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Search results 1 to 100 out of 514 for Abcg2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
9429 | ABCG2
Type: gene
Organism: human
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Gene
734088 | abcg2
Type: gene
Organism: frog, western clawed
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Gene
312382 | Abcg2
Type: gene
Organism: rat
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Gene
478472 | ABCG2
Type: gene
Organism: dog, domestic
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Gene
471251 | ABCG2
Type: gene
Organism: chimpanzee
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Gene
536203 | ABCG2
Type: gene
Organism: cattle
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Gene
423767 | ABCG2
Type: gene
Organism: chicken
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Gene
574307 | ABCG2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030256 | ABCG2
Type: Family
Description: ATP-binding cassette subfamily G member 2 (ABCG2) is a eukaryotic member of the ABC transporter family. In humans, ABCG2 is a high-capacity urate exporter, functioning in both renal and extrarenal urate excretion []. It is a major factor contributing to gout [, ]. It also coordinates with another transporter, ABCB6, to modulate porphyrin concentrations under normal physiological and pathological conditions []. In addition, it can function as a xenobiotic transporter and may play a major role in multi-drug resistance []. The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [].
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Protein Coding Gene
MGI:1347061 | Abcg2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A0N4SWA2
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
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Protein
D3YZX5
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
D3Z150
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
Q7TMS5
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
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Protein
S4R2E1
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
W8DLN2
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: true
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Protein
A0A0R4J0B6
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
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Publication
30042379 | J:269673
First Author: Takada T
Year: 2018
Journal: Sci Rep
Title: Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.
Volume: 8
Issue: 1
Pages: 11147
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Publication
- | J:165703
     
First Author: Santamarina-Fojo S
Year: 2006
Journal: MGI Direct Data Submission
Title: Generation of a conditional Abcg2 allele
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Publication
26739701 | J:353166
First Author: Chang HM
Year: 2016
Journal: Exp Dermatol
Title: ABCG2 deficiency in skin impairs re-epithelialization in cutaneous wound healing.
Volume: 25
Issue: 5
Pages: 355-61
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Publication
21118089 | -
First Author: Krishnamurthy P
Year: 2011
Journal: Curr Pharm Biotechnol
Title: The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival.
Volume: 12
Issue: 4
Pages: 647-55
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Publication
22132963 | -
First Author: Matsuo H
Year: 2011
Journal: Nucleosides Nucleotides Nucleic Acids
Title: Identification of ABCG2 dysfunction as a major factor contributing to gout.
Volume: 30
Issue: 12
Pages: 1098-104
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Publication
22132962 | -
First Author: Nakayama A
Year: 2011
Journal: Nucleosides Nucleotides Nucleic Acids
Title: ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans.
Volume: 30
Issue: 12
Pages: 1091-7
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Publication
32217099 | J:298106
 
First Author: Garcia-Lino AM
Year: 2020
Journal: Biochem Pharmacol
Title: Abcg2 transporter affects plasma, milk and tissue levels of meloxicam.
Volume: 175
Pages: 113924
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Publication
20538997 | J:171401
First Author: Kubota M
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: The anti-oxidative role of ABCG2 in corneal epithelial cells.
Volume: 51
Issue: 11
Pages: 5617-22
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Publication
22707564 | J:192407
First Author: van de Wetering K
Year: 2012
Journal: FASEB J
Title: ABCG2 functions as a general phytoestrogen sulfate transporter in vivo.
Volume: 26
Issue: 10
Pages: 4014-24
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Publication
26199091 | J:225582
First Author: Morfouace M
Year: 2015
Journal: Cancer Res
Title: ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.
Volume: 75
Issue: 18
Pages: 3879-89
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Publication
22134889 | J:189206
First Author: Fatima S
Year: 2012
Journal: Stem Cells
Title: Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model.
Volume: 30
Issue: 2
Pages: 210-21
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Publication
24727496 | J:213129
First Author: Maher TJ
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress.
Volume: 306
Issue: 12
Pages: H1610-8
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Publication
22578166 | J:186567
First Author: Zeng Y
Year: 2012
Journal: J Neurochem
Title: Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice.
Volume: 122
Issue: 2
Pages: 456-69
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Publication
32488095 | J:292268
First Author: Hoque KM
Year: 2020
Journal: Nat Commun
Title: The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion.
Volume: 11
Issue: 1
Pages: 2767
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Publication
19032939 | J:143064
First Author: Scharenberg C
Year: 2009
Journal: Biochem Biophys Res Commun
Title: ABCG2 is expressed in late spermatogenesis and is associated with the acrosome.
Volume: 378
Issue: 2
Pages: 302-7
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Publication
31555729 | J:284701
First Author: Wang P
Year: 2019
Journal: Sci Adv
Title: The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria.
Volume: 5
Issue: 9
Pages: eaaw6127
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Publication
28270772 | J:292660
 
First Author: Nagy BM
Year: 2017
Journal: Front Physiol
Title: Lack of ABCG2 Leads to Biventricular Dysfunction and Remodeling in Response to Hypoxia.
Volume: 8
Pages: 98
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Publication
25117410 | J:215573
First Author: Wu AM
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland.
Volume: 307
Issue: 7
Pages: E596-610
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Publication
25868794 | J:224217
First Author: Zhang P
Year: 2015
Journal: Int J Cancer
Title: ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.
Volume: 137
Issue: 8
Pages: 2007-18
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Publication
15126373 | J:89740
First Author: Cisternino S
Year: 2004
Journal: Cancer Res
Title: Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.
Volume: 64
Issue: 9
Pages: 3296-301
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Publication
15546952 | J:98134
First Author: Zhou S
Year: 2005
Journal: Blood
Title: Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels.
Volume: 105
Issue: 6
Pages: 2571-6
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Publication
16885162 | J:116937
First Author: Zong Y
Year: 2006
Journal: J Biol Chem
Title: Expression of mouse Abcg2 mRNA during hematopoiesis is regulated by alternative use of multiple leader exons and promoters.
Volume: 281
Issue: 40
Pages: 29625-32
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Publication
22132966 | -
First Author: Matsuo H
Year: 2011
Journal: Nucleosides Nucleotides Nucleic Acids
Title: ABCG2/BCRP dysfunction as a major cause of gout.
Volume: 30
Issue: 12
Pages: 1117-28
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Publication
25162314 | -
First Author: Bruhn O
Year: 2014
Journal: Expert Opin Drug Metab Toxicol
Title: Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.
Volume: 10
Issue: 10
Pages: 1337-54
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Publication
28790147 | J:321789
First Author: Traxl A
Year: 2017
Journal: Drug Metab Dispos
Title: Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [11C]erlotinib and Positron Emission Tomography.
Volume: 45
Issue: 10
Pages: 1093-1100
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Publication
18787193 | J:155146
First Author: Pfister O
Year: 2008
Journal: Circ Res
Title: Role of the ATP-binding cassette transporter Abcg2 in the phenotype and function of cardiac side population cells.
Volume: 103
Issue: 8
Pages: 825-35
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Publication
32087611 | J:332692
First Author: Wang Y
Year: 2020
Journal: Br J Pharmacol
Title: OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation.
Volume: 177
Issue: 13
Pages: 3060-3074
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Protein
Q3UQE4
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Publication
22767648 | J:320930
First Author: Zander SA
Year: 2012
Journal: Cancer Prev Res (Phila)
Title: Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrol.
Volume: 5
Issue: 8
Pages: 1053-60
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Publication
22116099 | J:195968
First Author: Higashikuni Y
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response.
Volume: 32
Issue: 3
Pages: 654-61
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Publication
31461347 | J:290697
First Author: Gewin LS
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney.
Volume: 317
Issue: 5
Pages: F1201-F1210
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Protein
S4R2M4
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Publication
11441126 | -
First Author: Dean M
Year: 2001
Journal: J Lipid Res
Title: The human ATP-binding cassette (ABC) transporter superfamily.
Volume: 42
Issue: 7
Pages: 1007-17
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Publication
30858238 | J:291926
First Author: Garcia-Mateos D
Year: 2019
Journal: Drug Metab Dispos
Title: Role of ABCG2 in Secretion into Milk of the Anti-Inflammatory Flunixin and Its Main Metabolite: In Vitro-In Vivo Correlation in Mice and Cows.
Volume: 47
Issue: 5
Pages: 516-524
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Publication
10485464 | J:57248
First Author: Allen JD
Year: 1999
Journal: Cancer Res
Title: The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.
Volume: 59
Issue: 17
Pages: 4237-41
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Publication
9850061 | J:56609
First Author: Allikmets R
Year: 1998
Journal: Cancer Res
Title: A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.
Volume: 58
Issue: 23
Pages: 5337-9
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Publication
12429862 | J:80519
First Author: Jonker JW
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Volume: 99
Issue: 24
Pages: 15649-54
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Publication
17145775 | J:118277
First Author: van Herwaarden AE
Year: 2007
Journal: Mol Cell Biol
Title: Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.
Volume: 27
Issue: 4
Pages: 1247-53
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Publication
24189494 | J:210039
First Author: Xie Y
Year: 2013
Journal: Biochim Biophys Acta
Title: Bcrp1 transcription in mouse testis is controlled by a promoter upstream of a novel first exon (E1U) regulated by steroidogenic factor-1.
Volume: 1829
Issue: 12
Pages: 1288-99
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Publication
23954234 | J:201884
First Author: Lin YH
Year: 2013
Journal: FEBS Lett
Title: Protoporphyrin IX accumulation disrupts mitochondrial dynamics and function in ABCG2-deficient hepatocytes.
Volume: 587
Issue: 19
Pages: 3202-9
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Publication
25122876 | J:223114
First Author: Marriott S
Year: 2014
Journal: Am J Physiol Cell Physiol
Title: ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling.
Volume: 307
Issue: 8
Pages: C684-98
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Publication
23662173 | J:233248
First Author: Chow K
Year: 2013
Journal: Pulm Circ
Title: Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling.
Volume: 3
Issue: 1
Pages: 31-49
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Publication
28463231 | J:244100
First Author: Gaskill CF
Year: 2017
Journal: J Clin Invest
Title: Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.
Volume: 127
Issue: 6
Pages: 2262-2276
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Publication
22473008 | J:220924
 
First Author: Ichida K
Year: 2012
Journal: Nat Commun
Title: Decreased extra-renal urate excretion is a common cause of hyperuricemia.
Volume: 3
Pages: 764
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Publication
25380981 | J:321098
First Author: Karibe T
Year: 2015
Journal: Pharm Res
Title: Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.
Volume: 32
Issue: 5
Pages: 1634-47
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Publication
23136123 | J:212871
First Author: Sereti KI
Year: 2013
Journal: Circ Res
Title: ATP-binding cassette G-subfamily transporter 2 regulates cell cycle progression and asymmetric division in mouse cardiac side population progenitor cells.
Volume: 112
Issue: 1
Pages: 27-34
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Publication
16484343 | J:128682
First Author: Tadjali M
Year: 2006
Journal: Stem Cells
Title: Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele.
Volume: 24
Issue: 6
Pages: 1556-63
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Publication
21159928 | J:170394
First Author: Petropoulos S
Year: 2011
Journal: Biol Reprod
Title: Breast cancer-resistance protein (BCRP1) in the fetal mouse brain: development and glucocorticoid regulation.
Volume: 84
Issue: 4
Pages: 783-9
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Publication
21351087 | J:178582
First Author: Tang SC
Year: 2012
Journal: Int J Cancer
Title: Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.
Volume: 130
Issue: 1
Pages: 223-33
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Publication
17638908 | J:123165
First Author: Takenaka K
Year: 2007
Journal: Cancer Res
Title: Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution.
Volume: 67
Issue: 14
Pages: 6965-72
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Publication
23436212 | J:199960
First Author: Lin F
Year: 2013
Journal: Int J Cancer
Title: Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2.
Volume: 133
Issue: 5
Pages: 1222-33
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Publication
32533805 | J:340975
First Author: Summers ME
Year: 2020
Journal: FASEB J
Title: Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling.
Volume: 34
Issue: 8
Pages: 10267-10285
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Publication
14697368 | J:87367
First Author: Martin CM
Year: 2004
Journal: Dev Biol
Title: Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart.
Volume: 265
Issue: 1
Pages: 262-75
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Publication
24037730 | J:211972
First Author: Tang SC
Year: 2014
Journal: Int J Cancer
Title: Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
Volume: 134
Issue: 6
Pages: 1484-94
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Publication
22536451 | J:187201
First Author: Spiro AS
Year: 2012
Journal: PLoS One
Title: Enhanced brain disposition and effects of Δ9-tetrahydrocannabinol in P-glycoprotein and breast cancer resistance protein knockout mice.
Volume: 7
Issue: 4
Pages: e35937
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Publication
26465636 | J:321106
First Author: Hoque MT
Year: 2015
Journal: J Neurochem
Title: In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator-activated receptor alpha (Pparα) at the blood-brain barrier.
Volume: 135
Issue: 6
Pages: 1113-22
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Publication
17229149 | J:135561
First Author: de Wolf CJ
Year: 2007
Journal: FEBS J
Title: cGMP transport by vesicles from human and mouse erythrocytes.
Volume: 274
Issue: 2
Pages: 439-50
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Publication
22396548 | J:185630
First Author: Hamdan AM
Year: 2012
Journal: J Biol Chem
Title: Intestinal expression of mouse Abcg2/breast cancer resistance protein (BCRP) gene is under control of circadian clock-activating transcription factor-4 pathway.
Volume: 287
Issue: 21
Pages: 17224-31
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Publication
20145144 | J:157686
First Author: Zander SA
Year: 2010
Journal: Cancer Res
Title: Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.
Volume: 70
Issue: 4
Pages: 1700-10
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Publication
22545122 | J:187191
First Author: Schumacher T
Year: 2012
Journal: PLoS One
Title: ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.
Volume: 7
Issue: 4
Pages: e35613
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Publication
32239172 | J:288975
First Author: Ristic B
Year: 2020
Journal: Biochem J
Title: Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2.
Volume: 477
Issue: 8
Pages: 1499-1513
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Publication
21073982 | J:170274
First Author: Li L
Year: 2011
Journal: Gene Expr Patterns
Title: Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor.
Volume: 11
Issue: 3-4
Pages: 163-70
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Publication
24647572 | J:318188
First Author: Lin F
Year: 2014
Journal: Clin Cancer Res
Title: ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy.
Volume: 20
Issue: 10
Pages: 2703-13
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Publication
16458078 | J:111161
First Author: Sawicki WT
Year: 2006
Journal: Gene Expr Patterns
Title: Temporal/spatial expression and efflux activity of ABC transporter, P-glycoprotein/Abcb1 isoforms and Bcrp/Abcg2 during early murine development.
Volume: 6
Issue: 7
Pages: 738-46
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Protein Coding Gene
MGP_CAROLIEiJ_G0028446 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030712 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1347061 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031254 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029908 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030483 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030634 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030583 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031280 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029989 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022187 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029448 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
17314268 | J:125849
First Author: Jonker JW
Year: 2007
Journal: Am J Physiol Cell Physiol
Title: Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.
Volume: 292
Issue: 6
Pages: C2204-12
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Publication
20829509 | J:182096
First Author: Higashikuni Y
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.
Volume: 30
Issue: 11
Pages: 2128-35
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