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Search results 1 to 100 out of 659 for Abl1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: This entry includes animal ABL1 and viral oncogene products that are homologous to ABL1 []. ABL1 plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodelling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis [, , , ]. Normal ABL1 can serve as a tumour suppressor and therapeutic target in leukemias expressing oncogenic forms of the kinase [].ABL tyrosine kinases are nonreceptor tyrosine kinases containing an SH3-SH2-TK (Src homology 3-Src homology 2-tyrosine kinase) domain cassette, which confers autoregulated kinase activity. This cassette is coupled to an actin-binding and -bundling domain, which makes ABL proteins capable of connecting phosphoregulation with actin-filament reorganization. Two vertebrate ABL tyrosine kinases have been identified, ABL1 and ABL2 [].A downstream effector of RAS, RIN1, have been found to bind to the SH3 and SH2 domains of ABL1/ABL2 to relieve autoinhibition and regulate their activity [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 71  
Fragment?: false
Protein
Organism: Mus musculus
Length: 78  
Fragment?: false
Protein
Organism: Mus musculus
Length: 64  
Fragment?: true
Protein
Organism: Mus musculus
Length: 114  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1123  
Fragment?: false
Publication
First Author: Dasgupta Y
Year: 2016
Journal: Blood
Title: Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.
Volume: 127
Issue: 17
Pages: 2131-43
Publication
First Author: Colicelli J
Year: 2010
Journal: Sci Signal
Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.
Volume: 3
Issue: 139
Pages: re6
Publication
First Author: Bueno MJ
Year: 2008
Journal: Cancer Cell
Title: Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.
Volume: 13
Issue: 6
Pages: 496-506
Publication
First Author: Zukerberg LR
Year: 2000
Journal: Neuron
Title: Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.
Volume: 26
Issue: 3
Pages: 633-46
Publication
First Author: Virgili A
Year: 2011
Journal: Cancer Res
Title: Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele.
Volume: 71
Issue: 16
Pages: 5381-6
Publication
First Author: Kim DH
Year: 2016
Journal: Cell Rep
Title: Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2.
Volume: 17
Issue: 6
Pages: 1671-1682
Publication
First Author: Raimondi C
Year: 2014
Journal: J Exp Med
Title: Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.
Volume: 211
Issue: 6
Pages: 1167-83
Publication
First Author: Cao X
Year: 2008
Journal: J Biol Chem
Title: Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.
Volume: 283
Issue: 46
Pages: 31401-7
Publication
First Author: Yogalingam G
Year: 2008
Journal: J Biol Chem
Title: Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
Volume: 283
Issue: 51
Pages: 35941-53
Publication
First Author: Groffen J
Year: 1983
Journal: Nature
Title: Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products.
Volume: 304
Issue: 5922
Pages: 167-9
Publication
First Author: Sossey-Alaoui K
Year: 2007
Journal: J Biol Chem
Title: c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.
Volume: 282
Issue: 36
Pages: 26257-65
Publication
First Author: Tanos B
Year: 2006
Journal: J Biol Chem
Title: Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
Volume: 281
Issue: 43
Pages: 32714-23
Publication
First Author: Yoshida K
Year: 2002
Journal: Mol Cell Biol
Title: c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
Volume: 22
Issue: 10
Pages: 3292-300
Protein
Organism: Mus musculus
Length: 368  
Fragment?: true
Protein
Organism: Mus musculus
Length: 368  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1142  
Fragment?: false
Publication
First Author: Wang JY
Year: 1984
Journal: Cell
Title: The mouse c-abl locus: molecular cloning and characterization.
Volume: 36
Issue: 2
Pages: 349-56
Publication
First Author: Tybulewicz VL
Year: 1991
Journal: Cell
Title: Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.
Volume: 65
Issue: 7
Pages: 1153-63
Publication
First Author: Oppi C
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation.
Volume: 84
Issue: 23
Pages: 8200-4
Publication
First Author: Bernards A
Year: 1988
Journal: Oncogene
Title: Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing.
Volume: 2
Issue: 4
Pages: 297-304
Publication
First Author: Schwartzberg PL
Year: 1991
Journal: Cell
Title: Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations.
Volume: 65
Issue: 7
Pages: 1165-75
Publication
First Author: Cong F
Year: 2000
Journal: Mol Cell
Title: Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.
Volume: 6
Issue: 6
Pages: 1413-23
Publication
First Author: Taagepera S
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase.
Volume: 95
Issue: 13
Pages: 7457-62
Publication
First Author: Kain KH
Year: 2001
Journal: J Biol Chem
Title: Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.
Volume: 276
Issue: 19
Pages: 16185-92
Publication
First Author: Tanis KQ
Year: 2003
Journal: Mol Cell Biol
Title: Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
Volume: 23
Issue: 11
Pages: 3884-96
Publication
First Author: Sato H
Year: 2002
Journal: Biochim Biophys Acta
Title: ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.
Volume: 1574
Issue: 2
Pages: 157-63
Publication
First Author: Plattner R
Year: 2004
Journal: Mol Cell Biol
Title: Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
Volume: 24
Issue: 6
Pages: 2573-83
Publication
First Author: Zambrano N
Year: 2001
Journal: J Biol Chem
Title: The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.
Volume: 276
Issue: 23
Pages: 19787-92
Publication
First Author: Kharbanda S
Year: 1997
Journal: Nature
Title: Functional interaction between DNA-PK and c-Abl in response to DNA damage.
Volume: 386
Issue: 6626
Pages: 732-5
Publication
First Author: Chen A
Year: 2011
Journal: Mol Cell Biol
Title: c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation.
Volume: 31
Issue: 16
Pages: 3445-56
Publication
First Author: Hardin JD
Year: 1996
Journal: Oncogene
Title: Transgenes encoding both type I and type IV c-abl proteins rescue the lethality of c-abl mutant mice.
Volume: 12
Issue: 12
Pages: 2669-77
Publication
First Author: Tsuji K
Year: 2002
Journal: J Biol Chem
Title: Differential effect of ik3-1/cables on p53- and p73-induced cell death.
Volume: 277
Issue: 4
Pages: 2951-7
Publication
First Author: Preyer M
Year: 2007
Journal: Cell Death Differ
Title: Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals.
Volume: 14
Issue: 6
Pages: 1139-48
Publication
First Author: Finn AJ
Year: 2003
Journal: Nat Neurosci
Title: Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
Volume: 6
Issue: 7
Pages: 717-23
Publication
First Author: Khatri A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia.
Volume: 116
Issue: 5
Pages: 1603-1612
Publication
First Author: Singh J
Year: 2010
Journal: Genes Dev
Title: Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation.
Volume: 24
Issue: 19
Pages: 2157-68
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Raina D
Year: 2005
Journal: J Biol Chem
Title: c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
Volume: 280
Issue: 12
Pages: 11147-51
Publication
First Author: Symons RC
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.
Volume: 99
Issue: 17
Pages: 11299-304
Publication
First Author: Brahmachari S
Year: 2016
Journal: J Clin Invest
Title: Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.
Volume: 126
Issue: 8
Pages: 2970-88
Publication  
First Author: Cleary RA
Year: 2013
Journal: Respir Res
Title: Role of Abl in airway hyperresponsiveness and airway remodeling.
Volume: 14
Pages: 105
Publication
First Author: Schwartzberg PL
Year: 1989
Journal: Science
Title: Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.
Volume: 246
Issue: 4931
Pages: 799-803
Publication
First Author: Schwartzberg PL
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.
Volume: 87
Issue: 8
Pages: 3210-4
Publication
First Author: Hardin JD
Year: 1996
Journal: Cell Immunol
Title: Abnormal peripheral lymphocyte function in c-abl mutant mice.
Volume: 172
Issue: 1
Pages: 100-7
Publication
First Author: Zipfel PA
Year: 2000
Journal: J Immunol
Title: The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.
Volume: 165
Issue: 12
Pages: 6872-9
Publication
First Author: Lam QL
Year: 2007
Journal: Int Immunol
Title: Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.
Volume: 19
Issue: 3
Pages: 267-76
Publication
First Author: Nunes I
Year: 2001
Journal: J Exp Med
Title: c-abl is required for the development of hyperoxia-induced retinopathy.
Volume: 193
Issue: 12
Pages: 1383-91
Publication
First Author: Li B
Year: 2000
Journal: Nat Genet
Title: Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation.
Volume: 24
Issue: 3
Pages: 304-8
Publication
First Author: Kharbanda S
Year: 1998
Journal: Oncogene
Title: Functional role for the c-Abl tyrosine kinase in meiosis I.
Volume: 16
Issue: 14
Pages: 1773-7
Publication
First Author: Wang X
Year: 2011
Journal: Cell Death Differ
Title: A positive role for c-Abl in Atm and Atr activation in DNA damage response.
Volume: 18
Issue: 1
Pages: 5-15
Publication
First Author: Liu H
Year: 2018
Journal: Biochim Biophys Acta Mol Cell Res
Title: The nonreceptor tyrosine kinase c-Abl phosphorylates Runx1 and regulates Runx1-mediated megakaryocyte maturation.
Volume: 1865
Issue: 8
Pages: 1060-1072
Publication
First Author: Wu R
Year: 2017
Journal: Diabetologia
Title: c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice.
Volume: 60
Issue: 5
Pages: 900-910
Publication
First Author: Rosenbaum H
Year: 1990
Journal: EMBO J
Title: An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene.
Volume: 9
Issue: 3
Pages: 897-905
Publication
First Author: Imam SZ
Year: 2007
Journal: Nucleic Acids Res
Title: Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase.
Volume: 35
Issue: 15
Pages: 4941-51
Publication
First Author: Yu HH
Year: 2001
Journal: Oncogene
Title: Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor.
Volume: 20
Issue: 30
Pages: 3995-4006
Publication
First Author: Sun J
Year: 2001
Journal: J Biol Chem
Title: c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.
Volume: 276
Issue: 31
Pages: 28984-90
Publication
First Author: Sato M
Year: 2011
Journal: FEBS Lett
Title: Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1.
Volume: 585
Issue: 6
Pages: 834-40
Publication
First Author: Escalante M
Year: 2000
Journal: J Biol Chem
Title: Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis.
Volume: 275
Issue: 32
Pages: 24787-97
Publication
First Author: Risser R
Year: 1978
Journal: Proc Natl Acad Sci U S A
Title: Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice.
Volume: 75
Issue: 8
Pages: 3918-22
Publication
First Author: Van de Ven WJ
Year: 1980
Journal: Virology
Title: The nonstructural components of polyproteins encoded by replication-defective mammalian transforming retroviruses are phosphorylated and have associated protein kinase activity.
Volume: 101
Issue: 1
Pages: 185-97
Publication
First Author: Goff SP
Year: 1980
Journal: Cell
Title: Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA.
Volume: 22
Issue: 3
Pages: 777-85
Publication
First Author: Heisterkamp N
Year: 1982
Journal: Nature
Title: Chromosomal localization of human cellular homologues of two viral oncogenes.
Volume: 299
Issue: 5885
Pages: 747-9
Publication
First Author: Goff SP
Year: 1982
Journal: Science
Title: Chromosomal assignment of the endogenous proto-oncogene C-abl.
Volume: 218
Issue: 4579
Pages: 1317-9
Publication
First Author: Wang JY
Year: 1983
Journal: Mol Cell Biol
Title: Cellular RNA homologous to the Abelson murine leukemia virus transforming gene: expression and relationship to the viral sequence.
Volume: 3
Issue: 5
Pages: 773-9
Publication
First Author: Ponzetto C
Year: 1985
Journal: Mol Cell Biol
Title: Haploid expression of a unique c-abl transcript in the mouse male germ line.
Volume: 5
Issue: 7
Pages: 1791-4
Publication
First Author: Ben-Neriah Y
Year: 1986
Journal: Cell
Title: Alternative 5' exons in c-abl mRNA.
Volume: 44
Issue: 4
Pages: 577-86
Publication
First Author: Meijer D
Year: 1987
Journal: EMBO J
Title: Molecular characterization of the testis specific c-abl mRNA in mouse.
Volume: 6
Issue: 13
Pages: 4041-8
Publication
First Author: Trakhtenbrot L
Year: 1990
Journal: Leukemia
Title: Chromosomal mapping of the murine c-abl proto-oncogene by in situ hybridization.
Volume: 4
Issue: 2
Pages: 136-7
Publication
First Author: Shore SK
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation.
Volume: 87
Issue: 17
Pages: 6502-6
Publication
First Author: Bazzoni G
Year: 1996
Journal: J Clin Invest
Title: Bcr/Abl expression stimulates integrin function in hematopoietic cell lines.
Volume: 98
Issue: 2
Pages: 521-8
Publication
First Author: Dale B
Year: 1981
Journal: Mol Cell Biol
Title: Characterization of mouse cellular deoxyribonucleic acid homologous to Abelson murine leukemia virus-specific sequences.
Volume: 1
Issue: 8
Pages: 731-42
Publication
First Author: Van Etten RA
Year: 1999
Journal: Trends Cell Biol
Title: Cycling, stressed-out and nervous: cellular functions of c-Abl.
Volume: 9
Issue: 5
Pages: 179-86