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Search results 801 to 900 out of 964 for Parp1

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Type Details Score
Allele
Parpbp<tm1Chum> | MGI:6343508
Name: PARP1 binding protein; targeted mutation 1, Shinichiro Chuma
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Parpbp<tm1.1Chum> | MGI:6343509
Name: PARP1 binding protein; targeted mutation 1.1, Shinichiro Chuma
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Parpbp<em14Gpt> | MGI:7303883
Name: PARP1 binding protein; endonuclease-mediated mutation 14, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Parpbp<em1Gpt> | MGI:7462241
Name: PARP1 binding protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Parp1<em2Smoc> | MGI:7291535
Name: poly (ADP-ribose) polymerase family, member 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Wang X (2007)
Description: Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
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Interaction Experiment
Yu C (2016)
Description: FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.
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Allele
Parpbp<Gt(IST14841F12)Tigm> | MGI:5260366
 
Name: PARP1 binding protein; gene trap IST14841F12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:6353305 | B6.Cg-Parpbp<tm1.1Chum>/ChumRbrc
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6768920 | C57BL/6JGpt-Parpbp<em14Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7469281 | C57BL/6JGpt-Parpbp<em1Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6429322 | C57BL/6JSmoc-Parp1<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Interaction Experiment
Zhang N (2020)
Description: Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
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HT Experiment
GSE171852 | Poly (ADP-Ribose) Polymerase 1 Regulates Cajal-Retzius Cell Development and Neural Precursor Cell Adhesion
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Parp1<em1Smoc> | MGI:7291534
Name: poly (ADP-ribose) polymerase family, member 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Parpbp/Parpbp<+>
Background: C57BL/6N-Parpbp/J
Zygosity: ht
Has Mutant Allele: true
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Publication
27662363 | -
First Author: Yu C
Year: 2016
Journal: Cell Death Differ
Title: FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration.
Volume: 23
Issue: 11
Pages: 1873-1885
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Protein
P11103
Organism: Mus musculus/domesticus
Length: 1013  
Fragment?: false
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Protein
P11103-2
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
32139900 | -
First Author: Zhang N
Year: 2020
Journal: Cell Death Differ
Title: Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
Volume: 27
Issue: 9
Pages: 2605-2619
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Strain
MGI:6475954 | C57BL/6JSmoc-Parp1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Domain
IPR035579 | TXK_SH3
Type: Domain
Description: TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK.
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Publication
27209204 | J:231879
First Author: Sokolowski K
Year: 2016
Journal: Neural Dev
Title: Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei.
Volume: 11
Issue: 1
Pages: 12
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Publication
34216590 | J:310903
First Author: Gresakova V
Year: 2021
Journal: Exp Cell Res
Title: Dual role of Fam208a during zygotic cleavage and early embryonic development.
Volume: 406
Issue: 2
Pages: 112723
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Publication
21266351 | -
First Author: Chang HY
Year: 2011
Journal: Cancer Res
Title: hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress.
Volume: 71
Issue: 3
Pages: 1126-34
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Publication
25512524 | -
First Author: Qiu C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization.
Volume: 111
Issue: 52
Pages: 18554-9
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Publication
15198983 | -
First Author: Gu W
Year: 2004
Journal: Genes Dev
Title: A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization.
Volume: 18
Issue: 12
Pages: 1452-65
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Protein Domain
IPR040059 | PUM3
Type: Family
Description: Proteins in this family contain a CPL domain, which is a C-terminal domain found in Penguin-like proteins, and Pumilio RNA-binding repeats. Proteins include the following:Pumilio homologue 3 (PUM3; also known as Puf-A), which inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress []. Tertiary structure determination has revealed that PUM3 has eleven PUM repeats arranged in an L-shape, and in contrast to classical PUF proteins, PUM3 forms sequence-independent interactions with DNA or RNA, mediated by conserved basic residues [].Pumilio homology domain family member 6 from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which is an RNA-binding protein involved in post-transcriptional regulation and represses ASH1 mRNA translation. ASH1 is a a protein determinant for mating-type switching [].Protein penguin from Drosophila melanogaster.
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Allele
Parp1<tm1.1(PARP1)Abu> | MGI:3842115
Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1.1, Alexander Burkle
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Parp1<tm2.1(PARP1)Abu> | MGI:3842119
Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 2.1, Alexander Burkle
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
23268447 | J:200220
First Author: Liu C
Year: 2013
Journal: Nucleic Acids Res
Title: CHFR is important for the first wave of ubiquitination at DNA damage sites.
Volume: 41
Issue: 3
Pages: 1698-710
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HT Experiment
E-GEOD-62194 | A High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Series Id: GSE62194
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
26941064 | J:236339
 
First Author: Rai R
Year: 2016
Journal: Nat Commun
Title: TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.
Volume: 7
Pages: 10881
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Publication
36848231 | J:340963
First Author: Brabson JP
Year: 2023
Journal: Cell Rep
Title: Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia.
Volume: 42
Issue: 1
Pages: 112027
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Publication
29290468 | J:259106
First Author: Margalef P
Year: 2018
Journal: Cell
Title: Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe.
Volume: 172
Issue: 3
Pages: 439-453.e14
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Publication
25440059 | J:218788
First Author: Scheibye-Knudsen M
Year: 2014
Journal: Cell Metab
Title: A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Volume: 20
Issue: 5
Pages: 840-55
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Publication
28363999 | J:242304
First Author: Schmitt A
Year: 2017
Journal: Cancer Res
Title: ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma.
Volume: 77
Issue: 11
Pages: 3040-3056
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Publication
29894693 | J:262541
First Author: Gogola E
Year: 2018
Journal: Cancer Cell
Title: Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Volume: 33
Issue: 6
Pages: 1078-1093.e12
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Publication
35417665 | J:325710
First Author: Lee G
Year: 2022
Journal: Cell Metab
Title: SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity.
Volume: 34
Issue: 5
Pages: 702-718.e5
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Publication
33027668 | J:298886
First Author: Le BV
Year: 2020
Journal: Cell Rep
Title: TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.
Volume: 33
Issue: 1
Pages: 108221
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Publication
38851747 | J:352599
First Author: Serrano J
Year: 2024
Journal: Nat Commun
Title: The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity.
Volume: 15
Issue: 1
Pages: 4915
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Publication
27635653 | J:237370
First Author: Sun X
Year: 2016
Journal: PLoS Biol
Title: Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation.
Volume: 14
Issue: 9
Pages: e1002543
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Publication
23443543 | J:221237
 
First Author: Liu X
Year: 2013
Journal: Nat Commun
Title: Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction.
Volume: 4
Pages: 1515
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Publication
31541116 | J:279424
First Author: Sambeat A
Year: 2019
Journal: Nat Commun
Title: Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage.
Volume: 10
Issue: 1
Pages: 4291
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Publication
23731385 | J:214536
First Author: Dantzer F
Year: 2013
Journal: FEBS J
Title: The expanding role of PARPs in the establishment and maintenance of heterochromatin.
Volume: 280
Issue: 15
Pages: 3508-18
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Publication
28336669 | J:242318
First Author: Li J
Year: 2017
Journal: Science
Title: A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
Volume: 355
Issue: 6331
Pages: 1312-1317
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Publication
21447800 | J:259527
First Author: Pyndiah S
Year: 2011
Journal: Sci Signal
Title: c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance.
Volume: 4
Issue: 166
Pages: ra19
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Publication
29284668 | J:258234
First Author: Azad GK
Year: 2018
Journal: J Cell Biol
Title: PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation.
Volume: 217
Issue: 2
Pages: 473-481
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Publication
29983321 | J:266355
First Author: Hanzlikova H
Year: 2018
Journal: Mol Cell
Title: The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.
Volume: 71
Issue: 2
Pages: 319-331.e3
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Publication
28805810 | J:318438
First Author: Schmutz I
Year: 2017
Journal: Nat Struct Mol Biol
Title: TRF2 binds branched DNA to safeguard telomere integrity.
Volume: 24
Issue: 9
Pages: 734-742
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Publication
11535586 | -
First Author: Forwood JK
Year: 2001
Journal: J Biol Chem
Title: The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.
Volume: 276
Issue: 49
Pages: 46575-82
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Publication
5297880 | -
First Author: Anson BJ
Year: 1967
Journal: Arch Otolaryngol
Title: The vestibular system. Anatomic considerations.
Volume: 85
Issue: 5
Pages: 497-514
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Publication
16504207 | -
First Author: Phillips NB
Year: 2006
Journal: J Mol Biol
Title: SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.
Volume: 358
Issue: 1
Pages: 172-92
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Publication
16106197 | -
First Author: Kellermayer R
Year: 2005
Journal: Diagn Mol Pathol
Title: A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis.
Volume: 14
Issue: 3
Pages: 159-63
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Publication
7789944 | -
First Author: Ogata T
Year: 1995
Journal: Hum Genet
Title: Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features.
Volume: 95
Issue: 6
Pages: 607-29
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Publication
12793612 | -
First Author: Maier EM
Year: 2003
Journal: J Pediatr Endocrinol Metab
Title: True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene.
Volume: 16
Issue: 4
Pages: 575-80
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Protein Domain
IPR017253 | SRY
Type: Family
Description: This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch inmale development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells []. Sry is involved in different aspects of gene regulation including promoter activation or repression and contains a high-mobility-group (HMG) box that recognises DNA by partial intercalation in the minor groove []. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Sry also facilitates DNA bending and is involved in pre-mRNA splicing. It is also involved in maintenance of motor functions of dopaminergic neurons in the male adult brain. Sry interacts with a number of partners, including CALM, EP300 (modulates Sry DNA-binding activity), HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1 (impaired Sry DNA-binding activity), SLC9A3R2 and WT1. The C-terminal nuclear localization signal in Sry HMG-box domain mediates nuclear import through importin beta 1 [].Defects in Sry can cause gonadal dysgenesis XY female type (GDXY) (OMIM:306100), which is also known as 'XY females' or Swyer syndrome []. Patients suffer rapid and early degeneration of their gonads, which prevents the development secondary sexual characteristics at puberty. Defects in Sry are also found Turner's Syndrome, a disease characterised by gonadal dysgenesis in a 45,X female type []. Defects in Sry can also cause true hermaphroditism (OMIM:235600), genetically heterogeneous condition whre patients have both mature ovarian and mature testicular tissue (46,XX, 46,XY or a mosaic of 46,XX/46,XY) [].
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Publication
15010206 | J:88423
First Author: García-Frigola C
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain.
Volume: 122
Issue: 2
Pages: 133-50
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Publication
30356214 | J:267189
First Author: Liu H
Year: 2018
Journal: Nature
Title: Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Volume: 563
Issue: 7729
Pages: 131-136
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Publication
20972425 | J:168151
First Author: Kornberg MD
Year: 2010
Journal: Nat Cell Biol
Title: GAPDH mediates nitrosylation of nuclear proteins.
Volume: 12
Issue: 11
Pages: 1094-100
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Publication
26000965 | J:274078
First Author: Robert I
Year: 2015
Journal: PLoS Genet
Title: Parp3 negatively regulates immunoglobulin class switch recombination.
Volume: 11
Issue: 5
Pages: e1005240
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Publication
21825151 | J:175986
First Author: Kang HC
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
Volume: 108
Issue: 34
Pages: 14103-8
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Publication
26832955 | J:293379
First Author: Shahzad K
Year: 2016
Journal: J Am Soc Nephrol
Title: Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
Volume: 27
Issue: 8
Pages: 2270-5
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Publication
25448685 | J:217529
First Author: Ganesan S
Year: 2014
Journal: Toxicol Appl Pharmacol
Title: Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage.
Volume: 281
Issue: 2
Pages: 203-10
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Publication
23345425 | J:194338
First Author: Lottersberger F
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Role of 53BP1 oligomerization in regulating double-strand break repair.
Volume: 110
Issue: 6
Pages: 2146-51
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Publication
38579991 | J:348385
First Author: Eden M
Year: 2024
Journal: J Biol Chem
Title: Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy.
Volume: 300
Issue: 5
Pages: 107255
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Publication
16287996 | J:103412
First Author: Hay T
Year: 2005
Journal: Cancer Res
Title: Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.
Volume: 65
Issue: 22
Pages: 10145-8
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Publication
31080552 | J:316037
First Author: Ordonez LD
Year: 2019
Journal: Oncotarget
Title: Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.
Volume: 10
Issue: 27
Pages: 2586-2606
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Publication
37540725 | J:340695
First Author: Lee JY
Year: 2023
Journal: PLoS One
Title: PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells.
Volume: 18
Issue: 8
Pages: e0285159
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Publication
22363515 | J:185321
First Author: Blaise S
Year: 2012
Journal: PLoS One
Title: In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis.
Volume: 7
Issue: 2
Pages: e30917
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Publication
33231937 | J:349656
First Author: Zhou Z
Year: 2020
Journal: EMBO Mol Med
Title: New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy.
Volume: 12
Issue: 12
Pages: e12391
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Publication
30842506 | J:276920
First Author: Vidal-Gil L
Year: 2019
Journal: Sci Rep
Title: Poly ADP ribosylation and extracellular vesicle activity in rod photoreceptor degeneration.
Volume: 9
Issue: 1
Pages: 3758
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Publication
19607827 | J:154493
First Author: Quénet D
Year: 2009
Journal: Exp Cell Res
Title: Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.
Volume: 315
Issue: 16
Pages: 2824-34
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Publication
38157451 | J:352540
First Author: Yang X
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation.
Volume: 121
Issue: 1
Pages: e2307395120
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Publication
33594040 | J:313998
First Author: Huna A
Year: 2021
Journal: Cell Death Dis
Title: PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging.
Volume: 12
Issue: 2
Pages: 190
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Publication
32231242 | J:348174
First Author: Arora K
Year: 2020
Journal: Sci Rep
Title: Transcriptome Profile of Nicotinic Receptor-Linked Sensitization of Beta Amyloid Neurotoxicity.
Volume: 10
Issue: 1
Pages: 5696
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Publication
31395736 | J:279136
First Author: Srinivasan G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers.
Volume: 116
Issue: 35
Pages: 17438-17443
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Publication
37298584 | J:353931
 
First Author: Jung SY
Year: 2023
Journal: Int J Mol Sci
Title: Skeletal Muscle-Specific Bis Depletion Leads to Muscle Dysfunction and Early Death Accompanied by Impairment in Protein Quality Control.
Volume: 24
Issue: 11
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Publication
31591441 | J:284242
First Author: Santos L
Year: 2019
Journal: Sci Rep
Title: A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.
Volume: 9
Issue: 1
Pages: 14381
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Publication
34648372 | J:333678
First Author: Yi T
Year: 2022
Journal: Exp Biol Med (Maywood)
Title: Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
Volume: 247
Issue: 2
Pages: 165-173
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Publication
34339838 | J:318650
First Author: Liu Z
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.
Volume: 1867
Issue: 11
Pages: 166237
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Publication
11454873 | J:71663
First Author: Kaminker PG
Year: 2001
Journal: J Biol Chem
Title: TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.
Volume: 276
Issue: 38
Pages: 35891-9
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Publication
23116180 | J:193994
First Author: Guastafierro T
Year: 2013
Journal: Biochem J
Title: ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement(1).
Volume: 449
Issue: 3
Pages: 623-30
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Publication
25082302 | J:219247
First Author: Tseng SH
Year: 2015
Journal: Int J Cancer
Title: K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression.
Volume: 136
Issue: 6
Pages: 1263-75
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Journal: EMBO J
Title: BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
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17177976 | -
First Author: Maruyama T
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Protein
Q8BKS9
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
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Protein
Q8C0F4
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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