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Search results 1 to 100 out of 116 for Akt1s1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
84335 | AKT1S1
Type: gene
Organism: human
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Gene
496515 | akt1s1
Type: gene
Organism: frog, western clawed
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Gene
292887 | Akt1s1
Type: gene
Organism: rat
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Gene
610130 | AKT1S1
Type: gene
Organism: dog, domestic
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Gene
456218 | AKT1S1
Type: gene
Organism: chimpanzee
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Gene
514859 | AKT1S1
Type: gene
Organism: cattle
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Gene
566559 | akt1s1
Type: gene
Organism: zebrafish
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Gene
719101 | AKT1S1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR026682 | AKT1S1
Type: Family
Description: Proline-rich AKT1 substrate 1 protein (AKT1S1, PRAS40) is part of the mammalian target of rapamycin complex 1 (mTORC1, contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR), which regulates cell growth and survival in response to nutrient and hormonal signals []. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. AKT1S1 is a substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. It may also play a role in nerve growth factor-mediated neuroprotection [, ].
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Protein Coding Gene
MGI:1914855 | Akt1s1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
14973226 | J:116239
First Author: Saito A
Year: 2004
Journal: J Neurosci
Title: Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Volume: 24
Issue: 7
Pages: 1584-93
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Publication
16397181 | J:116422
First Author: Saito A
Year: 2006
Journal: Stroke
Title: Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Volume: 37
Issue: 2
Pages: 513-7
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GXD Expression
GXD Expression
   
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189760
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Akt1s1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6189760
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Akt1s1
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6189760
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Akt1s1
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6189760
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Akt1s1
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189760
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Akt1s1
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189760
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Akt1s1
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6167237
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6189760
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Akt1s1
Detected: false
Specimen Num: 7
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Protein
Q9D1F4
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Protein
E9QKI4
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
E9QKI5
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
D3YWZ1
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
F6R8S6
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
A0A140LHA0
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Publication
12150925 | -
First Author: Kim DH
Year: 2002
Journal: Cell
Title: mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Volume: 110
Issue: 2
Pages: 163-75
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Protein Coding Gene
MGP_CAROLIEiJ_G0029678 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032181 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032172 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031888 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032664 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031216 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031852 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032010 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031961 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031998 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030939 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012903 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030776 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
24583056 | J:231219
 
First Author: Xiong X
Year: 2014
Journal: Neurobiol Dis
Title: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
Volume: 66
Pages: 43-52
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Publication
25931147 | J:223322
First Author: Malla R
Year: 2015
Journal: Biochem Pharmacol
Title: Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways.
Volume: 96
Issue: 1
Pages: 65-75
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Publication
12163404 | J:78416
First Author: Chern JJ
Year: 2002
Journal: Development
Title: Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc.
Volume: 129
Issue: 17
Pages: 4005-13
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Publication
23842089 | J:198784
First Author: Völkers M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
Volume: 110
Issue: 31
Pages: 12661-6
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Publication
24408966 | J:319046
First Author: Völkers M
Year: 2014
Journal: EMBO Mol Med
Title: PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
Volume: 6
Issue: 1
Pages: 57-65
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GXD Expression
GXD Expression
     
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529190
Age: embryonic day 15.5
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529190
Age: embryonic day 15.5
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529190
Age: embryonic day 15.5
Specimen Label: E15.5 K465E
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529190
Age: embryonic day 15.5
Specimen Label: E15.5 K465E
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529190
Age: postnatal adult
Specimen Label: ADULT WT
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529190
Age: postnatal adult
Specimen Label: ADULT WT
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529190
Age: postnatal adult
Specimen Label: ADULT K465E
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:7529179
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529190
Age: postnatal adult
Specimen Label: ADULT K465E
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529191
Age: embryonic day 15.5
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529191
Age: embryonic day 15.5
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529191
Age: embryonic day 15.5
Specimen Label: E15.5 K465E
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7529191
Age: embryonic day 15.5
Specimen Label: E15.5 K465E
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529191
Age: postnatal adult
Specimen Label: ADULT WT
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529191
Age: postnatal adult
Specimen Label: ADULT WT
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529191
Age: postnatal adult
Specimen Label: ADULT K465E
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:7529180
Assay Type: Western blot
Annotation Date: 2023-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529191
Age: postnatal adult
Specimen Label: ADULT K465E
Detected: true
Specimen Num: 8
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Publication
21266573 | J:170949
First Author: Caccamo A
Year: 2011
Journal: J Biol Chem
Title: Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
Volume: 286
Issue: 11
Pages: 8924-32
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Publication
20068142 | J:164333
First Author: Chakrabarti P
Year: 2010
Journal: Diabetes
Title: Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage.
Volume: 59
Issue: 4
Pages: 775-81
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Publication
27349859 | J:238146
First Author: Rho O
Year: 2016
Journal: J Invest Dermatol
Title: Overexpression of PRAS40(T246A) in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration, and Skin Tumor Development.
Volume: 136
Issue: 10
Pages: 2070-2079
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Publication
27340174 | J:233300
First Author: Smithson LJ
Year: 2016
Journal: Genes Dev
Title: Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.
Volume: 30
Issue: 12
Pages: 1383-8
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Publication
20457809 | J:162664
First Author: Feng Q
Year: 2010
Journal: Mol Cell Biol
Title: PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.
Volume: 30
Issue: 14
Pages: 3711-21
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Publication
27644329 | J:243001
     
First Author: Cordón-Barris L
Year: 2016
Journal: Mol Cell Biol
Title: Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors.
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Publication
23275438 | J:315254
First Author: Zurashvili T
Year: 2013
Journal: Mol Cell Biol
Title: Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
Volume: 33
Issue: 5
Pages: 1027-40
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Publication
26633882 | J:269511
   
First Author: Roy A
Year: 2015
Journal: Elife
Title: Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.
Volume: 4
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Publication
28880149 | J:248325
   
First Author: Figlia G
Year: 2017
Journal: Elife
Title: Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.
Volume: 6
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Journal: Nature
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Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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