Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Members of ABC (ATP-binding cassette) transporter subfamily A are full-length transporters [], which consist of a single long polypeptide chain organised into two tandemly arranged halves. Each half contains a membrane-spanning domain (MSD) followed by a cytoplasmic nucleotide binding domain (NBD) []. ATP-binding cassette sub-family A member 1 (ABCA1) interacts with apo-A1, an extracellular lipid acceptor in the plasma [, ]. ABCA1 is involved in cholesterol efflux from peripheral tissues in a process known as the reverse cholesterol transport (RCT). Mutations in the ABCA1 gene cause Tangier disease, which is an autosomal recessive disorder characterised by a severe reduction in the amount of high density lipoprotein (HDL) in the bloodstream []. Mutations in the ABCA1 gene also cause a defect in the clearance of apoptotic cells by macrophages [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Williamson P |
Year: |
2007 |
Journal: |
PLoS One |
Title: |
Transbilayer phospholipid movements in ABCA1-deficient cells. |
Volume: |
2 |
Issue: |
8 |
Pages: |
e729 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hamon Y |
Year: |
2000 |
Journal: |
Nat Cell Biol |
Title: |
ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. |
Volume: |
2 |
Issue: |
7 |
Pages: |
399-406 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2261
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiu Y |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Human and mouse ABCA1 comparative sequencing and transgenesis studies revealing novel regulatory sequences. |
Volume: |
73 |
Issue: |
1 |
Pages: |
66-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bodzioch M |
Year: |
1999 |
Journal: |
Nat Genet |
Title: |
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. |
Volume: |
22 |
Issue: |
4 |
Pages: |
347-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chroni A |
Year: |
2004 |
Journal: |
Biochemistry |
Title: |
Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1. |
Volume: |
43 |
Issue: |
7 |
Pages: |
2126-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Denis M |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). |
Volume: |
279 |
Issue: |
9 |
Pages: |
7384-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bungert S |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation sites. |
Volume: |
276 |
Issue: |
26 |
Pages: |
23539-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coleman JA |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport. |
Volume: |
1831 |
Issue: |
3 |
Pages: |
555-74 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1487
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Karasinska JM |
Year: |
2013 |
Journal: |
Neurobiol Dis |
Title: |
ABCA1 influences neuroinflammation and neuronal death. |
Volume: |
54 |
|
Pages: |
445-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Viaud M |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms. |
Volume: |
30 |
Issue: |
10 |
Pages: |
3397-3410.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singaraja RR |
Year: |
2002 |
Journal: |
J Clin Invest |
Title: |
Increased ABCA1 activity protects against atherosclerosis. |
Volume: |
110 |
Issue: |
1 |
Pages: |
35-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bowden K |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
OSBP negatively regulates ABCA1 protein stability. |
Volume: |
283 |
Issue: |
26 |
Pages: |
18210-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaisman BL |
Year: |
2001 |
Journal: |
J Clin Invest |
Title: |
ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. |
Volume: |
108 |
Issue: |
2 |
Pages: |
303-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sallam T |
Year: |
2018 |
Journal: |
Nat Med |
Title: |
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. |
Volume: |
24 |
Issue: |
3 |
Pages: |
304-312 |
|
•
•
•
•
•
|
Publication |
First Author: |
Key CC |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis. |
Volume: |
19 |
Issue: |
10 |
Pages: |
2116-2129 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin X |
Year: |
2015 |
Journal: |
J Lipid Res |
Title: |
ABCA1 contributes to macrophage deposition of extracellular cholesterol. |
Volume: |
56 |
Issue: |
9 |
Pages: |
1720-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Othman A |
Year: |
2023 |
Journal: |
Front Physiol |
Title: |
Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids. |
Volume: |
14 |
|
Pages: |
1208719 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Haan W |
Year: |
2014 |
Journal: |
Diabetes |
Title: |
Hepatic ABCA1 expression improves β-cell function and glucose tolerance. |
Volume: |
63 |
Issue: |
12 |
Pages: |
4076-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brunham LR |
Year: |
2006 |
Journal: |
J Clin Invest |
Title: |
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. |
Volume: |
116 |
Issue: |
4 |
Pages: |
1052-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park DW |
Year: |
2013 |
Journal: |
Biochem Biophys Res Commun |
Title: |
TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway. |
Volume: |
430 |
Issue: |
3 |
Pages: |
933-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmitz G |
Year: |
2005 |
Journal: |
Biochim Biophys Acta |
Title: |
Transcriptional regulatory networks in lipid metabolism control ABCA1 expression. |
Volume: |
1735 |
Issue: |
1 |
Pages: |
1-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Costet P |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Retinoic acid receptor-mediated induction of ABCA1 in macrophages. |
Volume: |
23 |
Issue: |
21 |
Pages: |
7756-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cavelier C |
Year: |
2006 |
Journal: |
Biochim Biophys Acta |
Title: |
Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. |
Volume: |
1761 |
Issue: |
7 |
Pages: |
655-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang N |
Year: |
2003 |
Journal: |
J Clin Invest |
Title: |
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. |
Volume: |
111 |
Issue: |
1 |
Pages: |
99-107 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lammers B |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice. |
Volume: |
7 |
Issue: |
10 |
Pages: |
e48080 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2012 |
Journal: |
Circ Res |
Title: |
Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection. |
Volume: |
111 |
Issue: |
11 |
Pages: |
1398-409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirsch-Reinshagen V |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. |
Volume: |
279 |
Issue: |
39 |
Pages: |
41197-207 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brunham LR |
Year: |
2009 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. |
Volume: |
29 |
Issue: |
4 |
Pages: |
548-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou L |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. |
Volume: |
4 |
Issue: |
8 |
Pages: |
e6853 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang C |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. |
Volume: |
284 |
Issue: |
47 |
Pages: |
32336-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan J |
Year: |
2013 |
Journal: |
J Lipid Res |
Title: |
Hormonal modulators of glial ABCA1 and apoE levels. |
Volume: |
54 |
Issue: |
11 |
Pages: |
3139-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bates SR |
Year: |
2005 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Pulmonary abnormalities due to ABCA1 deficiency in mice. |
Volume: |
289 |
Issue: |
6 |
Pages: |
L980-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wahrle SE |
Year: |
2008 |
Journal: |
J Clin Invest |
Title: |
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. |
Volume: |
118 |
Issue: |
2 |
Pages: |
671-82 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Publication |
First Author: |
Fitz NF |
Year: |
2017 |
Journal: |
J Alzheimers Dis |
Title: |
ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice. |
Volume: |
56 |
Issue: |
3 |
Pages: |
1075-1085 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wijesekara N |
Year: |
2012 |
Journal: |
Diabetes |
Title: |
miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. |
Volume: |
61 |
Issue: |
3 |
Pages: |
653-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wijesekara N |
Year: |
2016 |
Journal: |
Diabetologia |
Title: |
ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice. |
Volume: |
59 |
Issue: |
6 |
Pages: |
1242-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brunham LR |
Year: |
2007 |
Journal: |
Nat Med |
Title: |
Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. |
Volume: |
13 |
Issue: |
3 |
Pages: |
340-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oku H |
Year: |
2007 |
Journal: |
FEBS Lett |
Title: |
Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver. |
Volume: |
581 |
Issue: |
26 |
Pages: |
5029-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun D |
Year: |
2012 |
Journal: |
FEBS Lett |
Title: |
MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7. |
Volume: |
586 |
Issue: |
10 |
Pages: |
1472-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao JH |
Year: |
2019 |
Journal: |
J Lipid Res |
Title: |
CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway. |
Volume: |
60 |
Issue: |
12 |
Pages: |
2020-2033 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pedrelli M |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice. |
Volume: |
9 |
Issue: |
4 |
Pages: |
e93552 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang C |
Year: |
2016 |
Journal: |
J Lipid Res |
Title: |
Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice. |
Volume: |
57 |
Issue: |
1 |
Pages: |
100-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burns MP |
Year: |
2006 |
Journal: |
J Neurochem |
Title: |
The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. |
Volume: |
98 |
Issue: |
3 |
Pages: |
792-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Timmins JM |
Year: |
2005 |
Journal: |
J Clin Invest |
Title: |
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. |
Volume: |
115 |
Issue: |
5 |
Pages: |
1333-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karasinska JM |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. |
Volume: |
29 |
Issue: |
11 |
Pages: |
3579-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kruit JK |
Year: |
2011 |
Journal: |
Diabetes |
Title: |
Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. |
Volume: |
60 |
Issue: |
12 |
Pages: |
3186-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cuffe H |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. |
Volume: |
38 |
Issue: |
4 |
Pages: |
733-743 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Haan W |
Year: |
2014 |
Journal: |
J Lipid Res |
Title: |
ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity. |
Volume: |
55 |
Issue: |
3 |
Pages: |
516-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen W |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes. |
Volume: |
280 |
Issue: |
32 |
Pages: |
29277-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang MH |
Year: |
2013 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145. |
Volume: |
33 |
Issue: |
12 |
Pages: |
2724-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koldamova R |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice. |
Volume: |
280 |
Issue: |
52 |
Pages: |
43224-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2023 |
Journal: |
Metabolism |
Title: |
ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease. |
Volume: |
139 |
|
Pages: |
155377 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yvan-Charvet L |
Year: |
2010 |
Journal: |
Circ Res |
Title: |
ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. |
Volume: |
106 |
Issue: |
12 |
Pages: |
1861-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Temel RE |
Year: |
2005 |
Journal: |
J Lipid Res |
Title: |
Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. |
Volume: |
46 |
Issue: |
11 |
Pages: |
2423-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Combes V |
Year: |
2005 |
Journal: |
Am J Pathol |
Title: |
ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology. |
Volume: |
166 |
Issue: |
1 |
Pages: |
295-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Eck M |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. |
Volume: |
99 |
Issue: |
9 |
Pages: |
6298-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu W |
Year: |
2008 |
Journal: |
J Lipid Res |
Title: |
Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo. |
Volume: |
49 |
Issue: |
2 |
Pages: |
386-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hou L |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Apolipoprotein A-I improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1. |
Volume: |
33 |
Issue: |
7 |
Pages: |
8479-8489 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu M |
Year: |
2017 |
Journal: |
Biochim Biophys Acta |
Title: |
Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion. |
Volume: |
1862 |
Issue: |
10 Pt A |
Pages: |
1035-1043 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez LO |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. |
Volume: |
278 |
Issue: |
39 |
Pages: |
37368-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Post SM |
Year: |
2006 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol. |
Volume: |
26 |
Issue: |
12 |
Pages: |
2724-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. |
Volume: |
117 |
Issue: |
8 |
Pages: |
2216-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fitz NF |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice. |
Volume: |
32 |
Issue: |
38 |
Pages: |
13125-36 |
|
•
•
•
•
•
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Publication |
First Author: |
Wahrle SE |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. |
Volume: |
279 |
Issue: |
39 |
Pages: |
40987-93 |
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Publication |
First Author: |
Zhu X |
Year: |
2010 |
Journal: |
J Lipid Res |
Title: |
Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. |
Volume: |
51 |
Issue: |
11 |
Pages: |
3196-206 |
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Publication |
First Author: |
Zhu X |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. |
Volume: |
283 |
Issue: |
34 |
Pages: |
22930-41 |
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Publication |
First Author: |
Ito M |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease. |
Volume: |
13 |
Issue: |
1 |
Pages: |
9616 |
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Publication |
First Author: |
Yvan-Charvet L |
Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. |
Volume: |
117 |
Issue: |
12 |
Pages: |
3900-8 |
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Publication |
First Author: |
Hirsch-Reinshagen V |
Year: |
2007 |
Journal: |
J Lipid Res |
Title: |
Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo. |
Volume: |
48 |
Issue: |
4 |
Pages: |
914-23 |
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Publication |
First Author: |
Shridas P |
Year: |
2010 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages. |
Volume: |
30 |
Issue: |
10 |
Pages: |
2014-21 |
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Publication |
First Author: |
Zhang L |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism. |
Volume: |
1831 |
Issue: |
6 |
Pages: |
1134-45 |
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Publication |
First Author: |
Bi X |
Year: |
2013 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. |
Volume: |
33 |
Issue: |
10 |
Pages: |
2288-96 |
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Publication |
First Author: |
Kypreos KE |
Year: |
2007 |
Journal: |
Biochem J |
Title: |
Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT. |
Volume: |
403 |
Issue: |
2 |
Pages: |
359-67 |
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Publication |
First Author: |
Wahrle SE |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. |
Volume: |
280 |
Issue: |
52 |
Pages: |
43236-42 |
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Publication |
First Author: |
Nelson JK |
Year: |
2017 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux. |
Volume: |
37 |
Issue: |
3 |
Pages: |
423-432 |
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Publication |
First Author: |
Okoro EU |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e44430 |
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Publication |
First Author: |
Ouvrier A |
Year: |
2009 |
Journal: |
J Lipid Res |
Title: |
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner. |
Volume: |
50 |
Issue: |
9 |
Pages: |
1766-75 |
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Publication |
First Author: |
Pagler TA |
Year: |
2011 |
Journal: |
Circ Res |
Title: |
Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling. |
Volume: |
108 |
Issue: |
2 |
Pages: |
194-200 |
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Publication |
First Author: |
Tamehiro N |
Year: |
2008 |
Journal: |
Biochemistry |
Title: |
SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. |
Volume: |
47 |
Issue: |
23 |
Pages: |
6138-47 |
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Publication |
First Author: |
Brunham LR |
Year: |
2006 |
Journal: |
Circ Res |
Title: |
Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. |
Volume: |
99 |
Issue: |
7 |
Pages: |
672-4 |
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Publication |
First Author: |
Zhao Y |
Year: |
2022 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Specific Loss of ABCA1 (ATP-Binding Cassette Transporter A1) Suppresses TCR (T-Cell Receptor) Signaling and Provides Protection Against Atherosclerosis. |
Volume: |
42 |
Issue: |
12 |
Pages: |
e311-e326 |
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Publication |
First Author: |
Lee JY |
Year: |
2005 |
Journal: |
J Lipid Res |
Title: |
HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney. |
Volume: |
46 |
Issue: |
10 |
Pages: |
2233-45 |
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Publication |
First Author: |
Duka A |
Year: |
2013 |
Journal: |
J Lipid Res |
Title: |
ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT. |
Volume: |
54 |
Issue: |
1 |
Pages: |
107-15 |
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Publication |
First Author: |
Jiang M |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Activation of PPARγ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI. |
Volume: |
482 |
Issue: |
4 |
Pages: |
849-856 |
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Publication |
First Author: |
Lammers B |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. |
Volume: |
6 |
Issue: |
10 |
Pages: |
e26095 |
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Publication |
First Author: |
Li Y |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Nucleolin protects macrophages from oxLDL-induced foam cell formation through up-regulating ABCA1 expression. |
Volume: |
486 |
Issue: |
2 |
Pages: |
364-371 |
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Publication |
First Author: |
Price NL |
Year: |
2019 |
Journal: |
Circ Res |
Title: |
Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development. |
Volume: |
124 |
Issue: |
6 |
Pages: |
874-880 |
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