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Search results 1 to 92 out of 92 for Abhd12

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Hits by Strain

Type Details Score
Gene
26090 | ABHD12
Type: gene
Organism: human
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Gene
100216158 | abhd12
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR026605 | ABHD12
Type: Family
Description: ABHD12 (also known as the abhydrolase domain-containing protein 12) is a lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes [, ]. In humans, defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC). PHARC is a slowly progressive neurologic disorder [].
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Gene
499913 | Abhd12
Type: gene
Organism: rat
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Gene
477004 | ABHD12
Type: gene
Organism: dog, domestic
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Gene
744997 | ABHD12
Type: gene
Organism: chimpanzee
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Gene
768242 | ABHD12
Type: gene
Organism: cattle
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Gene
421249 | ABHD12
Type: gene
Organism: chicken
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Gene
767657 | abhd12
Type: gene
Organism: zebrafish
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Gene
705915 | ABHD12
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1923442 | Abhd12
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30237167 | J:272811
First Author: Joshi A
Year: 2018
Journal: J Biol Chem
Title: Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids.
Volume: 293
Issue: 44
Pages: 16953-16963
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Publication
23297193 | J:193716
First Author: Blankman JL
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC.
Volume: 110
Issue: 4
Pages: 1500-5
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Protein
D6RFU2
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Protein
Q99LR1
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Publication
20797687 | -
First Author: Fiskerstrand T
Year: 2010
Journal: Am J Hum Genet
Title: Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism.
Volume: 87
Issue: 3
Pages: 410-7
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Publication
30643283 | J:273578
First Author: Kelkar DS
Year: 2019
Journal: Nat Chem Biol
Title: A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase.
Volume: 15
Issue: 2
Pages: 169-178
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Publication
25580854 | J:232688
First Author: Kamat SS
Year: 2015
Journal: Nat Chem Biol
Title: Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.
Volume: 11
Issue: 2
Pages: 164-71
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Publication
31213981 | J:313112
 
First Author: Leishman E
Year: 2019
Journal: Front Mol Neurosci
Title: Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype.
Volume: 12
Pages: 142
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Publication
18096503 | J:217994
First Author: Blankman JL
Year: 2007
Journal: Chem Biol
Title: A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol.
Volume: 14
Issue: 12
Pages: 1347-56
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Publication
33571455 | J:347783
First Author: Khandelwal N
Year: 2021
Journal: Cell Chem Biol
Title: Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs.
Volume: 28
Issue: 8
Pages: 1169-1179.e6
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Publication
32462874 | J:304879
First Author: Singh S
Year: 2020
Journal: Biochemistry
Title: Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC.
Volume: 59
Issue: 24
Pages: 2299-2311
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Protein Coding Gene
MGP_CAROLIEiJ_G0024429 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026632 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026599 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026570 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026609 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1923442 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027057 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025812 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026331 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026465 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026430 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026569 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026452 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027112 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025547 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025885 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025872 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025349 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
26779719 | J:229982
 
First Author: Viader A
Year: 2016
Journal: Elife
Title: A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation.
Volume: 5
Pages: e12345
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Publication
27307232 | J:248443
First Author: Yokoi N
Year: 2016
Journal: J Neurosci
Title: Identification of PSD-95 Depalmitoylating Enzymes.
Volume: 36
Issue: 24
Pages: 6431-44
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Publication
23806692 | J:205325
First Author: Siegmund SV
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations.
Volume: 437
Issue: 1
Pages: 48-54
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Publication
25871848 | J:229253
 
First Author: Spies N
Year: 2015
Journal: Elife
Title: Constraint and divergence of global gene expression in the mammalian embryo.
Volume: 4
Pages: e05538
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Publication
22632720 | J:188364
First Author: Schwenk J
Year: 2012
Journal: Neuron
Title: High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.
Volume: 74
Issue: 4
Pages: 621-33
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Publication
15010206 | J:88423
First Author: García-Frigola C
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain.
Volume: 122
Issue: 2
Pages: 133-50
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q99LR1-2
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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UniProt Feature
UniProt Feature
Begin: 1
Description: Lysophosphatidylserine lipase ABHD12
Type: chain
End: 398
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Publication
30420694 | -
First Author: Ogasawara D
Year: 2018
Journal: Nat Chem Biol
Title: Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo.
Volume: 14
Issue: 12
Pages: 1099-1108
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Protein
D6RI21
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: false
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Protein
F7BHM8
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: true
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Allele
Abhd12<em1Smoc> | MGI:7288048
Name: abhydrolase domain containing 12; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6474706 | C57BL/6JSmoc-Abhd12<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
20657592 | J:163762
First Author: Marrs WR
Year: 2010
Journal: Nat Neurosci
Title: The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.
Volume: 13
Issue: 8
Pages: 951-7
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Publication
36891866 | J:335550
 
First Author: Bennett TM
Year: 2023
Journal: G3 (Bethesda)
Title: Whole-exome sequencing prioritizes candidate genes for hereditary cataract in the Emory mouse mutant.
Volume: 13
Issue: 5
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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