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Search results 1 to 100 out of 825 for Alk

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Drosophila melanogaster
Protein Domain
Type: Family
Description: ALK tyrosine kinase receptor (also known as anaplastic lymphoma kinase, ALK) is a neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system [].ALK transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 [, , ]. ALK acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation [, ]. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Motegi A
Year: 2004
Journal: J Cell Sci
Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Volume: 117
Issue: Pt 15
Pages: 3319-29
Protein
Organism: Mus musculus
Length: 1621  
Fragment?: false
Publication
First Author: Degoutin J
Year: 2007
Journal: FEBS Lett
Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.
Volume: 581
Issue: 4
Pages: 727-34
Publication
First Author: Orthofer M
Year: 2020
Journal: Cell
Title: Identification of ALK in Thinness.
Volume: 181
Issue: 6
Pages: 1246-1262.e22
Publication
First Author: Souttou B
Year: 2001
Journal: J Biol Chem
Title: Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.
Volume: 276
Issue: 12
Pages: 9526-31
Publication
First Author: Bowden ET
Year: 2002
Journal: J Biol Chem
Title: Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.
Volume: 277
Issue: 39
Pages: 35862-8
Publication
First Author: Stoica GE
Year: 2001
Journal: J Biol Chem
Title: Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.
Volume: 276
Issue: 20
Pages: 16772-9
Publication
First Author: Stoica GE
Year: 2002
Journal: J Biol Chem
Title: Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.
Volume: 277
Issue: 39
Pages: 35990-8
Publication
First Author: Vernersson E
Year: 2006
Journal: Gene Expr Patterns
Title: Characterization of the expression of the ALK receptor tyrosine kinase in mice.
Volume: 6
Issue: 5
Pages: 448-61
Publication
First Author: Degoutin J
Year: 2009
Journal: Eur J Neurosci
Title: ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction.
Volume: 29
Issue: 2
Pages: 275-86
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Lopez-Delisle L
Year: 2014
Journal: Oncotarget
Title: Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.
Volume: 5
Issue: 9
Pages: 2703-13
Publication
First Author: Ono S
Year: 2019
Journal: Genesis
Title: Generation of conditional ALK F1174L mutant mouse models for the study of neuroblastoma pathogenesis.
Volume: 57
Issue: 10
Pages: e23323
Publication
First Author: Iwahara T
Year: 1997
Journal: Oncogene
Title: Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.
Volume: 14
Issue: 4
Pages: 439-49
Publication
First Author: Piva R
Year: 2006
Journal: Blood
Title: Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas.
Volume: 107
Issue: 2
Pages: 689-97
Publication
First Author: Witek B
Year: 2015
Journal: PLoS One
Title: Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism.
Volume: 10
Issue: 5
Pages: e0123542
Publication
First Author: Lopez-Delisle L
Year: 2018
Journal: Oncogene
Title: Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.
Volume: 37
Issue: 11
Pages: 1417-1429
Publication
First Author: Cazes A
Year: 2014
Journal: Oncotarget
Title: Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma.
Volume: 5
Issue: 9
Pages: 2688-702
Publication  
First Author: Lu J
Year: 2017
Journal: Cancer Lett
Title: The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.
Volume: 400
Pages: 61-68
Publication
First Author: Ouyang T
Year: 2003
Journal: J Biol Chem
Title: Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
Volume: 278
Issue: 32
Pages: 30028-36
Publication  
First Author: Gualandi M
Year: 2020
Journal: Life Sci Alliance
Title: Oncogenic ALK F1174L drives tumorigenesis in cutaneous squamous cell carcinoma.
Volume: 3
Issue: 6
Protein
Organism: Mus musculus
Length: 127  
Fragment?: false
Protein
Organism: Mus musculus
Length: 151  
Fragment?: false
Gene
Type: gene
Organism: Rattus norvegicus
Author
Publication
First Author: Lasek AW
Year: 2011
Journal: PLoS One
Title: An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.
Volume: 6
Issue: 7
Pages: e22636
Publication
First Author: Weiss JB
Year: 2012
Journal: Pharmacol Biochem Behav
Title: Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.
Volume: 100
Issue: 3
Pages: 566-74
Publication
First Author: Lovly CM
Year: 2014
Journal: Nat Med
Title: Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.
Volume: 20
Issue: 9
Pages: 1027-34
Publication
First Author: Jamin Y
Year: 2014
Journal: PLoS One
Title: Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma.
Volume: 9
Issue: 3
Pages: e92886
Publication  
First Author: Weiss JB
Year: 2017
Journal: Behav Brain Res
Title: Pharmacological inhibition of Anaplastic Lymphoma Kinase rescues spatial memory impairments in Neurofibromatosis 1 mutant mice.
Volume: 332
Pages: 337-342
Publication  
First Author: Weiss JB
Year: 2017
Journal: Behav Brain Res
Title: Genetic inhibition of Anaplastic Lymphoma Kinase rescues cognitive impairments in Neurofibromatosis 1 mutant mice.
Volume: 321
Pages: 148-156
Publication
First Author: Berry T
Year: 2012
Journal: Cancer Cell
Title: The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma.
Volume: 22
Issue: 1
Pages: 117-30
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Danio rerio
Publication
First Author: Bilsland JG
Year: 2008
Journal: Neuropsychopharmacology
Title: Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.
Volume: 33
Issue: 3
Pages: 685-700
Publication
First Author: Chun MG
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis.
Volume: 107
Issue: 40
Pages: 17268-73
Publication
First Author: Blasco RB
Year: 2014
Journal: Cell Rep
Title: Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology.
Volume: 9
Issue: 4
Pages: 1219-27
Publication
First Author: Morris SW
Year: 1997
Journal: Oncogene
Title: ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
Volume: 14
Issue: 18
Pages: 2175-88
Publication
First Author: Chiarle R
Year: 2008
Journal: Nat Med
Title: The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.
Volume: 14
Issue: 6
Pages: 676-80
Publication
First Author: Azarova AM
Year: 2011
Journal: Semin Cancer Biol
Title: Emerging importance of ALK in neuroblastoma.
Volume: 21
Issue: 4
Pages: 267-75
Publication
First Author: Ueda T
Year: 2016
Journal: Oncogene
Title: ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.
Volume: 35
Issue: 34
Pages: 4447-58
Publication
First Author: Gonzalez Malagon SG
Year: 2018
Journal: Nat Commun
Title: Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus.
Volume: 9
Issue: 1
Pages: 1126
Publication
First Author: Martinengo C
Year: 2014
Journal: Cancer Res
Title: ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis.
Volume: 74
Issue: 21
Pages: 6094-106
Publication
First Author: Lange K
Year: 2003
Journal: Oncogene
Title: Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.
Volume: 22
Issue: 4
Pages: 517-27
Interaction Term
Interaction Term
Publication
First Author: Reshetnyak AV
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
Volume: 112
Issue: 52
Pages: 15862-7
Publication
First Author: Heukamp LC
Year: 2012
Journal: Sci Transl Med
Title: Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.
Volume: 4
Issue: 141
Pages: 141ra91
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:5750208
Assay Type: Western blot
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:5750209
Age: postnatal adult
Image: S2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5750208
Assay Type: Western blot
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:5750209
Age: postnatal adult
Image: S2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5750208
Assay Type: Western blot
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:5750209
Age: postnatal adult
Image: S2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3640080
Assay Type: Immunohistochemistry
Annotation Date: 2006-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3640131
Age: embryonic day 10.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3640080
Assay Type: Immunohistochemistry
Annotation Date: 2006-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3640131
Age: embryonic day 11.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1698120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3640085
Age: embryonic day 12.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1698121
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3640085
Age: embryonic day 13.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1698122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3640085
Age: embryonic day 14.5
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1698120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3640085
Age: embryonic day 12.5
Image: 1f
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1698121
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3640085
Age: embryonic day 13.5
Detected: true
Specimen Num: 28
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1698122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3640085
Age: embryonic day 14.5
Detected: true
Specimen Num: 29
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:3640085
Age: embryonic day 12.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3640085
Age: embryonic day 13.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3640085
Age: embryonic day 14.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3640085
Age: embryonic day 16.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3640078
Assay Type: RNA in situ
Annotation Date: 2006-08-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270423
Stage: TS23
Assay Id: MGI:3640085
Age: embryonic day 15.5
Detected: false
Specimen Num: 30
GXD Expression  
Probe: MGI:5750206
Assay Type: RNA in situ
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3588326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5750210
Age: embryonic day 18.5
Image: 3A Vn WT
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:5750206
Assay Type: RNA in situ
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3588326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5750210
Age: embryonic day 18.5
Image: 3A Vn HM
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:5750206
Assay Type: RNA in situ
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3588326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5750210
Age: embryonic day 18.5
Image: 3B Vn WT
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:5750206
Assay Type: RNA in situ
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3588326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5750210
Age: embryonic day 18.5
Image: 3B Vn HM
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:5750206
Assay Type: RNA in situ
Annotation Date: 2016-02-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3588327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5750210
Age: postnatal day 0
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:4884532
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691619
Stage: TS19
Assay Id: MGI:4945862
Age: embryonic day 11.5
Image: g01860 E11.5
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:4884532
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945862
Age: embryonic day 15.5
Image: g01860 E15.5
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 2