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Search results 1 to 66 out of 66 for Alkal1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
389658 | ALKAL1
Type: gene
Organism: human
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Gene
100297122 | ALKAL1
Type: gene
Organism: cattle
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Gene
100910984 | Alkal1
Type: gene
Organism: rat
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Gene
100535009 | alkal1
Type: gene
Organism: zebrafish
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Gene
717570 | ALKAL1
Type: gene
Organism: macaque, rhesus
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Gene
100487397 | alkal1
Type: gene
Organism: frog, western clawed
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Gene
608857 | ALKAL1
Type: gene
Organism: dog, domestic
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Gene
739899 | ALKAL1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:3645495 | Alkal1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0013931 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0015819 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0015801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0015760 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0015757 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3645495 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015663 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0015736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0015687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016256 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0014955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023887 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0014735 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
35412887 | J:324631
First Author: Ahmed M
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: A hypothalamic pathway for Augmentor α-controlled body weight regulation.
Volume: 119
Issue: 16
Pages: e2200476119
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Publication
25331893 | J:216664
First Author: Zhang H
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.
Volume: 111
Issue: 44
Pages: 15741-5
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Protein
Q80UG6
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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Protein
J3QPP8
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Publication
26630010 | -
First Author: Reshetnyak AV
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
Volume: 112
Issue: 52
Pages: 15862-7
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Publication
26418745 | -
 
First Author: Guan J
Year: 2015
Journal: Elife
Title: FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.
Volume: 4
Pages: e09811
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Publication
34819673 | -
First Author: Reshetnyak AV
Year: 2021
Journal: Nature
Title: Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Volume: 600
Issue: 7887
Pages: 153-157
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Protein Domain
IPR029364 | ALKL1/2
Type: Family
Description: This entry includes ALK and LTK ligand 1 and 2 (ALKL1/2, also known as FAM150A and FAM150B, respectively) from vertebrates. ALKL1/2 are activating ligands for the receptor anaplastic lymphoma kinase (ALK) and the receptor leukocyte tyrosine kinase (LTK) [, ]. However, ALKL1 does not act as a potent physiological ligand for ALK, in contrast to ALKL2 [, ]. Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation [, ]. It is not yet clear if ALKL2 activates ALK as a homodimer or a monomer [, ].
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Publication
34646012 | -
First Author: De Munck S
Year: 2021
Journal: Nature
Title: Structural basis of cytokine-mediated activation of ALK family receptors.
Volume: 600
Issue: 7887
Pages: 143-147
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Publication
9223670 | -
First Author: Ueno H
Year: 1997
Journal: Oncogene
Title: The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Volume: 14
Issue: 25
Pages: 3067-72
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Publication
18849880 | -
First Author: Yamada S
Year: 2008
Journal: Neuroreport
Title: Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.
Volume: 19
Issue: 17
Pages: 1733-8
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Publication
20548102 | -
First Author: Farhan H
Year: 2010
Journal: J Cell Biol
Title: MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.
Volume: 189
Issue: 6
Pages: 997-1011
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Publication
10445845 | J:227540
First Author: Honda H
Year: 1999
Journal: Oncogene
Title: Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.
Volume: 18
Issue: 26
Pages: 3821-30
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Publication
30061385 | -
First Author: Reshetnyak AV
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Volume: 115
Issue: 33
Pages: 8340-8345
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Protein Domain
IPR026984 | LTK
Type: Family
Description: Leukocyte tyrosine kinase (LTK) receptor is an orphan receptor with a tyrosine-protein kinase activity [, , ]. This receptor is activated by ALKAL1 or ALKAL2 ligands at the cell surface and transduces an extracellular signal into an intracellular response [, ]. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway [].The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. LTK is involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport [, , ].
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Protein
P08923
Organism: Mus musculus/domesticus
Length: 888  
Fragment?: false
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Protein
B9EJ30
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Protein
F6V2R5
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
A0A804AW03
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
Q0VGZ5
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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