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Search results 1 to 100 out of 115 for Akt1s1

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0.067s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Proline-rich AKT1 substrate 1 protein (AKT1S1, PRAS40) is part of the mammalian target of rapamycin complex 1 (mTORC1, contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR), which regulates cell growth and survival in response to nutrient and hormonal signals []. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. AKT1S1 is a substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. It may also play a role in nerve growth factor-mediated neuroprotection [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Saito A
Year: 2004
Journal: J Neurosci
Title: Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Volume: 24
Issue: 7
Pages: 1584-93
Publication
First Author: Saito A
Year: 2006
Journal: Stroke
Title: Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Volume: 37
Issue: 2
Pages: 513-7
GXD Expression    
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189760
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Akt1s1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6189760
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Akt1s1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6189760
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Akt1s1
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6189760
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Akt1s1
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189760
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Akt1s1
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189760
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Akt1s1
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189760
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Akt1s1
Detected: false
Specimen Num: 7
Protein
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
Publication
First Author: Kim DH
Year: 2002
Journal: Cell
Title: mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Volume: 110
Issue: 2
Pages: 163-75
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication  
First Author: Xiong X
Year: 2014
Journal: Neurobiol Dis
Title: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
Volume: 66
Pages: 43-52
Publication
First Author: Malla R
Year: 2015
Journal: Biochem Pharmacol
Title: Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways.
Volume: 96
Issue: 1
Pages: 65-75
Publication
First Author: Chern JJ
Year: 2002
Journal: Development
Title: Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc.
Volume: 129
Issue: 17
Pages: 4005-13
Publication
First Author: Völkers M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
Volume: 110
Issue: 31
Pages: 12661-6
Publication
First Author: Völkers M
Year: 2014
Journal: EMBO Mol Med
Title: PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
Volume: 6
Issue: 1
Pages: 57-65
GXD Expression      
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529190
Age: embryonic day 15.5
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529190
Age: embryonic day 15.5
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529190
Age: embryonic day 15.5
Specimen Label: E15.5 K465E
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529190
Age: embryonic day 15.5
Specimen Label: E15.5 K465E
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529190
Age: postnatal adult
Specimen Label: ADULT WT
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529190
Age: postnatal adult
Specimen Label: ADULT WT
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529190
Age: postnatal adult
Specimen Label: ADULT K465E
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529190
Age: postnatal adult
Specimen Label: ADULT K465E
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529191
Age: embryonic day 15.5
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529191
Age: embryonic day 15.5
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529191
Age: embryonic day 15.5
Specimen Label: E15.5 K465E
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529191
Age: embryonic day 15.5
Specimen Label: E15.5 K465E
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529191
Age: postnatal adult
Specimen Label: ADULT WT
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529191
Age: postnatal adult
Specimen Label: ADULT WT
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529191
Age: postnatal adult
Specimen Label: ADULT K465E
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529191
Age: postnatal adult
Specimen Label: ADULT K465E
Detected: true
Specimen Num: 8
Publication
First Author: Caccamo A
Year: 2011
Journal: J Biol Chem
Title: Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
Volume: 286
Issue: 11
Pages: 8924-32
Publication
First Author: Chakrabarti P
Year: 2010
Journal: Diabetes
Title: Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage.
Volume: 59
Issue: 4
Pages: 775-81
Publication
First Author: Rho O
Year: 2016
Journal: J Invest Dermatol
Title: Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development.
Volume: 136
Issue: 10
Pages: 2070-2079
Publication
First Author: Smithson LJ
Year: 2016
Journal: Genes Dev
Title: Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.
Volume: 30
Issue: 12
Pages: 1383-8
Publication
First Author: Feng Q
Year: 2010
Journal: Mol Cell Biol
Title: PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.
Volume: 30
Issue: 14
Pages: 3711-21
Publication      
First Author: Cordón-Barris L
Year: 2016
Journal: Mol Cell Biol
Title: Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors.
Publication
First Author: Zurashvili T
Year: 2013
Journal: Mol Cell Biol
Title: Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
Volume: 33
Issue: 5
Pages: 1027-40
Publication    
First Author: Figlia G
Year: 2017
Journal: Elife
Title: Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.
Volume: 6
Publication    
First Author: Roy A
Year: 2015
Journal: Elife
Title: Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.
Volume: 4
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer