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Search results 1 to 100 out of 559 for Akt3

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Domain
Description: Protein kinase B gamma (PKB-gamma), also known as AKT3, is one of three closely related serine/threonine-protein kinases: AKT1/alpha, AKT2/beta and AKT3/gamma. PKBs contain an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain []. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number []. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumours []. It acts as a key mediator in the genesis of ovarian cancer [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Easton RM
Year: 2005
Journal: Mol Cell Biol
Title: Role for Akt3/protein kinase Bgamma in attainment of normal brain size.
Volume: 25
Issue: 5
Pages: 1869-78
Gene
Type: gene
Organism: human
Publication
First Author: Nakatani K
Year: 1999
Journal: J Biol Chem
Title: Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.
Volume: 274
Issue: 31
Pages: 21528-32
Publication
First Author: Cristiano BE
Year: 2006
Journal: Cancer Res
Title: A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition.
Volume: 66
Issue: 24
Pages: 11718-25
Publication
First Author: Chung S
Year: 2013
Journal: Oncogene
Title: N-cadherin regulates mammary tumor cell migration through Akt3 suppression.
Volume: 32
Issue: 4
Pages: 422-30
Publication
First Author: Wright GL
Year: 2008
Journal: FASEB J
Title: VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase.
Volume: 22
Issue: 9
Pages: 3264-75
Publication
First Author: O'Brien KA
Year: 2011
Journal: Blood
Title: An important role for Akt3 in platelet activation and thrombosis.
Volume: 118
Issue: 15
Pages: 4215-23
Publication
First Author: Zboray K
Year: 2018
Journal: Cancer Med
Title: AKT3 drives adenoid cystic carcinoma development in salivary glands.
Volume: 7
Issue: 2
Pages: 445-453
Publication
First Author: Phung TL
Year: 2015
Journal: Cancer Res
Title: Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.
Volume: 75
Issue: 1
Pages: 40-50
Publication
First Author: Ding L
Year: 2012
Journal: Cell Metab
Title: Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Volume: 15
Issue: 6
Pages: 861-72
Protein
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
Publication
First Author: Ko HR
Year: 2019
Journal: J Biol Chem
Title: SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development.
Volume: 294
Issue: 42
Pages: 15435-15445
Publication  
First Author: Bergeron Y
Year: 2017
Journal: Front Mol Neurosci
Title: Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice.
Volume: 10
Pages: 102
Publication
First Author: Gu S
Year: 2020
Journal: Aging (Albany NY)
Title: AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling.
Volume: 12
Issue: 8
Pages: 6928-6946
Publication
First Author: Zhu LP
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3).
Volume: 37
Issue: 5
Pages: 957-968
Publication
First Author: Corum DG
Year: 2014
Journal: FASEB J
Title: AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.
Volume: 28
Issue: 1
Pages: 395-407
Publication  
First Author: Coffer PJ
Year: 1998
Journal: Biochem J
Title: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
Volume: 335 ( Pt 1)
Pages: 1-13
Publication
First Author: Tokuda S
Year: 2011
Journal: Hum Mol Genet
Title: A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice.
Volume: 20
Issue: 5
Pages: 988-99
Publication
First Author: Tsiperson V
Year: 2013
Journal: J Immunol
Title: Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling.
Volume: 190
Issue: 4
Pages: 1528-39
Publication
First Author: Polytarchou C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox.
Volume: 117
Issue: 46
Pages: 28806-28815
Publication
First Author: Zhang X
Year: 2019
Journal: Stem Cells
Title: AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.
Volume: 37
Issue: 8
Pages: 1095-1107
Publication
First Author: Wang H
Year: 2017
Journal: CNS Neurosci Ther
Title: Impaired Spatial Learning is Associated with Disrupted Integrity of the White Matter in Akt3 Knockout Mice.
Volume: 23
Issue: 1
Pages: 99-102
Publication
First Author: Boland E
Year: 2007
Journal: Am J Hum Genet
Title: Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum.
Volume: 81
Issue: 2
Pages: 292-303
Publication
First Author: Brand Y
Year: 2015
Journal: PLoS One
Title: All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.
Volume: 10
Issue: 3
Pages: e0121599
Publication
First Author: Dummler B
Year: 2006
Journal: Mol Cell Biol
Title: Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies.
Volume: 26
Issue: 21
Pages: 8042-51
Publication
First Author: Murthy SS
Year: 2000
Journal: Cytogenet Cell Genet
Title: Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization.
Volume: 88
Issue: 1-2
Pages: 38-40
Publication
First Author: Li G
Year: 2007
Journal: J Neurosci
Title: Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death.
Volume: 27
Issue: 1
Pages: 203-11
Publication    
First Author: Wong H
Year: 2020
Journal: Elife
Title: Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders.
Volume: 9
Publication    
First Author: Levenga J
Year: 2017
Journal: Elife
Title: AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.
Volume: 6
Publication
First Author: Babaev VR
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice.
Volume: 39
Issue: 2
Pages: 156-169
Publication
First Author: Hollander MC
Year: 2011
Journal: Oncogene
Title: Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Volume: 30
Issue: 15
Pages: 1812-21
Publication
First Author: Linnerth-Petrik NM
Year: 2014
Journal: PLoS One
Title: Opposing functions of Akt isoforms in lung tumor initiation and progression.
Volume: 9
Issue: 4
Pages: e94595
Publication
First Author: Valls Serón M
Year: 2016
Journal: Acta Neuropathol Commun
Title: V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.
Volume: 4
Issue: 1
Pages: 50
Publication
First Author: Howell KR
Year: 2017
Journal: PLoS One
Title: PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia.
Volume: 12
Issue: 5
Pages: e0175993
Publication  
First Author: DuBois JC
Year: 2019
Journal: Front Immunol
Title: Akt3-Mediated Protection Against Inflammatory Demyelinating Disease.
Volume: 10
Pages: 1738
Publication
First Author: Wang Q
Year: 2016
Journal: Cancer Cell
Title: Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.
Volume: 29
Issue: 4
Pages: 523-535
Publication
First Author: Matheny RW Jr
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts.
Volume: 389
Issue: 1
Pages: 117-21
Publication
First Author: Yang ZZ
Year: 2005
Journal: Mol Cell Biol
Title: Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice.
Volume: 25
Issue: 23
Pages: 10407-18
Publication
First Author: Maroulakou IG
Year: 2007
Journal: Cancer Res
Title: Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.
Volume: 67
Issue: 1
Pages: 167-77
Publication
First Author: Levenga J
Year: 2021
Journal: Cereb Cortex Commun
Title: Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT's Role in Complex Brain Disorders and Neurological Disease.
Volume: 2
Issue: 2
Pages: tgab036
Publication
First Author: Nawa M
Year: 2008
Journal: Cell Signal
Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.
Volume: 20
Issue: 3
Pages: 493-505
Publication
First Author: Chen WS
Year: 2009
Journal: Mol Cell Biol
Title: Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.
Volume: 29
Issue: 11
Pages: 3151-62
Publication
First Author: Mao C
Year: 2007
Journal: J Immunol
Title: Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.
Volume: 178
Issue: 9
Pages: 5443-53
Publication
First Author: O'Brien KA
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.
Volume: 32
Issue: 9
Pages: 2232-40
Publication
First Author: Kanekura K
Year: 2005
Journal: J Biol Chem
Title: A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death.
Volume: 280
Issue: 6
Pages: 4532-43
Publication
First Author: Domènech-Estévez E
Year: 2016
Journal: J Neurosci
Title: Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS.
Volume: 36
Issue: 16
Pages: 4506-21
Publication  
First Author: Sanchez-Gurmaches J
Year: 2019
Journal: Mol Metab
Title: Brown fat organogenesis and maintenance requires AKT1 and AKT2.
Volume: 23
Pages: 60-74
Publication
First Author: Rajala A
Year: 2013
Journal: J Biol Chem
Title: Insulin receptor signaling in cones.
Volume: 288
Issue: 27
Pages: 19503-15
Publication  
First Author: Zhu Z
Year: 2019
Journal: Life Sci Alliance
Title: The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.
Volume: 2
Issue: 6
Publication
First Author: Muendlein HI
Year: 2020
Journal: Cell Rep
Title: Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation.
Volume: 30
Issue: 3
Pages: 699-713.e4
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Brodbeck D
Year: 1999
Journal: J Biol Chem
Title: A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain.
Volume: 274
Issue: 14
Pages: 9133-6
Publication
First Author: Brodbeck D
Year: 2001
Journal: J Biol Chem
Title: Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain.
Volume: 276
Issue: 31
Pages: 29550-8
Publication
First Author: Tschopp O
Year: 2005
Journal: Development
Title: Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis.
Volume: 132
Issue: 13
Pages: 2943-54
GXD Expression        
Probe: MGI:3842962
Assay Type: Western blot
Annotation Date: 2009-05-06
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876727
Stage: TS27
Assay Id: MGI:3843032
Age: postnatal newborn
Specimen Label: Spleen
Specimen Num: 8
GXD Expression    
Probe: MGI:6369374
Assay Type: Western blot
Annotation Date: 2019-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6369447
Age: postnatal adult
Image: 2
Specimen Label: WT
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:6369374
Assay Type: Western blot
Annotation Date: 2019-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6369447
Age: postnatal adult
Image: 2
Specimen Label: Ex5-KO
Detected: true
Specimen Num: 20
GXD Expression    
Probe: MGI:6369374
Assay Type: Western blot
Annotation Date: 2019-11-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6369447
Age: postnatal adult
Image: 2
Specimen Label: Ex1-KO
Detected: true
Specimen Num: 21
GXD Expression    
Probe: MGI:7344376
Assay Type: RT-PCR
Annotation Date: 2022-10-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:7344390
Age: postnatal
Image: 1
Specimen Label: Spleen
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3842962
Assay Type: Western blot
Annotation Date: 2009-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:3843032
Age: postnatal newborn
Specimen Label: Kidney
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5304505
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304509
Age: postnatal
Image: 4
Specimen Label: Normal1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5304505
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304509
Age: postnatal
Image: 4
Specimen Label: Normal2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5304505
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304509
Age: postnatal
Image: 4
Specimen Label: Normal3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5304505
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304509
Age: postnatal
Image: 4
Specimen Label: Normal4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5304506
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304512
Age: postnatal
Image: 4
Specimen Label: Normal1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5304506
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304512
Age: postnatal
Image: 4
Specimen Label: Normal2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5304506
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304512
Age: postnatal
Image: 4
Specimen Label: Normal3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5304506
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304512
Age: postnatal
Image: 4
Specimen Label: Normal4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5304371
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304519
Age: postnatal
Image: 4
Specimen Label: Normal1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5304371
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304519
Age: postnatal
Image: 4
Specimen Label: Normal2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5304371
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304519
Age: postnatal
Image: 4
Specimen Label: Normal3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5304371
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304519
Age: postnatal
Image: 4
Specimen Label: Normal4
Detected: true
Specimen Num: 4