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Search results 1 to 92 out of 92 for Alkbh2

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
121642 | ALKBH2
Type: gene
Organism: human
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Gene
511380 | ALKBH2
Type: gene
Organism: cattle
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Gene
416897 | ALKBH2
Type: gene
Organism: chicken
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Gene
569291 | alkbh2
Type: gene
Organism: zebrafish
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Gene
706708 | ALKBH2
Type: gene
Organism: macaque, rhesus
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Gene
100492480 | alkbh2
Type: gene
Organism: frog, western clawed
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Gene
107967636 | ALKBH2
Type: gene
Organism: chimpanzee
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Gene
304578 | Alkbh2
Type: gene
Organism: rat
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Gene
477524 | ALKBH2
Type: gene
Organism: dog, domestic
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Protein Domain
IPR032852 | ALKBH2
Type: Family
Description: AlkB is a dioxygenase that repairs alkylation damage to DNA and RNA []. AlkB homologues (ABHs) are found in all multicellular organisms, as well as in many bacteria and fungi, and some viruses []. Nine mammalian AlkB homologues exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes [].This entry represents AlkB homologue 2 (ALKBH2, ABH2), which has a strong preference for double-stranded DNA []. Together with alkyl-N-adenine-DNA glycosylase, comprises the cellular defence against 1,N(6)-ethenoadenine lesions []. ABH2 also has an important role in maintaining ribosomal DNA gene integrity and transcription []. This entry also includes uncharacterised bacterial homologues.
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Protein Coding Gene
MGI:2141032 | Alkbh2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18519673 | J:136424
First Author: Ringvoll J
Year: 2008
Journal: Cancer Res
Title: AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.
Volume: 68
Issue: 11
Pages: 4142-9
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Protein
Q6P6J4
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Publication
22429847 | J:316069
First Author: Nay SL
Year: 2012
Journal: DNA Repair (Amst)
Title: Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.
Volume: 11
Issue: 5
Pages: 502-10
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Publication
23972994 | -
First Author: Li P
Year: 2013
Journal: Cell Rep
Title: ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair.
Volume: 4
Issue: 4
Pages: 817-29
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Publication
18718927 | -
First Author: van den Born E
Year: 2008
Journal: Nucleic Acids Res
Title: Viral AlkB proteins repair RNA damage by oxidative demethylation.
Volume: 36
Issue: 17
Pages: 5451-61
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Publication
12594517 | -
First Author: Aas PA
Year: 2003
Journal: Nature
Title: Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Volume: 421
Issue: 6925
Pages: 859-63
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Publication
26152727 | -
First Author: Fedeles BI
Year: 2015
Journal: J Biol Chem
Title: The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.
Volume: 290
Issue: 34
Pages: 20734-42
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Publication
16642038 | J:108782
First Author: Ringvoll J
Year: 2006
Journal: EMBO J
Title: Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
Volume: 25
Issue: 10
Pages: 2189-98
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Publication
16174769 | J:104108
First Author: Lee DH
Year: 2005
Journal: J Biol Chem
Title: Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
Volume: 280
Issue: 47
Pages: 39448-59
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Publication
22684101 | J:190468
First Author: Calvo JA
Year: 2012
Journal: J Clin Invest
Title: DNA repair is indispensable for survival after acute inflammation.
Volume: 122
Issue: 7
Pages: 2680-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0027589 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029931 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029896 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029834 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029907 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2141032 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030361 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029035 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029594 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029744 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029833 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029732 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030402 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028749 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024171 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028587 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
28726787 | J:299035
First Author: Jordan JJ
Year: 2017
Journal: Cell Death Dis
Title: ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.
Volume: 8
Issue: 7
Pages: e2947
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: DNA oxidative demethylase ALKBH2
Type: chain
End: 239
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Protein
A0A0G2JER8
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
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Allele
Alkbh2<tm1Troc> | MGI:6833879
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase; targeted mutation 1, Timothy R O'Connor
Allele Type: Targeted
Attribute String: Null/knockout
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Protein Domain
IPR032862 | ALKBH6
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].AlkB homologue 6 (ALKBH6) is a probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. Its function is not known.
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Publication
23177736 | J:194218
First Author: Zheng G
Year: 2013
Journal: Mol Cell
Title: ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Volume: 49
Issue: 1
Pages: 18-29
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Publication
21264265 | -
First Author: Thalhammer A
Year: 2011
Journal: PLoS One
Title: Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).
Volume: 6
Issue: 1
Pages: e16210
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Publication
24778178 | -
First Author: Xu C
Year: 2014
Journal: J Biol Chem
Title: Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Volume: 289
Issue: 25
Pages: 17299-311
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Publication
24489119 | -
First Author: Aik W
Year: 2014
Journal: Nucleic Acids Res
Title: Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
Volume: 42
Issue: 7
Pages: 4741-54
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Protein Domain
IPR032860 | ALKBH5
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].ALKBH5 is an dioxygenase that has been shown to specifically demethylate m(6)A in single-stranded RNA [, , ]. Reversible m(6)A modification is one of the most abundant RNA modifications, and is probably involved in broad and fundamental functions in mammalian cells []. ALKBH5 may have a role in the regulation of cellular responses to hypoxia [].
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Publication
23673617 | J:205739
 
First Author: Li MM
Year: 2013
Journal: Nat Commun
Title: ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Volume: 4
Pages: 1832
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Protein
D6RFR9
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Protein
F7B4H2
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
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Publication
21166655 | -
First Author: Bjørnstad LG
Year: 2011
Journal: Biochem J
Title: Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4.
Volume: 434
Issue: 3
Pages: 391-8
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Publication
25936839 | -
First Author: Greer EL
Year: 2015
Journal: Cell
Title: DNA Methylation on N6-Adenine in C. elegans.
Volume: 161
Issue: 4
Pages: 868-78
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Protein Domain
IPR032857 | ALKBH4
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].ALKBH4 has been demonstrated to be an active Fe(II)/2OG-dependent decarboxylase in vitro[]. ALKBH4 mediates demethylation of actin and thereby regulates the actin-myosin II interaction. Depletion of ALKBH4 leads to defects in cytokinesis and cell motility [].This entry also includes Nmad-1, one of the five members of the ALKB family found in C. elegans, which is a 6mA DNA demethylase and may be involved in epigenetic inheritance [].
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Publication
26003568 | -
First Author: Ougland R
Year: 2015
Journal: J Mol Cell Biol
Title: Non-homologous functions of the AlkB homologs.
Volume: 7
Issue: 6
Pages: 494-504
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Protein
Q3TSG4
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q9D8F1
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
D3Z7X9
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
Q8K2U2
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
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Protein
D3Z1T0
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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