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Search results 1 to 100 out of 1405 for Ahr

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0.038s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the biological and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dioxin-like compounds (DLC), as well as some drugs and endogenous tryptophan metabolites []. Without ligands, AHR is part of the Hsp90/XAP2 (heat shock protein 90/hepatitis B virus X-associated protein) multi-chaperone protein complex. Upon ligand binding, the receptor dissociates from the chaperone complex and translocates into the nucleus where it heterodimerises with ARNT (AHR nuclear translocator). The respective heterodimeric complex then modulates the cell's transcriptional activity by binding to specific xenobiotic response elements (XREs) in the promoters of AHR target genes [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Seok SH
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.
Volume: 114
Issue: 21
Pages: 5431-5436
Protein
Organism: Mus musculus
Length: 48  
Fragment?: true
Protein
Organism: Mus musculus
Length: 848  
Fragment?: false
Protein
Organism: Mus musculus
Length: 883  
Fragment?: false
Protein
Organism: Mus musculus
Length: 848  
Fragment?: false
Protein
Organism: Mus musculus
Length: 429  
Fragment?: true
Protein
Organism: Mus musculus
Length: 429  
Fragment?: true
Protein
Organism: Mus musculus
Length: 429  
Fragment?: true
Protein
Organism: Mus musculus
Length: 429  
Fragment?: true
Protein
Organism: Mus musculus
Length: 429  
Fragment?: true
Publication  
First Author: Oshida K
Year: 2015
Journal: Toxicology
Title: Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR).
Volume: 336
Pages: 99-112
Publication
First Author: Tarnow P
Year: 2016
Journal: Arch Toxicol
Title: G protein-coupled receptor 30 ligand G-1 increases aryl hydrocarbon receptor signalling by inhibition of tubulin assembly and cell cycle arrest in human MCF-7 cells.
Volume: 90
Issue: 8
Pages: 1939-48
Publication
First Author: Lahvis GP
Year: 1998
Journal: Biochem Pharmacol
Title: Ahr null alleles: distinctive or different?
Volume: 56
Issue: 7
Pages: 781-7
Publication
First Author: Moura-Alves P
Year: 2014
Journal: Nature
Title: AhR sensing of bacterial pigments regulates antibacterial defence.
Volume: 512
Issue: 7515
Pages: 387-92
Protein
Organism: Mus musculus
Length: 114  
Fragment?: false
Publication
First Author: Falahatpisheh MH
Year: 2011
Journal: Mol Med
Title: AHR regulates WT1 genetic programming during murine nephrogenesis.
Volume: 17
Issue: 11-12
Pages: 1275-84
Publication
First Author: Schiering C
Year: 2017
Journal: Nature
Title: Feedback control of AHR signalling regulates intestinal immunity.
Volume: 542
Issue: 7640
Pages: 242-245
Protein
Organism: Mus musculus
Length: 848  
Fragment?: false
Protein
Organism: Mus musculus
Length: 420  
Fragment?: true
Protein
Organism: Mus musculus
Length: 420  
Fragment?: true
Protein
Organism: Mus musculus
Length: 805  
Fragment?: false
Protein
Organism: Mus musculus
Length: 420  
Fragment?: true
Protein
Organism: Mus musculus
Length: 420  
Fragment?: true
Publication
First Author: Thomae TL
Year: 2004
Journal: J Biol Chem
Title: A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis.
Volume: 279
Issue: 29
Pages: 30189-94
Publication
First Author: Wu D
Year: 2011
Journal: Biochem Biophys Res Commun
Title: AhR deficiency impairs expression of LPS-induced inflammatory genes in mice.
Volume: 410
Issue: 2
Pages: 358-63
Publication
First Author: Kim YC
Year: 2018
Journal: Nat Commun
Title: AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.
Volume: 9
Issue: 1
Pages: 540
Publication
First Author: Bennett JA
Year: 2018
Journal: PLoS One
Title: Conditional deletion of Ahr alters gene expression profiles in hematopoietic stem cells.
Volume: 13
Issue: 11
Pages: e0206407
Publication
First Author: Cochez PM
Year: 2016
Journal: Eur J Immunol
Title: AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model.
Volume: 46
Issue: 6
Pages: 1449-59
Publication  
First Author: de la Parra J
Year: 2018
Journal: eNeuro
Title: AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory.
Volume: 5
Issue: 4
Publication
First Author: Takenaka MC
Year: 2019
Journal: Nat Neurosci
Title: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.
Volume: 22
Issue: 5
Pages: 729-740
Publication
First Author: Noda S
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse.
Volume: 303
Issue: 1
Pages: 105-11
Publication
First Author: Schmidt JV
Year: 1993
Journal: J Biol Chem
Title: Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment.
Volume: 268
Issue: 29
Pages: 22203-9
Publication
First Author: de Araújo EF
Year: 2020
Journal: Sci Rep
Title: Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses.
Volume: 10
Issue: 1
Pages: 11312
Publication
First Author: Smith SH
Year: 2017
Journal: J Invest Dermatol
Title: Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans.
Volume: 137
Issue: 10
Pages: 2110-2119
Publication
First Author: Falahatpisheh MH
Year: 2003
Journal: Oncogene
Title: Ligand-activated Ahr signaling leads to disruption of nephrogenesis and altered Wilms' tumor suppressor mRNA splicing.
Volume: 22
Issue: 14
Pages: 2160-71
Publication
First Author: van den Bogaard EH
Year: 2015
Journal: J Invest Dermatol
Title: Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation.
Volume: 135
Issue: 5
Pages: 1320-1328
Publication
First Author: Izawa T
Year: 2016
Journal: J Immunol
Title: The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis.
Volume: 197
Issue: 12
Pages: 4639-4650
Publication      
First Author: Wilson RH
Year: 2021
Journal: Toxicol Sci
Title: Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach.
Publication
First Author: Bhattacharya S
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator.
Volume: 307
Issue: 7
Pages: L516-23
Publication      
First Author: Gérard D
Year: 2018
Journal: Nucleic Acids Res
Title: Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency.
Publication
First Author: Pollet M
Year: 2018
Journal: Cell Death Differ
Title: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis.
Volume: 25
Issue: 10
Pages: 1823-1836
Publication
First Author: Walisser JA
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development.
Volume: 101
Issue: 47
Pages: 16677-82
Publication
First Author: Bui LC
Year: 2016
Journal: Toxicol Sci
Title: Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration.
Volume: 149
Issue: 1
Pages: 158-66
Publication
First Author: Mascanfroni ID
Year: 2015
Journal: Nat Med
Title: Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
Volume: 21
Issue: 6
Pages: 638-46
Publication
First Author: Zhang W
Year: 2004
Journal: Toxicol Sci
Title: A Cyp1a2-luciferase transgenic CD-1 mouse model: responses to aryl hydrocarbons similar to the humanized AhR mice.
Volume: 82
Issue: 1
Pages: 297-307
Publication
First Author: Sarić N
Year: 2020
Journal: Sci Rep
Title: The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma.
Volume: 10
Issue: 1
Pages: 148
Publication  
First Author: Merches K
Year: 2020
Journal: Int J Mol Sci
Title: AHR Signaling Dampens Inflammatory Signature in Neonatal Skin γδ T Cells.
Volume: 21
Issue: 6
Publication
First Author: Kubli SP
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.
Volume: 116
Issue: 9
Pages: 3604-3613
Publication
First Author: Hidaka T
Year: 2017
Journal: Nat Immunol
Title: The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.
Volume: 18
Issue: 1
Pages: 64-73
Publication
First Author: Dant TA
Year: 2017
Journal: Blood
Title: T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD.
Volume: 130
Issue: 3
Pages: 348-359
Publication
First Author: Metidji A
Year: 2018
Journal: Immunity
Title: The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.
Volume: 49
Issue: 2
Pages: 353-362.e5
Publication
First Author: Wheeler JL
Year: 2013
Journal: J Immunol
Title: Novel cellular targets of AhR underlie alterations in neutrophilic inflammation and inducible nitric oxide synthase expression during influenza virus infection.
Volume: 190
Issue: 2
Pages: 659-68
Publication  
First Author: Makhloufi C
Year: 2020
Journal: Int J Mol Sci
Title: Female AhR Knockout Mice Develop a Minor Renal Insufficiency in an Adenine-Diet Model of Chronic Kidney Disease.
Volume: 21
Issue: 7
Publication
First Author: Franchini AM
Year: 2019
Journal: Immunohorizons
Title: Genome-Wide Transcriptional Analysis Reveals Novel AhR Targets That Regulate Dendritic Cell Function during Influenza A Virus Infection.
Volume: 3
Issue: 6
Pages: 219-235
Publication
First Author: Shinde R
Year: 2018
Journal: Nat Immunol
Title: Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.
Volume: 19
Issue: 6
Pages: 571-582
Publication
First Author: Lee JS
Year: 2011
Journal: Nat Immunol
Title: AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.
Volume: 13
Issue: 2
Pages: 144-51
Publication
First Author: Boule LA
Year: 2015
Journal: Toxicol Sci
Title: Developmental Activation of the AHR Increases Effector CD4+ T Cells and Exacerbates Symptoms in Autoimmune Disease-Prone Gnaq+/- Mice.
Volume: 148
Issue: 2
Pages: 555-66
Publication
First Author: Kim SY
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Deletion of aryl hydrocarbon receptor AHR in mice leads to subretinal accumulation of microglia and RPE atrophy.
Volume: 55
Issue: 9
Pages: 6031-40
Publication
First Author: Hong CH
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Selective AhR knockout in langerin-expressing cells abates Langerhans cells and polarizes Th2/Tr1 in epicutaneous protein sensitization.
Volume: 117
Issue: 23
Pages: 12980-12990
Publication
First Author: Smith AG
Year: 1998
Journal: Mol Pharmacol
Title: Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism.
Volume: 53
Issue: 1
Pages: 52-61
Publication
First Author: Zago M
Year: 2017
Journal: PLoS One
Title: Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability.
Volume: 12
Issue: 7
Pages: e0180881
Publication
First Author: Karchner SI
Year: 2002
Journal: J Biol Chem
Title: Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2.
Volume: 277
Issue: 9
Pages: 6949-59
Publication
First Author: Schmidt JV
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
Volume: 93
Issue: 13
Pages: 6731-6
Publication
First Author: Butler RA
Year: 2001
Journal: Gene
Title: An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding.
Volume: 278
Issue: 1-2
Pages: 223-34
Publication
First Author: Curran CP
Year: 2011
Journal: Toxicol Sci
Title: In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.
Volume: 119
Issue: 1
Pages: 189-208
Publication
First Author: Sahlberg C
Year: 2002
Journal: Int J Dev Biol
Title: Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth.
Volume: 46
Issue: 3
Pages: 295-300
Publication
First Author: Neamah WH
Year: 2019
Journal: J Immunol
Title: AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes.
Volume: 203
Issue: 7
Pages: 1830-1844
Publication
First Author: Curran CP
Year: 2011
Journal: Environ Health Perspect
Title: In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes.
Volume: 119
Issue: 9
Pages: 1286-93
Publication  
First Author: Moyer BJ
Year: 2016
Journal: Toxicol Appl Pharmacol
Title: Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1.
Volume: 300
Pages: 13-24
Publication      
First Author: Biagioli M
Year: 2021
Journal: bioRxiv
Title: Discovery of a AhR flavonoid agonist that counter-regulates ACE2 expression in rodent models of inflammation and attenuates ACE2 - SARS-CoV2 interaction in vitro.
Publication
First Author: Kerkvliet NI
Year: 2002
Journal: Toxicol Appl Pharmacol
Title: T lymphocytes are direct, aryl hydrocarbon receptor (AhR)-dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): AhR expression in both CD4+ and CD8+ T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD.
Volume: 185
Issue: 2
Pages: 146-52
Publication
First Author: Andersson P
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors.
Volume: 99
Issue: 15
Pages: 9990-5
Publication
First Author: Moennikes O
Year: 2004
Journal: Cancer Res
Title: A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice.
Volume: 64
Issue: 14
Pages: 4707-10
Author
Author
Author
Publication
First Author: Andersson P
Year: 2003
Journal: Biochem Biophys Res Commun
Title: A constitutively active aryl hydrocarbon receptor causes loss of peritoneal B1 cells.
Volume: 302
Issue: 2
Pages: 336-41
Publication
First Author: Ye J
Year: 2017
Journal: Cell Rep
Title: The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.
Volume: 21
Issue: 8
Pages: 2277-2290
Publication
First Author: Moriguchi T
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.
Volume: 100
Issue: 10
Pages: 5652-7
Publication
First Author: Li S
Year: 2018
Journal: Immunity
Title: Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function.
Volume: 49
Issue: 5
Pages: 915-928.e5
GO Term
Publication  
First Author: Gonzalez FJ
Year: 1995
Journal: Toxicol Lett
Title: Xenobiotic receptor knockout mice.
Volume: 82-83
Pages: 117-21
Publication
First Author: Puga A
Year: 2002
Journal: Chem Biol Interact
Title: Role of the aryl hydrocarbon receptor in cell cycle regulation.
Volume: 141
Issue: 1-2
Pages: 117-30
Publication
First Author: Nakahama T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis.
Volume: 108
Issue: 34
Pages: 14222-7
Publication
First Author: Ide F
Year: 2004
Journal: Cancer Lett
Title: Skin and salivary gland carcinogenicity of 7,12-dimethylbenz[a]anthracene is equivalent in the presence or absence of aryl hydrocarbon receptor.
Volume: 214
Issue: 1
Pages: 35-41
Publication
First Author: Ohtake F
Year: 2007
Journal: Nature
Title: Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.
Volume: 446
Issue: 7135
Pages: 562-6
Publication
First Author: Goudot C
Year: 2017
Journal: Immunity
Title: Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages.
Volume: 47
Issue: 3
Pages: 582-596.e6
Publication
First Author: Zhou Y
Year: 2013
Journal: Blood
Title: Aryl hydrocarbon receptor controls murine mast cell homeostasis.
Volume: 121
Issue: 16
Pages: 3195-204
Publication
First Author: Funatake CJ
Year: 2005
Journal: J Immunol
Title: Cutting edge: activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+ CD25+ cells with characteristics of regulatory T cells.
Volume: 175
Issue: 7
Pages: 4184-8
Publication
First Author: Korkalainen M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Restructured transactivation domain in hamster AH receptor.
Volume: 273
Issue: 1
Pages: 272-81
Publication
First Author: Wanner R
Year: 1995
Journal: Biochem Biophys Res Commun
Title: The differentiation-related upregulation of aryl hydrocarbon receptor transcript levels is suppressed by retinoic acid.
Volume: 209
Issue: 2
Pages: 706-11
Publication
First Author: Peters JM
Year: 1995
Journal: Toxicol Appl Pharmacol
Title: Evidence that murine preimplantation embryos express aryl hydrocarbon receptor.
Volume: 134
Issue: 2
Pages: 214-21
Publication
First Author: Iseki M
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Growth suppression of Leydig TM3 cells mediated by aryl hydrocarbon receptor.
Volume: 331
Issue: 4
Pages: 902-8
Publication
First Author: Walisser JA
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types.
Volume: 102
Issue: 49
Pages: 17858-63
Publication
First Author: Fernandez-Salguero P
Year: 1995
Journal: Science
Title: Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.
Volume: 268
Issue: 5211
Pages: 722-6
Publication
First Author: Ma Q
Year: 1995
Journal: J Biol Chem
Title: Transcriptional activation by the mouse Ah receptor. Interplay between multiple stimulatory and inhibitory functions.
Volume: 270
Issue: 21
Pages: 12697-703