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Search results 1 to 100 out of 307 for Abcc8

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
6833 | ABCC8
Type: gene
Organism: human
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Gene
538996 | ABCC8
Type: gene
Organism: cattle
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Gene
423072 | ABCC8
Type: gene
Organism: chicken
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Gene
553281 | abcc8
Type: gene
Organism: zebrafish
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Gene
654490 | ABCC8
Type: gene
Organism: macaque, rhesus
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Gene
101730668 | abcc8
Type: gene
Organism: frog, western clawed
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Gene
101733944 | abcc8
Type: gene
Organism: frog, western clawed
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Gene
25559 | Abcc8
Type: gene
Organism: rat
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Gene
485402 | ABCC8
Type: gene
Organism: dog, domestic
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Gene
451056 | ABCC8
Type: gene
Organism: chimpanzee
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Protein Domain
IPR000844 | ABCC8
Type: Family
Description: ATP-binding cassette subfamily C member 8 (ABCC8, also known as the sulphonylurea receptor SUR1) is a member of the ABC transporter family. ABCC8 is comprised of three transmembrane helical bundles, TMD0, TMD1 and TMD2. It also contains two cytosolic nucleotide binding domains (NBDs) located between TMD1 and TMD2 and in the cytoplasmic C-terminal domain, respectively []. It is a regulator of the potassium ATP channel. Its NBD domains control channel activity through their interaction with cytosolic nucleotides []. Together with ABCC9 (SUR2), ABCC8 regulates the Kir6.2 potassium channel []. It also controls insulin secretion after feeding [].ABCC8 and 9 are the targets of sulphonylurea oral hypoglycaemic agents that are used widely for the treatment of non-insulin dependent diabetes mellitus and ABCC8 genetic variants have been linked to risk of the disease [, ].
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Protein Coding Gene
MGI:1352629 | Abcc8
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825727
Age: embryonic day 14.5
Image: Additional file 4 Abcc8
Specimen Label: Additional file 4 Abcc8
Detected: true
Specimen Num: 1
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Publication
24768178 | -
First Author: Haghverdizadeh P
Year: 2014
Journal: Gene
Title: ABCC8 genetic variants and risk of diabetes mellitus.
Volume: 545
Issue: 2
Pages: 198-204
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Publication
20410530 | J:167879
First Author: Simard JM
Year: 2010
Journal: Sci Transl Med
Title: Brief suppression of Abcc8 prevents autodestruction of spinal cord after trauma.
Volume: 2
Issue: 28
Pages: 28ra29
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Publication
26493453 | J:303607
First Author: Andrikopoulos S
Year: 2016
Journal: J Endocrinol
Title: Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice.
Volume: 228
Issue: 1
Pages: 61-73
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Publication
33940936 | J:344700
First Author: Tata S
Year: 2021
Journal: J Neurotrauma
Title: Abcc8 (Sulfonylurea Receptor-1) Impact on Brain Atrophy after Traumatic Brain Injury Varies by Sex.
Volume: 38
Issue: 17
Pages: 2473-2485
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Publication
10204114 | -
First Author: Aguilar-Bryan L
Year: 1999
Journal: Endocr Rev
Title: Molecular biology of adenosine triphosphate-sensitive potassium channels.
Volume: 20
Issue: 2
Pages: 101-35
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Publication
25143473 | -
First Author: Rolim AL
Year: 2014
Journal: J Mol Endocrinol
Title: The insulin-sensitivity sulphonylurea receptor variant is associated with thyrotoxic paralysis.
Volume: 53
Issue: 2
Pages: 295-301
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Publication
16416420 | -
First Author: Gloyn AL
Year: 2006
Journal: Hum Mutat
Title: Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.
Volume: 27
Issue: 3
Pages: 220-31
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Publication
18767144 | -
First Author: Flanagan SE
Year: 2009
Journal: Hum Mutat
Title: Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism.
Volume: 30
Issue: 2
Pages: 170-80
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Publication
25236767 | -
First Author: Lodwick D
Year: 2014
Journal: Biochem J
Title: Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge.
Volume: 464
Issue: 3
Pages: 343-54
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Publication
36681815 | J:344541
First Author: Cummings J
Year: 2023
Journal: J Neuroinflammation
Title: Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis.
Volume: 20
Issue: 1
Pages: 12
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Protein
A0A1B0GRD7
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
Q8BNE2
Organism: Mus musculus/domesticus
Length: 1087  
Fragment?: false
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Protein
B2RUS7
Organism: Mus musculus/domesticus
Length: 1588  
Fragment?: false
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Protein
Q9Z2P2
Organism: Mus musculus/domesticus
Length: 899  
Fragment?: true
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Protein
Q6PGE2
Organism: Mus musculus/domesticus
Length: 909  
Fragment?: true
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Publication
28550109 | J:249474
First Author: Stancill JS
Year: 2017
Journal: Diabetes
Title: Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes.
Volume: 66
Issue: 8
Pages: 2175-2187
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Publication
23903354 | J:208932
First Author: Shimomura K
Year: 2013
Journal: Diabetes
Title: A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.
Volume: 62
Issue: 11
Pages: 3797-806
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Publication
37358194 | J:339722
First Author: Peterson SM
Year: 2023
Journal: Diabetes
Title: Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism.
Volume: 72
Issue: 9
Pages: 1320-1329
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Publication
27246103 | J:324133
First Author: Kurland DB
Year: 2016
Journal: J Neuroinflammation
Title: The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia.
Volume: 13
Issue: 1
Pages: 130
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Publication
32332159 | J:293253
First Author: Osipovich AB
Year: 2020
Journal: Diabetes
Title: Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells.
Volume: 69
Issue: 7
Pages: 1476-1491
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Protein Coding Gene
MGP_CAROLIEiJ_G0029757 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032239 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032175 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032251 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1352629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032743 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031294 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031931 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032040 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032167 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032077 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032758 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031017 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031412 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012982 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030855 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7716547 | J:39110
First Author: Aguilar-Bryan L
Year: 1995
Journal: Science
Title: Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
Volume: 268
Issue: 5209
Pages: 423-6
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Publication
24621811 | J:215008
First Author: Nakamura Y
Year: 2014
Journal: PLoS One
Title: Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells.
Volume: 9
Issue: 3
Pages: e91525
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Publication
10734066 | J:61356
First Author: Seghers V
Year: 2000
Journal: J Biol Chem
Title: Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion.
Volume: 275
Issue: 13
Pages: 9270-7
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Publication
14613926 | J:95414
First Author: Sieg A
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Epinephrine-induced hyperpolarization of islet cells without KATP channels.
Volume: 286
Issue: 3
Pages: E463-71
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Publication
16123162 | J:129834
First Author: Muñoz A
Year: 2005
Journal: Endocrinology
Title: Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement.
Volume: 146
Issue: 12
Pages: 5514-21
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Publication
19805912 | J:154622
First Author: Gier B
Year: 2009
Journal: J Clin Invest
Title: Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.
Volume: 119
Issue: 11
Pages: 3246-56
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Publication
17389589 | J:122542
First Author: Szollosi A
Year: 2007
Journal: J Biol Chem
Title: Overnight culture unmasks glucose-induced insulin secretion in mouse islets lacking ATP-sensitive K+ channels by improving the triggering Ca2+ signal.
Volume: 282
Issue: 20
Pages: 14768-76
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Publication
19808893 | J:164171
First Author: Slucca M
Year: 2010
Journal: Diabetes
Title: ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.
Volume: 59
Issue: 1
Pages: 128-34
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Publication
12453898 | J:107167
First Author: Nakazaki M
Year: 2002
Journal: Diabetes
Title: cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.
Volume: 51
Issue: 12
Pages: 3440-9
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Publication
22187376 | J:191514
First Author: Su Y
Year: 2012
Journal: Diabetes
Title: Hypothalamic leucine metabolism regulates liver glucose production.
Volume: 61
Issue: 1
Pages: 85-93
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Publication
19095654 | J:147907
First Author: Ackermann S
Year: 2009
Journal: J Biol Chem
Title: 17beta-Estradiol modulates apoptosis in pancreatic beta-cells by specific involvement of the sulfonylurea receptor (SUR) isoform SUR1.
Volume: 284
Issue: 8
Pages: 4905-13
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Publication
32160005 | J:293969
First Author: Glendinning JI
Year: 2020
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Olfaction contributes to the learned avidity for glucose relative to fructose in mice.
Volume: 318
Issue: 5
Pages: R901-R916
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Publication
15830184 | J:99668
First Author: Haspel D
Year: 2005
Journal: Diabetologia
Title: Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice.
Volume: 48
Issue: 5
Pages: 913-21
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Publication
31695594 | J:284363
 
First Author: Fisher C
Year: 2019
Journal: Front Neurosci
Title: Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice.
Volume: 13
Pages: 1122
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Publication
17138562 | J:120300
First Author: Hambrock A
Year: 2007
Journal: J Biol Chem
Title: Resveratrol binds to the sulfonylurea receptor (SUR) and induces apoptosis in a SUR subtype-specific manner.
Volume: 282
Issue: 5
Pages: 3347-56
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Publication
15846348 | J:98261
First Author: Pocai A
Year: 2005
Journal: Nature
Title: Hypothalamic K(ATP) channels control hepatic glucose production.
Volume: 434
Issue: 7036
Pages: 1026-31
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Publication
31067750 | J:304515
 
First Author: Luu W
Year: 2019
Journal: Int J Mol Sci
Title: Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice.
Volume: 20
Issue: 9
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Publication
17138557 | J:118538
First Author: Szollosi A
Year: 2007
Journal: J Biol Chem
Title: Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.
Volume: 282
Issue: 3
Pages: 1747-56
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Publication
17593344 | J:143822
First Author: Guiot Y
Year: 2007
Journal: Diabetologia
Title: Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas.
Volume: 50
Issue: 9
Pages: 1889-99
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Publication
15175349 | J:91776
First Author: Nenquin M
Year: 2004
Journal: J Biol Chem
Title: Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.
Volume: 279
Issue: 31
Pages: 32316-24
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Publication
15757648 | J:97378
First Author: Kikuta T
Year: 2005
Journal: FEBS Lett
Title: Docking and fusion of insulin secretory granules in SUR1 knock out mouse beta-cells observed by total internal reflection fluorescence microscopy.
Volume: 579
Issue: 7
Pages: 1602-6
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Publication
29180017 | J:273008
First Author: Cai M
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Role of osteopontin and its regulation in pancreatic islet.
Volume: 495
Issue: 1
Pages: 1426-1431
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Publication
26592666 | J:233187
First Author: Cai M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney.
Volume: 469
Issue: 1
Pages: 108-113
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Publication
14736703 | J:95412
First Author: Doliba NM
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
Volume: 286
Issue: 5
Pages: E834-43
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Publication
12601083 | J:105833
First Author: Eliasson L
Year: 2003
Journal: J Gen Physiol
Title: SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
Volume: 121
Issue: 3
Pages: 181-97
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Publication
18840760 | J:144415
First Author: Huang W
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels.
Volume: 295
Issue: 6
Pages: E1439-46
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Publication
15561909 | J:107153
 
First Author: Gromada J
Year: 2004
Journal: Diabetes
Title: ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
Volume: 53 Suppl 3
Pages: S181-9
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Publication
18316485 | J:148446
First Author: Elrod JW
Year: 2008
Journal: Circulation
Title: Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.
Volume: 117
Issue: 11
Pages: 1405-13
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Publication
14736887 | J:89159
First Author: Li C
Year: 2004
Journal: J Biol Chem
Title: A signaling role of glutamine in insulin secretion.
Volume: 279
Issue: 14
Pages: 13393-401
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Publication
15613469 | J:327473
First Author: Bancila V
Year: 2005
Journal: J Biol Chem
Title: Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel.
Volume: 280
Issue: 10
Pages: 8793-9
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Publication
25771886 | J:327477
First Author: Slepchenko KG
Year: 2015
Journal: Endocrine
Title: Autocrine effect of Zn²⁺ on the glucose-stimulated insulin secretion.
Volume: 50
Issue: 1
Pages: 110-22
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Publication
11248115 | J:68070
First Author: Hernández-Sánchez C
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death.
Volume: 98
Issue: 6
Pages: 3549-54
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Publication
9003005 | J:38425
First Author: Hernández-Sánchez C
Year: 1997
Journal: Endocrinology
Title: Developmental and tissue-specific sulfonylurea receptor gene expression.
Volume: 138
Issue: 2
Pages: 705-11
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GXD Expression
GXD Expression
     
Probe: MGI:3707808
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733125
Stage: TS25
Assay Id: MGI:3708130
Age: embryonic day 17.5
Specimen Label: Fetus
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3707808
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733127
Stage: TS27
Assay Id: MGI:3708130
Age: postnatal day 1
Specimen Label: Neonate
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3707808
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Male
Emaps: EMAPS:1733128
Stage: TS28
Assay Id: MGI:3708130
Age: postnatal week 5-8
Specimen Label: Adult
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706619
Stage: TS19
Assay Id: MGI:3826473
Age: embryonic day 11.5
Image: 4
Specimen Label: TS19
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:3826473
Age: embryonic day 13.5
Image: 4
Specimen Label: TS21
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Stage: TS23
Assay Id: MGI:3826473
Age: embryonic day 15.5
Image: 4
Specimen Label: TS23
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:3826473
Age: embryonic day 18.5
Image: 4
Specimen Label: TS26
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3295228
Stage: TS28
Assay Id: MGI:3826473
Age: postnatal adult
Image: 4
Specimen Label: Ducts
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292728
Stage: TS28
Assay Id: MGI:3826473
Age: postnatal adult
Image: 4
Specimen Label: Islets
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Specimen Label: EB2685; Specimen B991
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Specimen Label: EB2685; Specimen B991
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Specimen Label: EB2685; Specimen B991
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Specimen Label: EB2685; Specimen B991
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Specimen Label: EB2685; Specimen B991
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Specimen Label: EB2685; Specimen B991
Detected: false
Specimen Num: 1
•
•
•
•
•




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