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Search results 1 to 93 out of 93 for Adm2

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
79924 | ADM2
Type: gene
Organism: human
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Gene
470251 | ADM2
Type: gene
Organism: chimpanzee
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Gene
618896 | ADM2
Type: gene
Organism: cattle
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Gene
720666 | ADM2
Type: gene
Organism: macaque, rhesus
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Gene
100494191 | adm2
Type: gene
Organism: frog, western clawed
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Gene
112532887 | ADM2
Type: gene
Organism: chicken
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Gene
399475 | Adm2
Type: gene
Organism: rat
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Gene
606919 | ADM2
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:2675256 | Adm2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
14615490 | J:306342
First Author: Roh J
Year: 2004
Journal: J Biol Chem
Title: Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes.
Volume: 279
Issue: 8
Pages: 7264-74
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Publication
14706825 | J:87391
First Author: Takei Y
Year: 2004
Journal: FEBS Lett
Title: Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator.
Volume: 556
Issue: 1-3
Pages: 53-8
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Publication
27621315 | J:237374
First Author: Lv Y
Year: 2016
Journal: J Biol Chem
Title: Adrenomedullin 2 Enhances Beiging in White Adipose Tissue Directly in an Adipocyte-autonomous Manner and Indirectly through Activation of M2 Macrophages.
Volume: 291
Issue: 45
Pages: 23390-23402
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Publication
37879153 | J:343309
 
First Author: Zhang YR
Year: 2023
Journal: Atherosclerosis
Title: Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Volume: 385
Pages: 117342
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Protein Coding Gene
MGP_CAROLIEiJ_G0020160 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022225 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022184 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021960 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2675256 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022635 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021482 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022033 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022053 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022650 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021531 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020165 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021057 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
29980671 | J:266495
First Author: Xiao F
Year: 2018
Journal: Nat Commun
Title: Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses.
Volume: 9
Issue: 1
Pages: 2644
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Publication
29242270 | J:283405
First Author: Wang LJ
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Intermedin Enlarges the Vascular Lumen by Inducing the Quiescent Endothelial Cell Proliferation.
Volume: 38
Issue: 2
Pages: 398-413
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Publication
19592612 | J:154234
First Author: Smith RS Jr
Year: 2009
Journal: Am J Physiol Heart Circ Physiol
Title: Intermedin is a new angiogenic growth factor.
Volume: 297
Issue: 3
Pages: H1040-7
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Publication
26786353 | J:263595
First Author: Zhang H
Year: 2016
Journal: Int J Obes (Lond)
Title: Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice.
Volume: 40
Issue: 5
Pages: 852-60
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Publication
31408662 | J:293563
 
First Author: Xue CD
Year: 2019
Journal: Peptides
Title: Endogenous intermedin protects against intimal hyperplasia by inhibiting endoplasmic reticulum stress.
Volume: 121
Pages: 170131
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Publication
29053988 | J:309798
 
First Author: Zhu Q
Year: 2017
Journal: Atherosclerosis
Title: Intermedin reduces neointima formation by regulating vascular smooth muscle cell phenotype via cAMP/PKA pathway.
Volume: 266
Pages: 212-222
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Publication
36875025 | J:345158
 
First Author: Yallampalli C
Year: 2023
Journal: Front Physiol
Title: Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice.
Volume: 14
Pages: 1116042
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Publication
37352568 | J:343162
 
First Author: Feng Z
Year: 2023
Journal: Int Immunopharmacol
Title: Intermedin (adrenomedullin 2) plays a protective role in sepsis by regulating T- and B-cell proliferation and activity.
Volume: 121
Pages: 110488
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692778
Age: postnatal adult
Image: UC Davis_1870412
Note: vas deferens
Specimen Label: UC Davis_1870412
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692778
Age: postnatal adult
Image: UC Davis_1870410
Specimen Label: UC Davis_1870410
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692778
Age: postnatal adult
Image: UC Davis_1870411
Specimen Label: UC Davis_1870411
Detected: true
Specimen Num: 2
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Publication
27634835 | J:252129
First Author: Lu WW
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Intermedin1-53 Attenuates Abdominal Aortic Aneurysm by Inhibiting Oxidative Stress.
Volume: 36
Issue: 11
Pages: 2176-2190
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Publication
33535178 | J:309004
First Author: Ni XQ
Year: 2021
Journal: Aging (Albany NY)
Title: Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway.
Volume: 13
Issue: 4
Pages: 5164-5184
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Publication
24253523 | J:219535
First Author: Dai XY
Year: 2014
Journal: Cardiovasc Res
Title: Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA.
Volume: 101
Issue: 2
Pages: 297-305
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Publication
19555761 | J:154243
First Author: Fischer M
Year: 2009
Journal: Mol Cell Neurosci
Title: P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
Volume: 42
Issue: 2
Pages: 134-41
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q7TNK8
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Allele
Adm2<em1Smoc> | MGI:7288149
Name: adrenomedullin 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Edn1<tm1Mki> | MGI:5751245
Name: endothelin 1; targeted mutation 1, Masao Kakoki
Allele Type: Targeted
Attribute String: Conditional ready, Hypomorph
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Strain
MGI:6454694 | B6.129P2-Edn1<tm1Mki>/J
Attribute String: targeted mutation, mutant strain, congenic
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Publication
27207558 | J:252013
First Author: Zhang SY
Year: 2016
Journal: Diabetes
Title: Adrenomedullin 2 Improves Early Obesity-Induced Adipose Insulin Resistance by Inhibiting the Class II MHC in Adipocytes.
Volume: 65
Issue: 8
Pages: 2342-55
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Publication
29520277 | -
 
First Author: Geven C
Year: 2018
Journal: Front Immunol
Title: Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis.
Volume: 9
Pages: 292
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Publication
31960799 | -
First Author: Li FJ
Year: 2020
Journal: Neural Regen Res
Title: Adrenomedullin: an important participant in neurological diseases.
Volume: 15
Issue: 7
Pages: 1199-1207
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Protein Domain
IPR001710 | Pro-ADM
Type: Family
Description: Pro-adrenomedullin (Pro-ADM) is a 185 amino acid long protein. It consists of a pro-ADM N-terminal 20 peptide (PAMP), a midregional pro-ADM (MR-proADM), an adrenotensin and a glycine-extended 53-amino acid peptides. The latter is subsequently converted to the mature ADM consisting of 52 amino acid by enzymatic amidation [].Adrenomedullin (ADM) is a hypotensive peptide, and was first discovered in human pheochromocytoma, it belongs to the calcitonin gene-related peptide family. The first described effects were vasodilation and blood pressure lowering effects but later, other actions were discovered in health and disease, among them stabilisation and development of the endothelial barrier and immunoregulation. ADM is widely expressed in virtually all human tissues with highest levels in adrenal medulla, cardiac atria, and lungs. Many cells are capable of producing ADM, including ECs, vascular smooth muscle cells (VSMCs), monocytes, renal parenchymal cells, and macrophages. ADM exerts its effects by interaction of its C-terminal moiety with ADM1 and ADM2 receptors which are complexes consisting of the calcitonin receptor-like receptor (CRLR) combined with a specific receptor activity-modifying protein 2 and 3 (RAMP2 and RAMP3), respectively, mostly referred to as "ADM receptors". These receptors have been detected in various tissues and organs, such as blood vessels, skeletal muscles, heart, lungs, and nerve tissue [].Recently, ADM has been characterised as pronociceptive mediator, acting as an upstream factor in the transmission of noxious information for various types of pathological pain including acute and chronic inflammatory pain, cancer pain, neuropathic pain induced by spinal nerve injury and diabetic neuropathy. It may also have a role in nerve regeneration in pathological conditions [].
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Publication
36098211 | J:340272
First Author: Kim JT
Year: 2022
Journal: J Pathol
Title: Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions.
Volume: 258
Issue: 3
Pages: 264-277
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Publication
25848038 | J:220962
First Author: Hathaway CK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.
Volume: 112
Issue: 16
Pages: 5141-6
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Protein
P97297
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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