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Search results 1 to 100 out of 714 for A1cf

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
29974 | A1CF
Type: gene
Organism: human
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Gene
100493284 | a1cf
Type: gene
Organism: frog, western clawed
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Gene
477581 | A1CF
Type: gene
Organism: dog, domestic
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Gene
170912 | A1cf
Type: gene
Organism: rat
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Gene
466076 | A1CF
Type: gene
Organism: chimpanzee
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Gene
100336715 | A1CF
Type: gene
Organism: cattle
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Gene
423680 | A1CF
Type: gene
Organism: chicken
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Gene
562916 | a1cf
Type: gene
Organism: zebrafish
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Gene
703806 | A1CF
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033111 | A1CF
Type: Family
Description: APOBEC1 complementation factor (A1CF or ACF) and APOBEC1 (an RNA-binding cytidine deaminase) form the apolipoprotein B (apoB) mRNA editing enzyme complex, which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in apoB mRNA [, ]. APOBEC1 alone induces nonsense-mediated decay (NMD), while the APOBEC1-ACF complex edits and remains associated with the edited RNA to protect it from NMD []. ACF has been shown to bind with high affinity to single-stranded but not double-stranded apoB mRNA [].
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Protein Coding Gene
MGI:1917115 | A1cf
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31597092 | J:281365
First Author: Nikolaou KC
Year: 2019
Journal: Cell Rep
Title: The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing.
Volume: 29
Issue: 2
Pages: 283-300.e8
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Publication
27582469 | J:235574
First Author: Carouge D
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.
Volume: 113
Issue: 37
Pages: E5425-33
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Protein
Q5YD48
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
A0A286YDF7
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Publication
10781591 | -
First Author: Lellek H
Year: 2000
Journal: J Biol Chem
Title: Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex.
Volume: 275
Issue: 26
Pages: 19848-56
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Publication
10669759 | -
First Author: Mehta A
Year: 2000
Journal: Mol Cell Biol
Title: Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.
Volume: 20
Issue: 5
Pages: 1846-54
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Publication
12881431 | -
First Author: Chester A
Year: 2003
Journal: EMBO J
Title: The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.
Volume: 22
Issue: 15
Pages: 3971-82
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Publication
11871661 | -
First Author: Mehta A
Year: 2002
Journal: RNA
Title: Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing.
Volume: 8
Issue: 1
Pages: 69-82
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Publication
27165291 | J:231727
First Author: Harkins S
Year: 2016
Journal: Transgenic Res
Title: Chromosomal mapping of the αMHC-MerCreMer transgene in mice reveals a large genomic deletion.
Volume: 25
Issue: 5
Pages: 639-48
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Publication
24916387 | J:217130
First Author: Fossat N
Year: 2014
Journal: EMBO Rep
Title: C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.
Volume: 15
Issue: 8
Pages: 903-10
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Publication
35948620 | J:336337
First Author: Hirose N
Year: 2022
Journal: Sci Rep
Title: Genetically-biased fertilization in APOBEC1 complementation factor (A1cf) mutant mice.
Volume: 12
Issue: 1
Pages: 13599
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Publication
23248315 | J:192621
First Author: Porrello ER
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.
Volume: 110
Issue: 1
Pages: 187-92
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Publication
24412363 | J:208824
First Author: Kalsotra A
Year: 2014
Journal: Cell Rep
Title: The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression.
Volume: 6
Issue: 2
Pages: 336-45
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Publication
21536850 | J:173254
First Author: Hall ME
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic mice.
Volume: 301
Issue: 1
Pages: H253-60
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Publication
12594183 | J:128410
First Author: Petrich BG
Year: 2003
Journal: FASEB J
Title: Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination.
Volume: 17
Issue: 6
Pages: 749-51
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Publication
17646583 | J:139853
First Author: Ruan H
Year: 2007
Journal: Circulation
Title: Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Volume: 116
Issue: 6
Pages: 596-605
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Publication
33523960 | J:316727
 
First Author: Dhandapany PS
Year: 2021
Journal: Sci Adv
Title: Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin.
Volume: 7
Issue: 2
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Publication
30309881 | J:277521
First Author: Blanc V
Year: 2019
Journal: RNA
Title: Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver.
Volume: 25
Issue: 1
Pages: 70-81
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Publication
28069890 | J:240626
First Author: Snyder EM
Year: 2017
Journal: RNA
Title: APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.
Volume: 23
Issue: 4
Pages: 457-465
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Publication
30844405 | J:331360
First Author: Wolfe AD
Year: 2019
Journal: J Mol Biol
Title: Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells.
Volume: 431
Issue: 7
Pages: 1506-1517
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Publication
25589557 | J:234138
First Author: Zhao QD
Year: 2015
Journal: Circulation
Title: NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways.
Volume: 131
Issue: 7
Pages: 643-55
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Publication
26841808 | J:244457
First Author: Xiang FL
Year: 2016
Journal: Circulation
Title: Overexpression of Tbx20 in Adult Cardiomyocytes Promotes Proliferation and Improves Cardiac Function After Myocardial Infarction.
Volume: 133
Issue: 11
Pages: 1081-92
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Publication
33106234 | J:300342
 
First Author: Wang X
Year: 2020
Journal: Dis Model Mech
Title: Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites.
Volume: 13
Issue: 12
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Publication
28461495 | J:242208
First Author: Wei EQ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.
Volume: 114
Issue: 20
Pages: E4010-E4019
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Publication
23732814 | J:199093
First Author: Hull TD
Year: 2013
Journal: Lab Invest
Title: Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase.
Volume: 93
Issue: 8
Pages: 868-79
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Publication
23568341 | J:196679
First Author: Cao DJ
Year: 2013
Journal: J Am Heart Assoc
Title: Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy.
Volume: 2
Issue: 2
Pages: e000016
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Publication
22375032 | J:182234
First Author: Ichikawa Y
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export.
Volume: 109
Issue: 11
Pages: 4152-7
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Publication
36649053 | J:341876
   
First Author: Karsenty C
Year: 2023
Journal: Elife
Title: Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests.
Volume: 12
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Publication
36105283 | J:330837
 
First Author: Jiang X
Year: 2022
Journal: Front Physiol
Title: Protections of transcription factor BACH2 and natural product myricetin against pathological cardiac hypertrophy and dysfunction.
Volume: 13
Pages: 971424
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Publication
36709920 | J:337793
 
First Author: Balakrishnan B
Year: 2023
Journal: Transl Res
Title: AAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a mouse model of phosphoglucomutase 1 deficiency (PGM1-CDG).
Volume: 257
Pages: 1-14
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Publication
29769314 | J:267100
First Author: Hershberger KA
Year: 2018
Journal: J Biol Chem
Title: Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.
Volume: 293
Issue: 27
Pages: 10630-10645
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Publication
36108935 | J:345360
 
First Author: Li H
Year: 2022
Journal: Free Radic Biol Med
Title: Dual-specificity phosphatase 12 attenuates oxidative stress injury and apoptosis in diabetic cardiomyopathy via the ASK1-JNK/p38 signaling pathway.
Volume: 192
Pages: 13-24
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Publication
24413772 | J:229299
First Author: Zhang Y
Year: 2014
Journal: Cardiovasc Res
Title: Dickkopf-3 attenuates pressure overload-induced cardiac remodelling.
Volume: 102
Issue: 1
Pages: 35-45
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Publication
24382354 | J:207999
First Author: Ichikawa Y
Year: 2014
Journal: J Clin Invest
Title: Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation.
Volume: 124
Issue: 2
Pages: 617-30
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Publication
29892894 | J:311960
First Author: Hou L
Year: 2018
Journal: Basic Res Cardiol
Title: Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis.
Volume: 113
Issue: 4
Pages: 28
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Publication
26199228 | J:236439
 
First Author: Kiermayer C
Year: 2015
Journal: J Am Heart Assoc
Title: Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
Volume: 4
Issue: 7
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Publication
28819685 | J:311981
First Author: Xu X
Year: 2017
Journal: Basic Res Cardiol
Title: Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Volume: 112
Issue: 5
Pages: 55
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Publication
36520055 | J:333202
First Author: Tang C
Year: 2023
Journal: FASEB J
Title: Cardiomyocyte-specific Peli1 contributes to the pressure overload-induced cardiac fibrosis through miR-494-3p-dependent exosomal communication.
Volume: 37
Issue: 1
Pages: e22699
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Publication
26896449 | J:229593
First Author: Chang HC
Year: 2016
Journal: EMBO Mol Med
Title: Reduction in mitochondrial iron alleviates cardiac damage during injury.
Volume: 8
Issue: 3
Pages: 247-67
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Publication
38224947 | J:346986
First Author: Lee E
Year: 2024
Journal: J Biol Chem
Title: The MYPT2-regulated striated muscle-specific myosin light chain phosphatase limits cardiac myosin phosphorylation in vivo.
Volume: 300
Issue: 2
Pages: 105652
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Publication
27146447 | J:308293
 
First Author: Xu Z
Year: 2016
Journal: J Am Heart Assoc
Title: C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.
Volume: 5
Issue: 5
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Publication
27630136 | J:237830
First Author: Methawasin M
Year: 2016
Journal: Circulation
Title: Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction.
Volume: 134
Issue: 15
Pages: 1085-1099
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Publication
24658400 | J:229795
First Author: Kwong JQ
Year: 2014
Journal: Cell Death Differ
Title: Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy.
Volume: 21
Issue: 8
Pages: 1209-17
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Publication
28373586 | J:351956
First Author: Wang X
Year: 2017
Journal: Hypertension
Title: Critical Role of ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) in Cardiac Hypertrophy Induced by Pressure Overload.
Volume: 69
Issue: 6
Pages: 1060-1069
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Publication
35907876 | J:327369
First Author: Huang J
Year: 2022
Journal: Nat Commun
Title: CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation.
Volume: 13
Issue: 1
Pages: 4433
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Publication
34540911 | J:310845
 
First Author: Pang Y
Year: 2021
Journal: Front Cardiovasc Med
Title: TANK Promotes Pressure Overload Induced Cardiac Hypertrophy via Activating AKT Signaling Pathway.
Volume: 8
Pages: 687540
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Publication
38188257 | J:345774
 
First Author: Liu J
Year: 2023
Journal: Front Cardiovasc Med
Title: Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure.
Volume: 10
Pages: 1226586
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Publication
23708736 | J:218658
First Author: Kienesberger PC
Year: 2013
Journal: Cardiovasc Res
Title: Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation.
Volume: 99
Issue: 3
Pages: 442-51
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Publication
35680100 | J:341775
 
First Author: Sun S
Year: 2022
Journal: Metabolism
Title: TBC1D15-Drp1 interaction-mediated mitochondrial homeostasis confers cardioprotection against myocardial ischemia/reperfusion injury.
Volume: 134
Pages: 155239
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Publication
21339484 | J:183751
First Author: van Oort RJ
Year: 2011
Journal: Circulation
Title: Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
Volume: 123
Issue: 9
Pages: 979-88
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Publication
26175717 | J:236578
 
First Author: Coleman JL
Year: 2015
Journal: Front Endocrinol (Lausanne)
Title: Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study.
Volume: 6
Pages: 105
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Publication
35475001 | J:361139
First Author: Bekdash R
Year: 2021
Journal: Cell Rep Methods
Title: GEM-IL: A highly responsive fluorescent lactate indicator.
Volume: 1
Issue: 7
Pages: 100092
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Publication
38994028 | J:351071
First Author: Chen T
Year: 2024
Journal: Theranostics
Title: Transfer of cardiomyocyte-derived extracellular vesicles to neighboring cardiac cells requires tunneling nanotubes during heart development.
Volume: 14
Issue: 10
Pages: 3843-3858
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Publication
34376683 | J:314347
First Author: Raso A
Year: 2021
Journal: Nat Commun
Title: A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration.
Volume: 12
Issue: 1
Pages: 4808
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Publication
17190866 | J:128060
First Author: Xiong D
Year: 2007
Journal: Circulation
Title: Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy.
Volume: 115
Issue: 1
Pages: 94-102
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Publication
29146153 | J:257536
 
First Author: Yan J
Year: 2018
Journal: J Mol Cell Cardiol
Title: The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart.
Volume: 114
Pages: 105-115
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Publication
35163412 | J:321697
 
First Author: Kim SH
Year: 2022
Journal: Int J Mol Sci
Title: Protein Kinase B2 (PKB2/AKT2) Is Essential for Host Protection in CVB3-Induced Acute Viral Myocarditis.
Volume: 23
Issue: 3
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Publication
32850000 | J:313544
 
First Author: Yu H
Year: 2020
Journal: Oxid Med Cell Longev
Title: O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes.
Volume: 2020
Pages: 5602396
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Publication
33486096 | J:304094
First Author: Brainard RE
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Cardiac hypertrophy drives PGC-1α suppression associated with enhanced O-glycosylation.
Volume: 1867
Issue: 5
Pages: 166080
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Publication
31131693 | J:294577
First Author: Zhu WZ
Year: 2019
Journal: J Am Heart Assoc
Title: O-GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O-GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload.
Volume: 8
Issue: 11
Pages: e011260
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Publication
20876116 | J:165404
First Author: Watson LJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart.
Volume: 107
Issue: 41
Pages: 17797-802
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Publication
27864509 | J:239091
First Author: Yang L
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure.
Volume: 113
Issue: 49
Pages: E7976-E7985
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Publication
25329697 | J:217697
First Author: Wu R
Year: 2014
Journal: J Clin Invest
Title: Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy.
Volume: 124
Issue: 11
Pages: 4795-806
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Publication
32258062 | J:290018
 
First Author: El Azzouzi H
Year: 2020
Journal: Front Cardiovasc Med
Title: Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality.
Volume: 7
Pages: 30
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Publication
23771945 | J:218736
First Author: Hamdi H
Year: 2013
Journal: Cardiovasc Res
Title: Efficacy of epicardially delivered adipose stroma cell sheets in dilated cardiomyopathy.
Volume: 99
Issue: 4
Pages: 640-7
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Publication
29187823 | J:277641
 
First Author: Deloux R
Year: 2017
Journal: Front Physiol
Title: Voluntary Exercise Improves Cardiac Function and Prevents Cardiac Remodeling in a Mouse Model of Dilated Cardiomyopathy.
Volume: 8
Pages: 899
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Publication
16260633 | J:135043
First Author: Parlakian A
Year: 2005
Journal: Circulation
Title: Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart.
Volume: 112
Issue: 19
Pages: 2930-9
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Publication
32946258 | J:299876
First Author: DiNello E
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve.
Volume: 319
Issue: 5
Pages: H1021-H1035
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Publication
32239217 | J:288666
First Author: Peng L
Year: 2020
Journal: Nucleic Acids Res
Title: Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis.
Volume: 48
Issue: 9
Pages: 4992-5005
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Publication
20444417 | J:160929
First Author: Kim BE
Year: 2010
Journal: Cell Metab
Title: Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.
Volume: 11
Issue: 5
Pages: 353-63
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Publication
23192947 | J:212866
First Author: Gao Z
Year: 2013
Journal: Circ Res
Title: Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.
Volume: 112
Issue: 2
Pages: 309-17
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Publication
25125302 | J:272204
First Author: Ahmad F
Year: 2014
Journal: J Am Coll Cardiol
Title: Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure.
Volume: 64
Issue: 7
Pages: 696-706
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Publication
39011088 | J:352298
 
First Author: Marrow JP
Year: 2024
Journal: Front Physiol
Title: Cardiomyocyte crosstalk with endothelium modulates cardiac structure, function, and ischemia-reperfusion injury susceptibility through erythropoietin.
Volume: 15
Pages: 1397049
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Publication
30928428 | J:275923
 
First Author: Ahmad F
Year: 2019
Journal: J Mol Cell Cardiol
Title: Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload.
Volume: 130
Pages: 65-75
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Publication
32777030 | J:322053
First Author: Rathjens FS
Year: 2021
Journal: Cardiovasc Res
Title: Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control.
Volume: 117
Issue: 8
Pages: 1908-1922
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Publication
29150445 | J:256051
First Author: Bidwell PA
Year: 2018
Journal: J Biol Chem
Title: The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart.
Volume: 293
Issue: 1
Pages: 359-367
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Publication
22290441 | J:183687
First Author: Turski ML
Year: 2012
Journal: Mol Cell Biol
Title: A novel role for copper in Ras/mitogen-activated protein kinase signaling.
Volume: 32
Issue: 7
Pages: 1284-95
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Publication
32635769 | J:302860
First Author: Spinozzi S
Year: 2020
Journal: Circ Heart Fail
Title: Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes.
Volume: 13
Issue: 7
Pages: e006935
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Publication
33253217 | J:298626
First Author: Dassanayaka S
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