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Search results 1 to 100 out of 385 for Abcc8

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Hits by Strain

Type Details Score
Gene
Type: gene
Organism: human
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Gene
Type: gene
Organism: frog, western clawed
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Gene
Type: gene
Organism: frog, western clawed
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Gene
Type: gene
Organism: rat
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Gene
Type: gene
Organism: dog, domestic
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Gene
Type: gene
Organism: chimpanzee
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Gene
Type: gene
Organism: cattle
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Gene
Type: gene
Organism: chicken
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Gene
Type: gene
Organism: zebrafish
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Gene
Type: gene
Organism: macaque, rhesus
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Protein Domain
Type: Family
Description: ATP-binding cassette subfamily C member 8 (ABCC8, also known as the sulphonylurea receptor SUR1) is a member of the ABC transporter family. ABCC8 is comprised of three transmembrane helical bundles, TMD0, TMD1 and TMD2. It also contains two cytosolic nucleotide binding domains (NBDs) located between TMD1 and TMD2 and in the cytoplasmic C-terminal domain, respectively []. It is a regulator of the potassium ATP channel. Its NBD domains control channel activity through their interaction with cytosolic nucleotides [].
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression  
Probe: MGI:3820874
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825727
Age: embryonic day 14.5
Image: Additional file 4 Abcc8
Specimen Label: Additional file 4 Abcc8
Detected: true
Specimen Num: 1
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Publication
First Author: Haghvirdizadeh P
Year: 2014
Journal: Gene
Title: ABCC8 genetic variants and risk of diabetes mellitus.
Volume: 545
Issue: 2
Pages: 198-204
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Publication
First Author: Ikle JM
Year: 2022
Journal: Islets
Title: Genome-edited zebrafish model of ABCC8 loss-of-function disease.
Volume: 14
Issue: 1
Pages: 200-209
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Publication
First Author: Simard JM
Year: 2010
Journal: Sci Transl Med
Title: Brief suppression of Abcc8 prevents autodestruction of spinal cord after trauma.
Volume: 2
Issue: 28
Pages: 28ra29
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Publication
First Author: Muzyamba M
Year: 2007
Journal: Clin Endocrinol (Oxf)
Title: Complex ABCC8 DNA variations in congenital hyperinsulinism: lessons from functional studies.
Volume: 67
Issue: 1
Pages: 115-24
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Publication
First Author: Andrikopoulos S
Year: 2016
Journal: J Endocrinol
Title: Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice.
Volume: 228
Issue: 1
Pages: 61-73
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Publication
First Author: Tata S
Year: 2021
Journal: J Neurotrauma
Title: Abcc8 (Sulfonylurea Receptor-1) Impact on Brain Atrophy after Traumatic Brain Injury Varies by Sex.
Volume: 38
Issue: 17
Pages: 2473-2485
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Publication
First Author: Aguilar-Bryan L
Year: 1999
Journal: Endocr Rev
Title: Molecular biology of adenosine triphosphate-sensitive potassium channels.
Volume: 20
Issue: 2
Pages: 101-35
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Publication
First Author: Rolim AL
Year: 2014
Journal: J Mol Endocrinol
Title: The insulin-sensitivity sulphonylurea receptor variant is associated with thyrotoxic paralysis.
Volume: 53
Issue: 2
Pages: 295-301
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Publication
First Author: Gloyn AL
Year: 2006
Journal: Hum Mutat
Title: Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.
Volume: 27
Issue: 3
Pages: 220-31
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Publication
First Author: Flanagan SE
Year: 2009
Journal: Hum Mutat
Title: Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism.
Volume: 30
Issue: 2
Pages: 170-80
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Publication
First Author: Lodwick D
Year: 2014
Journal: Biochem J
Title: Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge.
Volume: 464
Issue: 3
Pages: 343-54
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Publication
First Author: Cummings J
Year: 2023
Journal: J Neuroinflammation
Title: Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis.
Volume: 20
Issue: 1
Pages: 12
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Protein
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
Organism: Mus musculus/domesticus
Length: 1588  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1588  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1087  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 899  
Fragment?: true
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Publication
First Author: Shimomura K
Year: 2013
Journal: Diabetes
Title: A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.
Volume: 62
Issue: 11
Pages: 3797-806
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Publication
First Author: Fisher C
Year: 2024
Journal: Diabetes
Title: Loss of ATP-Sensitive Potassium Channel Expression and Function in the Nervous System Decreases Opioid Sensitivity in a High-Fat Diet-Fed Mouse Model of Diet-Induced Obesity.
Volume: 73
Issue: 8
Pages: 1244-1254
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Publication
First Author: Peterson SM
Year: 2023
Journal: Diabetes
Title: Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism.
Volume: 72
Issue: 9
Pages: 1320-1329
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Publication
First Author: Osipovich AB
Year: 2020
Journal: Diabetes
Title: Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic ?-Cells.
Volume: 69
Issue: 7
Pages: 1476-1491
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Publication
First Author: Stancill JS
Year: 2017
Journal: Diabetes
Title: Chronic ?-Cell Depolarization Impairs ?-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes.
Volume: 66
Issue: 8
Pages: 2175-2187
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Publication
First Author: Kurland DB
Year: 2016
Journal: J Neuroinflammation
Title: The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia.
Volume: 13
Issue: 1
Pages: 130
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Publication  
First Author: Tsymbalyuk O
Year: 2021
Journal: Mol Pain
Title: SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury.
Volume: 17
Pages: 17448069211006603
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
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Publication
First Author: Aguilar-Bryan L
Year: 1995
Journal: Science
Title: Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
Volume: 268
Issue: 5209
Pages: 423-6
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Publication
First Author: Seghers V
Year: 2000
Journal: J Biol Chem
Title: Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion.
Volume: 275
Issue: 13
Pages: 9270-7
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Publication
First Author: Haspel D
Year: 2005
Journal: Diabetologia
Title: Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice.
Volume: 48
Issue: 5
Pages: 913-21
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Publication  
First Author: Luu W
Year: 2019
Journal: Int J Mol Sci
Title: Modulation of SUR1 K(ATP) Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice.
Volume: 20
Issue: 9
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Publication
First Author: Glendinning JI
Year: 2020
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Olfaction contributes to the learned avidity for glucose relative to fructose in mice.
Volume: 318
Issue: 5
Pages: R901-R916
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Publication
First Author: Mu?oz A
Year: 2005
Journal: Endocrinology
Title: Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement.
Volume: 146
Issue: 12
Pages: 5514-21
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Publication
First Author: Kikuta T
Year: 2005
Journal: FEBS Lett
Title: Docking and fusion of insulin secretory granules in SUR1 knock out mouse beta-cells observed by total internal reflection fluorescence microscopy.
Volume: 579
Issue: 7
Pages: 1602-6
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Publication  
First Author: Fisher C
Year: 2019
Journal: Front Neurosci
Title: Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype K(ATP) Channel Activity in Mice.
Volume: 13
Pages: 1122
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Publication
First Author: Slucca M
Year: 2010
Journal: Diabetes
Title: ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.
Volume: 59
Issue: 1
Pages: 128-34
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Publication
First Author: Nakazaki M
Year: 2002
Journal: Diabetes
Title: cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.
Volume: 51
Issue: 12
Pages: 3440-9
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Publication
First Author: Szollosi A
Year: 2007
Journal: J Biol Chem
Title: Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.
Volume: 282
Issue: 3
Pages: 1747-56
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Publication
First Author: Gier B
Year: 2009
Journal: J Clin Invest
Title: Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.
Volume: 119
Issue: 11
Pages: 3246-56
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Publication
First Author: Pocai A
Year: 2005
Journal: Nature
Title: Hypothalamic K(ATP) channels control hepatic glucose production.
Volume: 434
Issue: 7036
Pages: 1026-31
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Publication
First Author: Sieg A
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Epinephrine-induced hyperpolarization of islet cells without KATP channels.
Volume: 286
Issue: 3
Pages: E463-71
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Publication
First Author: Szollosi A
Year: 2007
Journal: J Biol Chem
Title: Overnight culture unmasks glucose-induced insulin secretion in mouse islets lacking ATP-sensitive K+ channels by improving the triggering Ca2+ signal.
Volume: 282
Issue: 20
Pages: 14768-76
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Publication
First Author: Su Y
Year: 2012
Journal: Diabetes
Title: Hypothalamic leucine metabolism regulates liver glucose production.
Volume: 61
Issue: 1
Pages: 85-93
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Publication
First Author: Nenquin M
Year: 2004
Journal: J Biol Chem
Title: Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.
Volume: 279
Issue: 31
Pages: 32316-24
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Publication
First Author: Guiot Y
Year: 2007
Journal: Diabetologia
Title: Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas.
Volume: 50
Issue: 9
Pages: 1889-1899
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Publication
First Author: Nakamura Y
Year: 2014
Journal: PLoS One
Title: Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells.
Volume: 9
Issue: 3
Pages: e91525
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Publication  
First Author: Gromada J
Year: 2004
Journal: Diabetes
Title: ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
Volume: 53 Suppl 3
Pages: S181-9
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Publication
First Author: Doliba NM
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
Volume: 286
Issue: 5
Pages: E834-43
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Publication
First Author: Eliasson L
Year: 2003
Journal: J Gen Physiol
Title: SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
Volume: 121
Issue: 3
Pages: 181-97
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Publication
First Author: Huang W
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels.
Volume: 295
Issue: 6
Pages: E1439-46
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Publication
First Author: Li C
Year: 2004
Journal: J Biol Chem
Title: A signaling role of glutamine in insulin secretion.
Volume: 279
Issue: 14
Pages: 13393-401
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Publication
First Author: Liu M
Year: 2022
Journal: Aging Cell
Title: Role of upregulation of the K(ATP) channel subunit SUR1 in dopaminergic neuron degeneration in Parkinson's disease.
Volume: 21
Issue: 5
Pages: e13618
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Publication
First Author: Cai M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney.
Volume: 469
Issue: 1
Pages: 108-113
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Publication
First Author: Cai M
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Role of osteopontin and its regulation in pancreatic islet.
Volume: 495
Issue: 1
Pages: 1426-1431
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Publication
First Author: Bancila V
Year: 2005
Journal: J Biol Chem
Title: Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel.
Volume: 280
Issue: 10
Pages: 8793-9
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Publication
First Author: Slepchenko KG
Year: 2015
Journal: Endocrine
Title: Autocrine effect of Zn?? on the glucose-stimulated insulin secretion.
Volume: 50
Issue: 1
Pages: 110-22
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Publication
First Author: Hern?ndez-S?nchez C
Year: 1997
Journal: Endocrinology
Title: Developmental and tissue-specific sulfonylurea receptor gene expression.
Volume: 138
Issue: 2
Pages: 705-11
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Publication
First Author: Nicholson JD
Year: 2016
Journal: PLoS One
Title: SUR1-Associated Mechanisms Are Not Involved in Ischemic Optic Neuropathy 1 Day Post-Injury.
Volume: 11
Issue: 8
Pages: e0148855
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Publication
First Author: Gurzeler E
Year: 2021
Journal: PLoS One
Title: SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice.
Volume: 16
Issue: 11
Pages: e0258408
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Publication  
First Author: Sakamaki G
Year: 2021
Journal: Behav Brain Res
Title: Loss of SUR1 subtype K(ATP) channels alters antinociception and locomotor activity after opioid administration.
Volume: 414
Pages: 113467
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Publication
First Author: Zerangue N
Year: 1999
Journal: Neuron
Title: A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.
Volume: 22
Issue: 3
Pages: 537-48
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Publication
First Author: Reimann F
Year: 1999
Journal: J Physiol
Title: Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.
Volume: 518 ( Pt 2)
Issue: Pt 2
Pages: 325-36
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Publication
First Author: Sakura H
Year: 1999
Journal: J Physiol
Title: Altered functional properties of KATP channel conferred by a novel splice variant of SUR1.
Volume: 521 Pt 2
Issue: Pt 2
Pages: 337-50
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Publication
First Author: Tanizawa Y
Year: 2000
Journal: Diabetes
Title: Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy: nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1.
Volume: 49
Issue: 1
Pages: 114-20
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Publication
First Author: McKay NG
Year: 2000
Journal: Br J Pharmacol
Title: Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K(ATP) channel inhibitors, ciclazindol and englitazone.
Volume: 130
Issue: 4
Pages: 857-66
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Publication
First Author: Mikhailov MV
Year: 2000
Journal: FEBS Lett
Title: Investigation of the molecular assembly of beta-cell K(ATP) channels.
Volume: 482
Issue: 1-2
Pages: 59-64
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Publication
First Author: Haller M
Year: 2001
Journal: J Physiol
Title: Dynamic activation of K(ATP) channels in rhythmically active neurons.
Volume: 537
Issue: Pt 1
Pages: 69-81
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Publication
First Author: Mu??oz A
Year: 2003
Journal: Stroke
Title: Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.
Volume: 34
Issue: 1
Pages: 164-70
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Publication
First Author: Geng X
Year: 2003
Journal: Diabetes
Title: The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas.
Volume: 52
Issue: 3
Pages: 767-76
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Publication
First Author: Lacza Z
Year: 2003
Journal: J Mol Cell Cardiol
Title: Heart mitochondria contain functional ATP-dependent K+ channels.
Volume: 35
Issue: 11
Pages: 1339-47
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Publication
First Author: D??fer M
Year: 2004
Journal: Diabetologia
Title: Oscillations of membrane potential and cytosolic Ca(2+) concentration in SUR1(-/-) beta cells.
Volume: 47
Issue: 3
Pages: 488-498
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