Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
24
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
256
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Li XJ |
Year: |
1995 |
Journal: |
Nature |
Title: |
A huntingtin-associated protein enriched in brain with implications for pathology. |
Volume: |
378 |
Issue: |
6555 |
Pages: |
398-402 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu LL |
Year: |
2009 |
Journal: |
Cell Adh Migr |
Title: |
Huntingtin associated protein 1 and its functions. |
Volume: |
3 |
Issue: |
1 |
Pages: |
71-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lumsden AL |
Year: |
2016 |
Journal: |
BMC Evol Biol |
Title: |
Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. |
Volume: |
16 |
Issue: |
1 |
Pages: |
214 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a N-terminal conserved region found in huntingtin-associated protein 1 (HAP1), trafficking Kinesin proteins TRAK1 and TRAK2 (vertebrate), Milton (Drosophila) and T27A3.1 (C. elegans) []. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner [, , ]. It is involved in intracellular trafficking []. HAP1 is also linked to Alzheimer's disease. It regulates amyloid precursor protein subcellular trafficking to the non-amyloidogenic pathway and may negatively regulate Abeta production in neurons [].TRAK1 binds to both kinesin-1 and dynein/dynactin, is prominently localized in axons, and is needed for normal axon outgrowth, whereas TRAK2 predominantly interacts with dynein/dynactin, is more abundantly present in dendrites, and is required for dendritic development []. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Hap1-cre)RE55Gsat/? |
Background: |
involves: 129S4/SvJaeSor * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
939
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
606
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
664
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
968
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
947
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
560
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
524
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
731
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
672
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
913
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
913
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
van Spronsen M |
Year: |
2013 |
Journal: |
Neuron |
Title: |
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. |
Volume: |
77 |
Issue: |
3 |
Pages: |
485-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loregger A |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1128 |
|
•
•
•
•
•
|
Publication |
First Author: |
Firat-Karalar EN |
Year: |
2014 |
Journal: |
J Cell Sci |
Title: |
Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. |
Volume: |
127 |
Issue: |
Pt 19 |
Pages: |
4128-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goto H |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases. |
Volume: |
296 |
|
Pages: |
100605 |
|
•
•
•
•
•
|
Publication |
First Author: |
Werner ER |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens. |
Volume: |
117 |
Issue: |
14 |
Pages: |
7792-7798 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geng X |
Year: |
2018 |
Journal: |
Metallomics |
Title: |
Role of ZIP8 in regulating cell morphology and NF-κB/Snail2 signaling. |
Volume: |
10 |
Issue: |
7 |
Pages: |
953-964 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meira LB |
Year: |
2001 |
Journal: |
Cancer Res |
Title: |
Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress. |
Volume: |
61 |
Issue: |
14 |
Pages: |
5552-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sawai M |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. |
Volume: |
292 |
Issue: |
37 |
Pages: |
15538-15551 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2003 |
Journal: |
Hum Mol Genet |
Title: |
Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. |
Volume: |
12 |
Issue: |
16 |
Pages: |
2021-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mandal M |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin. |
Volume: |
286 |
Issue: |
39 |
Pages: |
33719-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geng X |
Year: |
2019 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Role of ZIP8 in regulation of cisplatin sensitivity through Bcl-2. |
Volume: |
362 |
|
Pages: |
52-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rong J |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. |
Volume: |
26 |
Issue: |
22 |
Pages: |
6019-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Olbrich T |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A p53-dependent response limits the viability of mammalian haploid cells. |
Volume: |
114 |
Issue: |
35 |
Pages: |
9367-9372 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gadalla MR |
Year: |
2020 |
Journal: |
Biochem J |
Title: |
Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20. |
Volume: |
477 |
Issue: |
1 |
Pages: |
285-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colomer V |
Year: |
1997 |
Journal: |
Hum Mol Genet |
Title: |
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. |
Volume: |
6 |
Issue: |
9 |
Pages: |
1519-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerfen CR |
Year: |
2013 |
Journal: |
Neuron |
Title: |
GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits. |
Volume: |
80 |
Issue: |
6 |
Pages: |
1368-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|