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Search results 1 to 100 out of 363 for Ago2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Argonaute proteins are involved in RNA interference (RNAi) and microRNA (miRNA) pathways. They can be classified into three paralogous groups: Argonaute-like proteins, which are similar to Arabidopsis thaliana AGO1; Piwi-like proteins, which are closely related to D. melanogaster PIWI (P-element induced wimpy testis); and the Caenorhabditis elegans-specific group 3 Argonautes []. Protein argonaute-2 (AGO2) belongs to the first group (Argonaute-like proteins). It is a component of the RNA-induced silencing complex (RISC) that functions in RNA-mediated gene silencing (RNAi) [, ]. AGO2 is the catalytic engine that drives mRNA cleavage in the RNAi pathway []. AGO2 suffers a phosphorylation cycle that is triggered by target engagement and negatively regulates target association, which is essential to maintain the global efficiency of miRNA-mediated silencing []. It is also the primary AGO variant involved in modulating expression of progesterone receptor by antigene RNAs []. AGO1 and AGO2 reside in three complexes with distinct Dicer and RNA-induced silencing complex activities []. The structure of AGO2 has been solved [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Liu J
Year: 2004
Journal: Science
Title: Argonaute2 is the catalytic engine of mammalian RNAi.
Volume: 305
Issue: 5689
Pages: 1437-41
Publication
First Author: Li X
Year: 2020
Journal: Mol Cell
Title: High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down.
Volume: 79
Issue: 1
Pages: 167-179.e11
Publication      
First Author: Li X
Year: 2019
Journal: bioRxiv
Title: High-resolution in vivo identification of miRNA targets by Halo-Enhanced Ago2 Pulldown
Publication
First Author: Carouge D
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.
Volume: 113
Issue: 37
Pages: E5425-33
Publication  
First Author: Tien JC
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.
Volume: 118
Issue: 20
Publication
First Author: Schirle NT
Year: 2012
Journal: Science
Title: The crystal structure of human Argonaute2.
Volume: 336
Issue: 6084
Pages: 1037-40
Publication
First Author: Chu Y
Year: 2010
Journal: Nucleic Acids Res
Title: Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter.
Volume: 38
Issue: 21
Pages: 7736-48
Publication
First Author: Höck J
Year: 2007
Journal: EMBO Rep
Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
Volume: 8
Issue: 11
Pages: 1052-60
Publication
First Author: Golden RJ
Year: 2017
Journal: Nature
Title: An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.
Volume: 542
Issue: 7640
Pages: 197-202
Publication
First Author: Vickers TA
Year: 2009
Journal: Nucleic Acids Res
Title: Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.
Volume: 37
Issue: 20
Pages: 6927-41
Publication  
First Author: Bhattacharjee J
Year: 2021
Journal: Endocrinology
Title: Hepatic Ago2 Regulates PPARα for Oxidative Metabolism Linked to Glycemic Control in Obesity and Post Bariatric Surgery.
Volume: 162
Issue: 4
Publication
First Author: Hutvagner G
Year: 2008
Journal: Nat Rev Mol Cell Biol
Title: Argonaute proteins: key players in RNA silencing.
Volume: 9
Issue: 1
Pages: 22-32
Publication
First Author: Volk N
Year: 2014
Journal: J Neurosci
Title: MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1.
Volume: 34
Issue: 45
Pages: 15070-82
Protein
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
Publication
First Author: Bélanger C
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome.
Volume: 115
Issue: 4
Pages: E620-E629
Publication
First Author: Tan GS
Year: 2009
Journal: Nucleic Acids Res
Title: Expanded RNA-binding activities of mammalian Argonaute 2.
Volume: 37
Issue: 22
Pages: 7533-45
Publication
First Author: Savas JN
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.
Volume: 105
Issue: 31
Pages: 10820-5
Publication
First Author: O'Carroll D
Year: 2007
Journal: Genes Dev
Title: A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway.
Volume: 21
Issue: 16
Pages: 1999-2004
Publication
First Author: Jee D
Year: 2018
Journal: Mol Cell
Title: Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals.
Volume: 69
Issue: 2
Pages: 265-278.e6
Publication
First Author: Bronevetsky Y
Year: 2013
Journal: J Exp Med
Title: T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
Volume: 210
Issue: 2
Pages: 417-32
Publication
First Author: Maniataki E
Year: 2005
Journal: Genes Dev
Title: A human, ATP-independent, RISC assembly machine fueled by pre-miRNA.
Volume: 19
Issue: 24
Pages: 2979-90
Publication
First Author: Shapiro D
Year: 2022
Journal: Sci Rep
Title: Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1G93A mice.
Volume: 12
Issue: 1
Pages: 4630
Publication
First Author: Fan B
Year: 2023
Journal: Glia
Title: Ablation of Argonaute 2 in Schwann cells accelerates the progression of diabetic peripheral neuropathy.
Volume: 71
Issue: 9
Pages: 2196-2209
Publication
First Author: Juvvuna PK
Year: 2012
Journal: Nucleic Acids Res
Title: Argonaute identity defines the length of mature mammalian microRNAs.
Volume: 40
Issue: 14
Pages: 6808-20
Publication
First Author: Dueck A
Year: 2012
Journal: Nucleic Acids Res
Title: microRNAs associated with the different human Argonaute proteins.
Volume: 40
Issue: 19
Pages: 9850-62
Publication
First Author: Zhang C
Year: 2018
Journal: Nat Commun
Title: Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.
Volume: 9
Issue: 1
Pages: 3658
Publication
First Author: Lu K
Year: 2016
Journal: Stem Cells
Title: Slicer Endonuclease Argonaute 2 Is a Negative Regulator of Hematopoietic Stem Cell Quiescence.
Volume: 34
Issue: 5
Pages: 1343-53
Publication
First Author: Chen CY
Year: 2009
Journal: Nat Struct Mol Biol
Title: Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.
Volume: 16
Issue: 11
Pages: 1160-6
Publication
First Author: Lü J
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Differential expression of components of the microRNA machinery during mouse organogenesis.
Volume: 334
Issue: 2
Pages: 319-23
Publication
First Author: Tattikota SG
Year: 2014
Journal: Cell Metab
Title: Argonaute2 mediates compensatory expansion of the pancreatic β cell.
Volume: 19
Issue: 1
Pages: 122-34
Publication
First Author: Shui B
Year: 2023
Journal: Mol Cell
Title: Oncogenic K-Ras suppresses global miRNA function.
Volume: 83
Issue: 14
Pages: 2509-2523.e13
Publication
First Author: Cheloufi S
Year: 2010
Journal: Nature
Title: A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.
Volume: 465
Issue: 7298
Pages: 584-9
Publication
First Author: Shankar S
Year: 2020
Journal: Nat Commun
Title: An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development.
Volume: 11
Issue: 1
Pages: 2817
Publication
First Author: Schaefer A
Year: 2010
Journal: J Exp Med
Title: Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.
Volume: 207
Issue: 9
Pages: 1843-51
Publication
First Author: Stein P
Year: 2015
Journal: PLoS Genet
Title: Essential Role for endogenous siRNAs during meiosis in mouse oocytes.
Volume: 11
Issue: 2
Pages: e1005013
Publication
First Author: Jung E
Year: 2017
Journal: Biochim Biophys Acta
Title: Global analysis of AGO2-bound RNAs reveals that miRNAs induce cleavage of target RNAs with limited complementarity.
Volume: 1860
Issue: 11
Pages: 1148-1158
Publication
First Author: Trombly MI
Year: 2009
Journal: Nucleic Acids Res
Title: A genetic screen for components of the mammalian RNA interference pathway in Bloom-deficient mouse embryonic stem cells.
Volume: 37
Issue: 4
Pages: e34
Publication
First Author: Yang JS
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.
Volume: 107
Issue: 34
Pages: 15163-8
Publication
First Author: Kenny PJ
Year: 2020
Journal: Nucleic Acids Res
Title: The FMRP-MOV10 complex: a translational regulatory switch modulated by G-Quadruplexes.
Volume: 48
Issue: 2
Pages: 862-878
Publication
First Author: Wang D
Year: 2012
Journal: Genes Dev
Title: Quantitative functions of Argonaute proteins in mammalian development.
Volume: 26
Issue: 7
Pages: 693-704
Publication
First Author: Rybak A
Year: 2009
Journal: Nat Cell Biol
Title: The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.
Volume: 11
Issue: 12
Pages: 1411-20
Publication
First Author: Chen J
Year: 2012
Journal: Genes Dev
Title: The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling.
Volume: 26
Issue: 8
Pages: 803-15
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Rasmussen KD
Year: 2010
Journal: J Exp Med
Title: The miR-144/451 locus is required for erythroid homeostasis.
Volume: 207
Issue: 7
Pages: 1351-8
Publication
First Author: Gibbings D
Year: 2012
Journal: Nat Struct Mol Biol
Title: Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.
Volume: 19
Issue: 5
Pages: 517-24, S1
Publication
First Author: Vickers TA
Year: 2012
Journal: Nucleic Acids Res
Title: siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs.
Volume: 40
Issue: 13
Pages: 6223-34
GXD Expression      
Probe: MGI:3615019
Assay Type: RT-PCR
Annotation Date: 2006-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3616568
Age: embryonic day 13.5
Specimen Label: RT-PCR E13.5 brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3615019
Assay Type: RT-PCR
Annotation Date: 2006-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3616568
Age: postnatal day 0
Specimen Label: RT-PCR P0 brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3614783
Assay Type: RT-PCR
Annotation Date: 2006-03-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3616841
Age: embryonic day 13.5
Specimen Label: RT-PCR E13.5 brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3614783
Assay Type: RT-PCR
Annotation Date: 2006-03-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3616841
Age: postnatal day 0
Specimen Label: RT-PCR P0 brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-A1-1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-A1-2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-A2-1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-A2-2
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-B1-1
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-B1-2
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-B2-1
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-B2-2
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-C1-1
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-C1-2
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-C2-1
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289653
Age: embryonic day 1.5
Specimen Label: 2-cell-C2-2
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-A1-1
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-A1-2
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-A2-1
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-A2-2
Detected: true
Specimen Num: 16
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-A3-1
Detected: true
Specimen Num: 17
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-A3-2
Detected: true
Specimen Num: 18
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-A4-1
Detected: true
Specimen Num: 19
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-A4-2
Detected: true
Specimen Num: 20
GXD Expression      
Probe: MGI:5289100
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289653
Age: embryonic day 2.0
Specimen Label: 4-cell-B1-1
Detected: true
Specimen Num: 21