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Search results 1 to 100 out of 106 for Alkbh3

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Hits by Strain

Type Details Score
Gene
221120 | ALKBH3
Type: gene
Organism: human
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Gene
100495476 | alkbh3
Type: gene
Organism: frog, western clawed
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Gene
362169 | Alkbh3
Type: gene
Organism: rat
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Gene
475938 | ALKBH3
Type: gene
Organism: dog, domestic
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Gene
741336 | ALKBH3
Type: gene
Organism: chimpanzee
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Gene
514579 | ALKBH3
Type: gene
Organism: cattle
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Gene
423169 | ALKBH3
Type: gene
Organism: chicken
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Gene
792266 | alkbh3
Type: gene
Organism: zebrafish
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Gene
715921 | ALKBH3
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1916363 | Alkbh3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR032854 | ALKBH3
Type: Family
Description: AlkB proteins are dioxygenases that repair alkylation damage to DNA and RNA []. Nine mammalian AlkB homologues exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes [].This entry represents AlkB homologue 3 (ALKBH3, ABH3), which has a strong preference for single-stranded DNA also demethylates 1-methyladenine (1meA) and 3-methylcytosine (3meC) in RNA [, , ]. ALKBH3 is overexpressed in various cancers and contributes to cancer cell survival [, , ].
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Gene
100507300 | ALKBH3-AS1
Type: gene
Organism: human
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Publication
30541109 | J:273474
First Author: Chen Z
Year: 2019
Journal: Nucleic Acids Res
Title: Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.
Volume: 47
Issue: 5
Pages: 2533-2545
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Publication
26221185 | -
First Author: Liefke R
Year: 2015
Journal: Genome Med
Title: The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Volume: 7
Issue: 1
Pages: 66
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Publication
22850567 | -
First Author: Shimada K
Year: 2012
Journal: Clin Cancer Res
Title: ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and tweak/Fn14/VEGF signals.
Volume: 18
Issue: 19
Pages: 5247-55
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Publication
16858410 | -
First Author: Sundheim O
Year: 2006
Journal: EMBO J
Title: Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
Volume: 25
Issue: 14
Pages: 3389-97
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Publication
21285982 | -
First Author: Tasaki M
Year: 2011
Journal: Br J Cancer
Title: ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
Volume: 104
Issue: 4
Pages: 700-6
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Publication
15229293 | -
First Author: Falnes PØ
Year: 2004
Journal: Nucleic Acids Res
Title: Substrate specificities of bacterial and human AlkB proteins.
Volume: 32
Issue: 11
Pages: 3456-61
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Publication
22429847 | J:316069
First Author: Nay SL
Year: 2012
Journal: DNA Repair (Amst)
Title: Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.
Volume: 11
Issue: 5
Pages: 502-10
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Protein
A2AKV7
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Publication
26152727 | -
First Author: Fedeles BI
Year: 2015
Journal: J Biol Chem
Title: The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.
Volume: 290
Issue: 34
Pages: 20734-42
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Publication
12594517 | -
First Author: Aas PA
Year: 2003
Journal: Nature
Title: Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Volume: 421
Issue: 6925
Pages: 859-63
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Protein
Q8K1E6
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
A2AKV6
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
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Protein
S4R1M6
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Publication
22684101 | J:190468
First Author: Calvo JA
Year: 2012
Journal: J Clin Invest
Title: DNA repair is indispensable for survival after acute inflammation.
Volume: 122
Issue: 7
Pages: 2680-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0023995 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026144 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026153 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025904 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026604 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026018 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025981 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026122 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025436 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025431 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024905 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16642038 | J:108782
First Author: Ringvoll J
Year: 2006
Journal: EMBO J
Title: Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
Volume: 25
Issue: 10
Pages: 2189-98
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Publication
18519673 | J:136424
First Author: Ringvoll J
Year: 2008
Journal: Cancer Res
Title: AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.
Volume: 68
Issue: 11
Pages: 4142-9
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Publication
16174769 | J:104108
First Author: Lee DH
Year: 2005
Journal: J Biol Chem
Title: Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
Volume: 280
Issue: 47
Pages: 39448-59
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Publication
37198424 | J:335822
First Author: Capriati M
Year: 2023
Journal: Sci Rep
Title: Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites.
Volume: 13
Issue: 1
Pages: 8003
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Alkbh3<em1Smoc> | MGI:7288234
Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Alkbh3<tm1Troc> | MGI:6833880
Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase; targeted mutation 1, Timothy R O'Connor
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:6354533 | C57BL/6JSmoc-Alkbh3<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein Domain
IPR032862 | ALKBH6
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].AlkB homologue 6 (ALKBH6) is a probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. Its function is not known.
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Publication
23177736 | J:194218
First Author: Zheng G
Year: 2013
Journal: Mol Cell
Title: ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Volume: 49
Issue: 1
Pages: 18-29
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Publication
21264265 | -
First Author: Thalhammer A
Year: 2011
Journal: PLoS One
Title: Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).
Volume: 6
Issue: 1
Pages: e16210
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Publication
24778178 | -
First Author: Xu C
Year: 2014
Journal: J Biol Chem
Title: Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Volume: 289
Issue: 25
Pages: 17299-311
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Publication
24489119 | -
First Author: Aik W
Year: 2014
Journal: Nucleic Acids Res
Title: Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
Volume: 42
Issue: 7
Pages: 4741-54
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Protein Domain
IPR032860 | ALKBH5
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].ALKBH5 is an dioxygenase that has been shown to specifically demethylate m(6)A in single-stranded RNA [, , ]. Reversible m(6)A modification is one of the most abundant RNA modifications, and is probably involved in broad and fundamental functions in mammalian cells []. ALKBH5 may have a role in the regulation of cellular responses to hypoxia [].
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Publication
23673617 | J:205739
 
First Author: Li MM
Year: 2013
Journal: Nat Commun
Title: ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Volume: 4
Pages: 1832
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Protein
D6RFR9
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Protein
F7B4H2
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
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Publication
21166655 | -
First Author: Bjørnstad LG
Year: 2011
Journal: Biochem J
Title: Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4.
Volume: 434
Issue: 3
Pages: 391-8
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Publication
25936839 | -
First Author: Greer EL
Year: 2015
Journal: Cell
Title: DNA Methylation on N6-Adenine in C. elegans.
Volume: 161
Issue: 4
Pages: 868-78
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Protein Domain
IPR032857 | ALKBH4
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].ALKBH4 has been demonstrated to be an active Fe(II)/2OG-dependent decarboxylase in vitro[]. ALKBH4 mediates demethylation of actin and thereby regulates the actin-myosin II interaction. Depletion of ALKBH4 leads to defects in cytokinesis and cell motility [].This entry also includes Nmad-1, one of the five members of the ALKB family found in C. elegans, which is a 6mA DNA demethylase and may be involved in epigenetic inheritance [].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
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