| Type |
Details |
Score |
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13456A3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13616H7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13622C1, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13624A9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13579E10, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13609B4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13684G1, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13836C3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13804D3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13902E7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST13903F9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14108G8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14117A3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14168E12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14202A12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14151C5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14305A2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14436B3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14425B11, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14568B11, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14522D5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14613D9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14649C4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14651C2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14850G3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST14801D2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST15061E7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST15077C6, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST15057H8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST15088A9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ENAH actin regulator; gene trap IST15097E9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Enah/Enah |
| Background: |
involves: 129S4/SvJaeSor |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Enah/Enah Vasp/Vasp |
| Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Enah/Enah<+> |
| Background: |
involves: 129S4/SvJaeSor |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the N terminus of actin-like protein 7A. This domain interacts and forms a heterodimer with TES, a putative human tumor suppressor. This heterodimer then interacts with ENAH to form a heterotrimer []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Actin-like protein 7A belongs to the actin family. Its function is not clear. Its N terminus interacts and forms a heterodimer with TES, a putative human tumor suppressor. This heterodimer then interacts with ENAH to form a heterotrimer []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boëda B |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. |
| Volume: |
286 |
| Issue: |
13 |
| Pages: |
11543-54 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Enah/Enah Pfn1/Pfn1<+> |
| Background: |
involves: 129S4/SvJae |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Enah/Enah Evl/Evl Vasp/Vasp |
| Background: |
involves: 129 * BALB/c * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Enah/Enah Evl/Evl Vasp/Vasp |
| Background: |
involves: 129 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
ESRP2 has been identified as an epithelial cell type-specific regulator of fibroblast growth factor receptor 2 (FGFR2) splicing []. It is required for expression of epithelial FGFR2-IIIb and the regulation of CD44, CTNND1 (also termed p120-Catenin) and ENAH (also termed hMena) splicing. It enhances epithelial-specific exons of CD44 and ENAH, silences mesenchymal exons of CTNND1, or both within FGFR2 []. ESRP2 contains three RNA recognition motifs (RRMs). |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Enah/Enah<+> Evl/Evl Vasp/Vasp |
| Background: |
involves: 129 * BALB/c * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Warzecha CC |
| Year: |
2009 |
| Journal: |
Mol Cell |
| Title: |
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. |
| Volume: |
33 |
| Issue: |
5 |
| Pages: |
591-601 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Warzecha CC |
| Year: |
2009 |
| Journal: |
RNA Biol |
| Title: |
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. |
| Volume: |
6 |
| Issue: |
5 |
| Pages: |
546-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Leontieva OV |
| Year: |
2009 |
| Journal: |
Cell Cycle |
| Title: |
RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer. |
| Volume: |
8 |
| Issue: |
3 |
| Pages: |
490-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fagoonee S |
| Year: |
2017 |
| Journal: |
Oncotarget |
| Title: |
The RNA-binding protein ESRP1 promotes human colorectal cancer progression. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
10007-10024 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the RNA recognition motif 1 (RRM1) of epithelial splicing regulatory protein 1 (ESRP1). ESRP1 has been identified as an epithelial cell type-specific regulator of fibroblast growth factor receptor 2 (FGFR2) splicing []. It is required for expression of epithelial FGFR2-IIIb and the regulation of CD44, CTNND1 (p120-Catenin) and ENAH (hMena) splicing. It enhances epithelial-specific exons of CD44 and ENAH, silences mesenchymal exons of CTNND1, or both within FGFR2 []. ESRP1 has been shown to function as a tumour suppressor in colon cancer cells, due to its ability to bind to the 5' UTR of several cancer-related genes and regulate their translation []. However, high ESRP1 expression has been linked to colorectal cancer progression []. ESRP1 contains three RNA recognition motifs (RRMs). |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
440
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
512
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
680
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
717
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
592
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
659
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
681
 |
| Fragment?: |
false |
|
•
•
•
•
•
|