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Search results 1 to 100 out of 893 for Abca1

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0.045s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Members of ABC (ATP-binding cassette) transporter subfamily A are full-length transporters [], which consist of a single long polypeptide chain organised into two tandemly arranged halves. Each half contains a membrane-spanning domain (MSD) followed by a cytoplasmic nucleotide binding domain (NBD) []. ATP-binding cassette sub-family A member 1 (ABCA1) interacts with apo-A1, an extracellular lipid acceptor in the plasma [, ]. ABCA1 is involved in cholesterol efflux from peripheral tissues in a process known as the reverse cholesterol transport (RCT). Mutations in the ABCA1 gene cause Tangier disease, which is an autosomal recessive disorder characterised by a severe reduction in the amount of high density lipoprotein (HDL) in the bloodstream []. Mutations in the ABCA1 gene also cause a defect in the clearance of apoptotic cells by macrophages [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Williamson P
Year: 2007
Journal: PLoS One
Title: Transbilayer phospholipid movements in ABCA1-deficient cells.
Volume: 2
Issue: 8
Pages: e729
Publication
First Author: Hamon Y
Year: 2000
Journal: Nat Cell Biol
Title: ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.
Volume: 2
Issue: 7
Pages: 399-406
Protein
Organism: Mus musculus/domesticus
Length: 2261  
Fragment?: false
Publication
First Author: Qiu Y
Year: 2001
Journal: Genomics
Title: Human and mouse ABCA1 comparative sequencing and transgenesis studies revealing novel regulatory sequences.
Volume: 73
Issue: 1
Pages: 66-76
Publication
First Author: Bodzioch M
Year: 1999
Journal: Nat Genet
Title: The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease.
Volume: 22
Issue: 4
Pages: 347-51
Publication
First Author: Chroni A
Year: 2004
Journal: Biochemistry
Title: Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.
Volume: 43
Issue: 7
Pages: 2126-39
Publication
First Author: Denis M
Year: 2004
Journal: J Biol Chem
Title: Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).
Volume: 279
Issue: 9
Pages: 7384-94
Publication
First Author: Bungert S
Year: 2001
Journal: J Biol Chem
Title: Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation sites.
Volume: 276
Issue: 26
Pages: 23539-46
Publication
First Author: Coleman JA
Year: 2013
Journal: Biochim Biophys Acta
Title: Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport.
Volume: 1831
Issue: 3
Pages: 555-74
Publication  
First Author: Karasinska JM
Year: 2013
Journal: Neurobiol Dis
Title: ABCA1 influences neuroinflammation and neuronal death.
Volume: 54
Pages: 445-55
Publication
First Author: Viaud M
Year: 2020
Journal: Cell Rep
Title: ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.
Volume: 30
Issue: 10
Pages: 3397-3410.e5
Protein
Organism: Mus musculus/domesticus
Length: 1487  
Fragment?: true
Publication
First Author: Singaraja RR
Year: 2002
Journal: J Clin Invest
Title: Increased ABCA1 activity protects against atherosclerosis.
Volume: 110
Issue: 1
Pages: 35-42
Publication
First Author: Bowden K
Year: 2008
Journal: J Biol Chem
Title: OSBP negatively regulates ABCA1 protein stability.
Volume: 283
Issue: 26
Pages: 18210-7
Publication
First Author: Vaisman BL
Year: 2001
Journal: J Clin Invest
Title: ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice.
Volume: 108
Issue: 2
Pages: 303-9
Publication
First Author: Sallam T
Year: 2018
Journal: Nat Med
Title: Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.
Volume: 24
Issue: 3
Pages: 304-312
Publication
First Author: Key CC
Year: 2017
Journal: Cell Rep
Title: Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis.
Volume: 19
Issue: 10
Pages: 2116-2129
Publication
First Author: Jin X
Year: 2015
Journal: J Lipid Res
Title: ABCA1 contributes to macrophage deposition of extracellular cholesterol.
Volume: 56
Issue: 9
Pages: 1720-6
Publication
First Author: Brunham LR
Year: 2006
Journal: J Clin Invest
Title: Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.
Volume: 116
Issue: 4
Pages: 1052-62
Publication
First Author: de Haan W
Year: 2014
Journal: Diabetes
Title: Hepatic ABCA1 expression improves β-cell function and glucose tolerance.
Volume: 63
Issue: 12
Pages: 4076-82
Publication
First Author: Park DW
Year: 2013
Journal: Biochem Biophys Res Commun
Title: TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway.
Volume: 430
Issue: 3
Pages: 933-7
Publication
First Author: Schmitz G
Year: 2005
Journal: Biochim Biophys Acta
Title: Transcriptional regulatory networks in lipid metabolism control ABCA1 expression.
Volume: 1735
Issue: 1
Pages: 1-19
Publication
First Author: Cavelier C
Year: 2006
Journal: Biochim Biophys Acta
Title: Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1.
Volume: 1761
Issue: 7
Pages: 655-66
Publication
First Author: Costet P
Year: 2003
Journal: Mol Cell Biol
Title: Retinoic acid receptor-mediated induction of ABCA1 in macrophages.
Volume: 23
Issue: 21
Pages: 7756-66
Publication
First Author: Wang N
Year: 2003
Journal: J Clin Invest
Title: A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.
Volume: 111
Issue: 1
Pages: 99-107
Publication
First Author: Zhu X
Year: 2012
Journal: Circ Res
Title: Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection.
Volume: 111
Issue: 11
Pages: 1398-409
Publication
First Author: Lammers B
Year: 2012
Journal: PLoS One
Title: Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice.
Volume: 7
Issue: 10
Pages: e48080
Publication
First Author: Tang C
Year: 2009
Journal: J Biol Chem
Title: The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor.
Volume: 284
Issue: 47
Pages: 32336-43
Publication
First Author: Fan J
Year: 2013
Journal: J Lipid Res
Title: Hormonal modulators of glial ABCA1 and apoE levels.
Volume: 54
Issue: 11
Pages: 3139-50
Publication
First Author: Brunham LR
Year: 2009
Journal: Arterioscler Thromb Vasc Biol
Title: Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Volume: 29
Issue: 4
Pages: 548-54
Publication
First Author: Hirsch-Reinshagen V
Year: 2004
Journal: J Biol Chem
Title: Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.
Volume: 279
Issue: 39
Pages: 41197-207
Publication
First Author: Zhou L
Year: 2009
Journal: PLoS One
Title: LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export.
Volume: 4
Issue: 8
Pages: e6853
Publication
First Author: Bates SR
Year: 2005
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Pulmonary abnormalities due to ABCA1 deficiency in mice.
Volume: 289
Issue: 6
Pages: L980-9
Publication
First Author: Wahrle SE
Year: 2008
Journal: J Clin Invest
Title: Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.
Volume: 118
Issue: 2
Pages: 671-82
Publication
First Author: Fitz NF
Year: 2017
Journal: J Alzheimers Dis
Title: ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice.
Volume: 56
Issue: 3
Pages: 1075-1085
Publication
First Author: Wijesekara N
Year: 2012
Journal: Diabetes
Title: miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.
Volume: 61
Issue: 3
Pages: 653-8
Publication
First Author: Wijesekara N
Year: 2016
Journal: Diabetologia
Title: ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.
Volume: 59
Issue: 6
Pages: 1242-6
Publication
First Author: Brunham LR
Year: 2007
Journal: Nat Med
Title: Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.
Volume: 13
Issue: 3
Pages: 340-7
Publication
First Author: Oku H
Year: 2007
Journal: FEBS Lett
Title: Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver.
Volume: 581
Issue: 26
Pages: 5029-33
Publication
First Author: Sun D
Year: 2012
Journal: FEBS Lett
Title: MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7.
Volume: 586
Issue: 10
Pages: 1472-9
Publication
First Author: Gao JH
Year: 2019
Journal: J Lipid Res
Title: CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway.
Volume: 60
Issue: 12
Pages: 2020-2033
Publication
First Author: Pedrelli M
Year: 2014
Journal: PLoS One
Title: Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.
Volume: 9
Issue: 4
Pages: e93552
Publication
First Author: Koldamova R
Year: 2005
Journal: J Biol Chem
Title: Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
Volume: 280
Issue: 52
Pages: 43224-35
Publication
First Author: Tang C
Year: 2016
Journal: J Lipid Res
Title: Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice.
Volume: 57
Issue: 1
Pages: 100-8
Publication
First Author: Burns MP
Year: 2006
Journal: J Neurochem
Title: The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.
Volume: 98
Issue: 3
Pages: 792-800
Publication
First Author: Timmins JM
Year: 2005
Journal: J Clin Invest
Title: Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I.
Volume: 115
Issue: 5
Pages: 1333-42
Publication
First Author: Karasinska JM
Year: 2009
Journal: J Neurosci
Title: Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
Volume: 29
Issue: 11
Pages: 3579-89
Publication
First Author: de Haan W
Year: 2014
Journal: J Lipid Res
Title: ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity.
Volume: 55
Issue: 3
Pages: 516-23
Publication
First Author: Kruit JK
Year: 2011
Journal: Diabetes
Title: Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.
Volume: 60
Issue: 12
Pages: 3186-96
Publication  
First Author: Zhang J
Year: 2023
Journal: Metabolism
Title: ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease.
Volume: 139
Pages: 155377
Publication
First Author: Chen W
Year: 2005
Journal: J Biol Chem
Title: A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes.
Volume: 280
Issue: 32
Pages: 29277-81
Publication
First Author: Kang MH
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145.
Volume: 33
Issue: 12
Pages: 2724-32
Publication
First Author: Cuffe H
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.
Volume: 38
Issue: 4
Pages: 733-743
Publication
First Author: Yvan-Charvet L
Year: 2010
Journal: Circ Res
Title: ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis.
Volume: 106
Issue: 12
Pages: 1861-9
Publication
First Author: Temel RE
Year: 2005
Journal: J Lipid Res
Title: Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.
Volume: 46
Issue: 11
Pages: 2423-31
Publication
First Author: Combes V
Year: 2005
Journal: Am J Pathol
Title: ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology.
Volume: 166
Issue: 1
Pages: 295-302
Publication
First Author: Hu W
Year: 2008
Journal: J Lipid Res
Title: Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo.
Volume: 49
Issue: 2
Pages: 386-93
Publication
First Author: van Eck M
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.
Volume: 99
Issue: 9
Pages: 6298-303
Publication
First Author: Hou L
Year: 2019
Journal: FASEB J
Title: Apolipoprotein A-I improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1.
Volume: 33
Issue: 7
Pages: 8479-8489
Publication
First Author: Liu M
Year: 2017
Journal: Biochim Biophys Acta
Title: Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.
Volume: 1862
Issue: 10 Pt A
Pages: 1035-1043
Publication
First Author: Ito M
Year: 2023
Journal: Sci Rep
Title: ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease.
Volume: 13
Issue: 1
Pages: 9616
Publication
First Author: Martinez LO
Year: 2003
Journal: J Biol Chem
Title: Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I.
Volume: 278
Issue: 39
Pages: 37368-74
Publication
First Author: Zhang L
Year: 2013
Journal: Biochim Biophys Acta
Title: DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.
Volume: 1831
Issue: 6
Pages: 1134-45
Publication
First Author: Yvan-Charvet L
Year: 2007
Journal: J Clin Invest
Title: Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice.
Volume: 117
Issue: 12
Pages: 3900-8
Publication
First Author: Shridas P
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
Volume: 30
Issue: 10
Pages: 2014-21
Publication
First Author: Zhu X
Year: 2010
Journal: J Lipid Res
Title: Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.
Volume: 51
Issue: 11
Pages: 3196-206
Publication
First Author: Zhu X
Year: 2008
Journal: J Biol Chem
Title: Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages.
Volume: 283
Issue: 34
Pages: 22930-41
Publication
First Author: Post SM
Year: 2006
Journal: Arterioscler Thromb Vasc Biol
Title: Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol.
Volume: 26
Issue: 12
Pages: 2724-30
Publication
First Author: Wang X
Year: 2007
Journal: J Clin Invest
Title: Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo.
Volume: 117
Issue: 8
Pages: 2216-24
Publication
First Author: Fitz NF
Year: 2012
Journal: J Neurosci
Title: Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.
Volume: 32
Issue: 38
Pages: 13125-36
Publication
First Author: Wahrle SE
Year: 2004
Journal: J Biol Chem
Title: ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.
Volume: 279
Issue: 39
Pages: 40987-93
Publication
First Author: Hirsch-Reinshagen V
Year: 2007
Journal: J Lipid Res
Title: Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.
Volume: 48
Issue: 4
Pages: 914-23
Publication
First Author: Bi X
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis.
Volume: 33
Issue: 10
Pages: 2288-96
Publication
First Author: Ouvrier A
Year: 2009
Journal: J Lipid Res
Title: LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.
Volume: 50
Issue: 9
Pages: 1766-75
Publication
First Author: Wahrle SE
Year: 2005
Journal: J Biol Chem
Title: Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
Volume: 280
Issue: 52
Pages: 43236-42
Publication
First Author: Kypreos KE
Year: 2007
Journal: Biochem J
Title: Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.
Volume: 403
Issue: 2
Pages: 359-67
Publication
First Author: Okoro EU
Year: 2012
Journal: PLoS One
Title: Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway.
Volume: 7
Issue: 9
Pages: e44430
Publication
First Author: Nelson JK
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux.
Volume: 37
Issue: 3
Pages: 423-432
Publication
First Author: Pagler TA
Year: 2011
Journal: Circ Res
Title: Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling.
Volume: 108
Issue: 2
Pages: 194-200
Publication
First Author: Tamehiro N
Year: 2008
Journal: Biochemistry
Title: SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.
Volume: 47
Issue: 23
Pages: 6138-47
Publication
First Author: Brunham LR
Year: 2006
Journal: Circ Res
Title: Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.
Volume: 99
Issue: 7
Pages: 672-4
Publication
First Author: Lee JY
Year: 2005
Journal: J Lipid Res
Title: HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney.
Volume: 46
Issue: 10
Pages: 2233-45
Publication
First Author: Duka A
Year: 2013
Journal: J Lipid Res
Title: ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT.
Volume: 54
Issue: 1
Pages: 107-15
Publication
First Author: Jiang M
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Activation of PPARγ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI.
Volume: 482
Issue: 4
Pages: 849-856
Publication
First Author: Li Y
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Nucleolin protects macrophages from oxLDL-induced foam cell formation through up-regulating ABCA1 expression.
Volume: 486
Issue: 2
Pages: 364-371
Publication
First Author: Lammers B
Year: 2011
Journal: PLoS One
Title: Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE.
Volume: 6
Issue: 10
Pages: e26095
Publication
First Author: Price NL
Year: 2019
Journal: Circ Res
Title: Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development.
Volume: 124
Issue: 6
Pages: 874-880
Publication
First Author: Kruit JK
Year: 2012
Journal: Diabetes
Title: Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.
Volume: 61
Issue: 3
Pages: 659-64
Publication
First Author: Zhu X
Year: 2013
Journal: J Lipid Res
Title: Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models.
Volume: 54
Issue: 10
Pages: 2708-17
Publication
First Author: Gulshan K
Year: 2016
Journal: Circ Res
Title: PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.
Volume: 119
Issue: 7
Pages: 827-38