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Search results 401 to 500 out of 580 for Mcc

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Hits by Strain

Type Details Score
GO Term
GO:0070941 | eisosome assembly
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Publication
36565697 | J:334121
First Author: de Carvalho RVH
Year: 2023
Journal: Cell
Title: Clonal replacement sustains long-lived germinal centers primed by respiratory viruses.
Volume: 186
Issue: 1
Pages: 131-146.e13
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Publication
38448581 | J:354843
First Author: Nakandakari-Higa S
Year: 2024
Journal: Nature
Title: Universal recording of immune cell interactions in vivo.
Volume: 627
Issue: 8003
Pages: 399-406
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Publication
36451809 | J:335150
 
First Author: Nakandakari-Higa S
Year: 2022
Journal: Front Immunol
Title: A minimally-edited mouse model for infection with multiple SARS-CoV-2 strains.
Volume: 13
Pages: 1007080
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Publication
34903646 | J:329520
 
First Author: Yamagata T
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: The hypothalamic link between arousal and sleep homeostasis in mice.
Volume: 118
Issue: 51
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Allele
Gt(ROSA)26Sor<tm1(MCPyV168)Jdec> | MGI:5576261
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, James A DeCaprio
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, No functional change
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Publication
25596282 | J:219802
First Author: Spurgeon ME
Year: 2015
Journal: Cancer Res
Title: Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice.
Volume: 75
Issue: 6
Pages: 1068-79
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Allele
Gt(ROSA)26Sor<tm1(CAG-MCPySTco)Cvp> | MGI:5911880
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Patrick Moore
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Publication
30877126 | J:274880
 
First Author: Lu H
Year: 2019
Journal: Development
Title: Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals.
Volume: 146
Issue: 6
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Protein
P60007
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
Q9D3A0
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Protein
G5E8M3
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
E9Q0Y1
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
A0A1W2P6Q9
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
A0A140T8L6
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
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Protein
H3BIU1
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
A0A1B0GRU6
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
Q66JW5
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Publication
21926987 | -
First Author: Mansfeld J
Year: 2011
Journal: Nat Cell Biol
Title: APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
Volume: 13
Issue: 10
Pages: 1234-43
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Publication
11726501 | -
First Author: Fraschini R
Year: 2001
Journal: EMBO J
Title: Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores.
Volume: 20
Issue: 23
Pages: 6648-59
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Publication
10436016 | -
First Author: Chen RH
Year: 1999
Journal: Mol Biol Cell
Title: The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.
Volume: 10
Issue: 8
Pages: 2607-18
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Protein Domain
IPR026182 | ANAPC15
Type: Family
Description: Human ANAPC15 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, it plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C; it is not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. It also required for degradation of CDC20 [].
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Protein Domain
IPR027097 | Mad2
Type: Family
Description: Mad2 is a central component of the spindle assembly checkpoint, which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis [, ]. In Saccharomyces cerevisiae, it is a component of the mitotic checkpoint complex (MCC) which consists of MAD2, MAD3, BUB3 and CDC20, and of the MAD2-CDC20 subcomplex, both of which appear to be assembled during mitoisis independently of the kinetochore. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 [, , ].
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Strain
MGI:5911883 | B6J.129P2-Gt(ROSA)26Sor<tm1(CAG-MCPySTco)Cvp>/Mmmh
Attribute String: congenic, mutant strain, targeted mutation
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Publication
26544690 | J:243752
First Author: Shuda M
Year: 2015
Journal: PLoS One
Title: Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model.
Volume: 10
Issue: 11
Pages: e0142329
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Publication
32133718 | J:290564
First Author: Roberson EC
Year: 2020
Journal: Dev Dyn
Title: A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain.
Volume: 249
Issue: 7
Pages: 898-905
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Protein
A0A1D5RLD3
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
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Publication
19555689 | -
First Author: Arnaud C
Year: 2009
Journal: FEBS Lett
Title: MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.
Volume: 583
Issue: 14
Pages: 2326-32
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Publication
18591935 | -
First Author: Fukuyama R
Year: 2008
Journal: Oncogene
Title: Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription.
Volume: 27
Issue: 46
Pages: 6044-55
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Protein Domain
IPR040171 | USBP1-like
Type: Family
Description: This entry includes Harmonin-binding protein USHBP1 also known as MCC2) and colorectal mutant cancer protein known as MCC. MCC has been found to suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells [, ]. It may works as a scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2 []. MCC1 inhibits DNA binding of b-catenin/TCF/LEF transcription factors, and it is involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation [, , ].MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumour suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75 [, ].
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Publication
28846109 | J:252675
First Author: Kwun HJ
Year: 2017
Journal: Oncogene
Title: Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting.
Volume: 36
Issue: 49
Pages: 6784-6792
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Publication
26947080 | J:234561
First Author: Marshall CB
Year: 2016
Journal: Cell Rep
Title: p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network.
Volume: 14
Issue: 10
Pages: 2289-300
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Publication
11181649 | J:67587
First Author: Baumgartner MR
Year: 2001
Journal: J Clin Invest
Title: The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency.
Volume: 107
Issue: 4
Pages: 495-504
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Publication
25598413 | J:219725
 
First Author: Takahashi C
Year: 2015
Journal: Nat Commun
Title: mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes.
Volume: 6
Pages: 6017
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Publication
23540693 | J:197248
First Author: Shukla R
Year: 2013
Journal: Cell
Title: Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.
Volume: 153
Issue: 1
Pages: 101-11
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Publication
27257214 | J:232849
First Author: Nemajerova A
Year: 2016
Journal: Genes Dev
Title: TAp73 is a central transcriptional regulator of airway multiciliogenesis.
Volume: 30
Issue: 11
Pages: 1300-12
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Publication
24424413 | J:207985
 
First Author: Lo WL
Year: 2014
Journal: Elife
Title: T cell immunodominance is dictated by the positively selecting self-peptide.
Volume: 3
Pages: e01457
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Publication
38316902 | J:348967
First Author: Shiratsuchi G
Year: 2024
Journal: EMBO Rep
Title: Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons.
Volume: 25
Issue: 3
Pages: 1176-1207
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Publication
26933123 | J:231675
First Author: Terré B
Year: 2016
Journal: EMBO J
Title: GEMC1 is a critical regulator of multiciliated cell differentiation.
Volume: 35
Issue: 9
Pages: 942-60
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Publication
25712475 | J:220709
First Author: Funk MC
Year: 2015
Journal: EMBO J
Title: Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.
Volume: 34
Issue: 8
Pages: 1078-89
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Publication
26565021 | J:230936
First Author: Goretsky T
Year: 2016
Journal: J Biol Chem
Title: A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer.
Volume: 291
Issue: 8
Pages: 4166-77
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Publication
31025935 | J:275103
   
First Author: Nanjundappa R
Year: 2019
Journal: Elife
Title: Regulation of cilia abundance in multiciliated cells.
Volume: 8
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Publication
27573463 | J:242663
First Author: Herawati E
Year: 2016
Journal: J Cell Biol
Title: Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton.
Volume: 214
Issue: 5
Pages: 571-86
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Publication
30560893 | J:268391
First Author: Hancock LA
Year: 2018
Journal: Nat Commun
Title: Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice.
Volume: 9
Issue: 1
Pages: 5363
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Publication
30405130 | J:269158
First Author: Revinski DR
Year: 2018
Journal: Nat Commun
Title: CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.
Volume: 9
Issue: 1
Pages: 4668
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Publication
28512245 | J:242571
First Author: Verhaegen ME
Year: 2017
Journal: Cancer Res
Title: Merkel Cell Polyomavirus Small T Antigen Initiates Merkel Cell Carcinoma-like Tumor Development in Mice.
Volume: 77
Issue: 12
Pages: 3151-3157
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Publication
36973273 | J:340981
First Author: Thoudam T
Year: 2023
Journal: Nat Commun
Title: Enhanced Ca(2+)-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease.
Volume: 14
Issue: 1
Pages: 1703
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Publication
37257637 | J:338212
     
First Author: Weber M
Year: 2023
Journal: J Invest Dermatol
Title: Merkel Cell Polyomavirus T Antigen-Mediated Reprogramming in Adult Merkel Cell Progenitors.
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Protein
Q8R370
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
G3UW40
Organism: Mus musculus/domesticus
Length: 828  
Fragment?: false
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Publication
15219944 | -
First Author: Hirai A
Year: 2004
Journal: Cancer Lett
Title: Expression of AIE-75 PDZ-domain protein induces G2/M cell cycle arrest in human colorectal adenocarcinoma SW480 cells.
Volume: 211
Issue: 2
Pages: 209-18
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Publication
8232541 | -
First Author: Li R
Year: 1993
Journal: Nature
Title: The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase.
Volume: 366
Issue: 6450
Pages: 82-4
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Publication
15879521 | -
First Author: Poddar A
Year: 2005
Journal: Eukaryot Cell
Title: Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae.
Volume: 4
Issue: 5
Pages: 867-78
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Publication
35322202 | J:327070
First Author: Li Q
Year: 2022
Journal: Cell Death Differ
Title: Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.
Volume: 29
Issue: 8
Pages: 1596-1610
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Publication
30665704 | J:277289
First Author: Bustamante-Marin XM
Year: 2019
Journal: Am J Hum Genet
Title: Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance.
Volume: 104
Issue: 2
Pages: 229-245
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Publication
8946200 | J:37497
First Author: Luongo C
Year: 1996
Journal: Genes Chromosomes Cancer
Title: Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse.
Volume: 17
Issue: 3
Pages: 194-8
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Publication
24291092 | J:252164
First Author: Tachibana-Konwalski K
Year: 2013
Journal: Curr Biol
Title: Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.
Volume: 23
Issue: 24
Pages: 2534-9
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Publication
35143422 | J:323007
 
First Author: Verhaegen ME
Year: 2022
Journal: J Clin Invest
Title: Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.
Volume: 132
Issue: 7
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Publication
23152617 | J:192454
First Author: Vandael DH
Year: 2012
Journal: J Neurosci
Title: Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells.
Volume: 32
Issue: 46
Pages: 16345-59
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Publication
25083992 | J:215765
First Author: Mizumura K
Year: 2014
Journal: J Clin Invest
Title: Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.
Volume: 124
Issue: 9
Pages: 3987-4003
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Publication
24200693 | J:207774
First Author: Lam HC
Year: 2013
Journal: J Clin Invest
Title: Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
Volume: 123
Issue: 12
Pages: 5212-30
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Publication
32814712 | J:345125
 
First Author: Vega G
Year: 2020
Journal: JCI Insight
Title: Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.
Volume: 5
Issue: 16
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Publication
27435107 | J:345147
First Author: Livraghi-Butrico A
Year: 2017
Journal: Mucosal Immunol
Title: Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.
Volume: 10
Issue: 2
Pages: 395-407
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Publication
34166809 | J:354900
First Author: He Y
Year: 2021
Journal: Osteoarthritis Cartilage
Title: Cell depleted areas do not repopulate after diphtheria toxin-induced killing of mandibular cartilage chondrocytes.
Volume: 29
Issue: 10
Pages: 1474-1484
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Publication
28607469 | J:275212
First Author: O' Brien MH
Year: 2017
Journal: Sci Rep
Title: PTH [1-34] induced differentiation and mineralization of mandibular condylar cartilage.
Volume: 7
Issue: 1
Pages: 3226
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Publication
27472059 | J:249684
First Author: Kaul R
Year: 2016
Journal: PLoS One
Title: The Effect of Altered Loading on Mandibular Condylar Cartilage.
Volume: 11
Issue: 7
Pages: e0160121
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Publication
37847709 | J:342458
     
First Author: Donoghue LJ
Year: 2023
Journal: Am J Physiol Lung Cell Mol Physiol
Title: BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.
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Publication
26968767 | J:235488
First Author: Grubb BR
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin.
Volume: 310
Issue: 9
Pages: L860-7
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Publication
30587058 | J:288121
First Author: Ding X
Year: 2019
Journal: J Am Heart Assoc
Title: Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Deficiency in Vascular Smooth Muscle Cells Prevents Arteriovenous Fistula Failure Despite Chronic Kidney Disease.
Volume: 8
Issue: 1
Pages: e011211
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Publication
33094908 | J:335165
First Author: Fujita H
Year: 2020
Journal: Aging Cell
Title: Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.
Volume: 19
Issue: 11
Pages: e13251
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Publication
11535616 | J:320291
First Author: Sudakin V
Year: 2001
Journal: J Cell Biol
Title: Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.
Volume: 154
Issue: 5
Pages: 925-36
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Publication
8055644 | J:19777
First Author: Davis LM
Year: 1994
Journal: Carcinogenesis
Title: Loss of heterozygosity in spontaneous and chemically induced tumors of the B6C3F1 mouse.
Volume: 15
Issue: 8
Pages: 1637-45
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Publication
21167473 | J:173589
First Author: Serrano MJ
Year: 2011
Journal: Arch Oral Biol
Title: Cell fate mediators Notch and Twist in mouse mandibular condylar cartilage.
Volume: 56
Issue: 6
Pages: 607-13
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Publication
25313532 | J:220621
First Author: Verhaegen ME
Year: 2015
Journal: J Invest Dermatol
Title: Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice.
Volume: 135
Issue: 5
Pages: 1415-1424
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Publication
27880818 | J:247365
First Author: Berrios C
Year: 2016
Journal: PLoS Pathog
Title: Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.
Volume: 12
Issue: 11
Pages: e1006020
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Publication
29321666 | J:261039
First Author: Sunshine JC
Year: 2018
Journal: Oncogene
Title: Are there multiple cells of origin of Merkel cell carcinoma?
Volume: 37
Issue: 11
Pages: 1409-1416
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Publication
33483524 | J:300454
First Author: Brenner L
Year: 2021
Journal: Sci Rep
Title: Functional disruption of cortical cingulate activity attenuates visceral hypersensitivity and anxiety induced by acute experimental colitis.
Volume: 11
Issue: 1
Pages: 2103
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Publication
33564066 | J:303957
First Author: Guo Z
Year: 2021
Journal: Oncogene
Title: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3.
Volume: 40
Issue: 10
Pages: 1821-1835
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Publication
35560034 | J:325278
First Author: Spurgeon ME
Year: 2022
Journal: PLoS Pathog
Title: Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.
Volume: 18
Issue: 5
Pages: e1010551
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Publication
36672392 | J:332805
 
First Author: Houben R
Year: 2023
Journal: Cancers (Basel)
Title: Merkel Cell Polyomavirus: Infection, Genome, Transcripts and Its Role in Development of Merkel Cell Carcinoma.
Volume: 15
Issue: 2
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Protein Coding Gene
MGI:3648807 | Mcidas
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0018899 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020869 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020683 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3648807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020645 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020768 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020752 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020844 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020780 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021366 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019956 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015970 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019778 | -
Type: protein_coding_gene
Organism: Mus spretus
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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