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Search results 1 to 94 out of 94 for Alkal2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
285016 | ALKAL2
Type: gene
Organism: human
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Gene
100379943 | alkal2
Type: gene
Organism: frog, western clawed
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Gene
679566 | Alkal2
Type: gene
Organism: rat
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Gene
742338 | ALKAL2
Type: gene
Organism: chimpanzee
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Gene
616690 | ALKAL2
Type: gene
Organism: cattle
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Gene
721400 | ALKAL2
Type: gene
Organism: macaque, rhesus
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Gene
102155602 | ALKAL2
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:3697448 | Alkal2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
35608912 | J:348090
 
First Author: Defaye M
Year: 2022
Journal: J Clin Invest
Title: The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain.
Volume: 132
Issue: 12
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Protein Coding Gene
MGP_CAROLIEiJ_G0017669 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019653 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019597 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019401 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3697448 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018956 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019372 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019486 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019556 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029427 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018511 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7544035
Age: embryonic day 15.5
Image: EV1
Specimen Label: E15.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7544035
Age: postnatal day 0
Image: EV1
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7544035
Age: postnatal day 2
Image: EV1
Specimen Label: P2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7544035
Age: postnatal day 7
Image: EV1
Specimen Label: P7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7544035
Age: postnatal adult
Image: EV1
Specimen Label: Adult
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7544037
Age: embryonic day 15.5
Image: EV1
Specimen Label: E15.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7544037
Age: postnatal day 0
Image: EV1
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7544037
Age: postnatal day 2
Image: EV1
Specimen Label: P2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7544037
Age: postnatal day 7
Image: EV1
Specimen Label: P7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7544037
Age: postnatal adult
Image: EV1
Specimen Label: Adult
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7544916
Age: embryonic day 15.5
Image: EV3
Specimen Label: E15.5 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7544916
Age: postnatal day 20
Image: EV3
Specimen Label: P20 WT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7544916
Age: postnatal month 3-6
Image: EV3
Specimen Label: Adult WT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:7544916
Age: embryonic day 15.5
Image: EV3
Specimen Label: E15.5 DKO
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7544916
Age: postnatal day 20
Image: EV3
Specimen Label: P20 DKO
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7543997
Assay Type: RT-PCR
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7544916
Age: postnatal month 3-6
Image: EV3
Specimen Label: Adult DKO
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1B
Specimen Label: EV1B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1A
Specimen Label: EV1A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1D
Specimen Label: EV1D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1E
Specimen Label: EV1E
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3585923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1E
Note: Expression was detected in the ventrolateral thalamic nucleus.
Specimen Label: EV1E
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1E
Note: Expression was detected in the hypothalamic area.
Specimen Label: EV1E
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1A
Specimen Label: EV1A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1E
Note: Expression was detected in the amygdaloid area.
Specimen Label: EV1E
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1A
Specimen Label: EV1A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1D
Specimen Label: EV1D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1E
Note: Expression was detected in the lateral olfactory bulb.
Specimen Label: EV1E
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:7544009
Assay Type: RNA in situ
Annotation Date: 2023-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7544901
Age: embryonic day 15.5
Image: EV1F
Specimen Label: EV1F
Detected: true
Specimen Num: 5
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Publication
35412887 | J:324631
First Author: Ahmed M
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: A hypothalamic pathway for Augmentor α-controlled body weight regulation.
Volume: 119
Issue: 16
Pages: e2200476119
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Publication
25331893 | J:216664
First Author: Zhang H
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.
Volume: 111
Issue: 44
Pages: 15741-5
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Publication
37291945 | J:338243
First Author: Christova T
Year: 2023
Journal: EMBO Rep
Title: LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
Volume: 24
Issue: 7
Pages: e56937
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
33411331 | J:304012
First Author: Borenäs M
Year: 2021
Journal: EMBO J
Title: ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
Volume: 40
Issue: 3
Pages: e105784
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Allele
Alkal2<em1Smoc> | MGI:7288232
Name: ALK and LTK ligand 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7717938 | C57BL/6JSmoc-Alkal2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
9223670 | -
First Author: Ueno H
Year: 1997
Journal: Oncogene
Title: The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Volume: 14
Issue: 25
Pages: 3067-72
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Publication
18849880 | -
First Author: Yamada S
Year: 2008
Journal: Neuroreport
Title: Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.
Volume: 19
Issue: 17
Pages: 1733-8
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Publication
20548102 | -
First Author: Farhan H
Year: 2010
Journal: J Cell Biol
Title: MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.
Volume: 189
Issue: 6
Pages: 997-1011
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Publication
10445845 | J:227540
First Author: Honda H
Year: 1999
Journal: Oncogene
Title: Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.
Volume: 18
Issue: 26
Pages: 3821-30
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Publication
30061385 | -
First Author: Reshetnyak AV
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Volume: 115
Issue: 33
Pages: 8340-8345
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Protein Domain
IPR026984 | LTK
Type: Family
Description: Leukocyte tyrosine kinase (LTK) receptor is an orphan receptor with a tyrosine-protein kinase activity [, , ]. This receptor is activated by ALKAL1 or ALKAL2 ligands at the cell surface and transduces an extracellular signal into an intracellular response [, ]. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway [].The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. LTK is involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport [, , ].
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Publication
34646012 | -
First Author: De Munck S
Year: 2021
Journal: Nature
Title: Structural basis of cytokine-mediated activation of ALK family receptors.
Volume: 600
Issue: 7887
Pages: 143-147
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Protein
P08923
Organism: Mus musculus/domesticus
Length: 888  
Fragment?: false
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Protein
B9EJ30
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Protein
F6V2R5
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
A0A804AW03
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
Q0VGZ5
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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