| Type |
Details |
Score |
| Publication |
| First Author: |
Van Meerbeke JP |
| Year: |
2013 |
| Journal: |
Hum Mol Genet |
| Title: |
The DcpS inhibitor RG3039 improves motor function in SMA mice. |
| Volume: |
22 |
| Issue: |
20 |
| Pages: |
4074-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Taylor AS |
| Year: |
2013 |
| Journal: |
Transgenic Res |
| Title: |
Restoration of SMN to Emx-1 expressing cortical neurons is not sufficient to provide benefit to a severe mouse model of Spinal Muscular Atrophy. |
| Volume: |
22 |
| Issue: |
5 |
| Pages: |
1029-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stachniak TJ |
| Year: |
2019 |
| Journal: |
J Neurosci |
| Title: |
Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons. |
| Volume: |
39 |
| Issue: |
23 |
| Pages: |
4461-4474 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Summa M |
| Year: |
2013 |
| Journal: |
Neuropharmacology |
| Title: |
Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. |
| Volume: |
66 |
|
| Pages: |
215-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sanchez G |
| Year: |
2013 |
| Journal: |
Hum Mol Genet |
| Title: |
A novel function for the survival motoneuron protein as a translational regulator. |
| Volume: |
22 |
| Issue: |
4 |
| Pages: |
668-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Khayrullina G |
| Year: |
2022 |
| Journal: |
Glia |
| Title: |
Survival motor neuron protein deficiency alters microglia reactivity. |
| Volume: |
70 |
| Issue: |
7 |
| Pages: |
1337-1358 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bosch-Marcé M |
| Year: |
2011 |
| Journal: |
Hum Mol Genet |
| Title: |
Increased IGF-1 in muscle modulates the phenotype of severe SMA mice. |
| Volume: |
20 |
| Issue: |
9 |
| Pages: |
1844-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kong L |
| Year: |
2021 |
| Journal: |
Sci Transl Med |
| Title: |
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA. |
| Volume: |
13 |
| Issue: |
578 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tejero R |
| Year: |
2020 |
| Journal: |
iScience |
| Title: |
R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy. |
| Volume: |
23 |
| Issue: |
2 |
| Pages: |
100826 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim JK |
| Year: |
2020 |
| Journal: |
J Clin Invest |
| Title: |
Muscle-specific SMN reduction reveals motor neuron-independent disease in spinal muscular atrophy models. |
| Volume: |
130 |
| Issue: |
3 |
| Pages: |
1271-1287 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iyer CC |
| Year: |
2015 |
| Journal: |
Hum Mol Genet |
| Title: |
Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA. |
| Volume: |
24 |
| Issue: |
21 |
| Pages: |
6160-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poppe L |
| Year: |
2019 |
| Journal: |
Front Neurosci |
| Title: |
Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy. |
| Volume: |
13 |
|
| Pages: |
1233 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Simon CM |
| Year: |
2017 |
| Journal: |
Cell Rep |
| Title: |
Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy. |
| Volume: |
21 |
| Issue: |
13 |
| Pages: |
3767-3780 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Malacarne C |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
Dysregulation of Muscle-Specific MicroRNAs as Common Pathogenic Feature Associated with Muscle Atrophy in ALS, SMA and SBMA: Evidence from Animal Models and Human Patients. |
| Volume: |
22 |
| Issue: |
11 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haramati S |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
miRNA malfunction causes spinal motor neuron disease. |
| Volume: |
107 |
| Issue: |
29 |
| Pages: |
13111-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Van Alstyne M |
| Year: |
2018 |
| Journal: |
Genes Dev |
| Title: |
Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy. |
| Volume: |
32 |
| Issue: |
15-16 |
| Pages: |
1045-1059 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Subramanian N |
| Year: |
2012 |
| Journal: |
Hum Mol Genet |
| Title: |
Role of Na(v)1.9 in activity-dependent axon growth in motoneurons. |
| Volume: |
21 |
| Issue: |
16 |
| Pages: |
3655-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tejero R |
| Year: |
2016 |
| Journal: |
Hum Mol Genet |
| Title: |
Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy. |
| Volume: |
25 |
| Issue: |
21 |
| Pages: |
4703-4716 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Little D |
| Year: |
2015 |
| Journal: |
Mol Ther |
| Title: |
PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy. |
| Volume: |
23 |
| Issue: |
2 |
| Pages: |
270-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feng Z |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
Activation of Muscle-Specific Kinase (MuSK) Reduces Neuromuscular Defects in the Delta7 Mouse Model of Spinal Muscular Atrophy (SMA). |
| Volume: |
22 |
| Issue: |
15 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Buettner JM |
| Year: |
2022 |
| Journal: |
Front Cell Neurosci |
| Title: |
p53-dependent c-Fos expression is a marker but not executor for motor neuron death in spinal muscular atrophy mouse models. |
| Volume: |
16 |
|
| Pages: |
1038276 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tseng YT |
| Year: |
2016 |
| Journal: |
Pharmacol Res |
| Title: |
Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy. |
| Volume: |
111 |
|
| Pages: |
58-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Farooq F |
| Year: |
2011 |
| Journal: |
J Clin Invest |
| Title: |
Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway. |
| Volume: |
121 |
| Issue: |
8 |
| Pages: |
3042-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kannan A |
| Year: |
2018 |
| Journal: |
Nucleic Acids Res |
| Title: |
Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy. |
| Volume: |
46 |
| Issue: |
16 |
| Pages: |
8326-8346 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ning K |
| Year: |
2010 |
| Journal: |
Hum Mol Genet |
| Title: |
PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons. |
| Volume: |
19 |
| Issue: |
16 |
| Pages: |
3159-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hennlein L |
| Year: |
2023 |
| Journal: |
J Cell Biol |
| Title: |
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy. |
| Volume: |
222 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fletcher EV |
| Year: |
2017 |
| Journal: |
Nat Neurosci |
| Title: |
Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. |
| Volume: |
20 |
| Issue: |
7 |
| Pages: |
905-916 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Simon CM |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy. |
| Volume: |
29 |
| Issue: |
12 |
| Pages: |
3885-3901.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim JK |
| Year: |
2017 |
| Journal: |
Hum Mol Genet |
| Title: |
Motor neuronal repletion of the NMJ organizer, Agrin, modulates the severity of the spinal muscular atrophy disease phenotype in model mice. |
| Volume: |
26 |
| Issue: |
13 |
| Pages: |
2377-2385 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miller N |
| Year: |
2023 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy. |
| Volume: |
120 |
| Issue: |
47 |
| Pages: |
e2300308120 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wishart TM |
| Year: |
2014 |
| Journal: |
J Clin Invest |
| Title: |
Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy. |
| Volume: |
124 |
| Issue: |
4 |
| Pages: |
1821-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reedich EJ |
| Year: |
2021 |
| Journal: |
Exp Neurol |
| Title: |
Spinal motor neuron loss occurs through a p53-and-p21-independent mechanism in the Smn2B/- mouse model of spinal muscular atrophy. |
| Volume: |
337 |
|
| Pages: |
113587 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Masugi M |
| Year: |
1999 |
| Journal: |
J Neurosci |
| Title: |
Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. |
| Volume: |
19 |
| Issue: |
3 |
| Pages: |
955-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vukojicic A |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA. |
| Volume: |
29 |
| Issue: |
10 |
| Pages: |
3087-3100.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Madaro L |
| Year: |
2018 |
| Journal: |
Nat Cell Biol |
| Title: |
Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis. |
| Volume: |
20 |
| Issue: |
8 |
| Pages: |
917-927 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miller N |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. |
| Volume: |
35 |
| Issue: |
15 |
| Pages: |
6038-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Foran E |
| Year: |
2016 |
| Journal: |
Neurobiol Dis |
| Title: |
CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy. |
| Volume: |
88 |
|
| Pages: |
118-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
d'Ydewalle C |
| Year: |
2017 |
| Journal: |
Neuron |
| Title: |
The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy. |
| Volume: |
93 |
| Issue: |
1 |
| Pages: |
66-79 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kariya S |
| Year: |
2008 |
| Journal: |
Hum Mol Genet |
| Title: |
Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. |
| Volume: |
17 |
| Issue: |
16 |
| Pages: |
2552-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bäumer D |
| Year: |
2009 |
| Journal: |
PLoS Genet |
| Title: |
Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. |
| Volume: |
5 |
| Issue: |
12 |
| Pages: |
e1000773 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kaupmann K |
| Year: |
1997 |
| Journal: |
Nature |
| Title: |
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. |
| Volume: |
386 |
| Issue: |
6622 |
| Pages: |
239-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tomioka NH |
| Year: |
2014 |
| Journal: |
Nat Commun |
| Title: |
Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures. |
| Volume: |
5 |
|
| Pages: |
4501 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Daniel JA |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
Analysis of SUMO1-conjugation at synapses. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vadasz C |
| Year: |
2007 |
| Journal: |
Neurochem Res |
| Title: |
Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. |
| Volume: |
32 |
| Issue: |
7 |
| Pages: |
1099-112 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Špirková A |
| Year: |
2022 |
| Journal: |
Biol Reprod |
| Title: |
Glutamate can act as a signaling molecule in mouse preimplantation embryos†. |
| Volume: |
107 |
| Issue: |
4 |
| Pages: |
916-927 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2016 |
| Journal: |
Cereb Cortex |
| Title: |
Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. |
| Volume: |
26 |
| Issue: |
6 |
| Pages: |
2517-2529 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo Z |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord. |
| Volume: |
32 |
| Issue: |
25 |
| Pages: |
8509-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ghai R |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. |
| Volume: |
110 |
| Issue: |
8 |
| Pages: |
E643-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deltagen Inc |
| Year: |
2005 |
| Journal: |
MGI Direct Data Submission |
| Title: |
NIH initiative supporting placement of Deltagen, Inc. mice into public repositories |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
| Journal: |
Database Download |
| Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2016 |
|
| Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barón-Mendoza I |
| Year: |
2021 |
| Journal: |
Front Cell Neurosci |
| Title: |
Changes in the Number and Morphology of Dendritic Spines in the Hippocampus and Prefrontal Cortex of the C58/J Mouse Model of Autism. |
| Volume: |
15 |
|
| Pages: |
726501 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Makoff A |
| Year: |
1996 |
| Journal: |
Brain Res Mol Brain Res |
| Title: |
Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. |
| Volume: |
40 |
| Issue: |
1 |
| Pages: |
165-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okamoto N |
| Year: |
1994 |
| Journal: |
J Biol Chem |
| Title: |
Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. |
| Volume: |
269 |
| Issue: |
2 |
| Pages: |
1231-6 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.GRM7 mRNA has a widespread distribution in many neuronal cells of the central nervoussystem, with highest levels in the hippocampal formation, cerebral cortexand cerebellum [, ]; it is thus different from the more limitedly expressedGRM4 or GRM6 mRNA []. GRM7 and GRM4 are believed to correspond to theputative L-2-amino-4-phosphonobutyrate receptor, which plays an importantrole in modulation of glutamate transmission in the CNS []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
188
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
209
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
381
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
915
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
922
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Abe T |
| Year: |
1992 |
| Journal: |
J Biol Chem |
| Title: |
Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. |
| Volume: |
267 |
| Issue: |
19 |
| Pages: |
13361-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Masu M |
| Year: |
1991 |
| Journal: |
Nature |
| Title: |
Sequence and expression of a metabotropic glutamate receptor. |
| Volume: |
349 |
| Issue: |
6312 |
| Pages: |
760-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Houamed KM |
| Year: |
1991 |
| Journal: |
Science |
| Title: |
Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain. |
| Volume: |
252 |
| Issue: |
5010 |
| Pages: |
1318-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sullivan R |
| Year: |
2000 |
| Journal: |
J Pharmacol Exp Ther |
| Title: |
Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor. |
| Volume: |
293 |
| Issue: |
2 |
| Pages: |
460-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ryba NJ |
| Year: |
1997 |
| Journal: |
Neuron |
| Title: |
A new multigene family of putative pheromone receptors. |
| Volume: |
19 |
| Issue: |
2 |
| Pages: |
371-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bräuner-Osborne H |
| Year: |
2007 |
| Journal: |
Curr Drug Targets |
| Title: |
Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
169-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brown EM |
| Year: |
1993 |
| Journal: |
Nature |
| Title: |
Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. |
| Volume: |
366 |
| Issue: |
6455 |
| Pages: |
575-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanabe Y |
| Year: |
1992 |
| Journal: |
Neuron |
| Title: |
A family of metabotropic glutamate receptors. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
169-79 |
|
•
•
•
•
•
|