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Search results 1 to 100 out of 285 for Abcc8

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: ATP-binding cassette subfamily C member 8 (ABCC8, also known as the sulphonylurea receptor SUR1) is a member of the ABC transporter family. ABCC8 is comprised of three transmembrane helical bundles, TMD0, TMD1 and TMD2. It also contains two cytosolic nucleotide binding domains (NBDs) located between TMD1 and TMD2 and in the cytoplasmic C-terminal domain, respectively []. It is a regulator of the potassium ATP channel. Its NBD domains control channel activity through their interaction with cytosolic nucleotides []. Together with ABCC9 (SUR2), ABCC8 regulates the Kir6.2 potassium channel []. It also controls insulin secretion after feeding [].ABCC8 and 9 are the targets of sulphonylurea oral hypoglycaemic agents that are used widely for the treatment of non-insulin dependent diabetes mellitus and ABCC8 genetic variants have been linked to risk of the disease [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 909  
Fragment?: true
Publication
First Author: Haghverdizadeh P
Year: 2014
Journal: Gene
Title: ABCC8 genetic variants and risk of diabetes mellitus.
Volume: 545
Issue: 2
Pages: 198-204
Publication
First Author: Simard JM
Year: 2010
Journal: Sci Transl Med
Title: Brief suppression of Abcc8 prevents autodestruction of spinal cord after trauma.
Volume: 2
Issue: 28
Pages: 28ra29
GXD Expression  
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825727
Age: embryonic day 14.5
Image: Additional file 4 Abcc8
Detected: true
Specimen Num: 1
Publication
First Author: Aguilar-Bryan L
Year: 1999
Journal: Endocr Rev
Title: Molecular biology of adenosine triphosphate-sensitive potassium channels.
Volume: 20
Issue: 2
Pages: 101-35
Publication
First Author: Rolim AL
Year: 2014
Journal: J Mol Endocrinol
Title: The insulin-sensitivity sulphonylurea receptor variant is associated with thyrotoxic paralysis.
Volume: 53
Issue: 2
Pages: 295-301
Publication
First Author: Gloyn AL
Year: 2006
Journal: Hum Mutat
Title: Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.
Volume: 27
Issue: 3
Pages: 220-31
Publication
First Author: Flanagan SE
Year: 2009
Journal: Hum Mutat
Title: Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism.
Volume: 30
Issue: 2
Pages: 170-80
Publication
First Author: Lodwick D
Year: 2014
Journal: Biochem J
Title: Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge.
Volume: 464
Issue: 3
Pages: 343-54
Protein
Organism: Mus musculus
Length: 123  
Fragment?: true
Protein
Organism: Mus musculus
Length: 158  
Fragment?: true
Protein
Organism: Mus musculus
Length: 228  
Fragment?: true
Protein
Organism: Mus musculus
Length: 910  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1087  
Fragment?: false
Protein
Organism: Mus musculus
Length: 683  
Fragment?: true
Protein
Organism: Mus musculus
Length: 899  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1588  
Fragment?: false
Publication
First Author: Stancill JS
Year: 2017
Journal: Diabetes
Title: Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes.
Volume: 66
Issue: 8
Pages: 2175-2187
Publication
First Author: Shimomura K
Year: 2013
Journal: Diabetes
Title: A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.
Volume: 62
Issue: 11
Pages: 3797-806
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Aguilar-Bryan L
Year: 1995
Journal: Science
Title: Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
Volume: 268
Issue: 5209
Pages: 423-6
Publication
First Author: Nakamura Y
Year: 2014
Journal: PLoS One
Title: Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells.
Volume: 9
Issue: 3
Pages: e91525
Publication
First Author: Seghers V
Year: 2000
Journal: J Biol Chem
Title: Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion.
Volume: 275
Issue: 13
Pages: 9270-7
Publication
First Author: Slucca M
Year: 2010
Journal: Diabetes
Title: ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.
Volume: 59
Issue: 1
Pages: 128-34
Publication
First Author: Gier B
Year: 2009
Journal: J Clin Invest
Title: Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.
Volume: 119
Issue: 11
Pages: 3246-56
Publication
First Author: Hambrock A
Year: 2007
Journal: J Biol Chem
Title: Resveratrol binds to the sulfonylurea receptor (SUR) and induces apoptosis in a SUR subtype-specific manner.
Volume: 282
Issue: 5
Pages: 3347-56
Publication
First Author: Pocai A
Year: 2005
Journal: Nature
Title: Hypothalamic K(ATP) channels control hepatic glucose production.
Volume: 434
Issue: 7036
Pages: 1026-31
Publication
First Author: Ackermann S
Year: 2009
Journal: J Biol Chem
Title: 17beta-Estradiol modulates apoptosis in pancreatic beta-cells by specific involvement of the sulfonylurea receptor (SUR) isoform SUR1.
Volume: 284
Issue: 8
Pages: 4905-13
Publication
First Author: Muñoz A
Year: 2005
Journal: Endocrinology
Title: Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement.
Volume: 146
Issue: 12
Pages: 5514-21
Publication
First Author: Nenquin M
Year: 2004
Journal: J Biol Chem
Title: Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.
Volume: 279
Issue: 31
Pages: 32316-24
Publication
First Author: Kikuta T
Year: 2005
Journal: FEBS Lett
Title: Docking and fusion of insulin secretory granules in SUR1 knock out mouse beta-cells observed by total internal reflection fluorescence microscopy.
Volume: 579
Issue: 7
Pages: 1602-6
Publication
First Author: Nakazaki M
Year: 2002
Journal: Diabetes
Title: cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.
Volume: 51
Issue: 12
Pages: 3440-9
Publication
First Author: Su Y
Year: 2012
Journal: Diabetes
Title: Hypothalamic leucine metabolism regulates liver glucose production.
Volume: 61
Issue: 1
Pages: 85-93
Publication
First Author: Guiot Y
Year: 2007
Journal: Diabetologia
Title: Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas.
Volume: 50
Issue: 9
Pages: 1889-99
Publication
First Author: Szollosi A
Year: 2007
Journal: J Biol Chem
Title: Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.
Volume: 282
Issue: 3
Pages: 1747-56
Publication
First Author: Sieg A
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Epinephrine-induced hyperpolarization of islet cells without KATP channels.
Volume: 286
Issue: 3
Pages: E463-71
Publication  
First Author: Fisher C
Year: 2019
Journal: Front Neurosci
Title: Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice.
Volume: 13
Pages: 1122
Publication
First Author: Szollosi A
Year: 2007
Journal: J Biol Chem
Title: Overnight culture unmasks glucose-induced insulin secretion in mouse islets lacking ATP-sensitive K+ channels by improving the triggering Ca2+ signal.
Volume: 282
Issue: 20
Pages: 14768-76
Publication
First Author: Haspel D
Year: 2005
Journal: Diabetologia
Title: Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice.
Volume: 48
Issue: 5
Pages: 913-21
Publication
First Author: Li C
Year: 2004
Journal: J Biol Chem
Title: A signaling role of glutamine in insulin secretion.
Volume: 279
Issue: 14
Pages: 13393-401
Publication
First Author: Elrod JW
Year: 2008
Journal: Circulation
Title: Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.
Volume: 117
Issue: 11
Pages: 1405-13
Publication
First Author: Doliba NM
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
Volume: 286
Issue: 5
Pages: E834-43
Publication  
First Author: Gromada J
Year: 2004
Journal: Diabetes
Title: ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
Volume: 53 Suppl 3
Pages: S181-9
Publication
First Author: Eliasson L
Year: 2003
Journal: J Gen Physiol
Title: SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
Volume: 121
Issue: 3
Pages: 181-97
Publication
First Author: Huang W
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels.
Volume: 295
Issue: 6
Pages: E1439-46
Publication
First Author: Cai M
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Role of osteopontin and its regulation in pancreatic islet.
Volume: 495
Issue: 1
Pages: 1426-1431
Publication
First Author: Cai M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney.
Volume: 469
Issue: 1
Pages: 108-113
Publication
First Author: Hernández-Sánchez C
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death.
Volume: 98
Issue: 6
Pages: 3549-54
Publication
First Author: Hernández-Sánchez C
Year: 1997
Journal: Endocrinology
Title: Developmental and tissue-specific sulfonylurea receptor gene expression.
Volume: 138
Issue: 2
Pages: 705-11
GXD Expression    
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3295228
Stage: TS28
Assay Id: MGI:3826473
Age: postnatal adult
Image: 4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292728
Stage: TS28
Assay Id: MGI:3826473
Age: postnatal adult
Image: 4
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706619
Stage: TS19
Assay Id: MGI:3826473
Age: embryonic day 11.5
Image: 4
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3707808
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Male
Emaps: EMAPS:1733128
Stage: TS28
Assay Id: MGI:3708130
Age: postnatal week 5-8
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3707808
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733127
Stage: TS27
Assay Id: MGI:3708130
Age: postnatal day 1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3707808
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733125
Stage: TS25
Assay Id: MGI:3708130
Age: embryonic day 17.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:3826473
Age: embryonic day 18.5
Image: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Stage: TS23
Assay Id: MGI:3826473
Age: embryonic day 15.5
Image: 4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3826399
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:3826473
Age: embryonic day 13.5
Image: 4
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753622
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274322
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647022
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3272922
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Note: Expression was not detected in the skeleton (limbs, shoulder, hip).
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1781522
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619422
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3286922
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3090122
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3283722
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736622
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Note: Expression was not detected in the genito-urinary system.
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1745822
Stage: TS22
Assay Id: MGI:5421745
Age: embryonic day 14.5
Detected: false
Specimen Num: 1