: 5
Pages: 4501
Publication    
First Author: Daniel JA
Year: 2017
Journal: Elife
Title: Analysis of SUMO1-conjugation at synapses.
Volume: 6
Publication
First Author: Vadasz C
Year: 2007
Journal: Neurochem Res
Title: Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.
Volume: 32
Issue: 7
Pages: 1099-112
Publication
First Author: Špirková A
Year: 2022
Journal: Biol Reprod
Title: Glutamate can act as a signaling molecule in mouse preimplantation embryos†.
Volume: 107
Issue: 4
Pages: 916-927
Publication
First Author: Bedogni F
Year: 2016
Journal: Cereb Cortex
Title: Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Volume: 26
Issue: 6
Pages: 2517-2529
Publication
First Author: Guo Z
Year: 2012
Journal: J Neurosci
Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Volume: 32
Issue: 25
Pages: 8509-20
Publication
First Author: Ghai R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Volume: 110
Issue: 8
Pages: E643-52
Publication      
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication  
First Author: Barón-Mendoza I
Year: 2021
Journal: Front Cell Neurosci
Title: Changes in the Number and Morphology of Dendritic Spines in the Hippocampus and Prefrontal Cortex of the C58/J Mouse Model of Autism.
Volume: 15
Pages: 726501
Publication
First Author: Makoff A
Year: 1996
Journal: Brain Res Mol Brain Res
Title: Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS.
Volume: 40
Issue: 1
Pages: 165-70
Publication
First Author: Okamoto N
Year: 1994
Journal: J Biol Chem
Title: Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.
Volume: 269
Issue: 2
Pages: 1231-6
Protein Domain
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.GRM7 mRNA has a widespread distribution in many neuronal cells of the central nervoussystem, with highest levels in the hippocampal formation, cerebral cortexand cerebellum [, ]; it is thus different from the more limitedly expressedGRM4 or GRM6 mRNA []. GRM7 and GRM4 are believed to correspond to theputative L-2-amino-4-phosphonobutyrate receptor, which plays an importantrole in modulation of glutamate transmission in the CNS [].
Protein
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
Publication
First Author: Abe T
Year: 1992
Journal: J Biol Chem
Title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
Volume: 267
Issue: 19
Pages: 13361-8
Publication
First Author: Masu M
Year: 1991
Journal: Nature
Title: Sequence and expression of a metabotropic glutamate receptor.
Volume: 349
Issue: 6312
Pages: 760-5
Publication
First Author: Houamed KM
Year: 1991
Journal: Science
Title: Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.
Volume: 252
Issue: 5010
Pages: 1318-21
Publication
First Author: Sullivan R
Year: 2000
Journal: J Pharmacol Exp Ther
Title: Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.
Volume: 293
Issue: 2
Pages: 460-7
Publication
First Author: Ryba NJ
Year: 1997
Journal: Neuron
Title: A new multigene family of putative pheromone receptors.
Volume: 19
Issue: 2
Pages: 371-9
Publication
First Author: Bräuner-Osborne H
Year: 2007
Journal: Curr Drug Targets
Title: Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Volume: 8
Issue: 1
Pages: 169-84
Publication
First Author: Brown EM
Year: 1993
Journal: Nature
Title: Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.
Volume: 366
Issue: 6455
Pages: 575-80
Publication
First Author: Tanabe Y
Year: 1992
Journal: Neuron
Title: A family of metabotropic glutamate receptors.
Volume: 8
Issue: 1
Pages: 169-79