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Search results 501 to 584 out of 584 for Adm

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Type Details Score
Publication
35532553 | J:332040
 
First Author: Han J
Year: 2022
Journal: J Exp Med
Title: Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity.
Volume: 219
Issue: 6
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Publication
23918941 | J:201628
First Author: Liou GY
Year: 2013
Journal: J Cell Biol
Title: Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs.
Volume: 202
Issue: 3
Pages: 563-77
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Publication
37844756 | J:341958
 
First Author: Jing T
Year: 2023
Journal: Cancer Lett
Title: POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target.
Volume: 577
Pages: 216444
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Allele
Hnf1b<tm2Ics> | MGI:6716050
Name: HNF1 homeobox B; targeted mutation 2, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Cxadr<tm1.1Ics> | MGI:5086256
Name: coxsackie virus and adenovirus receptor; targeted mutation 1.1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tg(Mt1-TGFBR2*)AM3Epb | MGI:5806465
Name: transgene insertion AM3, Erwin P Bottinger
Allele Type: Transgenic
Attribute String: Dominant negative, Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Kras/Kras<+> Pten/Pten Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ptf1a/Ptf1a<+>
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Smad4/Smad4 Ptf1a/Ptf1a<+> Tg(MtTGFA)Lmb/?
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cpa1/Cpa1
Background: involves: C57BL/6NCrl * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Publication
14615490 | J:306342
First Author: Roh J
Year: 2004
Journal: J Biol Chem
Title: Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes.
Volume: 279
Issue: 8
Pages: 7264-74
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Publication
22359542 | J:185224
First Author: Scotti ML
Year: 2012
Journal: PLoS One
Title: Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia.
Volume: 7
Issue: 2
Pages: e30509
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Publication
23284900 | J:195622
First Author: Avila JL
Year: 2012
Journal: PLoS One
Title: Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma.
Volume: 7
Issue: 12
Pages: e52133
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Publication
32554750 | J:296297
First Author: Zhao Y
Year: 2020
Journal: Cancer Res
Title: Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A.
Volume: 80
Issue: 16
Pages: 3359-3371
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Publication
28461470 | J:242214
First Author: Shen J
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.
Volume: 114
Issue: 20
Pages: E4020-E4029
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Publication
34249932 | J:308024
 
First Author: Urrutia G
Year: 2021
Journal: Front Cell Dev Biol
Title: Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks.
Volume: 9
Pages: 681153
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Publication
30058725 | J:267566
First Author: Saponara E
Year: 2018
Journal: J Pathol
Title: Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas.
Volume: 246
Issue: 3
Pages: 352-365
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Publication
20807812 | J:164210
First Author: Hill R
Year: 2010
Journal: Cancer Res
Title: PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
Volume: 70
Issue: 18
Pages: 7114-24
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Publication
24788257 | J:216102
First Author: Morris JP 4th
Year: 2014
Journal: PLoS One
Title: Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.
Volume: 9
Issue: 5
Pages: e95486
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Publication
30705405 | J:278756
First Author: Nishikawa Y
Year: 2019
Journal: Oncogene
Title: Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis.
Volume: 38
Issue: 22
Pages: 4283-4296
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Publication
32571902 | J:299302
 
First Author: Bangs FK
Year: 2020
Journal: Dis Model Mech
Title: Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.
Volume: 13
Issue: 7
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Publication
21860420 | J:186145
First Author: Caldwell ME
Year: 2012
Journal: Oncogene
Title: Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer.
Volume: 31
Issue: 12
Pages: 1599-608
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Publication
30626590 | J:273222
First Author: Carrer A
Year: 2019
Journal: Cancer Discov
Title: Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.
Volume: 9
Issue: 3
Pages: 416-435
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Publication
21684285 | J:275200
First Author: Heid I
Year: 2011
Journal: Gastroenterology
Title: Early requirement of Rac1 in a mouse model of pancreatic cancer.
Volume: 141
Issue: 2
Pages: 719-30, 730.e1-7
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Publication
32251323 | J:298940
First Author: Meyers N
Year: 2020
Journal: Sci Rep
Title: Differential impact of the ERBB receptors EGFR and ERBB2 on the initiation of precursor lesions of pancreatic ductal adenocarcinoma.
Volume: 10
Issue: 1
Pages: 5241
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Publication
23891977 | J:310917
First Author: Greer RL
Year: 2013
Journal: Gastroenterology
Title: Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.
Volume: 145
Issue: 5
Pages: 1088-1097.e8
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Publication
24909166 | J:221266
First Author: Kumar S
Year: 2015
Journal: Oncogene
Title: Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages.
Volume: 34
Issue: 16
Pages: 2052-60
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Publication
33864001 | J:305481
First Author: Azizi N
Year: 2021
Journal: Oncogene
Title: Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer.
Volume: 40
Issue: 17
Pages: 3118-3135
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Publication
30590101 | J:270061
 
First Author: Kibe S
Year: 2019
Journal: Cancer Lett
Title: Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion.
Volume: 444
Pages: 70-81
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Publication
27639167 | J:238001
First Author: Hidalgo-Sastre A
Year: 2016
Journal: Am J Pathol
Title: Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model.
Volume: 186
Issue: 11
Pages: 2934-2944
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Publication
21984419 | J:183335
First Author: Aichler M
Year: 2012
Journal: J Pathol
Title: Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.
Volume: 226
Issue: 5
Pages: 723-34
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Publication
26716510 | J:306215
First Author: Benitz S
Year: 2016
Journal: Oncotarget
Title: Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.
Volume: 7
Issue: 10
Pages: 11424-33
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Publication
29532564 | J:263063
First Author: Das KK
Year: 2018
Journal: Dev Dyn
Title: ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis.
Volume: 247
Issue: 6
Pages: 854-866
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Publication
26510396 | J:241115
First Author: Grabliauskaite K
Year: 2016
Journal: J Pathol
Title: Inactivation of TGFβ receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis.
Volume: 238
Issue: 3
Pages: 434-45
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Publication
23370328 | J:196877
First Author: Wauters E
Year: 2013
Journal: Cancer Res
Title: Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer.
Volume: 73
Issue: 7
Pages: 2357-67
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Publication
28322199 | J:242032
First Author: Imai A
Year: 2017
Journal: Am J Pathol
Title: Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.
Volume: 187
Issue: 5
Pages: 999-1015
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Publication
28639695 | J:246658
First Author: Ding L
Year: 2017
Journal: J Pathol
Title: Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.
Volume: 243
Issue: 1
Pages: 65-77
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Publication
33521935 | J:307061
First Author: Hidalgo-Sastre A
Year: 2021
Journal: Eur J Immunol
Title: Toll-like receptor 3 expression in myeloid cells is essential for efficient regeneration after acute pancreatitis in mice.
Volume: 51
Issue: 5
Pages: 1182-1194
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Publication
10661503 | J:59145
First Author: Zhang ZJ
Year: 2000
Journal: Brain Res
Title: Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice.
Volume: 852
Issue: 1
Pages: 116-26
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Publication
22993405 | J:192883
First Author: Portal-Nuñez S
Year: 2012
Journal: Cancer Res
Title: Aryl hydrocarbon receptor-induced adrenomedullin mediates cigarette smoke carcinogenicity in humans and mice.
Volume: 72
Issue: 22
Pages: 5790-800
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Publication
8609068 | J:31979
First Author: Watanabe T
Year: 1996
Journal: Jpn J Cancer Res
Title: Modulation of multidrug resistance by SDZ PSC 833 in leukemic and solid-tumor-bearing mouse models.
Volume: 87
Issue: 2
Pages: 184-93
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Publication
9757038 | J:50667
First Author: Nakamura Y
Year: 1998
Journal: Brain Res
Title: Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs.
Volume: 807
Issue: 1-2
Pages: 203-7
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Publication
27659014 | J:316250
First Author: Pitarresi JR
Year: 2016
Journal: Neoplasia
Title: Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.
Volume: 18
Issue: 9
Pages: 541-52
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Publication
25450522 | J:251058
First Author: Tausendschön M
Year: 2015
Journal: Biochim Biophys Acta
Title: Genome-wide identification of hypoxia-inducible factor-1 and -2 binding sites in hypoxic human macrophages alternatively activated by IL-10.
Volume: 1849
Issue: 1
Pages: 10-22
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Publication
38001687 | J:343062
 
First Author: Alavi M
Year: 2023
Journal: Cancers (Basel)
Title: Krüppel-like Factor 5 Plays an Important Role in the Pathogenesis of Chronic Pancreatitis.
Volume: 15
Issue: 22
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Publication
31469589 | J:299170
First Author: Nasyrov E
Year: 2019
Journal: FASEB J
Title: The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain.
Volume: 33
Issue: 11
Pages: 12812-12824
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Publication
34311032 | J:309423
 
First Author: Yan HH
Year: 2021
Journal: Cancer Lett
Title: ANGPTL4 accelerates KRASG12D-Induced acinar to ductal metaplasia and pancreatic carcinogenesis.
Volume: 519
Pages: 185-198
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Publication
32116793 | J:308774
 
First Author: DelGiorno KE
Year: 2020
Journal: Front Physiol
Title: Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis.
Volume: 11
Pages: 88
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Publication
34547282 | J:316409
First Author: Ge W
Year: 2022
Journal: Gastroenterology
Title: miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis.
Volume: 162
Issue: 1
Pages: 269-284
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Publication
35574446 | J:324549
 
First Author: Caplan LR
Year: 2022
Journal: Front Physiol
Title: Enteroendocrine Cell Formation Is an Early Event in Pancreatic Tumorigenesis.
Volume: 13
Pages: 865452
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Publication
35472437 | J:324679
 
First Author: He R
Year: 2022
Journal: Cancer Lett
Title: SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
Volume: 538
Pages: 215693
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Publication
36848578 | J:340317
First Author: Mello SS
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Multifaceted role for p53 in pancreatic cancer suppression.
Volume: 120
Issue: 10
Pages: e2211937120
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Publication
37643018 | J:342140
 
First Author: Bhalerao N
Year: 2023
Journal: JCI Insight
Title: ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.
Volume: 8
Issue: 19
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Protein Coding Gene
MGI:88478 | Cpa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Transgene
MGI:5806464 | Tg(Mt1-TGFBR2*)AM3Epb
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Cxadr/Cxadr Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Mt1-TGFBR2*)AM3Epb/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Publication
24889936 | J:214851
First Author: Martínez-Bosch N
Year: 2014
Journal: J Pathol
Title: Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer.
Volume: 234
Issue: 2
Pages: 214-27
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Publication
31877165 | J:283370
First Author: Park D
Year: 2019
Journal: PLoS One
Title: Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.
Volume: 14
Issue: 12
Pages: e0226714
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Publication
34303658 | J:312408
First Author: Zhang Z
Year: 2021
Journal: Gastroenterology
Title: AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.
Volume: 161
Issue: 5
Pages: 1601-1614.e23
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Publication
33388318 | J:314686
First Author: Zhao Y
Year: 2021
Journal: Gastroenterology
Title: mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote KrasG12D-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis.
Volume: 160
Issue: 5
Pages: 1755-1770.e17
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Publication
22665051 | J:197233
First Author: Shi G
Year: 2013
Journal: Oncogene
Title: Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.
Volume: 32
Issue: 15
Pages: 1950-8
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Publication
29367759 | J:261029
First Author: Fendrich V
Year: 2018
Journal: Oncogene
Title: Genetic and pharmacologic abrogation of Snail1 inhibits acinar-to-ductal metaplasia in precursor lesions of pancreatic ductal adenocarcinoma and pancreatic injury.
Volume: 37
Issue: 14
Pages: 1845-1856
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Publication
27215660 | J:236047
First Author: Gruber R
Year: 2016
Journal: Gastroenterology
Title: YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling.
Volume: 151
Issue: 3
Pages: 526-39
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Publication
31330317 | J:293294
First Author: Gao C
Year: 2019
Journal: Cell Mol Gastroenterol Hepatol
Title: PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654.
Volume: 8
Issue: 4
Pages: 561-578
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Publication
26717480 | J:231290
First Author: Karki A
Year: 2015
Journal: PLoS One
Title: Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis.
Volume: 10
Issue: 12
Pages: e0145724
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Publication
31367007 | J:278847
First Author: Sutaria DS
Year: 2019
Journal: Sci Rep
Title: Knockout of Acinar Enriched microRNAs in Mice Promote Duct Formation But Not Pancreatic Cancer.
Volume: 9
Issue: 1
Pages: 11147
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Publication
25212177 | J:218059
First Author: Grabliauskaite K
Year: 2015
Journal: J Pathol
Title: p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis.
Volume: 235
Issue: 3
Pages: 502-14
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Publication
31531867 | J:293787
First Author: Chen R
Year: 2020
Journal: J Pathol
Title: Akt1 signalling supports acinar proliferation and limits acinar-to-ductal metaplasia formation upon induction of acute pancreatitis.
Volume: 250
Issue: 1
Pages: 42-54
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Publication
12230553 | J:79155
First Author: Choi IY
Year: 2002
Journal: Eur J Biochem
Title: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism.
Volume: 269
Issue: 18
Pages: 4418-26
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Publication
9490198 | J:45966
First Author: Ehrke MJ
Year: 1998
Journal: Cancer Immunol Immunother
Title: Doxorubicin plus tumor necrosis factor alpha combination treatments in EL4-lymphoma-bearing C57BL/6 mice.
Volume: 45
Issue: 6
Pages: 287-98
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Publication
34695382 | J:318689
First Author: Ma Z
Year: 2022
Journal: Gastroenterology
Title: Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury.
Volume: 162
Issue: 2
Pages: 604-620.e20
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Publication
36180487 | J:329446
First Author: Nimmakayala RK
Year: 2022
Journal: Cell Death Dis
Title: PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer.
Volume: 13
Issue: 10
Pages: 839
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Genotype
Genotype
Symbol: Onecut1/Onecut1 Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hnf1b/Hnf1b<+>
Background: involves: 129 * C57BL/6N
Zygosity: ht
Has Mutant Allele: true
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Publication
29248441 | J:309349
First Author: He P
Year: 2018
Journal: Gastroenterology
Title: Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice.
Volume: 154
Issue: 5
Pages: 1494-1508.e13
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Allele
Onecut1<tm1.1Mga> | MGI:3526029
Name: one cut domain, family member 1; targeted mutation 1.1, Maureen A Gannon
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Protein Coding Gene
MGI:1196423 | Onecut1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98505 | Hnf1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1201679 | Cxadr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1206581 | Pik3ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Kras<tm4Tyj> | MGI:2429948
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout
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Protein Coding Gene
MGI:96680 | Kras
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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