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Search results 1 to 100 out of 185 for Ackr2

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0.042s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Atypical chemokine receptor 2 (ACKR2/D6) [], previously known as CCR9 or CCR10 [], is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [, ]. ACKR2 is highly promiscuous and can bind the majority of (if not all) inflammatory CC-chemokines []. It plays an essential role in the resolution of the inflammatory response [, , ]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signalling pathways downstream of ligand binding []. It has been shown to be involved in regulating vessel density [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Lee KM
Year: 2014
Journal: EMBO J
Title: The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.
Volume: 33
Issue: 21
Pages: 2564-80
Publication
First Author: Jamieson T
Year: 2005
Journal: Nat Immunol
Title: The chemokine receptor D6 limits the inflammatory response in vivo.
Volume: 6
Issue: 4
Pages: 403-11
Publication  
First Author: da Silva JM
Year: 2019
Journal: Cytokine
Title: Role of atypical chemokine receptor ACKR2 in experimental oral squamous cell carcinogenesis.
Volume: 118
Pages: 160-167
Publication
First Author: Hansell CAH
Year: 2018
Journal: J Immunol
Title: The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.
Volume: 201
Issue: 8
Pages: 2510-2519
Publication
First Author: Massara M
Year: 2018
Journal: Nat Commun
Title: ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.
Volume: 9
Issue: 1
Pages: 676
Publication  
First Author: Zheng S
Year: 2016
Journal: J Diabetes Res
Title: Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice.
Volume: 2016
Pages: 5362506
Publication
First Author: Wilson GJ
Year: 2017
Journal: Development
Title: Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland.
Volume: 144
Issue: 1
Pages: 74-82
Publication
First Author: Hansell CAH
Year: 2020
Journal: Eur J Immunol
Title: Analysis of lung stromal expression of the atypical chemokine receptor ACKR2 reveals unanticipated expression in murine blood endothelial cells.
Volume: 50
Issue: 5
Pages: 666-675
Publication
First Author: Teoh PJ
Year: 2014
Journal: J Immunol
Title: Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice.
Volume: 193
Issue: 10
Pages: 5218-28
Publication
First Author: Russo RC
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: The atypical chemokine receptor ACKR2 drives pulmonary fibrosis by tuning influx of CCR2+ and CCR5+ IFNγ-producing γδT cells in mice.
Volume: 314
Issue: 6
Pages: L1010-L1025
Publication
First Author: Tavares LP
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: ACKR2 contributes to pulmonary dysfunction by shaping CCL5:CCR5-dependent recruitment of lymphocytes during influenza A infection in mice.
Volume: 318
Issue: 4
Pages: L655-L670
Publication
First Author: Woodcock TM
Year: 2017
Journal: PLoS One
Title: The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury.
Volume: 12
Issue: 11
Pages: e0188305
Protein
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
Publication
First Author: Graham GJ
Year: 2013
Journal: J Pathol
Title: Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.
Volume: 229
Issue: 2
Pages: 168-75
Publication
First Author: Borroni EM
Year: 2013
Journal: Sci Signal
Title: β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.
Volume: 6
Issue: 273
Pages: ra30.1-11, S1-3
Publication
First Author: Graham GJ
Year: 2009
Journal: Eur J Immunol
Title: D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes.
Volume: 39
Issue: 2
Pages: 342-51
Publication
First Author: Fra AM
Year: 2003
Journal: J Immunol
Title: Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.
Volume: 170
Issue: 5
Pages: 2279-82
Publication
First Author: Weber M
Year: 2004
Journal: Mol Biol Cell
Title: The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines.
Volume: 15
Issue: 5
Pages: 2492-508
Publication  
First Author: Graham GJ
Year: 2015
Journal: Front Immunol
Title: D6/ACKR2.
Volume: 6
Pages: 280
Publication
First Author: McKimmie CS
Year: 2013
Journal: Blood
Title: An analysis of the function and expression of D6 on lymphatic endothelial cells.
Volume: 121
Issue: 18
Pages: 3768-77
Protein
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Publication
First Author: Shams K
Year: 2017
Journal: J Invest Dermatol
Title: Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2.
Volume: 137
Issue: 1
Pages: 85-94
Publication
First Author: Lux M
Year: 2019
Journal: Am J Pathol
Title: The Atypical Chemokine Receptor 2 Limits Progressive Fibrosis after Acute Ischemic Kidney Injury.
Volume: 189
Issue: 2
Pages: 231-247
Publication  
First Author: Lima ILA
Year: 2017
Journal: Bone
Title: Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling.
Volume: 101
Pages: 113-122
Publication
First Author: Ford LB
Year: 2014
Journal: J Immunol
Title: Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.
Volume: 193
Issue: 1
Pages: 400-11
Publication
First Author: Lee KM
Year: 2019
Journal: PLoS Biol
Title: Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.
Volume: 17
Issue: 5
Pages: e3000287
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Pashover-Schallinger E
Year: 2012
Journal: FASEB J
Title: The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation.
Volume: 26
Issue: 9
Pages: 3891-900
Publication
First Author: Déruaz M
Year: 2008
Journal: J Exp Med
Title: Ticks produce highly selective chemokine binding proteins with antiinflammatory activity.
Volume: 205
Issue: 9
Pages: 2019-31
Publication
First Author: Singh MD
Year: 2012
Journal: Am J Pathol
Title: Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis.
Volume: 181
Issue: 4
Pages: 1158-64
Publication
First Author: Vetrano S
Year: 2010
Journal: Gut
Title: The lymphatic system controls intestinal inflammation and inflammation-associated Colon Cancer through the chemokine decoy receptor D6.
Volume: 59
Issue: 2
Pages: 197-206
Publication
First Author: Whitehead GS
Year: 2007
Journal: Am J Respir Crit Care Med
Title: The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity.
Volume: 175
Issue: 3
Pages: 243-9
Publication
First Author: Rot A
Year: 2013
Journal: J Immunol
Title: Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.
Volume: 190
Issue: 12
Pages: 6450-6456
Publication
First Author: Martinez de la Torre Y
Year: 2005
Journal: Eur J Immunol
Title: Increased inflammation in mice deficient for the chemokine decoy receptor D6.
Volume: 35
Issue: 5
Pages: 1342-6
Publication
First Author: Nibbs RJ
Year: 2007
Journal: J Clin Invest
Title: The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors.
Volume: 117
Issue: 7
Pages: 1884-92
Publication
First Author: Hansell CA
Year: 2011
Journal: Blood
Title: Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice.
Volume: 117
Issue: 20
Pages: 5413-24
Publication
First Author: Martinez de la Torre Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.
Volume: 104
Issue: 7
Pages: 2319-24
Publication
First Author: Lee KM
Year: 2011
Journal: Blood
Title: D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion.
Volume: 118
Issue: 23
Pages: 6220-9
Publication
First Author: Liu L
Year: 2006
Journal: J Immunol
Title: Cutting edge: the silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitis.
Volume: 177
Issue: 1
Pages: 17-21
Publication
First Author: Di Liberto D
Year: 2008
Journal: J Exp Med
Title: Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection.
Volume: 205
Issue: 9
Pages: 2075-84
Publication
First Author: Bordon Y
Year: 2009
Journal: J Immunol
Title: The atypical chemokine receptor D6 contributes to the development of experimental colitis.
Volume: 182
Issue: 8
Pages: 5032-40
Publication
First Author: Baldwin HM
Year: 2013
Journal: J Biol Chem
Title: Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice.
Volume: 288
Issue: 51
Pages: 36473-83
Publication
First Author: Savino B
Year: 2012
Journal: Blood
Title: Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6.
Volume: 119
Issue: 22
Pages: 5250-60
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945886
Age: embryonic day 11.5
Image: g01906 E11.5
Specimen Label: g01906 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945886
Age: embryonic day 15.5
Image: g01906 E15.5
Specimen Label: g01906 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945886
Age: embryonic day 15.5
Image: g01906 E15.5
Specimen Label: g01906 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 7
Image: g01906 P7
Specimen Label: g01906 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 42
Image: g01906 Adult
Specimen Label: g01906 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945886
Age: embryonic day 11.5
Image: g01906 E11.5
Specimen Label: g01906 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945886
Age: embryonic day 15.5
Image: g01906 E15.5
Specimen Label: g01906 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 7
Image: g01906 P7
Specimen Label: g01906 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 42
Image: g01906 Adult
Specimen Label: g01906 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716823
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945886
Age: embryonic day 15.5
Image: g01906 E15.5
Specimen Label: g01906 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 7
Image: g01906 P7
Specimen Label: g01906 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 42
Image: g01906 Adult
Specimen Label: g01906 Adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7262727
Assay Type: RNA in situ
Annotation Date: 2022-04-19
Strength: Absent
Sex: Female
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:7262736
Age: postnatal
Image: 6Bi decidua
Specimen Label: 6Bi decidua
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:7262727
Assay Type: RNA in situ
Annotation Date: 2022-04-19
Strength: Absent
Sex: Female
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:7262736
Age: postnatal
Image: 6Bii decidua
Specimen Label: 6Bii decidua
Detected: false
Specimen Num: 4
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945886
Age: embryonic day 15.5
Image: g01906 E15.5
Specimen Label: g01906 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 7
Image: g01906 P7
Specimen Label: g01906 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 42
Image: g01906 Adult
Specimen Label: g01906 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778723
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945886
Age: embryonic day 15.5
Image: g01906 E15.5
Specimen Label: g01906 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 7
Image: g01906 P7
Specimen Label: g01906 P7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 42
Image: g01906 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01906 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 7
Image: g01906 P7
Specimen Label: g01906 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 42
Image: g01906 Adult
Specimen Label: g01906 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 7
Image: g01906 P7
Specimen Label: g01906 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 42
Image: g01906 Adult
Specimen Label: g01906 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945886
Age: embryonic day 11.5
Image: g01906 E11.5
Specimen Label: g01906 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945886
Age: embryonic day 15.5
Image: g01906 E15.5
Specimen Label: g01906 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 7
Image: g01906 P7
Specimen Label: g01906 P7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4885393
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945886
Age: postnatal day 42
Image: g01906 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01906 Adult
Detected: true
Specimen Num: 4