|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 683 for Akt2

<< First    < Previous  |  Next >    Last >>
0.037s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Domain
Description: Protein kinase B beta (PKB-beta), also known as AKT2, is one of three closely related serine/threonine-protein kinases: AKT1/alpha, AKT2/beta and AKT3/gamma. PKBs contain an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain []. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis []. It is also implicated in muscle cell differentiation []. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Cho H
Year: 2001
Journal: Science
Title: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).
Volume: 292
Issue: 5522
Pages: 1728-31
Publication
First Author: Héron-Milhavet L
Year: 2008
Journal: J Cell Physiol
Title: Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA.
Volume: 214
Issue: 1
Pages: 158-65
Publication
First Author: DeBosch B
Year: 2006
Journal: J Biol Chem
Title: Akt2 regulates cardiac metabolism and cardiomyocyte survival.
Volume: 281
Issue: 43
Pages: 32841-51
Publication
First Author: Zhang B
Year: 2009
Journal: Eur J Immunol
Title: Akt2 is required for macrophage chemotaxis.
Volume: 39
Issue: 3
Pages: 894-901
Publication
First Author: Altomare DA
Year: 1996
Journal: Cytogenet Cell Genet
Title: Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene.
Volume: 74
Issue: 4
Pages: 248-51
Protein
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
Publication
First Author: Shen YH
Year: 2013
Journal: Circ Res
Title: AKT2 confers protection against aortic aneurysms and dissections.
Volume: 112
Issue: 4
Pages: 618-32
Publication
First Author: Babaev VR
Year: 2014
Journal: J Lipid Res
Title: Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice.
Volume: 55
Issue: 11
Pages: 2296-308
Publication
First Author: Calamito M
Year: 2010
Journal: Blood
Title: Akt1 and Akt2 promote peripheral B-cell maturation and survival.
Volume: 115
Issue: 20
Pages: 4043-50
Publication
First Author: Rotllan N
Year: 2015
Journal: FASEB J
Title: Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.
Volume: 29
Issue: 2
Pages: 597-610
Publication
First Author: Du Z
Year: 2020
Journal: Cell Commun Signal
Title: AKT2 deficiency impairs formation of the BCR signalosome.
Volume: 18
Issue: 1
Pages: 56
Protein
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
Publication  
First Author: Coffer PJ
Year: 1998
Journal: Biochem J
Title: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
Volume: 335 ( Pt 1)
Pages: 1-13
Publication
First Author: Nie Y
Year: 2017
Journal: J Immunol
Title: AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation.
Volume: 198
Issue: 11
Pages: 4470-4480
Publication
First Author: Kum WW
Year: 2011
Journal: Infect Immun
Title: Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis.
Volume: 79
Issue: 7
Pages: 2554-66
Publication
First Author: Figueroa C
Year: 2003
Journal: J Biol Chem
Title: Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.
Volume: 278
Issue: 48
Pages: 47922-7
Publication
First Author: Juntilla MM
Year: 2010
Journal: Blood
Title: AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Volume: 115
Issue: 20
Pages: 4030-8
Publication
First Author: Xu PZ
Year: 2012
Journal: Oncogene
Title: The effect Akt2 deletion on tumor development in Pten(+/-) mice.
Volume: 31
Issue: 4
Pages: 518-26
Publication
First Author: Franks SE
Year: 2016
Journal: Oncotarget
Title: Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.
Volume: 7
Issue: 3
Pages: 3297-316
Publication
First Author: Lazorchak AS
Year: 2010
Journal: Mol Cell
Title: Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Volume: 39
Issue: 3
Pages: 433-43
Publication
First Author: Li J
Year: 2014
Journal: J Clin Invest
Title: Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation.
Volume: 124
Issue: 4
Pages: 1483-96
Publication
First Author: Altomare DA
Year: 1995
Journal: Oncogene
Title: Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.
Volume: 11
Issue: 6
Pages: 1055-60
Publication
First Author: Li G
Year: 2007
Journal: J Neurosci
Title: Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death.
Volume: 27
Issue: 1
Pages: 203-11
Publication
First Author: Arranz A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.
Volume: 109
Issue: 24
Pages: 9517-22
Publication
First Author: Canaud G
Year: 2013
Journal: Nat Med
Title: AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.
Volume: 19
Issue: 10
Pages: 1288-96
Publication
First Author: Koren S
Year: 2015
Journal: Diabetologia
Title: The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo.
Volume: 58
Issue: 5
Pages: 1063-70
Publication
First Author: Barazia A
Year: 2015
Journal: Blood
Title: Hydroxyurea with AKT2 inhibition decreases vaso-occlusive events in sickle cell disease mice.
Volume: 126
Issue: 22
Pages: 2511-7
Publication
First Author: Leavens KF
Year: 2009
Journal: Cell Metab
Title: Akt2 is required for hepatic lipid accumulation in models of insulin resistance.
Volume: 10
Issue: 5
Pages: 405-18
Publication
First Author: Altomare DA
Year: 1998
Journal: Oncogene
Title: Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin.
Volume: 16
Issue: 18
Pages: 2407-11
Publication
First Author: Mukherjee A
Year: 2010
Journal: Mol Cell Biol
Title: Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation.
Volume: 30
Issue: 4
Pages: 1018-27
Publication
First Author: Gu J
Year: 2018
Journal: Diabetes
Title: Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts.
Volume: 67
Issue: 3
Pages: 507-517
Publication  
First Author: Braccini L
Year: 2015
Journal: Nat Commun
Title: PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.
Volume: 6
Pages: 7400
Publication
First Author: Sakamoto K
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle.
Volume: 291
Issue: 5
Pages: E1031-7
Publication
First Author: Kearney AL
Year: 2019
Journal: J Biol Chem
Title: Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes.
Volume: 294
Issue: 45
Pages: 16729-16739
Publication
First Author: Cheng Y
Year: 2020
Journal: Int J Biol Sci
Title: The Role of Akt2 in the Protective Effect of Fenofibrate against Diabetic Nephropathy.
Volume: 16
Issue: 4
Pages: 553-567
Publication
First Author: Vergadi E
Year: 2014
Journal: J Immunol
Title: Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice.
Volume: 192
Issue: 1
Pages: 394-406
Publication
First Author: Li X
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density.
Volume: 301
Issue: 5
Pages: H1932-40
Publication
First Author: Chen X
Year: 2020
Journal: Mol Cell
Title: Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer.
Volume: 80
Issue: 1
Pages: 87-101.e5
Publication  
First Author: Lim CY
Year: 2015
Journal: Nat Commun
Title: Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.
Volume: 6
Pages: 5951
Publication
First Author: Dillon RL
Year: 2009
Journal: Cancer Res
Title: Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.
Volume: 69
Issue: 12
Pages: 5057-64
Publication
First Author: Gong Y
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism.
Volume: 1866
Issue: 10
Pages: 165855
Publication  
First Author: Zhang Y
Year: 2014
Journal: J Mol Cell Cardiol
Title: Ablation of Akt2 protects against lipopolysaccharide-induced cardiac dysfunction: role of Akt ubiquitination E3 ligase TRAF6.
Volume: 74
Pages: 76-87
Publication
First Author: Liu Z
Year: 2016
Journal: J Lipid Res
Title: Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice.
Volume: 57
Issue: 8
Pages: 1373-81
Publication  
First Author: Watson KL
Year: 2013
Journal: BMC Cancer
Title: Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.
Volume: 13
Pages: 375
Publication
First Author: He L
Year: 2010
Journal: Am J Pathol
Title: The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
Volume: 176
Issue: 5
Pages: 2302-8
Publication  
First Author: Sun W
Year: 2014
Journal: J Mol Cell Cardiol
Title: Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent.
Volume: 74
Pages: 88-97
Publication
First Author: Héron-Milhavet L
Year: 2006
Journal: Mol Cell Biol
Title: Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
Volume: 26
Issue: 22
Pages: 8267-80
Publication
First Author: Chen D
Year: 2017
Journal: Biochem Biophys Res Commun
Title: AKT2 deficiency induces retardation of myocyte development through EndoG-MEF2A signaling in mouse heart.
Volume: 493
Issue: 4
Pages: 1410-1417
Publication
First Author: Etzion S
Year: 2010
Journal: J Mol Cell Cardiol
Title: Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.
Volume: 49
Issue: 6
Pages: 931-40
Publication
First Author: Zhou GL
Year: 2006
Journal: J Biol Chem
Title: Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration.
Volume: 281
Issue: 47
Pages: 36443-53
Publication
First Author: McCurdy CE
Year: 2005
Journal: Diabetes
Title: Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle.
Volume: 54
Issue: 5
Pages: 1349-56
Publication
First Author: Hedl M
Year: 2016
Journal: Cell Rep
Title: IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.
Volume: 16
Issue: 9
Pages: 2442-55
Publication
First Author: Wan M
Year: 2011
Journal: Cell Metab
Title: Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Volume: 14
Issue: 4
Pages: 516-27
Publication
First Author: Sanchez-Gurmaches J
Year: 2018
Journal: Cell Metab
Title: Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.
Volume: 27
Issue: 1
Pages: 195-209.e6
Publication
First Author: Ren J
Year: 2017
Journal: Aging Cell
Title: Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation.
Volume: 16
Issue: 5
Pages: 976-987
Publication
First Author: Takenaka N
Year: 2019
Journal: PLoS One
Title: Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle.
Volume: 14
Issue: 2
Pages: e0212219
Publication
First Author: Jiang K
Year: 2009
Journal: Endocrinology
Title: Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid.
Volume: 150
Issue: 5
Pages: 2087-97
Publication
First Author: Polytarchou C
Year: 2011
Journal: Cancer Res
Title: Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.
Volume: 71
Issue: 13
Pages: 4720-31
Publication
First Author: Treins C
Year: 2012
Journal: Mol Cell Biol
Title: The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet.
Volume: 32
Issue: 19
Pages: 4001-11
Publication
First Author: Juntilla MM
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.
Volume: 104
Issue: 29
Pages: 12105-10
Publication
First Author: Cenni V
Year: 2011
Journal: Mol Biol Cell
Title: Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).
Volume: 22
Issue: 16
Pages: 2946-56
Publication
First Author: Wang S
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy.
Volume: 1865
Issue: 7
Pages: 1865-1875
Publication
First Author: Liu X
Year: 2006
Journal: J Biol Chem
Title: Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.
Volume: 281
Issue: 42
Pages: 31380-8
Publication
First Author: Dummler B
Year: 2006
Journal: Mol Cell Biol
Title: Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies.
Volume: 26
Issue: 21
Pages: 8042-51
Publication
First Author: Maroulakou IG
Year: 2007
Journal: Cancer Res
Title: Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.
Volume: 67
Issue: 1
Pages: 167-77
Publication
First Author: Brand Y
Year: 2015
Journal: PLoS One
Title: All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.
Volume: 10
Issue: 3
Pages: e0121599
Publication
First Author: Sudhahar V
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.
Volume: 38
Issue: 3
Pages: 529-541
Publication
First Author: Tan Y
Year: 2008
Journal: Cancer Res
Title: A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice.
Volume: 68
Issue: 5
Pages: 1296-302
Publication
First Author: Di Lorenzo A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.
Volume: 106
Issue: 34
Pages: 14552-7
Publication
First Author: Goncalves MD
Year: 2010
Journal: PLoS One
Title: Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.
Volume: 5
Issue: 9
Pages: e12707
Publication
First Author: Koral K
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Akt recruits Dab2 to albumin endocytosis in the proximal tubule.
Volume: 307
Issue: 12
Pages: F1380-9
Publication    
First Author: Wong H
Year: 2020
Journal: Elife
Title: Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders.
Volume: 9
Publication
First Author: Lee MY
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.
Volume: 111
Issue: 35
Pages: 12865-70
Publication
First Author: Pauta M
Year: 2016
Journal: Hepatology
Title: Akt-mediated foxo1 inhibition is required for liver regeneration.
Volume: 63
Issue: 5
Pages: 1660-74
Publication
First Author: Woulfe D
Year: 2004
Journal: J Clin Invest
Title: Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2.
Volume: 113
Issue: 3
Pages: 441-50
Publication
First Author: Hyde M
Year: 2021
Journal: Eur J Immunol
Title: Hyperlipidemia-induced metabolic changes in regulatory T cells result in altered function.
Volume: 51
Issue: 11
Pages: 2576-2589
Publication    
First Author: Levenga J
Year: 2017
Journal: Elife
Title: AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.
Volume: 6
Publication
First Author: Jin Y
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.
Volume: 37
Issue: 12
Pages: 2311-2321
Publication
First Author: Ock S
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts.
Volume: 1864
Issue: 4 Pt A
Pages: 1183-1191
Publication
First Author: Linnerth-Petrik NM
Year: 2014
Journal: PLoS One
Title: Opposing functions of Akt isoforms in lung tumor initiation and progression.
Volume: 9
Issue: 4
Pages: e94595
Publication
First Author: Hollander MC
Year: 2011
Journal: Oncogene
Title: Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Volume: 30
Issue: 15
Pages: 1812-21
Publication
First Author: Lu M
Year: 2012
Journal: Nat Med
Title: Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1.
Volume: 18
Issue: 3
Pages: 388-95
Publication
First Author: Jain SS
Year: 2015
Journal: FEBS Lett
Title: Fatty acid transport and transporters in muscle are critically regulated by Akt2.
Volume: 589
Issue: 19 Pt B
Pages: 2769-75
Publication
First Author: Wani R
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species.
Volume: 108
Issue: 26
Pages: 10550-5
Publication
First Author: Hu SH
Year: 2022
Journal: Cell Rep
Title: Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake.
Volume: 38
Issue: 11
Pages: 110509
Publication
First Author: Kim ST
Year: 2012
Journal: Reprod Sci
Title: Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm.
Volume: 19
Issue: 1
Pages: 31-42
Publication
First Author: Rastogi R
Year: 2013
Journal: J Biol Chem
Title: Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways.
Volume: 288
Issue: 47
Pages: 33966-77
Publication  
First Author: Zhu Z
Year: 2019
Journal: Life Sci Alliance
Title: The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.
Volume: 2
Issue: 6
Publication
First Author: Hu N
Year: 2014
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis.
Volume: 306
Issue: 10
Pages: R761-71