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Search results 1 to 100 out of 670 for Abl1

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Type Details Score
Gene
25 | ABL1
Type: gene
Organism: Homo sapiens
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Gene
RGD:1584969 | Abl1
Type: gene
Organism: Rattus norvegicus
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Gene
ZDB-GENE-100812-9 | abl1
Type: gene
Organism: Danio rerio
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Protein Domain
IPR033221 | ABL1
Type: Family
Description: ABL tyrosine kinases are nonreceptor tyrosine kinases containing an SH3-SH2-TK (Src homology 3-Src homology 2-tyrosine kinase) domain cassette, which confers autoregulated kinase activity. This cassette is coupled to an actin-binding and -bundling domain, which makes ABL proteins capable of connecting phosphoregulation with actin-filament reorganization. Two vertebrate ABL tyrosine kinases have been identified, ABL1 and ABL2 [].A downstream effector of RAS, RIN1, have been found to bind to the SH3 and SH2 domains of ABL1/ABL2 to relieve autoinhibition and regulate their activity [].This entry includes animal ABL1 and viral oncogene products that are homologous to ABL1 []. ABL1 plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodelling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis [, , , ]. Normal ABL1 can serve as a tumour suppressor and therapeutic target in leukemias expressing oncogenic forms of the kinase [].
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Protein Coding Gene
MGI:87859 | Abl1
Type: protein_coding_gene
Organism: Mus musculus
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Protein
P00520
Organism: Mus musculus
Length: 1123  
Fragment?: false
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Publication
26864341 | -
First Author: Dasgupta Y
Year: 2016
Journal: Blood
Title: Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.
Volume: 127
Issue: 17
Pages: 2131-43
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Publication
20841568 | -
First Author: Colicelli J
Year: 2010
Journal: Sci Signal
Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.
Volume: 3
Issue: 139
Pages: re6
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Publication
18538733 | J:138632
First Author: Bueno MJ
Year: 2008
Journal: Cancer Cell
Title: Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.
Volume: 13
Issue: 6
Pages: 496-506
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Publication
18796434 | -
First Author: Cao X
Year: 2008
Journal: J Biol Chem
Title: Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.
Volume: 283
Issue: 46
Pages: 31401-7
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Publication
18945674 | -
First Author: Yogalingam G
Year: 2008
Journal: J Biol Chem
Title: Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
Volume: 283
Issue: 51
Pages: 35941-53
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Publication
6191223 | -
First Author: Groffen J
Year: 1983
Journal: Nature
Title: Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products.
Volume: 304
Issue: 5922
Pages: 167-9
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Publication
17623672 | -
First Author: Sossey-Alaoui K
Year: 2007
Journal: J Biol Chem
Title: c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.
Volume: 282
Issue: 36
Pages: 26257-65
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Publication
16943190 | -
First Author: Tanos B
Year: 2006
Journal: J Biol Chem
Title: Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
Volume: 281
Issue: 43
Pages: 32714-23
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Publication
21693657 | J:175456
First Author: Virgili A
Year: 2011
Journal: Cancer Res
Title: Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele.
Volume: 71
Issue: 16
Pages: 5381-6
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Publication
27806304 | J:242336
First Author: Kim DH
Year: 2016
Journal: Cell Rep
Title: Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2.
Volume: 17
Issue: 6
Pages: 1671-1682
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Publication
31914386 | J:287553
First Author: Kim JY
Year: 2020
Journal: Cell Rep
Title: Timely Inhibitory Circuit Formation Controlled by Abl1 Regulates Innate Olfactory Behaviors in Mouse.
Volume: 30
Issue: 1
Pages: 187-201.e4
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Publication
11971963 | -
First Author: Yoshida K
Year: 2002
Journal: Mol Cell Biol
Title: c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
Volume: 22
Issue: 10
Pages: 3292-300
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Publication
24863063 | J:214295
First Author: Raimondi C
Year: 2014
Journal: J Exp Med
Title: Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.
Volume: 211
Issue: 6
Pages: 1167-83
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Publication
10896159 | J:63117
First Author: Zukerberg LR
Year: 2000
Journal: Neuron
Title: Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.
Volume: 26
Issue: 3
Pages: 633-46
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Protein
Q3SYK5
Organism: Mus musculus
Length: 1142  
Fragment?: false
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Publication
3317402 | J:40703
First Author: Oppi C
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation.
Volume: 84
Issue: 23
Pages: 8200-4
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Publication
6319018 | J:7292
First Author: Wang JY
Year: 1984
Journal: Cell
Title: The mouse c-abl locus: molecular cloning and characterization.
Volume: 36
Issue: 2
Pages: 349-56
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Publication
3283651 | J:9153
First Author: Bernards A
Year: 1988
Journal: Oncogene
Title: Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing.
Volume: 2
Issue: 4
Pages: 297-304
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Publication
2065352 | J:72875
First Author: Tybulewicz VL
Year: 1991
Journal: Cell
Title: Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.
Volume: 65
Issue: 7
Pages: 1153-63
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Publication
2065353 | J:14644
First Author: Schwartzberg PL
Year: 1991
Journal: Cell
Title: Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations.
Volume: 65
Issue: 7
Pages: 1165-75
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Publication
12748290 | J:116250
First Author: Tanis KQ
Year: 2003
Journal: Mol Cell Biol
Title: Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
Volume: 23
Issue: 11
Pages: 3884-96
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Publication
11279004 | J:116356
First Author: Kain KH
Year: 2001
Journal: J Biol Chem
Title: Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.
Volume: 276
Issue: 19
Pages: 16185-92
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Publication
9636171 | J:116366
First Author: Taagepera S
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase.
Volume: 95
Issue: 13
Pages: 7457-62
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Publication
11163214 | J:200513
First Author: Cong F
Year: 2000
Journal: Mol Cell
Title: Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.
Volume: 6
Issue: 6
Pages: 1413-23
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Publication
11955625 | J:76235
First Author: Sato H
Year: 2002
Journal: Biochim Biophys Acta
Title: ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.
Volume: 1574
Issue: 2
Pages: 157-63
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Publication
11279131 | J:230384
First Author: Zambrano N
Year: 2001
Journal: J Biol Chem
Title: The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.
Volume: 276
Issue: 23
Pages: 19787-92
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Publication
9109492 | J:116399
First Author: Kharbanda S
Year: 1997
Journal: Nature
Title: Functional interaction between DNA-PK and c-Abl in response to DNA damage.
Volume: 386
Issue: 6626
Pages: 732-5
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Publication
21690296 | J:175086
First Author: Chen A
Year: 2011
Journal: Mol Cell Biol
Title: c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation.
Volume: 31
Issue: 16
Pages: 3445-56
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Publication
14993293 | J:89062
First Author: Plattner R
Year: 2004
Journal: Mol Cell Biol
Title: Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
Volume: 24
Issue: 6
Pages: 2573-83
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Publication
8700526 | J:34643
First Author: Hardin JD
Year: 1996
Journal: Oncogene
Title: Transgenes encoding both type I and type IV c-abl proteins rescue the lethality of c-abl mutant mice.
Volume: 12
Issue: 12
Pages: 2669-77
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Publication
17363963 | J:139259
First Author: Preyer M
Year: 2007
Journal: Cell Death Differ
Title: Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals.
Volume: 14
Issue: 6
Pages: 1139-48
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Publication
12796783 | J:84071
First Author: Finn AJ
Year: 2003
Journal: Nat Neurosci
Title: Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
Volume: 6
Issue: 7
Pages: 717-23
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Publication
30655340 | J:270362
First Author: Khatri A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia.
Volume: 116
Issue: 5
Pages: 1603-1612
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Publication
20837657 | J:164680
First Author: Singh J
Year: 2010
Journal: Genes Dev
Title: Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation.
Volume: 24
Issue: 19
Pages: 2157-68
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Publication
11706030 | J:114013
First Author: Tsuji K
Year: 2002
Journal: J Biol Chem
Title: Differential effect of ik3-1/cables on p53- and p73-induced cell death.
Volume: 277
Issue: 4
Pages: 2951-7
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Protein Coding Gene
MGP_CAROLIEiJ_G0023416 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025589 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_AJ_G0025567 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_AKRJ_G0025536 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_BALBcJ_G0025563 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_C3HHeJ_G0025324 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGI_C57BL6J_87859 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_C57BL6NJ_G0026008 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_CASTEiJ_G0024786 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_CBAJ_G0025301 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_DBA2J_G0025434 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_FVBNJ_G0025397 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_LPJ_G0025520 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_NODShiLtJ_G0025427 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_NZOHlLtJ_G0026066 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_PWKPhJ_G0024533 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_WSBEiJ_G0024854 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_PahariEiJ_G0024873 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024333 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15657060 | J:196110
First Author: Raina D
Year: 2005
Journal: J Biol Chem
Title: c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
Volume: 280
Issue: 12
Pages: 11147-51
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Publication
27348587 | J:232550
First Author: Brahmachari S
Year: 2016
Journal: J Clin Invest
Title: Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration.
Volume: 126
Issue: 8
Pages: 2970-88
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Publication
12149518 | J:78523
First Author: Symons RC
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.
Volume: 99
Issue: 17
Pages: 11299-304
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Publication
24112389 | J:202814
 
First Author: Cleary RA
Year: 2013
Journal: Respir Res
Title: Role of Abl in airway hyperresponsiveness and airway remodeling.
Volume: 14
Pages: 105
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Publication
28074253 | J:240700
First Author: Wu R
Year: 2017
Journal: Diabetologia
Title: c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice.
Volume: 60
Issue: 5
Pages: 900-910
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Publication
29730354 | J:265864
First Author: Liu H
Year: 2018
Journal: Biochim Biophys Acta Mol Cell Res
Title: The nonreceptor tyrosine kinase c-Abl phosphorylates Runx1 and regulates Runx1-mediated megakaryocyte maturation.
Volume: 1865
Issue: 8
Pages: 1060-1072
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Publication
2554496 | J:72519
First Author: Schwartzberg PL
Year: 1989
Journal: Science
Title: Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.
Volume: 246
Issue: 4931
Pages: 799-803
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Publication
2155783 | J:78204
First Author: Rosenbaum H
Year: 1990
Journal: EMBO J
Title: An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene.
Volume: 9
Issue: 3
Pages: 897-905
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Publication
8806812 | J:34903
First Author: Hardin JD
Year: 1996
Journal: Cell Immunol
Title: Abnormal peripheral lymphocyte function in c-abl mutant mice.
Volume: 172
Issue: 1
Pages: 100-7
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Publication
2183226 | J:72518
First Author: Schwartzberg PL
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.
Volume: 87
Issue: 8
Pages: 3210-4
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Publication
17229817 | J:118698
First Author: Lam QL
Year: 2007
Journal: Int Immunol
Title: Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.
Volume: 19
Issue: 3
Pages: 267-76
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Publication
10700189 | J:60749
First Author: Li B
Year: 2000
Journal: Nat Genet
Title: Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation.
Volume: 24
Issue: 3
Pages: 304-8
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Publication
11120811 | J:66085
First Author: Zipfel PA
Year: 2000
Journal: J Immunol
Title: The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.
Volume: 165
Issue: 12
Pages: 6872-9
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Publication
11413193 | J:70012
First Author: Nunes I
Year: 2001
Journal: J Exp Med
Title: c-abl is required for the development of hyperoxia-induced retinopathy.
Volume: 193
Issue: 12
Pages: 1383-91
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Publication
9583675 | J:124453
First Author: Kharbanda S
Year: 1998
Journal: Oncogene
Title: Functional role for the c-Abl tyrosine kinase in meiosis I.
Volume: 16
Issue: 14
Pages: 1773-7
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Publication
20798688 | J:186979
First Author: Wang X
Year: 2011
Journal: Cell Death Differ
Title: A positive role for c-Abl in Atm and Atr activation in DNA damage response.
Volume: 18
Issue: 1
Pages: 5-15
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Publication
17626041 | J:172188
First Author: Imam SZ
Year: 2007
Journal: Nucleic Acids Res
Title: Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase.
Volume: 35
Issue: 15
Pages: 4941-51
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Publication
11494128 | J:197520
First Author: Yu HH
Year: 2001
Journal: Oncogene
Title: Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor.
Volume: 20
Issue: 30
Pages: 3995-4006
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Publication
11390389 | J:175114
First Author: Sun J
Year: 2001
Journal: J Biol Chem
Title: c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.
Volume: 276
Issue: 31
Pages: 28984-90
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Publication
21320496 | J:201300
First Author: Sato M
Year: 2011
Journal: FEBS Lett
Title: Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1.
Volume: 585
Issue: 6
Pages: 834-40
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Publication
10825157 | J:115336
First Author: Escalante M
Year: 2000
Journal: J Biol Chem
Title: Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis.
Volume: 275
Issue: 32
Pages: 24787-97
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Publication
211509 | J:6037
First Author: Risser R
Year: 1978
Journal: Proc Natl Acad Sci U S A
Title: Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice.
Volume: 75
Issue: 8
Pages: 3918-22
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Publication
6243819 | J:6269
First Author: Van de Ven WJ
Year: 1980
Journal: Virology
Title: The nonstructural components of polyproteins encoded by replication-defective mammalian transforming retroviruses are phosphorylated and have associated protein kinase activity.
Volume: 101
Issue: 1
Pages: 185-97
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Publication
6257398 | J:6460
First Author: Goff SP
Year: 1980
Journal: Cell
Title: Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA.
Volume: 22
Issue: 3
Pages: 777-85
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Publication
7121606 | J:6868
First Author: Heisterkamp N
Year: 1982
Journal: Nature
Title: Chromosomal localization of human cellular homologues of two viral oncogenes.
Volume: 299
Issue: 5885
Pages: 747-9
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Publication
6293057 | J:6910
First Author: Goff SP
Year: 1982
Journal: Science
Title: Chromosomal assignment of the endogenous proto-oncogene C-abl.
Volume: 218
Issue: 4579
Pages: 1317-9
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Publication
6306446 | J:7116
First Author: Wang JY
Year: 1983
Journal: Mol Cell Biol
Title: Cellular RNA homologous to the Abelson murine leukemia virus transforming gene: expression and relationship to the viral sequence.
Volume: 3
Issue: 5
Pages: 773-9
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Publication
4022013 | J:7958
First Author: Ponzetto C
Year: 1985
Journal: Mol Cell Biol
Title: Haploid expression of a unique c-abl transcript in the mouse male germ line.
Volume: 5
Issue: 7
Pages: 1791-4
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Publication
3512096 | J:8189
First Author: Ben-Neriah Y
Year: 1986
Journal: Cell
Title: Alternative 5' exons in c-abl mRNA.
Volume: 44
Issue: 4
Pages: 577-86
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Publication
3443101 | J:9089
First Author: Meijer D
Year: 1987
Journal: EMBO J
Title: Molecular characterization of the testis specific c-abl mRNA in mouse.
Volume: 6
Issue: 13
Pages: 4041-8
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Publication
2406516 | J:10317
First Author: Trakhtenbrot L
Year: 1990
Journal: Leukemia
Title: Chromosomal mapping of the murine c-abl proto-oncogene by in situ hybridization.
Volume: 4
Issue: 2
Pages: 136-7
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Publication
2168550 | J:14646
First Author: Shore SK
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation.
Volume: 87
Issue: 17
Pages: 6502-6
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Publication
8755665 | J:34379
First Author: Bazzoni G
Year: 1996
Journal: J Clin Invest
Title: Bcr/Abl expression stimulates integrin function in hematopoietic cell lines.
Volume: 98
Issue: 2
Pages: 521-8
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Publication
9279386 | J:32374
First Author: Dale B
Year: 1981
Journal: Mol Cell Biol
Title: Characterization of mouse cellular deoxyribonucleic acid homologous to Abelson murine leukemia virus-specific sequences.
Volume: 1
Issue: 8
Pages: 731-42
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Publication
10322452 | J:54650
First Author: Van Etten RA
Year: 1999
Journal: Trends Cell Biol
Title: Cycling, stressed-out and nervous: cellular functions of c-Abl.
Volume: 9
Issue: 5
Pages: 179-86
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Publication
10373409 | J:55870
First Author: Zou X
Year: 1999
Journal: J Biol Chem
Title: Signaling pathways activated by oncogenic forms of Abl tyrosine kinase.
Volume: 274
Issue: 26
Pages: 18141-4
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Publication
18624912 | J:141853
First Author: Jia DY
Year: 2008
Journal: J Neurochem
Title: c-Abl is involved in high glucose-induced apoptosis in embryonic E12.5 cortical neural progenitor cells from the mouse brain.
Volume: 106
Issue: 4
Pages: 1720-30
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Publication
20150913 | J:186367
First Author: Li X
Year: 2010
Journal: Cell Death Differ
Title: c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3.
Volume: 17
Issue: 8
Pages: 1277-87
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Publication
24412932 | J:210101
First Author: Mahul-Mellier AL
Year: 2014
Journal: Hum Mol Genet
Title: c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Volume: 23
Issue: 11
Pages: 2858-79
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GXD Expression
GXD Expression
       
Probe: MGI:5297826
Assay Type: Northern blot
Annotation Date: 2011-12-09
Strength: Not Specified
Sex: Male
Emaps: EMAPS:3570728
Stage: TS28
Assay Id: MGI:5297842
Age: postnatal adult
Specimen Num: 1
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