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Search results 1 to 100 out of 122 for Adam15

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: ADAM15 peptidase (or metargidin; MEROPS identifier M12.215) is a sheddase-like metalloendopeptidase with a propeptide, a metallopeptidase domain, a disintegrin domain, an ADAM-CR domain, a transmembrane region and a proline-rich cytoplasmic tail. It probably exists naturally in a heterodimer with an unidentified, 56kDa protein with which it immunoprecipitates []. The precursor is correctly processed by furin []. ADAM15 sheds the ectodomain of fibroblast growth factor 2iiib []. In human (but not mouse) the disintegrin domain contains an RGD motif and binding to integrins has been demonstrated []. Because platelets bind to ADAM15 and are activated, clotting can occur, and ADAM15 is a therapeutic target for cardiovascular disease []. The gene is overexpressed in several human cancers and has roles in pathological neovascularization and prostate cancer metastasis []. A shorter spliced form with a different cytoplasmic tail containing an Src-binding site has been isolated from cancer cells [, ].
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Lum L
Year: 1998
Journal: J Biol Chem
Title: Intracellular maturation of the mouse metalloprotease disintegrin MDC15.
Volume: 273
Issue: 40
Pages: 26236-47
Publication
First Author: Herren B
Year: 2001
Journal: Exp Cell Res
Title: ADAM15 overexpression in NIH3T3 cells enhances cell-cell interactions.
Volume: 271
Issue: 1
Pages: 152-60
Publication
First Author: Maretzky T
Year: 2009
Journal: Biochem J
Title: Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
Volume: 420
Issue: 1
Pages: 105-13
Publication
First Author: Maretzky T
Year: 2009
Journal: Cancer Res
Title: Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.
Volume: 69
Issue: 11
Pages: 4573-6
Publication
First Author: Kuefer R
Year: 2006
Journal: Neoplasia
Title: ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease.
Volume: 8
Issue: 4
Pages: 319-29
Publication
First Author: Charrier L
Year: 2005
Journal: Am J Physiol Gastrointest Liver Physiol
Title: ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers.
Volume: 288
Issue: 2
Pages: G346-53
Publication
First Author: Krätzschmar J
Year: 1996
Journal: J Biol Chem
Title: Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.
Volume: 271
Issue: 9
Pages: 4593-6
Publication  
First Author: Nath D
Year: 1999
Journal: J Cell Sci
Title: Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.
Volume: 112 ( Pt 4)
Pages: 579-87
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
Publication
First Author: Seldin MF
Year: 2000
Journal: Matrix Biol
Title: Chromosomal mapping of Adam9, Adam15 and Adam21.
Volume: 19
Issue: 2
Pages: 185-7
Publication
First Author: Horiuchi K
Year: 2003
Journal: Mol Cell Biol
Title: Potential role for ADAM15 in pathological neovascularization in mice.
Volume: 23
Issue: 16
Pages: 5614-24
Publication
First Author: Böhm BB
Year: 2005
Journal: Arthritis Rheum
Title: Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling.
Volume: 52
Issue: 4
Pages: 1100-9
Publication
First Author: Sun C
Year: 2013
Journal: Am J Physiol Lung Cell Mol Physiol
Title: ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice.
Volume: 304
Issue: 3
Pages: L135-42
Publication
First Author: Xie B
Year: 2008
Journal: FASEB J
Title: An Adam15 amplification loop promotes vascular endothelial growth factor-induced ocular neovascularization.
Volume: 22
Issue: 8
Pages: 2775-83
Publication
First Author: Pastén-Hidalgo K
Year: 2008
Journal: Reproduction
Title: Presence, processing, and localization of mouse ADAM15 during sperm maturation and the role of its disintegrin domain during sperm-egg binding.
Volume: 136
Issue: 1
Pages: 41-51
Protein
Organism: Mus musculus/domesticus
Length: 864  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 815  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 809  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
Publication
First Author: Maretzky T
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15.
Volume: 55
Issue: 10
Pages: 6774-82
Publication
First Author: Eto K
Year: 2002
Journal: J Biol Chem
Title: Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.
Volume: 277
Issue: 20
Pages: 17804-10
Publication
First Author: Yang X
Year: 2018
Journal: Cardiovasc Res
Title: A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation.
Volume: 114
Issue: 13
Pages: 1752-1763
Publication
First Author: Jana S
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm.
Volume: 40
Issue: 8
Pages: 1918-1934
Publication
First Author: Sun C
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity.
Volume: 32
Issue: 10
Pages: 2444-51
Publication
First Author: Shimizu E
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins.
Volume: 309
Issue: 4
Pages: 779-85
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2023-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3576022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444180
Age: embryonic day 14.5
Image: S1B
Note: Expression was detected primarily in the valve endothelium.
Specimen Label: S1B
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2023-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3515422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444180
Age: embryonic day 14.5
Image: S1B
Note: Expression was detected primarily in the valve endothelium.
Specimen Label: S1B
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_01
Specimen Label: euxassay_010547_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_02
Specimen Label: euxassay_010547_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_03
Specimen Label: euxassay_010547_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_04
Specimen Label: euxassay_010547_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_05
Specimen Label: euxassay_010547_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_06
Specimen Label: euxassay_010547_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_07
Specimen Label: euxassay_010547_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_08
Specimen Label: euxassay_010547_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_09
Specimen Label: euxassay_010547_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_10
Specimen Label: euxassay_010547_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_11
Specimen Label: euxassay_010547_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_12
Specimen Label: euxassay_010547_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_13
Specimen Label: euxassay_010547_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_14
Specimen Label: euxassay_010547_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_15
Specimen Label: euxassay_010547_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_16
Specimen Label: euxassay_010547_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_17
Specimen Label: euxassay_010547_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_18
Specimen Label: euxassay_010547_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_19
Specimen Label: euxassay_010547_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4417651
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Spotted
Stage: TS23
Assay Id: MGI:4822974
Age: embryonic day 14.5
Image: euxassay_010547_20
Specimen Label: euxassay_010547_20
Detected: true
Specimen Num: 20
Publication    
First Author: Shimizu E
Year: 2000
Journal: GenBank Submission
Title: Mus musculus ADAM 15 gene, complete cds
Pages: AB022089
Publication
First Author: Nath AK
Year: 2009
Journal: PLoS One
Title: Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects.
Volume: 4
Issue: 1
Pages: e4221
Publication
First Author: Abram CL
Year: 2003
Journal: J Biol Chem
Title: The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells.
Volume: 278
Issue: 19
Pages: 16844-51
Publication
First Author: Tousseyn T
Year: 2009
Journal: J Biol Chem
Title: ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.
Volume: 284
Issue: 17
Pages: 11738-47
Publication
First Author: Howard L
Year: 1999
Journal: J Biol Chem
Title: Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.
Volume: 274
Issue: 44
Pages: 31693-9
Publication
First Author: Weskamp G
Year: 2006
Journal: Nat Immunol
Title: ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Volume: 7
Issue: 12
Pages: 1293-8
Publication
First Author: Horiuchi K
Year: 2005
Journal: Dev Biol
Title: Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2.
Volume: 283
Issue: 2
Pages: 459-71
Publication
First Author: Sahin U
Year: 2004
Journal: J Cell Biol
Title: Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.
Volume: 164
Issue: 5
Pages: 769-79
Publication
First Author: Kawaguchi N
Year: 2007
Journal: J Cell Sci
Title: Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19.
Volume: 120
Issue: Pt 6
Pages: 943-52
Publication
First Author: Franzke CW
Year: 2009
Journal: J Biol Chem
Title: Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9.
Volume: 284
Issue: 35
Pages: 23386-96
Publication
First Author: Tomczuk M
Year: 2003
Journal: Exp Cell Res
Title: Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3.
Volume: 290
Issue: 1
Pages: 68-81
Publication
First Author: Karim SA
Year: 2004
Journal: Genomics
Title: A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation.
Volume: 83
Issue: 2
Pages: 225-30
Publication
First Author: Nuttall RK
Year: 2004
Journal: FEBS Lett
Title: Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.
Volume: 563
Issue: 1-3
Pages: 129-34
Publication  
First Author: Ahuja N
Year: 2022
Journal: Dev Biol
Title: Endothelial Cyp26b1 restrains murine heart valve growth during development.
Volume: 486
Pages: 81-95
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms