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Search results 601 to 679 out of 679 for Pkd2

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Type Details Score
Publication
16377259 | J:105949
First Author: Oster H
Year: 2006
Journal: Gene Expr Patterns
Title: Expression of the protein kinase D (PKD) family during mouse embryogenesis.
Volume: 6
Issue: 4
Pages: 400-8
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Publication
31515477 | J:279347
First Author: Lee EC
Year: 2019
Journal: Nat Commun
Title: Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease.
Volume: 10
Issue: 1
Pages: 4148
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Protein Domain
IPR003915 | PKD_2
Type: Family
Description: Polycystic kidney diseases (PKD) are disorders characterised by large numbers of cysts distributed throughout grossly-enlarged kidneys. Cystdevelopment is associated with impairment of kidney function, and ultimately kidney failure and death [, ]. Most cases of autosomal dominant PKD result from mutations in the PKD1 gene that cause premature protein termination. A second gene for autosomal dominant polycystic kidney disease has been identified by positional cloning []. The predicted 968-amino acid sequence of the PKD2 gene product (polycystin-2) contains 6 transmembrane domains, with intracellular N- and C-termini. Polycystin-2 shares some similarity with the family of voltage-activated calcium (and sodium) channels, and contains a potential calcium-binding domain [].Polycystin-2 is strongly expressed in ovary, foetal and adult kidney, testis, and small intestine. Polycystin-1 requires the presence of this protein for stable expression and is believed to interact with it via its C terminus. All mutations between exons 1 and 11 result in a truncated polycystin-2 that lacks a calcium-binding EF-hand domain and the cytoplasmic domains required for the interaction of polycystin-2 with polycystin-1 []. PKD2, although clinically milder than PKD1, has a deleterious impact on life expectancy.
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Protein
Q2EG98
Organism: Mus musculus/domesticus
Length: 2201  
Fragment?: false
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Protein
Q9Z0T6
Organism: Mus musculus/domesticus
Length: 2126  
Fragment?: false
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Protein
F8VQF3
Organism: Mus musculus/domesticus
Length: 2126  
Fragment?: false
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Protein
A2A258
Organism: Mus musculus/domesticus
Length: 2151  
Fragment?: false
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Publication
17226786 | J:180465
First Author: Sinnett-Smith J
Year: 2007
Journal: J Cell Physiol
Title: Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos accumulation and DNA synthesis induced by bombesin in Swiss 3T3 cells.
Volume: 211
Issue: 3
Pages: 781-90
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Publication
20819079 | J:166867
First Author: Matthews SA
Year: 2010
Journal: Biochem J
Title: Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells.
Volume: 432
Issue: 1
Pages: 153-63
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Publication
20856870 | J:165121
First Author: Wodarczyk C
Year: 2010
Journal: PLoS One
Title: Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals.
Volume: 5
Issue: 9
Pages: e12719
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Publication
18286309 | J:186064
First Author: Williams SS
Year: 2008
Journal: Pediatr Nephrol
Title: Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease.
Volume: 23
Issue: 5
Pages: 733-41
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Publication
24336289 | J:207900
First Author: DeCaen PG
Year: 2013
Journal: Nature
Title: Direct recording and molecular identification of the calcium channel of primary cilia.
Volume: 504
Issue: 7479
Pages: 315-8
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Publication
36466811 | J:331990
 
First Author: Koutník J
Year: 2022
Journal: Front Immunol
Title: T cell-intrinsic protein kinase D3 is dispensable for the cells' activation.
Volume: 13
Pages: 1049033
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Publication
12874458 | J:131887
First Author: Gallagher AR
Year: 2003
Journal: J Am Soc Nephrol
Title: Use of the tetracycline system for inducible protein synthesis in the kidney.
Volume: 14
Issue: 8
Pages: 2042-51
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Publication
35046933 | J:318764
 
First Author: Michaud D
Year: 2021
Journal: Front Immunol
Title: B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory B Cell Function in Pancreatic Cancer.
Volume: 12
Pages: 745873
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Publication
15029248 | J:131271
First Author: Gresh L
Year: 2004
Journal: EMBO J
Title: A transcriptional network in polycystic kidney disease.
Volume: 23
Issue: 7
Pages: 1657-68
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Publication
27020852 | J:293509
First Author: Leonhard WN
Year: 2016
Journal: J Am Soc Nephrol
Title: Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.
Volume: 27
Issue: 12
Pages: 3589-3599
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Publication
21736870 | J:176476
First Author: Bhavanasi D
Year: 2011
Journal: Biochem Pharmacol
Title: Protein kinase Cδ mediates the activation of protein kinase D2 in platelets.
Volume: 82
Issue: 7
Pages: 720-7
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Publication
22233340 | J:260655
First Author: Navarro MN
Year: 2012
Journal: Biochem J
Title: Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells.
Volume: 442
Issue: 3
Pages: 649-59
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Publication
26292219 | J:340233
First Author: Hajarnis SS
Year: 2015
Journal: J Biol Chem
Title: Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA.
Volume: 290
Issue: 41
Pages: 24793-805
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Publication
29891559 | J:272574
First Author: Cai J
Year: 2018
Journal: Genes Dev
Title: A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease.
Volume: 32
Issue: 11-12
Pages: 781-793
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Publication
20856231 | J:167185
First Author: Hassane S
Year: 2011
Journal: Lab Invest
Title: Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension.
Volume: 91
Issue: 1
Pages: 24-32
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Publication
36503993 | J:338389
First Author: Belyea BC
Year: 2023
Journal: Clin Sci (Lond)
Title: Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype.
Volume: 137
Issue: 1
Pages: 35-45
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Publication
24492625 | J:229519
First Author: Atik N
Year: 2014
Journal: Cell Struct Funct
Title: The role of PKD in cell polarity, biosynthetic pathways, and organelle/F-actin distribution.
Volume: 39
Issue: 1
Pages: 61-77
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Publication
34531379 | J:312432
First Author: Maerker M
Year: 2021
Journal: Nat Commun
Title: Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5.
Volume: 12
Issue: 1
Pages: 5482
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Publication
19966229 | J:155816
First Author: Cao Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models.
Volume: 106
Issue: 51
Pages: 21819-24
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Publication
28604386 | J:243943
First Author: Li LX
Year: 2017
Journal: J Clin Invest
Title: Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.
Volume: 127
Issue: 7
Pages: 2751-2764
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Publication
29931260 | J:266901
First Author: Parnell SC
Year: 2018
Journal: Hum Mol Genet
Title: A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.
Volume: 27
Issue: 19
Pages: 3313-3324
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Publication
21345977 | J:280014
First Author: Leonhard WN
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.
Volume: 300
Issue: 5
Pages: F1193-202
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Publication
16474191 | J:112771
First Author: Shiba D
Year: 2005
Journal: Cell Struct Funct
Title: Primary cilia of inv/inv mouse renal epithelial cells sense physiological fluid flow: bending of primary cilia and Ca2+ influx.
Volume: 30
Issue: 2
Pages: 93-100
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Publication
23778143 | J:201423
First Author: Zhou X
Year: 2013
Journal: J Clin Invest
Title: Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease.
Volume: 123
Issue: 7
Pages: 3084-98
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Publication
37730136 | J:341240
 
First Author: Connelly JA
Year: 2023
Journal: Neurobiol Dis
Title: Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke.
Volume: 187
Pages: 106305
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Publication
21527521 | J:174903
First Author: Konopatskaya O
Year: 2011
Journal: Blood
Title: Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.
Volume: 118
Issue: 2
Pages: 416-24
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Publication
25336615 | J:260008
First Author: Navarro MN
Year: 2014
Journal: Sci Signal
Title: Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8⁺ T cells.
Volume: 7
Issue: 348
Pages: ra99
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Publication
34962918 | J:347378
First Author: Smith AO
Year: 2021
Journal: PLoS Genet
Title: c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.
Volume: 17
Issue: 12
Pages: e1009711
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Publication
22725947 | J:317543
First Author: Stayner C
Year: 2012
Journal: Nephrology (Carlton)
Title: Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1-/- mutant mouse embryos: an investigation of the feasibility of renal cyst prevention in the foetus.
Volume: 17
Issue: 8
Pages: 739-47
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Publication
24789909 | J:212928
First Author: Mesner LD
Year: 2014
Journal: J Clin Invest
Title: Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
Volume: 124
Issue: 6
Pages: 2736-49
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Publication
23439951 | J:198147
First Author: Kurbegovic A
Year: 2013
Journal: Hum Mol Genet
Title: Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain.
Volume: 22
Issue: 12
Pages: 2361-75
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Publication
21900881 | J:196564
First Author: Fan LX
Year: 2012
Journal: Kidney Int
Title: Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.
Volume: 81
Issue: 1
Pages: 76-85
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Publication
28993480 | J:257362
     
First Author: Ishimoto Y
Year: 2017
Journal: Mol Cell Biol
Title: Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease.
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Publication
17656674 | J:134890
First Author: Hassane S
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model.
Volume: 27
Issue: 10
Pages: 2177-83
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Publication
32185407 | J:322927
First Author: Cabrita I
Year: 2020
Journal: J Mol Med (Berl)
Title: TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells.
Volume: 98
Issue: 5
Pages: 659-671
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Publication
33705824 | J:324272
First Author: Arroyo J
Year: 2021
Journal: Kidney Int
Title: The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1RC/RC mouse model of autosomal dominant polycystic kidney disease.
Volume: 99
Issue: 6
Pages: 1392-1407
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Publication
25474361 | J:225683
First Author: Smithline ZB
Year: 2014
Journal: PLoS One
Title: Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.
Volume: 9
Issue: 12
Pages: e114403
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Publication
23858461 | J:198775
First Author: Seeger-Nukpezah T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.
Volume: 110
Issue: 31
Pages: 12786-91
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Publication
12095915 | J:77927
First Author: Muto S
Year: 2002
Journal: Hum Mol Genet
Title: Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.
Volume: 11
Issue: 15
Pages: 1731-42
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Publication
24595031 | J:214699
First Author: Dang Y
Year: 2014
Journal: PLoS One
Title: Gpr48 deficiency induces polycystic kidney lesions and renal fibrosis in mice by activating Wnt signal pathway.
Volume: 9
Issue: 3
Pages: e89835
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Publication
19812035 | J:314377
First Author: Miyagi K
Year: 2009
Journal: J Biol Chem
Title: A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7.
Volume: 284
Issue: 49
Pages: 34400-12
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Publication
18439271 | J:136668
 
First Author: Ellwanger K
Year: 2008
Journal: BMC Dev Biol
Title: Expression patterns of protein kinase D 3 during mouse development.
Volume: 8
Pages: 47
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Publication
18753385 | J:138787
First Author: Yin DM
Year: 2008
Journal: J Neurosci
Title: Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.
Volume: 28
Issue: 35
Pages: 8832-43
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Publication
19028687 | J:146944
First Author: Chen LA
Year: 2009
Journal: J Biol Chem
Title: PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion.
Volume: 284
Issue: 4
Pages: 2459-71
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Publication
19244406 | J:149856
First Author: Tsiokas L
Year: 2009
Journal: Am J Physiol Renal Physiol
Title: Function and regulation of TRPP2 at the plasma membrane.
Volume: 297
Issue: 1
Pages: F1-9
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Publication
31492751 | J:283073
First Author: Wang Y
Year: 2019
Journal: J Biol Chem
Title: Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β.
Volume: 294
Issue: 43
Pages: 15759-15767
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Publication
24928905 | J:216242
First Author: Aicart-Ramos C
Year: 2014
Journal: J Cell Sci
Title: Protein kinase D activity controls endothelial nitric oxide synthesis.
Volume: 127
Issue: Pt 15
Pages: 3360-72
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Publication
24925129 | J:217953
First Author: Jin X
Year: 2014
Journal: Biochim Biophys Acta
Title: L-type calcium channel modulates cystic kidney phenotype.
Volume: 1842
Issue: 9
Pages: 1518-26
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Publication
25802335 | J:222160
First Author: Ryvkin V
Year: 2015
Journal: J Biol Chem
Title: Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.
Volume: 290
Issue: 17
Pages: 11199-208
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Publication
26148697 | J:254419
 
First Author: Müller M
Year: 2015
Journal: Sci Rep
Title: A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells.
Volume: 5
Pages: 11742
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Publication
31441214 | J:282579
First Author: Wang Z
Year: 2019
Journal: EMBO Rep
Title: The ion channel function of polycystin-1 in the polycystin-1/polycystin-2 complex.
Volume: 20
Issue: 11
Pages: e48336
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Publication
26374610 | J:291004
First Author: Ye H
Year: 2016
Journal: J Am Soc Nephrol
Title: Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies.
Volume: 27
Issue: 5
Pages: 1312-20
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Publication
32747433 | J:297086
 
First Author: Zhu Z
Year: 2020
Journal: Development
Title: Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.
Volume: 147
Issue: 16
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Publication
34315885 | J:322289
First Author: Ding H
Year: 2021
Journal: Nat Commun
Title: Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease.
Volume: 12
Issue: 1
Pages: 4548
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Publication
27278932 | J:319202
First Author: de Stephanis L
Year: 2017
Journal: Clin Exp Nephrol
Title: Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.
Volume: 21
Issue: 2
Pages: 203-211
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Publication
34486178 | J:331199
First Author: Yao Q
Year: 2021
Journal: FASEB J
Title: Polycystin-1 dependent regulation of polycystin-2 via GRP94, a member of HSP90 family that resides in the endoplasmic reticulum.
Volume: 35
Issue: 10
Pages: e21865
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Publication
36457161 | J:333096
 
First Author: Li Z
Year: 2023
Journal: Dis Model Mech
Title: A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models.
Volume: 16
Issue: 1
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Publication
34635846 | J:342659
First Author: Dong K
Year: 2021
Journal: Nat Genet
Title: Renal plasticity revealed through reversal of polycystic kidney disease in mice.
Volume: 53
Issue: 12
Pages: 1649-1663
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Publication
31773180 | J:293614
First Author: Formica C
Year: 2019
Journal: J Mol Med (Berl)
Title: Characterisation of transcription factor profiles in polycystic kidney disease (PKD): identification and validation of STAT3 and RUNX1 in the injury/repair response and PKD progression.
Volume: 97
Issue: 12
Pages: 1643-1656
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Publication
20549648 | J:163406
First Author: Hassane S
Year: 2010
Journal: J Pathol
Title: Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease.
Volume: 222
Issue: 1
Pages: 21-31
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Publication
18776127 | J:267159
First Author: Takakura A
Year: 2008
Journal: J Am Soc Nephrol
Title: Pkd1 inactivation induced in adulthood produces focal cystic disease.
Volume: 19
Issue: 12
Pages: 2351-63
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Publication
21051537 | J:167532
First Author: Sinnett-Smith J
Year: 2011
Journal: J Biol Chem
Title: Protein kinase D1 mediates stimulation of DNA synthesis and proliferation in intestinal epithelial IEC-18 cells and in mouse intestinal crypts.
Volume: 286
Issue: 1
Pages: 511-20
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Publication
29529391 | J:275692
First Author: Xu D
Year: 2018
Journal: FASEB J
Title: Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway.
Volume: 32
Issue: 8
Pages: 4394-4407
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Publication
35862648 | J:345517
First Author: Eckberg K
Year: 2022
Journal: Am J Physiol Renal Physiol
Title: Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth.
Volume: 323
Issue: 3
Pages: F335-F348
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Protein
Q7TN88
Organism: Mus musculus/domesticus
Length: 2461  
Fragment?: false
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Protein
E9QPG2
Organism: Mus musculus/domesticus
Length: 2462  
Fragment?: false
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Protein
E9Q4D4
Organism: Mus musculus/domesticus
Length: 2461  
Fragment?: false
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Protein
A0A0A0MQP1
Organism: Mus musculus/domesticus
Length: 2070  
Fragment?: false
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Protein
O08852
Organism: Mus musculus/domesticus
Length: 4293  
Fragment?: false
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Protein
Q3U306
Organism: Mus musculus/domesticus
Length: 1479  
Fragment?: true
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Protein
Q8R526
Organism: Mus musculus/domesticus
Length: 2615  
Fragment?: false
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Protein
A0A0A0MQK4
Organism: Mus musculus/domesticus
Length: 2521  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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