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Search results 1 to 100 out of 125 for Akap5

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
9495 | AKAP5
Type: gene
Organism: human
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Gene
467480 | AKAP5
Type: gene
Organism: chimpanzee
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Gene
281612 | AKAP5
Type: gene
Organism: cattle
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Gene
423506 | AKAP5
Type: gene
Organism: chicken
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Gene
707162 | AKAP5
Type: gene
Organism: macaque, rhesus
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Gene
171026 | Akap5
Type: gene
Organism: rat
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Gene
480354 | AKAP5
Type: gene
Organism: dog, domestic
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Protein Domain
IPR042375 | AKAP5
Type: Family
Description: A-kinase anchor protein 5 (AKAP5), also known as AKAP79, is a PKA anchoring protein that binds to adenylyl cyclase type 8 (AC8) and to regulate its responsiveness to store-operated Ca(2) entry (SOCE) []. The AKAP79 and AC8 interaction may occur in lipid raft domains of the plasma membrane, with palmitoylation of AKAP79 plays an important role in targeting the AKAP to the cholesterol- and sphingolipid-rich regions of the plasma membrane where it can impact on local Ca2 -stimulated AC8 activity [].
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Protein Coding Gene
MGI:2685104 | Akap5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
D3YVF0
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
H3BIV5
Organism: Mus musculus/domesticus
Length: 752  
Fragment?: false
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Publication
33082339 | J:296849
First Author: Prada MP
Year: 2020
Journal: Nat Commun
Title: AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2.
Volume: 11
Issue: 1
Pages: 5303
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Publication
20428246 | J:160134
First Author: Weisenhaus M
Year: 2010
Journal: PLoS One
Title: Mutations in AKAP5 disrupt dendritic signaling complexes and lead to electrophysiological and behavioral phenotypes in mice.
Volume: 5
Issue: 4
Pages: e10325
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Publication
25225170 | J:230190
First Author: Li X
Year: 2014
Journal: Cardiovasc Res
Title: Carvedilol reverses cardiac insufficiency in AKAP5 knockout mice by normalizing the activities of calcineurin and CaMKII.
Volume: 104
Issue: 2
Pages: 270-9
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Publication
31310785 | J:280052
 
First Author: Zhang M
Year: 2019
Journal: Neurosci Lett
Title: Maturation of thalamocortical synapses in the somatosensory cortex depends on neocortical AKAP5 expression.
Volume: 709
Pages: 134374
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Publication
20671242 | J:175022
First Author: Nichols CB
Year: 2010
Journal: Circ Res
Title: Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels.
Volume: 107
Issue: 6
Pages: 747-56
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Publication
20164376 | J:159250
First Author: Wu CY
Year: 2010
Journal: Am J Physiol Cell Physiol
Title: The contribution of AKAP5 in amylase secretion from mouse parotid acini.
Volume: 298
Issue: 5
Pages: C1151-8
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Publication
21771783 | -
First Author: Delint-Ramirez I
Year: 2011
Journal: J Biol Chem
Title: Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
Volume: 286
Issue: 38
Pages: 32962-75
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Publication
22976297 | -
First Author: Willoughby D
Year: 2012
Journal: J Cell Sci
Title: A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
Volume: 125
Issue: Pt 23
Pages: 5850-9
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Publication
30355502 | J:269375
First Author: Purkey AM
Year: 2018
Journal: Cell Rep
Title: AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.
Volume: 25
Issue: 4
Pages: 974-987.e4
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Publication
26713362 | J:233164
First Author: Han C
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Modified sympathetic nerve regulation in AKAP5-null mice.
Volume: 469
Issue: 4
Pages: 897-902
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Publication
31076080 | J:295534
First Author: Zhou HY
Year: 2019
Journal: Biol Psychiatry
Title: A-Kinase Anchoring Protein 150 and Protein Kinase A Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress.
Volume: 86
Issue: 2
Pages: 131-142
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Publication
24121510 | J:204978
First Author: Li X
Year: 2013
Journal: J Biol Chem
Title: Role of AKAP79/150 protein in β1-adrenergic receptor trafficking and signaling in mammalian cells.
Volume: 288
Issue: 47
Pages: 33797-812
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Publication
32579702 | J:311628
First Author: Masuoka T
Year: 2020
Journal: Br J Pharmacol
Title: Sensitization of glutamate receptor-mediated pain behaviour via nerve growth factor-dependent phosphorylation of transient receptor potential V1 under inflammatory conditions.
Volume: 177
Issue: 18
Pages: 4223-4241
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Protein Coding Gene
MGP_CAROLIEiJ_G0017862 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019813 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019788 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019792 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2685104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019147 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019684 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019671 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019756 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019710 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020280 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029619 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018709 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
27856611 | J:259655
First Author: Li L
Year: 2017
Journal: Cardiovasc Res
Title: Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.
Volume: 113
Issue: 2
Pages: 147-159
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Publication
18711127 | J:138972
First Author: Tunquist BJ
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Loss of AKAP150 perturbs distinct neuronal processes in mice.
Volume: 105
Issue: 34
Pages: 12557-62
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Publication
24835999 | J:211790
First Author: Murphy JG
Year: 2014
Journal: Cell Rep
Title: AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling.
Volume: 7
Issue: 5
Pages: 1577-1588
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Publication
26938443 | J:230855
First Author: Sanderson JL
Year: 2016
Journal: Neuron
Title: NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²⁺-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin.
Volume: 89
Issue: 5
Pages: 1000-15
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Publication
34610314 | J:332719
First Author: Sanderson JL
Year: 2021
Journal: Cell Rep
Title: β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca(2+)-permeable AMPA receptors.
Volume: 37
Issue: 1
Pages: 109786
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Publication
29440558 | J:259278
First Author: Sanderson JL
Year: 2018
Journal: J Neurosci
Title: Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca2+-Permeable AMPA Receptors.
Volume: 38
Issue: 11
Pages: 2863-2876
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Publication
26172554 | J:312160
First Author: Szteyn K
Year: 2015
Journal: Pain
Title: A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.
Volume: 156
Issue: 11
Pages: 2364-2372
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Publication
23100425 | J:191219
First Author: Sanderson JL
Year: 2012
Journal: J Neurosci
Title: AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors.
Volume: 32
Issue: 43
Pages: 15036-52
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Publication
27693258 | J:281217
First Author: Zhang J
Year: 2016
Journal: Neuron
Title: Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons.
Volume: 92
Issue: 2
Pages: 461-478
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Publication
21652711 | J:175374
First Author: Lu Y
Year: 2011
Journal: J Biol Chem
Title: A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density.
Volume: 286
Issue: 30
Pages: 26496-506
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Publication
21562284 | J:244567
First Author: Zhang J
Year: 2011
Journal: J Neurosci
Title: AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.
Volume: 31
Issue: 19
Pages: 7199-211
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Publication
11943807 | J:328021
First Author: Tavalin SJ
Year: 2002
Journal: J Neurosci
Title: Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression.
Volume: 22
Issue: 8
Pages: 3044-51
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Publication
19169250 | J:146138
First Author: Bhattacharyya S
Year: 2009
Journal: Nat Neurosci
Title: A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors.
Volume: 12
Issue: 2
Pages: 172-81
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GXD Expression
GXD Expression
   
Probe: MGI:5702994
Assay Type: Western blot
Annotation Date: 2016-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5703020
Age: postnatal week 10
Image: S1
Specimen Label: AKAP150
Detected: true
Specimen Num: 1
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Publication
18617570 | J:176385
First Author: Lu Y
Year: 2008
Journal: J Physiol
Title: AKAP150-anchored PKA activity is important for LTD during its induction phase.
Volume: 586
Issue: 17
Pages: 4155-64
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Publication
17110924 | J:119946
First Author: Sandoz G
Year: 2006
Journal: EMBO J
Title: AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels.
Volume: 25
Issue: 24
Pages: 5864-72
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Publication
20410303 | J:266119
First Author: Willoughby D
Year: 2010
Journal: J Biol Chem
Title: AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.
Volume: 285
Issue: 26
Pages: 20328-42
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Publication
32008372 | J:304345
First Author: Ottolini M
Year: 2020
Journal: Circulation
Title: Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.
Volume: 141
Issue: 16
Pages: 1318-1333
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Publication
23035250 | J:190389
First Author: Jones BW
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
Volume: 109
Issue: 42
Pages: 17099-104
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Publication
24323672 | J:223616
First Author: Nystoriak MA
Year: 2014
Journal: Circ Res
Title: AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.
Volume: 114
Issue: 4
Pages: 607-15
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Publication
21700933 | J:186599
First Author: Cheng EP
Year: 2011
Journal: Circ Res
Title: Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein.
Volume: 109
Issue: 3
Pages: 255-61
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Publication
25005230 | J:259641
First Author: Sonkusare SK
Year: 2014
Journal: Sci Signal
Title: AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.
Volume: 7
Issue: 333
Pages: ra66
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Publication
18174462 | J:145591
First Author: Navedo MF
Year: 2008
Journal: Circ Res
Title: AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension.
Volume: 102
Issue: 2
Pages: e1-e11
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Publication
22623657 | J:328024
First Author: Keith DJ
Year: 2012
Journal: J Neurosci
Title: Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms.
Volume: 32
Issue: 21
Pages: 7119-36
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Publication
20395454 | J:241478
First Author: Wang D
Year: 2010
Journal: FASEB J
Title: Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity.
Volume: 24
Issue: 9
Pages: 3511-21
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Publication
28119464 | J:242891
 
First Author: Nystoriak MA
Year: 2017
Journal: Sci Signal
Title: Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Volume: 10
Issue: 463
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Publication
22940692 | J:190017
First Author: Hinke SA
Year: 2012
Journal: EMBO J
Title: Anchored phosphatases modulate glucose homeostasis.
Volume: 31
Issue: 20
Pages: 3991-4004
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Publication
32163656 | J:305704
First Author: Zhu YR
Year: 2020
Journal: J Cell Mol Med
Title: Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3β signalling pathway in diabetes mellitus.
Volume: 24
Issue: 8
Pages: 4716-4725
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Publication
17279627 | J:128208
First Author: Hall DD
Year: 2007
Journal: Biochemistry
Title: Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons.
Volume: 46
Issue: 6
Pages: 1635-46
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Publication
18463244 | J:135192
First Author: Schnizler K
Year: 2008
Journal: J Neurosci
Title: Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons.
Volume: 28
Issue: 19
Pages: 4904-17
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Publication
20045463 | J:158396
First Author: Lin L
Year: 2010
Journal: Mol Cell Neurosci
Title: KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.
Volume: 43
Issue: 3
Pages: 315-25
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Publication
17972919 | J:127739
First Author: Lu Y
Year: 2007
Journal: EMBO J
Title: Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP.
Volume: 26
Issue: 23
Pages: 4879-90
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Publication
19091974 | J:143519
First Author: Di Biase V
Year: 2008
Journal: J Neurosci
Title: Stable membrane expression of postsynaptic CaV1.2 calcium channel clusters is independent of interactions with AKAP79/150 and PDZ proteins.
Volume: 28
Issue: 51
Pages: 13845-55
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Publication
21224388 | J:171157
First Author: Marshall MR
Year: 2011
Journal: J Biol Chem
Title: Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.
Volume: 286
Issue: 14
Pages: 12627-39
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Publication
23259949 | J:197655
First Author: Zhang J
Year: 2012
Journal: Neuron
Title: Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.
Volume: 76
Issue: 6
Pages: 1133-46
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Publication
22343722 | J:320049
First Author: Li H
Year: 2012
Journal: Nat Struct Mol Biol
Title: Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.
Volume: 19
Issue: 3
Pages: 337-45
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Publication
15757646 | J:320050
First Author: Weiwad M
Year: 2005
Journal: FEBS Lett
Title: A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.
Volume: 579
Issue: 7
Pages: 1591-6
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Publication
21614075 | J:172115
First Author: Jain A
Year: 2011
Journal: Nature
Title: Probing cellular protein complexes using single-molecule pull-down.
Volume: 473
Issue: 7348
Pages: 484-8
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Publication
17640527 | J:319981
First Author: Oliveria SF
Year: 2007
Journal: Neuron
Title: AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.
Volume: 55
Issue: 2
Pages: 261-75
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Publication
25762721 | J:222588
First Author: Russwurm C
Year: 2015
Journal: J Biol Chem
Title: Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum.
Volume: 290
Issue: 19
Pages: 11936-47
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Publication
21502359 | J:177007
First Author: Day ME
Year: 2011
Journal: J Cell Biol
Title: Isoform-specific targeting of PKA to multivesicular bodies.
Volume: 193
Issue: 2
Pages: 347-63
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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