| Type | Details | Score | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | human |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | frog, western clawed |  | • • • • • | 
          
              | Gene |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | dog, domestic |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | chimpanzee |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | cattle |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | chicken |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | macaque, rhesus |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | zebrafish |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Janssen L |  
                | Year: | 2016 |  
                | Journal: | Angiogenesis |  
                | Title: | ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. |  
                | Volume: | 19 |  
                | Issue: | 1 |  
                | Pages: | 53-65 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Le Goff C |  
                | Year: | 2006 |  
                | Journal: | Development |  
                | Title: | Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. |  
                | Volume: | 133 |  
                | Issue: | 8 |  
                | Pages: | 1587-96 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Bui HM |  
                | Year: | 2016 |  
                | Journal: | J Clin Invest |  
                | Title: | Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. |  
                | Volume: | 126 |  
                | Issue: | 6 |  
                | Pages: | 2167-80 |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus caroli |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus pahari |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus spretus |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5002538 |  
                | Assay Type: | RT-PCR |  
                | Annotation Date: | 2011-06-03 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1603911 |  
                |  |  
                | Stage: | TS11 |  
                | Assay Id: | MGI:5002854 |  
                | Age: | embryonic day 7.5 |  
                |  |  
                |  |  
                | Specimen Label: | E7.5 |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6450206 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2020-08-17 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1725119 |  
                | Pattern: | Not Specified |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:6450222 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | 3e |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:6450206 |  
                | Assay Type: | RNA in situ |  
                | Annotation Date: | 2020-08-17 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1724719 |  
                | Pattern: | Not Specified |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:6450222 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | 3e |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Ogino H |  
                | Year: | 2020 |  
                | Journal: | J Neurosci |  
                | Title: | The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex. |  
                | Volume: | 40 |  
                | Issue: | 40 |  
                | Pages: | 7625-7636 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Cao J |  
                | Year: | 2019 |  
                | Journal: | Nature |  
                | Title: | The single-cell transcriptional landscape of mammalian organogenesis. |  
                | Volume: | 566 |  
                | Issue: | 7745 |  
                | Pages: | 496-502 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Ogino H |  
                | Year: | 2017 |  
                | Journal: | J Neurosci |  
                | Title: | Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin. |  
                | Volume: | 37 |  
                | Issue: | 12 |  
                | Pages: | 3181-3191 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | van Berlo JH |  
                | Year: | 2010 |  
                | Journal: | Circ Res |  
                | Title: | The transcription factor GATA-6 regulates pathological cardiac hypertrophy. |  
                | Volume: | 107 |  
                | Issue: | 8 |  
                | Pages: | 1032-40 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Yamakage Y |  
                | Year: | 2019 |  
                | Journal: | Mol Cell Neurosci |  
                | Title: | A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum. |  
                | Volume: | 100 |  
                |  |  
                | Pages: | 103401 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Tonelli Gombalová Z |  
                | Year: | 2020 |  
                | Journal: | J Comp Neurol |  
                | Title: | Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species. |  
                | Volume: | 528 |  
                | Issue: | 15 |  
                | Pages: | 2523-2550 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Kaneko N |  
                | Year: | 2024 |  
                | Journal: | EMBO Rep |  
                | Title: | ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex. |  
                | Volume: | 25 |  
                | Issue: | 7 |  
                | Pages: | 3090-3115 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Neupane S |  
                | Year: | 2021 |  
                | Journal: | Glycobiology |  
                | Title: | Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ. |  
                | Volume: | 31 |  
                | Issue: | 8 |  
                | Pages: | 988-1004 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Yook C |  
                | Year: | 2019 |  
                | Journal: | Front Mol Neurosci |  
                | Title: | A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice. |  
                | Volume: | 12 |  
                |  |  
                | Pages: | 241 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Zhu R |  
                | Year: | 2019 |  
                | Journal: | Neuroscience |  
                | Title: | ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice. |  
                | Volume: | 399 |  
                |  |  
                | Pages: | 53-64 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Kim KH |  
                | Year: | 2018 |  
                | Journal: | Cell Rep |  
                | Title: | Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly. |  
                | Volume: | 23 |  
                | Issue: | 8 |  
                | Pages: | 2455-2466 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wilson R |  
                | Year: | 2016 |  
                | Journal: | Wellcome Open Res |  
                | Title: | Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. |  
                | Volume: | 1 |  
                |  |  
                | Pages: | 1 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Du J |  
                | Year: | 2010 |  
                | Journal: | Dev Biol |  
                | Title: | O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. |  
                | Volume: | 346 |  
                | Issue: | 1 |  
                | Pages: | 25-38 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics and the Consortium: Deciphering the Mechanisms of Developmental Disorders (DMDD) |  
                | Year: | 2017 |  
                | Journal: | Database Release |  
                | Title: | Obtaining and Loading Phenotype Annotations from Deciphering the Mechanisms of Developmental Disorders (DMDD) |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Perez-Garcia V |  
                | Year: | 2018 |  
                | Journal: | Nature |  
                | Title: | Placentation defects are highly prevalent in embryonic lethal mouse mutants. |  
                | Volume: | 555 |  
                | Issue: | 7697 |  
                | Pages: | 463-468 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Lee JG |  
                | Year: | 2024 |  
                | Journal: | Nat Commun |  
                | Title: | PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. |  
                | Volume: | 15 |  
                | Issue: | 1 |  
                | Pages: | 1487 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Ingham NJ |  
                | Year: | 2019 |  
                | Journal: | PLoS Biol |  
                | Title: | Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |  
                | Volume: | 17 |  
                | Issue: | 4 |  
                | Pages: | e3000194 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | International Knockout Mouse Consortium |  
                | Year: | 2014 |  
                | Journal: | Database Download |  
                | Title: | MGI download of modified allele data from IKMC and creation of new knockout alleles |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | International Mouse Strain Resource |  
                | Year: | 2014 |  
                | Journal: | Database Download |  
                | Title: | MGI download of germline transmission data for alleles from IMSR strain data |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wellcome Trust Sanger Institute |  
                | Year: | 2009 |  
                | Journal: | MGI Direct Data Submission |  
                | Title: | Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Shanghai Model Organisms Center |  
                | Year: | 2017 |  
                | Journal: | MGI Direct Data Submission |  
                | Title: | Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |  
                | Year: | 2014 |  
                | Journal: | Database Release |  
                | Title: | Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Magdaleno S |  
                | Year: | 2006 |  
                | Journal: | PLoS Biol |  
                | Title: | BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |  
                | Volume: | 4 |  
                | Issue: | 4 |  
                | Pages: | e86 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics Scientific Curators |  
                | Year: | 2003 |  
                |  |  
                | Title: | MGI Sequence Curation Reference |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics Scientific Curators |  
                | Year: | 2002 |  
                |  |  
                | Title: | Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Kawai J |  
                | Year: | 2001 |  
                | Journal: | Nature |  
                | Title: | Functional annotation of a full-length mouse cDNA collection. |  
                | Volume: | 409 |  
                | Issue: | 6821 |  
                | Pages: | 685-90 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Adams DJ |  
                | Year: | 2024 |  
                | Journal: | Nature |  
                | Title: | Genetic determinants of micronucleus formation in vivo. |  
                | Volume: | 627 |  
                | Issue: | 8002 |  
                | Pages: | 130-136 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | MGD Nomenclature Committee |  
                | Year: | 1995 |  
                |  |  
                | Title: | Nomenclature Committee Use |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Zambrowicz BP |  
                | Year: | 2003 |  
                | Journal: | Proc Natl Acad Sci U S A |  
                | Title: | Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |  
                | Volume: | 100 |  
                | Issue: | 24 |  
                | Pages: | 14109-14 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | GemPharmatech |  
                | Year: | 2020 |  
                |  |  
                | Title: | GemPharmatech Website. |  
                |  |  
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                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Skarnes WC |  
                | Year: | 2011 |  
                | Journal: | Nature |  
                | Title: | A conditional knockout resource for the genome-wide study of mouse gene function. |  
                | Volume: | 474 |  
                | Issue: | 7351 |  
                | Pages: | 337-42 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |  
                | Year: | 2008 |  
                | Journal: | Database Download |  
                | Title: | Mouse Gene Trap Data Load from dbGSS |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Okazaki Y |  
                | Year: | 2002 |  
                | Journal: | Nature |  
                | Title: | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |  
                | Volume: | 420 |  
                | Issue: | 6915 |  
                | Pages: | 563-73 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | The Gene Ontology Consortium |  
                | Year: | 2010 |  
                |  |  
                | Title: | Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | MGI Genome Annotation Group and UniGene Staff |  
                | Year: | 2015 |  
                | Journal: | Database Download |  
                | Title: | MGI-UniGene Interconnection Effort |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |  
                | Year: | 2010 |  
                |  |  
                | Title: | Annotation inferences using phylogenetic trees |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Database and National Center for Biotechnology Information |  
                | Year: | 2000 |  
                | Journal: | Database Release |  
                | Title: | Entrez Gene Load |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Allen Institute for Brain Science |  
                | Year: | 2004 |  
                | Journal: | Allen Institute |  
                | Title: | Allen Brain Atlas: mouse riboprobes |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics Scientific Curators |  
                | Year: | 2009 |  
                | Journal: | Database Download |  
                | Title: | Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |  
                | Year: | 2010 |  
                | Journal: | Database Download |  
                | Title: | Consensus CDS project |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics Group |  
                | Year: | 2003 |  
                | Journal: | Database Procedure |  
                | Title: | Automatic Encodes (AutoE) Reference |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Bairoch A |  
                | Year: | 1999 |  
                | Journal: | Database Release |  
                | Title: | SWISS-PROT Annotated protein sequence database |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics Scientific Curators |  
                | Year: | 2005 |  
                |  |  
                | Title: | Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mouse Genome Informatics Scientific Curators |  
                | Year: | 2005 |  
                |  |  
                | Title: | Obtaining and loading genome assembly coordinates from NCBI annotations |  
                |  |  
                |  |  
                |  |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 1204  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Dupont L |  
                | Year: | 2022 |  
                | Journal: | JCI Insight |  
                | Title: | ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis. |  
                | Volume: | 7 |  
                | Issue: | 8 |  
                |  |  | • • • • • | 
          
              | HT Experiment | 
              
                |  |  
                | Experiment Type: | transcription profiling by array |  
                | Study Type: | WT vs. Mutant |  
                | Source: | ArrayExpress |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Betterman KL |  
                | Year: | 2020 |  
                | Journal: | J Clin Invest |  
                | Title: | Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. |  
                | Volume: | 130 |  
                | Issue: | 6 |  
                | Pages: | 3315-3328 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Jha SK |  
                | Year: | 2017 |  
                | Journal: | Sci Rep |  
                | Title: | Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. |  
                | Volume: | 7 |  
                | Issue: | 1 |  
                | Pages: | 4916 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Dupont L |  
                | Year: | 2018 |  
                | Journal: | Matrix Biol |  
                | Title: | Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14. |  
                | Volume: | 70 |  
                |  |  
                | Pages: | 140-157 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Gerhard DS |  
                | Year: | 2004 |  
                | Journal: | Genome Res |  
                | Title: | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |  
                | Volume: | 14 |  
                | Issue: | 10B |  
                | Pages: | 2121-7 |  | • • • • • |