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Search results 1 to 100 out of 421 for Abcg2

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0.037s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: ATP-binding cassette subfamily G member 2 (ABCG2) is a eukaryotic member of the ABC transporter family. In humans, ABCG2 is a high-capacity urate exporter, functioning in both renal and extrarenal urate excretion []. It is a major factor contributing to gout [, ]. It also coordinates with another transporter, ABCB6, to modulate porphyrin concentrations under normal physiological and pathological conditions []. In addition, it can function as a xenobiotic transporter and may play a major role in multi-drug resistance []. The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Fatima S
Year: 2012
Journal: Stem Cells
Title: Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model.
Volume: 30
Issue: 2
Pages: 210-21
Publication
First Author: Maher TJ
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress.
Volume: 306
Issue: 12
Pages: H1610-8
Publication
First Author: Marriott S
Year: 2014
Journal: Am J Physiol Cell Physiol
Title: ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling.
Volume: 307
Issue: 8
Pages: C684-98
Publication
First Author: Gaskill CF
Year: 2017
Journal: J Clin Invest
Title: Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.
Volume: 127
Issue: 6
Pages: 2262-2276
Publication
First Author: Chow K
Year: 2013
Journal: Pulm Circ
Title: Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling.
Volume: 3
Issue: 1
Pages: 31-49
Publication      
First Author: Santamarina-Fojo S
Year: 2006
Journal: MGI Direct Data Submission
Title: Generation of a conditional Abcg2 allele
Protein
Organism: Mus musculus
Length: 115  
Fragment?: true
Protein
Organism: Mus musculus
Length: 159  
Fragment?: true
Publication
First Author: Takada T
Year: 2018
Journal: Sci Rep
Title: Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.
Volume: 8
Issue: 1
Pages: 11147
Protein
Organism: Mus musculus
Length: 130  
Fragment?: true
Protein
Organism: Mus musculus
Length: 172  
Fragment?: true
Protein
Organism: Mus musculus
Length: 657  
Fragment?: false
Protein
Organism: Mus musculus
Length: 657  
Fragment?: false
Protein
Organism: Mus musculus
Length: 623  
Fragment?: true
Protein
Organism: Mus musculus
Length: 576  
Fragment?: false
Allele
Name: Transgene insertion 1, Chia-Ning Shen
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Publication
First Author: Krishnamurthy P
Year: 2011
Journal: Curr Pharm Biotechnol
Title: The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival.
Volume: 12
Issue: 4
Pages: 647-55
Publication
First Author: Matsuo H
Year: 2011
Journal: Nucleosides Nucleotides Nucleic Acids
Title: Identification of ABCG2 dysfunction as a major factor contributing to gout.
Volume: 30
Issue: 12
Pages: 1098-104
Publication
First Author: Nakayama A
Year: 2011
Journal: Nucleosides Nucleotides Nucleic Acids
Title: ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans.
Volume: 30
Issue: 12
Pages: 1091-7
Allele
Name: ATP binding cassette subfamily G member 2 (Junior blood group); targeted mutation 3.1, Brian P Sorrentino
Allele Type: Targeted
Attribute String: Hypomorph, Inducible, Recombinase
Publication categories: ProxyCollection
Publication
First Author: van de Wetering K
Year: 2012
Journal: FASEB J
Title: ABCG2 functions as a general phytoestrogen sulfate transporter in vivo.
Volume: 26
Issue: 10
Pages: 4014-24
Publication
First Author: Kubota M
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: The anti-oxidative role of ABCG2 in corneal epithelial cells.
Volume: 51
Issue: 11
Pages: 5617-22
Publication  
First Author: Garcia-Lino AM
Year: 2020
Journal: Biochem Pharmacol
Title: Abcg2 transporter affects plasma, milk and tissue levels of meloxicam.
Volume: 175
Pages: 113924
Publication
First Author: Morfouace M
Year: 2015
Journal: Cancer Res
Title: ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.
Volume: 75
Issue: 18
Pages: 3879-89
Strain
Attribute String: mutant stock, targeted mutation
Genotype
Symbol: Abcg2/Abcg2<+>
Background: involves: 129 * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Zeng Y
Year: 2012
Journal: J Neurochem
Title: Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice.
Volume: 122
Issue: 2
Pages: 456-69
Publication
First Author: Hoque KM
Year: 2020
Journal: Nat Commun
Title: The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion.
Volume: 11
Issue: 1
Pages: 2767
Publication
First Author: Scharenberg C
Year: 2009
Journal: Biochem Biophys Res Commun
Title: ABCG2 is expressed in late spermatogenesis and is associated with the acrosome.
Volume: 378
Issue: 2
Pages: 302-7
Publication
First Author: Wang P
Year: 2019
Journal: Sci Adv
Title: The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria.
Volume: 5
Issue: 9
Pages: eaaw6127
Publication  
First Author: Nagy BM
Year: 2017
Journal: Front Physiol
Title: Lack of ABCG2 Leads to Biventricular Dysfunction and Remodeling in Response to Hypoxia.
Volume: 8
Pages: 98
Publication
First Author: Wu AM
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland.
Volume: 307
Issue: 7
Pages: E596-610
Publication
First Author: Zhang P
Year: 2015
Journal: Int J Cancer
Title: ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.
Volume: 137
Issue: 8
Pages: 2007-18
Publication
First Author: Cisternino S
Year: 2004
Journal: Cancer Res
Title: Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.
Volume: 64
Issue: 9
Pages: 3296-301
Publication
First Author: Zhou S
Year: 2005
Journal: Blood
Title: Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels.
Volume: 105
Issue: 6
Pages: 2571-6
Publication
First Author: Zong Y
Year: 2006
Journal: J Biol Chem
Title: Expression of mouse Abcg2 mRNA during hematopoiesis is regulated by alternative use of multiple leader exons and promoters.
Volume: 281
Issue: 40
Pages: 29625-32
Publication      
First Author: National Laboratory Animal Center
Year: 2013
Journal: MGI Direct Data Submission
Title: Transgene insertion mice at National Laboratory Animal Center, National Applied Research Laboratories.
Publication
First Author: Pfister O
Year: 2008
Journal: Circ Res
Title: Role of the ATP-binding cassette transporter Abcg2 in the phenotype and function of cardiac side population cells.
Volume: 103
Issue: 8
Pages: 825-35
Publication
First Author: Higashikuni Y
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response.
Volume: 32
Issue: 3
Pages: 654-61
Publication
First Author: Matsuo H
Year: 2011
Journal: Nucleosides Nucleotides Nucleic Acids
Title: ABCG2/BCRP dysfunction as a major cause of gout.
Volume: 30
Issue: 12
Pages: 1117-28
Publication
First Author: Bruhn O
Year: 2014
Journal: Expert Opin Drug Metab Toxicol
Title: Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.
Volume: 10
Issue: 10
Pages: 1337-54
Protein
Organism: Mus musculus
Length: 168  
Fragment?: false
Publication
First Author: Allikmets R
Year: 1998
Journal: Cancer Res
Title: A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.
Volume: 58
Issue: 23
Pages: 5337-9
Publication
First Author: Jonker JW
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Volume: 99
Issue: 24
Pages: 15649-54
Publication
First Author: van Herwaarden AE
Year: 2007
Journal: Mol Cell Biol
Title: Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.
Volume: 27
Issue: 4
Pages: 1247-53
Publication
First Author: Allen JD
Year: 1999
Journal: Cancer Res
Title: The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.
Volume: 59
Issue: 17
Pages: 4237-41
Publication
First Author: Garcia-Mateos D
Year: 2019
Journal: Drug Metab Dispos
Title: Role of ABCG2 in Secretion into Milk of the Anti-Inflammatory Flunixin and Its Main Metabolite: In Vitro-In Vivo Correlation in Mice and Cows.
Volume: 47
Issue: 5
Pages: 516-524
Publication
First Author: Dean M
Year: 2001
Journal: J Lipid Res
Title: The human ATP-binding cassette (ABC) transporter superfamily.
Volume: 42
Issue: 7
Pages: 1007-17
Publication
First Author: Gewin LS
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney.
Volume: 317
Issue: 5
Pages: F1201-F1210
Publication
First Author: Lin YH
Year: 2013
Journal: FEBS Lett
Title: Protoporphyrin IX accumulation disrupts mitochondrial dynamics and function in ABCG2-deficient hepatocytes.
Volume: 587
Issue: 19
Pages: 3202-9
Publication  
First Author: Ichida K
Year: 2012
Journal: Nat Commun
Title: Decreased extra-renal urate excretion is a common cause of hyperuricemia.
Volume: 3
Pages: 764
Publication
First Author: Tadjali M
Year: 2006
Journal: Stem Cells
Title: Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele.
Volume: 24
Issue: 6
Pages: 1556-63
Publication
First Author: Sereti KI
Year: 2013
Journal: Circ Res
Title: ATP-binding cassette G-subfamily transporter 2 regulates cell cycle progression and asymmetric division in mouse cardiac side population progenitor cells.
Volume: 112
Issue: 1
Pages: 27-34
Publication
First Author: Petropoulos S
Year: 2011
Journal: Biol Reprod
Title: Breast cancer-resistance protein (BCRP1) in the fetal mouse brain: development and glucocorticoid regulation.
Volume: 84
Issue: 4
Pages: 783-9
Publication
First Author: Lin F
Year: 2013
Journal: Int J Cancer
Title: Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2.
Volume: 133
Issue: 5
Pages: 1222-33
Publication
First Author: Tang SC
Year: 2012
Journal: Int J Cancer
Title: Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.
Volume: 130
Issue: 1
Pages: 223-33
Publication
First Author: Takenaka K
Year: 2007
Journal: Cancer Res
Title: Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution.
Volume: 67
Issue: 14
Pages: 6965-72
Publication
First Author: Martin CM
Year: 2004
Journal: Dev Biol
Title: Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart.
Volume: 265
Issue: 1
Pages: 262-75
Publication
First Author: Tang SC
Year: 2014
Journal: Int J Cancer
Title: Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
Volume: 134
Issue: 6
Pages: 1484-94
Publication
First Author: Spiro AS
Year: 2012
Journal: PLoS One
Title: Enhanced brain disposition and effects of Δ9-tetrahydrocannabinol in P-glycoprotein and breast cancer resistance protein knockout mice.
Volume: 7
Issue: 4
Pages: e35937
Publication
First Author: Ristic B
Year: 2020
Journal: Biochem J
Title: Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2.
Volume: 477
Issue: 8
Pages: 1499-1513
Publication
First Author: Hamdan AM
Year: 2012
Journal: J Biol Chem
Title: Intestinal expression of mouse Abcg2/breast cancer resistance protein (BCRP) gene is under control of circadian clock-activating transcription factor-4 pathway.
Volume: 287
Issue: 21
Pages: 17224-31
Publication
First Author: de Wolf CJ
Year: 2007
Journal: FEBS J
Title: cGMP transport by vesicles from human and mouse erythrocytes.
Volume: 274
Issue: 2
Pages: 439-50
Publication
First Author: Schumacher T
Year: 2012
Journal: PLoS One
Title: ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.
Volume: 7
Issue: 4
Pages: e35613
Publication
First Author: Zander SA
Year: 2010
Journal: Cancer Res
Title: Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan.
Volume: 70
Issue: 4
Pages: 1700-10
Publication
First Author: Li L
Year: 2011
Journal: Gene Expr Patterns
Title: Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor.
Volume: 11
Issue: 3-4
Pages: 163-70
Publication
First Author: Sawicki WT
Year: 2006
Journal: Gene Expr Patterns
Title: Temporal/spatial expression and efflux activity of ABC transporter, P-glycoprotein/Abcb1 isoforms and Bcrp/Abcg2 during early murine development.
Volume: 6
Issue: 7
Pages: 738-46
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Higashikuni Y
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.
Volume: 30
Issue: 11
Pages: 2128-35
Publication
First Author: van Herwaarden AE
Year: 2006
Journal: Carcinogenesis
Title: Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk.
Volume: 27
Issue: 1
Pages: 123-30
Publication
First Author: Jonker JW
Year: 2007
Journal: Am J Physiol Cell Physiol
Title: Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.
Volume: 292
Issue: 6
Pages: C2204-12
Publication
First Author: Merino G
Year: 2005
Journal: Mol Pharmacol
Title: Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver.
Volume: 67
Issue: 5
Pages: 1765-71
Publication
First Author: Tanaka Y
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.
Volume: 326
Issue: 1
Pages: 181-7
Publication
First Author: Pan G
Year: 2007
Journal: Drug Metab Dispos
Title: Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine.
Volume: 35
Issue: 7
Pages: 1165-73
GXD Expression    
Probe: MGI:3655144
Assay Type: RT-PCR
Annotation Date: 2006-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3655157
Age: embryonic day 1.0
Image: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6117352
Assay Type: RT-PCR
Annotation Date: 2018-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:6117376
Age: embryonic day 9.5
Image: 6
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6117352
Assay Type: RT-PCR
Annotation Date: 2018-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:6117376
Age: embryonic day 16.5
Image: 6
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6117352
Assay Type: RT-PCR
Annotation Date: 2018-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6117376
Age: postnatal day 6
Image: 6
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6117352
Assay Type: RT-PCR
Annotation Date: 2018-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6117376
Age: postnatal adult
Image: 6
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6117352
Assay Type: RT-PCR
Annotation Date: 2018-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608510
Stage: TS10
Assay Id: MGI:6117370
Age: embryonic day 7.0
Image: 4
Detected: true
Specimen Num: 1