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Search results 1 to 100 out of 729 for Adam17

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Hits by Strain

Type Details Score
Gene
Type: gene
Organism: human
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Gene
Type: gene
Organism: frog, western clawed
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Gene
Type: gene
Organism: rat
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Gene
Type: gene
Organism: chimpanzee
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Gene
Type: gene
Organism: dog, domestic
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Gene
Type: gene
Organism: cattle
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Gene
Type: gene
Organism: chicken
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Gene
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
First Author: Kommaddi RP
Year: 2011
Journal: FASEB J
Title: Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.
Volume: 25
Issue: 6
Pages: 2061-70
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Publication
First Author: Wang Y
Year: 2013
Journal: Biochim Biophys Acta
Title: ADAM17 cleaves CD16b (Fc?RIIIb) in human neutrophils.
Volume: 1833
Issue: 3
Pages: 680-5
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Publication
First Author: Arndt PG
Year: 2011
Journal: PLoS One
Title: Leukocyte ADAM17 regulates acute pulmonary inflammation.
Volume: 6
Issue: 5
Pages: e19938
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Publication
First Author: Pellegatta M
Year: 2022
Journal: J Neurosci
Title: ADAM17 Regulates p75(NTR)-Mediated Fibrinolysis and Nerve Remyelination.
Volume: 42
Issue: 12
Pages: 2433-2447
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Publication  
First Author: Shoykhet M
Year: 2023
Journal: Front Cell Dev Biol
Title: Cardiomyocyte cohesion is increased after ADAM17 inhibition.
Volume: 11
Pages: 1021595
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Publication
First Author: Saad MI
Year: 2021
Journal: Am J Respir Cell Mol Biol
Title: ADAM17 Deficiency Protects against Pulmonary Emphysema.
Volume: 64
Issue: 2
Pages: 183-195
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Publication
First Author: Lownik JC
Year: 2020
Journal: Adipocyte
Title: Adipocyte ADAM17 plays a limited role in metabolic inflammation.
Volume: 9
Issue: 1
Pages: 509-522
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Publication
First Author: Saad MI
Year: 2020
Journal: Carcinogenesis
Title: The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis.
Volume: 41
Issue: 4
Pages: 527-538
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Publication
First Author: Sel S
Year: 2012
Journal: Ann Anat
Title: Expression analysis of ADAM17 during mouse eye development.
Volume: 194
Issue: 4
Pages: 334-8
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Publication  
First Author: Sommer A
Year: 2016
Journal: Nat Commun
Title: Phosphatidylserine exposure is required for ADAM17 sheddase function.
Volume: 7
Pages: 11523
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Publication
First Author: Fredrickx E
Year: 2020
Journal: Glia
Title: Ablation of neuronal ADAM17 impairs oligodendrocyte differentiation and myelination.
Volume: 68
Issue: 6
Pages: 1148-1164
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Publication
First Author: Caolo V
Year: 2015
Journal: Angiogenesis
Title: ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis.
Volume: 18
Issue: 1
Pages: 13-22
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Publication
First Author: Groot AJ
Year: 2013
Journal: J Invest Dermatol
Title: Epidermal ADAM17 is dispensable for notch activation.
Volume: 133
Issue: 9
Pages: 2286-8
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Publication
First Author: Wang Y
Year: 2009
Journal: J Immunol
Title: Regulation of mature ADAM17 by redox agents for L-selectin shedding.
Volume: 182
Issue: 4
Pages: 2449-57
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Publication  
First Author: Wang X
Year: 2024
Journal: JCI Insight
Title: ADAM17 variant causes hair loss via ubiquitin ligase TRIM47-mediated degradation.
Volume: 9
Issue: 13
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Publication  
First Author: Bolik J
Year: 2022
Journal: J Exp Med
Title: Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Volume: 219
Issue: 1
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Publication
First Author: West MA
Year: 2008
Journal: J Cell Biol
Title: TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
Volume: 182
Issue: 5
Pages: 993-1005
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Publication
First Author: Mukerjee S
Year: 2019
Journal: Hypertension
Title: ACE2 and ADAM17 Interaction Regulates the Activity of Presympathetic Neurons.
Volume: 74
Issue: 5
Pages: 1181-1191
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Publication
First Author: Schmidt S
Year: 2018
Journal: J Exp Med
Title: ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Volume: 215
Issue: 4
Pages: 1205-1225
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Publication
First Author: Becker AM
Year: 2015
Journal: Exp Hematol
Title: ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors.
Volume: 43
Issue: 1
Pages: 44-52.e1-3
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Publication
First Author: Nicolaou A
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
Volume: 37
Issue: 2
Pages: 247-257
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Publication
First Author: Hall KC
Year: 2013
Journal: Mol Cell Biol
Title: ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.
Volume: 33
Issue: 16
Pages: 3077-90
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Publication  
First Author: Kefaloyianni E
Year: 2016
Journal: JCI Insight
Title: ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Volume: 1
Issue: 13
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Publication
First Author: Hassemer EL
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: ADAM17 transactivates EGFR signaling during embryonic eyelid closure.
Volume: 54
Issue: 1
Pages: 132-40
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Publication
First Author: Saad MI
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Blockade of the protease ADAM17 ameliorates experimental pancreatitis.
Volume: 119
Issue: 42
Pages: e2213744119
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GXD Expression    
Probe: MGI:6166928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189733
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Adam17
Detected: true
Specimen Num: 1
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GXD Expression    
Probe: MGI:6166928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189733
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Adam17
Detected: true
Specimen Num: 2
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GXD Expression      
Probe: MGI:6166928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6189733
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Adam17
Detected: false
Specimen Num: 4
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GXD Expression      
Probe: MGI:6166928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189733
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Adam17
Detected: false
Specimen Num: 5
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GXD Expression      
Probe: MGI:6166928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189733
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Adam17
Detected: false
Specimen Num: 7
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GXD Expression    
Probe: MGI:6166928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189733
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Adam17
Detected: true
Specimen Num: 3
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GXD Expression      
Probe: MGI:6166928
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189733
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Adam17
Detected: false
Specimen Num: 6
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Publication
First Author: Kubo S
Year: 2022
Journal: Nat Immunol
Title: Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease.
Volume: 23
Issue: 1
Pages: 75-85
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Publication  
First Author: Badenes M
Year: 2023
Journal: Life Sci Alliance
Title: The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth.
Volume: 6
Issue: 4
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Publication
First Author: Li Y
Year: 2006
Journal: Blood
Title: ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding.
Volume: 108
Issue: 7
Pages: 2275-9
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Publication
First Author: Wang X
Year: 2024
Journal: Angiogenesis
Title: Photoreceptors inhibit pathological retinal angiogenesis through transcriptional regulation of Adam17 via c-Fos.
Volume: 27
Issue: 3
Pages: 379-395
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Publication
First Author: Marczynska J
Year: 2014
Journal: J Immunol
Title: The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses.
Volume: 193
Issue: 6
Pages: 2753-63
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Publication
First Author: Aktas B
Year: 2005
Journal: J Biol Chem
Title: Aspirin induces platelet receptor shedding via ADAM17 (TACE).
Volume: 280
Issue: 48
Pages: 39716-22
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Publication
First Author: Long C
Year: 2012
Journal: J Leukoc Biol
Title: ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment.
Volume: 92
Issue: 3
Pages: 667-72
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Publication
First Author: Bozkulak EC
Year: 2009
Journal: Mol Cell Biol
Title: Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling.
Volume: 29
Issue: 21
Pages: 5679-95
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Publication
First Author: Schumacher N
Year: 2022
Journal: Biochim Biophys Acta Mol Cell Res
Title: ADAM17 orchestrates Interleukin-6, TNF? and EGF-R signaling in inflammation and cancer.
Volume: 1869
Issue: 1
Pages: 119141
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Publication
First Author: Suzuki S
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: ADAM17 protects against elastase-induced emphysema by suppressing CD62L(+) leukocyte infiltration in mice.
Volume: 318
Issue: 6
Pages: L1172-L1182
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Publication
First Author: Kawai T
Year: 2017
Journal: Hypertension
Title: Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/?-Aminopropionitrile-Induced Abdominal Aortic Aneurysm.
Volume: 70
Issue: 5
Pages: 959-963
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Publication  
First Author: Shalaby L
Year: 2020
Journal: J Clin Med
Title: Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy.
Volume: 9
Issue: 2
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Publication
First Author: Li Y
Year: 2018
Journal: Exp Cell Res
Title: ADAM17 promotes cell migration and invasion through the integrin ?1 pathway in hepatocellular carcinoma.
Volume: 370
Issue: 2
Pages: 373-382
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Publication
First Author: Xu J
Year: 2019
Journal: Hypertension
Title: Activation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation.
Volume: 73
Issue: 6
Pages: 1266-1274
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Publication
First Author: Schwarz J
Year: 2014
Journal: J Biol Chem
Title: Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor ? ectodomain shedding.
Volume: 289
Issue: 5
Pages: 3080-93
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Publication
First Author: Canault M
Year: 2010
Journal: PLoS One
Title: The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation.
Volume: 5
Issue: 10
Pages: e13433
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Publication  
First Author: Zhang X
Year: 2021
Journal: Biochem Biophys Res Commun
Title: ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase.
Volume: 537
Pages: 15-21
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Publication
First Author: Long C
Year: 2010
Journal: J Leukoc Biol
Title: In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli-mediated peritonitis.
Volume: 87
Issue: 6
Pages: 1097-101
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Publication
First Author: Lownik JC
Year: 2020
Journal: Biochem Biophys Res Commun
Title: B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138.
Volume: 522
Issue: 2
Pages: 442-447
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Publication
First Author: Bell JH
Year: 2007
Journal: J Leukoc Biol
Title: Role of ADAM17 in the ectodomain shedding of TNF-alpha and its receptors by neutrophils and macrophages.
Volume: 82
Issue: 1
Pages: 173-6
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Publication
First Author: Holdt LM
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice.
Volume: 28
Issue: 6
Pages: 1097-103
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Publication
First Author: Wang Y
Year: 2010
Journal: J Immunol
Title: ADAM17 activity and other mechanisms of soluble L-selectin production during death receptor-induced leukocyte apoptosis.
Volume: 184
Issue: 8
Pages: 4447-54
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Publication  
First Author: Saad MI
Year: 2019
Journal: EMBO Mol Med
Title: ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Volume: 11
Issue: 4
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Publication  
First Author: Kempen CG
Year: 2026
Journal: Nat Commun
Title: IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation.
Volume: 17
Issue: 1
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Publication
First Author: Ford BM
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice.
Volume: 305
Issue: 3
Pages: F323-32
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Publication
First Author: Rabie T
Year: 2005
Journal: J Biol Chem
Title: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.
Volume: 280
Issue: 15
Pages: 14462-8
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Publication
First Author: Hall KC
Year: 2012
Journal: PLoS One
Title: Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735.
Volume: 7
Issue: 2
Pages: e31600
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Publication
First Author: Cabron AS
Year: 2018
Journal: J Immunol
Title: Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.
Volume: 201
Issue: 10
Pages: 3106-3118
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Publication
First Author: Tang B
Year: 2020
Journal: FASEB J
Title: Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains.
Volume: 34
Issue: 4
Pages: 4956-4969
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Publication  
First Author: Palau V
Year: 2021
Journal: Int J Mol Sci
Title: Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy.
Volume: 22
Issue: 11
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Publication
First Author: Zbodakova O
Year: 2021
Journal: Sci Rep
Title: ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis.
Volume: 11
Issue: 1
Pages: 11414
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Publication
First Author: Vidal PM
Year: 2013
Journal: Cell Death Dis
Title: ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice.
Volume: 4
Issue: 12
Pages: e954
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Publication
First Author: Murthy A
Year: 2012
Journal: Immunity
Title: Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis.
Volume: 36
Issue: 1
Pages: 105-19
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Publication
First Author: Franzke CW
Year: 2012
Journal: J Exp Med
Title: Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.
Volume: 209
Issue: 6
Pages: 1105-19
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Publication
First Author: Pruessmeyer J
Year: 2014
Journal: Blood
Title: Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space.
Volume: 123
Issue: 26
Pages: 4077-88
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Publication
First Author: Le Gall SM
Year: 2010
Journal: J Cell Sci
Title: ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.
Volume: 123
Issue: Pt 22
Pages: 3913-22
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Publication
First Author: Li X
Year: 2017
Journal: J Cell Sci
Title: Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.
Volume: 130
Issue: 5
Pages: 868-878
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Publication
First Author: Riera M
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Paricalcitol modulates ACE2 shedding and renal ADAM17 in NOD mice beyond proteinuria.
Volume: 310
Issue: 6
Pages: F534-46
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Publication
First Author: Ma X
Year: 2021
Journal: J Biol Chem
Title: ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.
Volume: 297
Issue: 4
Pages: 101185
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Publication
First Author: Chalaris A
Year: 2010
Journal: J Exp Med
Title: Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Volume: 207
Issue: 8
Pages: 1617-24
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Publication
First Author: Gravano DM
Year: 2010
Journal: PLoS One
Title: ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression.
Volume: 5
Issue: 10
Pages: e13528
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Publication
First Author: Driscoll WS
Year: 2013
Journal: Circ Res
Title: Macrophage ADAM17 deficiency augments CD36-dependent apoptotic cell uptake and the linked anti-inflammatory phenotype.
Volume: 113
Issue: 1
Pages: 52-61
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Publication
First Author: Mustafi R
Year: 2017
Journal: Clin Cancer Res
Title: ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer.
Volume: 23
Issue: 2
Pages: 549-561
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Publication
First Author: Salem ES
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice.
Volume: 306
Issue: 6
Pages: F629-39
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Publication
First Author: Takayanagi T
Year: 2016
Journal: Hypertension
Title: Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II.
Volume: 68
Issue: 4
Pages: 949-955
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Publication
First Author: Li Q
Year: 2013
Journal: PLoS One
Title: ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex.
Volume: 8
Issue: 6
Pages: e65703
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Publication
First Author: Weskamp G
Year: 2020
Journal: J Biol Chem
Title: ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).
Volume: 295
Issue: 13
Pages: 4350-4358
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Publication
First Author: Weskamp G
Year: 2010
Journal: Circ Res
Title: Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes.
Volume: 106
Issue: 5
Pages: 932-40
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Publication  
First Author: Gutsaeva DR
Year: 2020
Journal: Int J Mol Sci
Title: Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neuronal and Vascular Damage.
Volume: 21
Issue: 15
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Publication
First Author: Sahin U
Year: 2004
Journal: J Cell Biol
Title: Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.
Volume: 164
Issue: 5
Pages: 769-79
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Publication  
First Author: Meganathan I
Year: 2025
Journal: Atherosclerosis
Title: Loss of ADAM17 in smooth muscle cells enhances their transformation to macrophage-like cells leading to more severe atherosclerosis in mice.
Volume: 411
Pages: 120567
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Publication  
First Author: Lora J
Year: 2021
Journal: J Biol Chem
Title: Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.
Volume: 296
Pages: 100733
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Publication
First Author: Fleck D
Year: 2013
Journal: J Neurosci
Title: Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.
Volume: 33
Issue: 18
Pages: 7856-69
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Publication
First Author: Li N
Year: 2007
Journal: J Immunol
Title: Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development.
Volume: 178
Issue: 7
Pages: 4214-21
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Publication
First Author: Kawasaki K
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Genetic variants of Adam17 differentially regulate TGF? signaling to modify vascular pathology in mice and humans.
Volume: 111
Issue: 21
Pages: 7723-8
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Publication  
First Author: Tang J
Year: 2018
Journal: Mol Cell Biol
Title: Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.
Volume: 38
Issue: 17
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Publication
First Author: Mishra HK
Year: 2016
Journal: J Leukoc Biol
Title: Targeting ADAM17 in leukocytes increases neutrophil recruitment and reduces bacterial spread during polymicrobial sepsis.
Volume: 100
Issue: 5
Pages: 999-1004
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Publication
First Author: Wilson CL
Year: 2013
Journal: Mech Dev
Title: Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.
Volume: 130
Issue: 4-5
Pages: 272-89
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Publication  
First Author: Rabinowitsch AI
Year: 2023
Journal: J Cell Sci
Title: Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice.
Volume: 136
Issue: 13
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