|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 72 out of 72 for Akap4

0.05s

Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
8852 | AKAP4
Type: gene
Organism: human
•
•
•
•
•
Gene
79254 | Akap4
Type: gene
Organism: rat
•
•
•
•
•
Gene
480917 | AKAP4
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
465971 | AKAP4
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
281611 | AKAP4
Type: gene
Organism: cattle
•
•
•
•
•
Gene
694888 | AKAP4
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Coding Gene
MGI:102794 | Akap4
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
38050179 | J:352416
First Author: Wei H
Year: 2023
Journal: Clin Transl Med
Title: A pathogenic AKAP4 variant, p.R429H, causes male in/subfertility in humans and mice.
Volume: 13
Issue: 12
Pages: e1463
•
•
•
•
•
Publication
31255637 | J:280424
First Author: Fang X
Year: 2019
Journal: Dev Biol
Title: Proteomics and single-cell RNA analysis of Akap4-knockout mice model confirm indispensable role of Akap4 in spermatogenesis.
Volume: 454
Issue: 2
Pages: 118-127
•
•
•
•
•
Publication
12167408 | J:86899
First Author: Miki K
Year: 2002
Journal: Dev Biol
Title: Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.
Volume: 248
Issue: 2
Pages: 331-42
•
•
•
•
•
Publication
12606363 | J:83525
First Author: Brown PR
Year: 2003
Journal: Biol Reprod
Title: A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum.
Volume: 68
Issue: 6
Pages: 2241-8
•
•
•
•
•
Publication
16687648 | J:111773
First Author: Nipper RW
Year: 2006
Journal: Biol Reprod
Title: Protein domains govern the intracellular distribution of mouse sperm AKAP4.
Volume: 75
Issue: 2
Pages: 189-96
•
•
•
•
•
Publication
31969357 | J:284173
 
First Author: Xu K
Year: 2020
Journal: Development
Title: Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility.
Volume: 147
Issue: 2
•
•
•
•
•
Publication
15385410 | J:104604
First Author: Huang Z
Year: 2005
Journal: Biol Reprod
Title: Changes in intracellular distribution and activity of protein phosphatase PP1gamma2 and its regulating proteins in spermatozoa lacking AKAP4.
Volume: 72
Issue: 2
Pages: 384-92
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0032881 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0035508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0035486 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0035419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0035482 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0035190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_102794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0036006 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0034490 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0035160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0035317 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0035264 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0035394 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0035303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0036024 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0034192 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0034613 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0031429 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0034029 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
8088444 | J:20326
First Author: Carrera A
Year: 1994
Journal: Dev Biol
Title: The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins.
Volume: 165
Issue: 1
Pages: 272-84
•
•
•
•
•
Publication
7711182 | J:22348
First Author: Fulcher KD
Year: 1995
Journal: Biol Reprod
Title: Characterization of Fsc1 cDNA for a mouse sperm fibrous sheath component.
Volume: 52
Issue: 1
Pages: 41-9
•
•
•
•
•
Publication
9822690 | J:51238
First Author: Turner RM
Year: 1998
Journal: J Biol Chem
Title: An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail.
Volume: 273
Issue: 48
Pages: 32135-41
•
•
•
•
•
Publication
11803562 | J:74041
First Author: Jha KN
Year: 2002
Journal: Mol Reprod Dev
Title: Identification of the major tyrosine phosphorylated protein of capacitated hamster spermatozoa as a homologue of mammalian sperm a kinase anchoring protein.
Volume: 61
Issue: 2
Pages: 258-70
•
•
•
•
•
Publication
10319321 | J:54430
First Author: Vijayaraghavan S
Year: 1999
Journal: Mol Endocrinol
Title: Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein.
Volume: 13
Issue: 5
Pages: 705-17
•
•
•
•
•
Publication
21715716 | J:176695
First Author: Sironen A
Year: 2011
Journal: Biol Reprod
Title: Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia.
Volume: 85
Issue: 4
Pages: 690-701
•
•
•
•
•
Publication
9021145 | J:38061
First Author: Moss SB
Year: 1997
Journal: Mamm Genome
Title: Mapping of a haploid transcribed and translated sperm-specific gene to the mouse X chromosome.
Volume: 8
Issue: 1
Pages: 37-8
•
•
•
•
•
Publication
12079992 | J:77520
First Author: Nakamura Y
Year: 2002
Journal: Biol Reprod
Title: Molecular cloning and characterization of oppo 1: a haploid germ cell-specific complementary DNA encoding sperm tail protein.
Volume: 67
Issue: 1
Pages: 1-7
•
•
•
•
•
Publication
9852104 | J:52123
First Author: Miki K
Year: 1998
Journal: J Biol Chem
Title: Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1.
Volume: 273
Issue: 51
Pages: 34384-90
•
•
•
•
•
Publication
20731842 | J:170225
 
First Author: Li YF
Year: 2010
Journal: Reprod Biol Endocrinol
Title: CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath.
Volume: 8
Pages: 101
•
•
•
•
•
Publication
17923693 | J:128983
First Author: Faul C
Year: 2007
Journal: Mol Cell Biol
Title: Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.
Volume: 27
Issue: 23
Pages: 8215-27
•
•
•
•
•
Publication
23675479 | J:202175
First Author: Riddle RC
Year: 2013
Journal: PLoS One
Title: Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.
Volume: 8
Issue: 5
Pages: e63323
•
•
•
•
•
Publication
9344676 | J:44020
First Author: Sutton KA
Year: 1997
Journal: Genomics
Title: The rapidly evolving Pem homeobox gene and Agtr2, Ant2, and Lamp2 are closely linked in the proximal region of the mouse X chromosome.
Volume: 45
Issue: 2
Pages: 447-50
•
•
•
•
•
Publication
16687649 | J:111771
First Author: Krisfalusi M
Year: 2006
Journal: Biol Reprod
Title: Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa.
Volume: 75
Issue: 2
Pages: 270-8
•
•
•
•
•
Publication
33913480 | J:305434
 
First Author: Scovell JM
Year: 2021
Journal: Development
Title: PRSS50 is a testis protease responsible for proper sperm tail formation and function.
Volume: 148
Issue: 8
•
•
•
•
•
Publication
10857745 | J:62168
First Author: Means GD
Year: 2000
Journal: Genomics
Title: A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation.
Volume: 65
Issue: 3
Pages: 213-23
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Protein
Q9D3V5
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
•
•
•
•
•
Protein
A0A2R8W6Q5
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
•
•
•
•
•
Protein Domain
IPR026246 | Fsip1
Type: Family
Description: Found in the main part of the sperm flagellum, the fibrous sheath is a cytoskeletal structure comprising two longitudinal columns connected by closely spaced circumferential ribs []. A-kinase anchoring proteins (AKAPs) secure cyclic AMP-dependent protein kinases within specific cytoplasmic domains; most abundant in the fibrous sheath is AKAP4 []. AKAP4 has been shown to bind AKAP3 and two spermatogenic cell-specific proteins, Fibrous Sheath Interacting Proteins 1 and 2 (FSIP1, FSIP2) [].How the fibrous sheath assembles is not yet fully understood. AKAP4 is synthesised and incorporated into the nascent fibrous sheath late in spermatid development; its precursor is processed in the flagellum, and only the mature form of AKAP4 appears to bind AKAP3 []. It is likely, therefore, that AKAP3 is involved in organising the basic structure of the fibrous sheath, while AKAP4 helps to complete fibrous sheath assembly.The FSIP1 protein is 435 amino acids in length, and is rich in glutamine and asparagine []. Minimum domains for its binding to AKAP4 have been localised to amino acids 351-359 and 692-721 of AKAP4 constructs [].
•
•
•
•
•
Publication
27913189 | J:251541
First Author: Silva JV
Year: 2017
Journal: Biochim Biophys Acta
Title: Construction and analysis of a human testis/sperm-enriched interaction network: Unraveling the PPP1CC2 interactome.
Volume: 1861
Issue: 2
Pages: 375-385
•
•
•
•
•
Publication
15257753 | J:218814
 
First Author: Lea IA
Year: 2004
Journal: Reprod Biol Endocrinol
Title: Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella.
Volume: 2
Pages: 57
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom