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Search results 1 to 100 out of 2573 for Akt1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
key_1584413 | Akt1
Type: gene
Organism: Not Specified
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Gene
207 | AKT1
Type: gene
Organism: human
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Gene
740898 | AKT1
Type: gene
Organism: chimpanzee
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Gene
280991 | AKT1
Type: gene
Organism: cattle
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Gene
395928 | AKT1
Type: gene
Organism: chicken
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Gene
697747 | AKT1
Type: gene
Organism: macaque, rhesus
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Gene
101910198 | akt1
Type: gene
Organism: zebrafish
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Gene
100490038 | akt1
Type: gene
Organism: frog, western clawed
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Gene
24185 | Akt1
Type: gene
Organism: rat
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Gene
490878 | AKT1
Type: gene
Organism: dog, domestic
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Protein Domain
IPR034676 | Akt1
Type: Domain
Description: Protein kinase B alpha (PKB-alpha), also known as AKT1, is one of three closely related serine/threonine-protein kinases: AKT1/alpha, AKT2/beta and AKT3/gamma. PKBs contain an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain []. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity []. It also plays a role in adipocyte differentiation []. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers [, ]. In some cancer cells, PKB-alpha may act as a suppressor of metastasis [].
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Protein Coding Gene
MGI:87986 | Akt1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17460049 | J:121297
First Author: Ju X
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Akt1 governs breast cancer progression in vivo.
Volume: 104
Issue: 18
Pages: 7438-43
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Gene
84335 | AKT1S1
Type: gene
Organism: human
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Publication
14973226 | J:116239
First Author: Saito A
Year: 2004
Journal: J Neurosci
Title: Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Volume: 24
Issue: 7
Pages: 1584-93
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Publication
16552185 | -
First Author: Somanath PR
Year: 2006
Journal: Cell Cycle
Title: Akt1 in endothelial cell and angiogenesis.
Volume: 5
Issue: 5
Pages: 512-8
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Protein
P31750
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Publication
16397181 | J:116422
First Author: Saito A
Year: 2006
Journal: Stroke
Title: Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Volume: 37
Issue: 2
Pages: 513-7
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Publication
16338656 | -
First Author: Wyszomierski SL
Year: 2005
Journal: Cancer Cell
Title: A knotty turnabout?: Akt1 as a metastasis suppressor.
Volume: 8
Issue: 6
Pages: 437-9
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Publication
9742206 | -
 
First Author: Coffer PJ
Year: 1998
Journal: Biochem J
Title: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
Volume: 335 ( Pt 1)
Pages: 1-13
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Publication
10827191 | -
First Author: Graff JR
Year: 2000
Journal: J Biol Chem
Title: Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression.
Volume: 275
Issue: 32
Pages: 24500-5
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Publication
15192111 | -
First Author: Xu J
Year: 2004
Journal: J Biol Chem
Title: Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation.
Volume: 279
Issue: 34
Pages: 35914-22
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Protein
Q9D1F4
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Protein
E9QKI4
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
E9QKI5
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
D3YWZ1
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
F6R8S6
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
A0A140LHA0
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Publication
16636172 | J:122451
First Author: DeBosch B
Year: 2006
Journal: Circulation
Title: Akt1 is required for physiological cardiac growth.
Volume: 113
Issue: 17
Pages: 2097-104
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Publication
26565903 | J:228953
First Author: Cho JH
Year: 2015
Journal: Cell Rep
Title: AKT1 Activation Promotes Development of Melanoma Metastases.
Volume: 13
Issue: 5
Pages: 898-905
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Publication
36269831 | J:345088
First Author: Demir S
Year: 2022
Journal: Sci Adv
Title: TSC22D4 interacts with Akt1 to regulate glucose metabolism.
Volume: 8
Issue: 42
Pages: eabo5555
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Publication
20042722 | J:160279
First Author: Calamito M
Year: 2010
Journal: Blood
Title: Akt1 and Akt2 promote peripheral B-cell maturation and survival.
Volume: 115
Issue: 20
Pages: 4043-50
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Publication
16763066 | J:129523
First Author: Rasoulpour T
Year: 2006
Journal: Endocrinology
Title: Akt1 suppresses radiation-induced germ cell apoptosis in vivo.
Volume: 147
Issue: 9
Pages: 4213-21
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Publication
23935948 | J:204947
First Author: Nojima A
Year: 2013
Journal: PLoS One
Title: Haploinsufficiency of akt1 prolongs the lifespan of mice.
Volume: 8
Issue: 7
Pages: e69178
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Publication
17957242 | J:130281
First Author: Kawamura N
Year: 2007
Journal: PLoS One
Title: Akt1 in osteoblasts and osteoclasts controls bone remodeling.
Volume: 2
Issue: 10
Pages: e1058
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Publication
21242979 | J:170765
First Author: Hollander MC
Year: 2011
Journal: Oncogene
Title: Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Volume: 30
Issue: 15
Pages: 1812-21
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Publication
20530873 | J:163718
First Author: Eke I
Year: 2010
Journal: J Clin Invest
Title: PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha.
Volume: 120
Issue: 7
Pages: 2516-27
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Publication
22885182 | J:188140
First Author: Choi YH
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Akt1 regulates phosphorylation and osteogenic activity of Dlx3.
Volume: 425
Issue: 4
Pages: 800-5
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Publication
31299858 | J:293589
First Author: Nie Y
Year: 2019
Journal: Innate Immun
Title: Akt1 regulates pulmonary fibrosis via modulating IL-13 expression in macrophages.
Volume: 25
Issue: 7
Pages: 451-461
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Publication
26921108 | J:254662
First Author: Larson-Casey JL
Year: 2016
Journal: Immunity
Title: Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis.
Volume: 44
Issue: 3
Pages: 582-596
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Publication
20816796 | J:166615
First Author: Chang Z
Year: 2010
Journal: Dev Biol
Title: Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.
Volume: 347
Issue: 2
Pages: 384-91
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Publication
25201081 | J:218454
First Author: Yun SJ
Year: 2014
Journal: Biochim Biophys Acta
Title: Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells.
Volume: 1842
Issue: 11
Pages: 2184-92
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Publication
16227992 | J:102877
First Author: Chen J
Year: 2005
Journal: Nat Med
Title: Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Volume: 11
Issue: 11
Pages: 1188-96
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Publication
24663486 | J:214152
First Author: Mukherjee A
Year: 2014
Journal: PLoS One
Title: Distinct actions of akt1 on skeletal architecture and function.
Volume: 9
Issue: 3
Pages: e93040
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Publication
17562714 | J:124800
First Author: Somanath PR
Year: 2007
Journal: J Biol Chem
Title: Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.
Volume: 282
Issue: 31
Pages: 22964-76
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Publication
23904165 | J:205816
First Author: Liu G
Year: 2013
Journal: J Immunol
Title: Kinase AKT1 negatively controls neutrophil recruitment and function in mice.
Volume: 191
Issue: 5
Pages: 2680-90
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Publication
22117619 | J:324970
First Author: Kunuthur SP
Year: 2012
Journal: J Cell Mol Med
Title: The Akt1 isoform is an essential mediator of ischaemic preconditioning.
Volume: 16
Issue: 8
Pages: 1739-49
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Publication
30833219 | J:294695
 
First Author: Sanchez-Gurmaches J
Year: 2019
Journal: Mol Metab
Title: Brown fat organogenesis and maintenance requires AKT1 and AKT2.
Volume: 23
Pages: 60-74
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Publication
19491266 | J:149659
First Author: Dillon RL
Year: 2009
Journal: Cancer Res
Title: Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.
Volume: 69
Issue: 12
Pages: 5057-64
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Publication
20363892 | J:160448
First Author: Beiser DG
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest.
Volume: 298
Issue: 6
Pages: H1761-8
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GXD Expression
GXD Expression
   
Probe: MGI:6167236
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189759
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Akt1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6167236
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189759
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Akt1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6167236
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189759
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Akt1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6167236
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189759
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Akt1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6167236
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189759
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Akt1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6167236
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189759
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Akt1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6167236
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189759
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Akt1
Detected: true
Specimen Num: 7
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Publication
19622728 | J:152016
First Author: Di Lorenzo A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.
Volume: 106
Issue: 34
Pages: 14552-7
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Publication
22647600 | J:185519
First Author: Arranz A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.
Volume: 109
Issue: 24
Pages: 9517-22
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Publication
25136137 | J:216407
First Author: Lee MY
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.
Volume: 111
Issue: 35
Pages: 12865-70
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Publication
19699171 | J:151838
First Author: Androulidaki A
Year: 2009
Journal: Immunity
Title: The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs.
Volume: 31
Issue: 2
Pages: 220-31
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Publication
18054314 | J:130443
First Author: Fernández-Hernando C
Year: 2007
Journal: Cell Metab
Title: Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease.
Volume: 6
Issue: 6
Pages: 446-57
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Publication
22151747 | J:198105
First Author: Chen YC
Year: 2012
Journal: Genes Brain Behav
Title: Akt1 deficiency modulates reward learning and reward prediction error in mice.
Volume: 11
Issue: 2
Pages: 157-69
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Publication
24400145 | J:227956
First Author: Vandoorne K
Year: 2013
Journal: Physiol Rep
Title: Multimodal imaging reveals a role for Akt1 in fetal cardiac development.
Volume: 1
Issue: 6
Pages: e00143
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Publication
22064480 | J:183672
First Author: Mukherjee A
Year: 2012
Journal: Mol Cell Biol
Title: Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development.
Volume: 32
Issue: 2
Pages: 490-500
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Publication
26654940 | J:302263
First Author: Franks SE
Year: 2016
Journal: Oncotarget
Title: Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.
Volume: 7
Issue: 3
Pages: 3297-316
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Publication
20354168 | J:160459
First Author: Juntilla MM
Year: 2010
Journal: Blood
Title: AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Volume: 115
Issue: 20
Pages: 4030-8
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Publication
25868464 | J:248769
First Author: Rotllan N
Year: 2015
Journal: Circ Res
Title: Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis.
Volume: 116
Issue: 11
Pages: 1744-52
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Publication
17077150 | J:117100
First Author: Lai WS
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning.
Volume: 103
Issue: 45
Pages: 16906-11
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Publication
23787999 | J:228616
First Author: Green BD
Year: 2013
Journal: Cell Death Differ
Title: Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.
Volume: 20
Issue: 10
Pages: 1341-9
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Publication
32931746 | J:297182
First Author: Chen X
Year: 2020
Journal: Mol Cell
Title: Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer.
Volume: 80
Issue: 1
Pages: 87-101.e5
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Publication
22037765 | J:182721
First Author: Wan M
Year: 2012
Journal: Mol Cell Biol
Title: Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity.
Volume: 32
Issue: 1
Pages: 96-106
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Publication
16778075 | J:109600
First Author: Chen ML
Year: 2006
Journal: Genes Dev
Title: The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Volume: 20
Issue: 12
Pages: 1569-74
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Publication
17141631 | J:129773
First Author: Boxer RB
Year: 2006
Journal: Cell Metab
Title: Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.
Volume: 4
Issue: 6
Pages: 475-90
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Publication
25388284 | J:218209
First Author: Phung TL
Year: 2015
Journal: Cancer Res
Title: Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.
Volume: 75
Issue: 1
Pages: 40-50
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Publication
32179553 | J:293069
 
First Author: Peng Z
Year: 2020
Journal: Mol Cell Biol
Title: AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic β Cells.
Volume: 40
Issue: 11
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Publication
30984553 | J:290242
First Author: Ha JM
Year: 2019
Journal: FEBS Open Bio
Title: Vascular leakage caused by loss of Akt1 is associated with impaired mural cell coverage.
Volume: 9
Issue: 4
Pages: 801-813
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Publication
29443546 | J:262191
First Author: Moriya N
Year: 2018
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation.
Volume: 314
Issue: 5
Pages: R741-R751
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Publication
33038070 | J:313524
First Author: Miyazaki M
Year: 2020
Journal: Physiol Rep
Title: Transient activation of mTORC1 signaling in skeletal muscle is independent of Akt1 regulation.
Volume: 8
Issue: 19
Pages: e14599
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Publication
27615800 | J:293081
 
First Author: Chang CY
Year: 2016
Journal: Sci Rep
Title: Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions.
Volume: 6
Pages: 33095
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Publication
22904301 | J:189917
First Author: Gantner BN
Year: 2012
Journal: J Immunol
Title: The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin.
Volume: 189
Issue: 6
Pages: 3104-11
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Publication
22930469 | J:190353
First Author: Pierau M
Year: 2012
Journal: Eur J Immunol
Title: Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function.
Volume: 42
Issue: 12
Pages: 3381-93
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Publication
24933620 | J:219438
 
First Author: Ahmad F
Year: 2014
Journal: Free Radic Biol Med
Title: Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases.
Volume: 74
Pages: 118-28
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Publication
23300339 | J:255333
First Author: Yao Y
Year: 2013
Journal: Sci Signal
Title: BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
Volume: 6
Issue: 257
Pages: ra2
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Publication
22562201 | J:184520
First Author: Kent LN
Year: 2012
Journal: Int J Dev Biol
Title: Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
Volume: 56
Issue: 4
Pages: 255-61
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Publication
21915327 | J:177888
First Author: LaRocca J
Year: 2011
Journal: PLoS One
Title: Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
Volume: 6
Issue: 9
Pages: e24432
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Publication
19270695 | J:158181
First Author: Gao D
Year: 2009
Journal: Nat Cell Biol
Title: Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.
Volume: 11
Issue: 4
Pages: 397-408
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Publication
31531867 | J:293787
First Author: Chen R
Year: 2020
Journal: J Pathol
Title: Akt1 signalling supports acinar proliferation and limits acinar-to-ductal metaplasia formation upon induction of acute pancreatitis.
Volume: 250
Issue: 1
Pages: 42-54
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Publication
24742286 | J:317511
 
First Author: Wu Y
Year: 2014
Journal: BMC Cancer
Title: Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice.
Volume: 14
Pages: 266
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Publication
24955524 | J:217945
First Author: Kong KA
Year: 2014
Journal: Biochim Biophys Acta
Title: Akt1 mediates the posterior Hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts.
Volume: 1839
Issue: 9
Pages: 793-9
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Publication
16982699 | J:114644
First Author: Héron-Milhavet L
Year: 2006
Journal: Mol Cell Biol
Title: Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
Volume: 26
Issue: 22
Pages: 8267-80
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Publication
25748236 | J:311968
First Author: Albury TM
Year: 2015
Journal: Neoplasia
Title: Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression.
Volume: 17
Issue: 2
Pages: 175-82
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Publication
17609365 | J:123155
First Author: Juntilla MM
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.
Volume: 104
Issue: 29
Pages: 12105-10
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Publication
25046438 | J:214225
First Author: Ma L
Year: 2014
Journal: Lab Invest
Title: Differential effects of Akt1 signaling on short- versus long-term consequences of myocardial infarction and reperfusion injury.
Volume: 94
Issue: 10
Pages: 1083-91
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Publication
18700973 | J:142118
First Author: Young CD
Year: 2008
Journal: Breast Cancer Res
Title: Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.
Volume: 10
Issue: 4
Pages: R70
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Publication
24106278 | J:204981
First Author: Abdalla M
Year: 2013
Journal: J Biol Chem
Title: Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.
Volume: 288
Issue: 46
Pages: 33483-93
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Publication
17012749 | J:117620
First Author: Zhou GL
Year: 2006
Journal: J Biol Chem
Title: Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration.
Volume: 281
Issue: 47
Pages: 36443-53
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Publication
25843685 | J:230544
First Author: Goc A
Year: 2015
Journal: Biochim Biophys Acta
Title: p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling.
Volume: 1853
Issue: 7
Pages: 1626-35
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Publication
33030203 | J:298839
First Author: Lindhurst MJ
Year: 2020
Journal: Hum Mol Genet
Title: Ubiquitous expression of Akt1 p.(E17K) results in vascular defects and embryonic lethality in mice.
Volume: 29
Issue: 20
Pages: 3350-3360
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Publication
32937140 | J:306411
First Author: Chen K
Year: 2020
Journal: Cell Rep
Title: Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation.
Volume: 32
Issue: 11
Pages: 108151
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