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Search results 1 to 100 out of 102 for Alkbh3

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: AlkB proteins are dioxygenases that repair alkylation damage to DNA and RNA []. Nine mammalian AlkB homologues exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes [].This entry represents AlkB homologue 3 (ALKBH3, ABH3), which has a strong preference for single-stranded DNA also demethylates 1-methyladenine (1meA) and 3-methylcytosine (3meC) in RNA [, , ]. ALKBH3 is overexpressed in various cancers and contributes to cancer cell survival [, , ].
Gene
Type: gene
Organism: human
Publication
First Author: Chen Z
Year: 2019
Journal: Nucleic Acids Res
Title: Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.
Volume: 47
Issue: 5
Pages: 2533-2545
Publication
First Author: Liefke R
Year: 2015
Journal: Genome Med
Title: The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.
Volume: 7
Issue: 1
Pages: 66
Publication
First Author: Shimada K
Year: 2012
Journal: Clin Cancer Res
Title: ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and tweak/Fn14/VEGF signals.
Volume: 18
Issue: 19
Pages: 5247-55
Publication
First Author: Sundheim O
Year: 2006
Journal: EMBO J
Title: Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
Volume: 25
Issue: 14
Pages: 3389-97
Publication
First Author: Tasaki M
Year: 2011
Journal: Br J Cancer
Title: ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
Volume: 104
Issue: 4
Pages: 700-6
Publication
First Author: Falnes PØ
Year: 2004
Journal: Nucleic Acids Res
Title: Substrate specificities of bacterial and human AlkB proteins.
Volume: 32
Issue: 11
Pages: 3456-61
Publication
First Author: Nay SL
Year: 2012
Journal: DNA Repair (Amst)
Title: Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.
Volume: 11
Issue: 5
Pages: 502-10
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
Publication
First Author: Fedeles BI
Year: 2015
Journal: J Biol Chem
Title: The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.
Volume: 290
Issue: 34
Pages: 20734-42
Publication
First Author: Aas PA
Year: 2003
Journal: Nature
Title: Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Volume: 421
Issue: 6925
Pages: 859-63
Protein
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
Publication
First Author: Calvo JA
Year: 2012
Journal: J Clin Invest
Title: DNA repair is indispensable for survival after acute inflammation.
Volume: 122
Issue: 7
Pages: 2680-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ringvoll J
Year: 2006
Journal: EMBO J
Title: Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
Volume: 25
Issue: 10
Pages: 2189-98
Publication
First Author: Ringvoll J
Year: 2008
Journal: Cancer Res
Title: AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.
Volume: 68
Issue: 11
Pages: 4142-9
Publication
First Author: Lee DH
Year: 2005
Journal: J Biol Chem
Title: Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
Volume: 280
Issue: 47
Pages: 39448-59
Publication
First Author: Capriati M
Year: 2023
Journal: Sci Rep
Title: Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites.
Volume: 13
Issue: 1
Pages: 8003
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Allele
Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase; targeted mutation 1, Timothy R O'Connor
Allele Type: Targeted
Attribute String: Null/knockout
Protein Domain
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].AlkB homologue 6 (ALKBH6) is a probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. Its function is not known.
Publication
First Author: Zheng G
Year: 2013
Journal: Mol Cell
Title: ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Volume: 49
Issue: 1
Pages: 18-29
Publication
First Author: Thalhammer A
Year: 2011
Journal: PLoS One
Title: Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).
Volume: 6
Issue: 1
Pages: e16210
Publication
First Author: Xu C
Year: 2014
Journal: J Biol Chem
Title: Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Volume: 289
Issue: 25
Pages: 17299-311
Publication
First Author: Aik W
Year: 2014
Journal: Nucleic Acids Res
Title: Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
Volume: 42
Issue: 7
Pages: 4741-54
Protein Domain
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].ALKBH5 is an dioxygenase that has been shown to specifically demethylate m(6)A in single-stranded RNA [, , ]. Reversible m(6)A modification is one of the most abundant RNA modifications, and is probably involved in broad and fundamental functions in mammalian cells []. ALKBH5 may have a role in the regulation of cellular responses to hypoxia [].
Publication  
First Author: Li MM
Year: 2013
Journal: Nat Commun
Title: ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Volume: 4
Pages: 1832
Protein
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
Publication
First Author: Bjørnstad LG
Year: 2011
Journal: Biochem J
Title: Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4.
Volume: 434
Issue: 3
Pages: 391-8
Publication
First Author: Greer EL
Year: 2015
Journal: Cell
Title: DNA Methylation on N6-Adenine in C. elegans.
Volume: 161
Issue: 4
Pages: 868-78
Protein Domain
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].ALKBH4 has been demonstrated to be an active Fe(II)/2OG-dependent decarboxylase in vitro[]. ALKBH4 mediates demethylation of actin and thereby regulates the actin-myosin II interaction. Depletion of ALKBH4 leads to defects in cytokinesis and cell motility [].This entry also includes Nmad-1, one of the five members of the ALKB family found in C. elegans, which is a 6mA DNA demethylase and may be involved in epigenetic inheritance [].
Publication
First Author: Ougland R
Year: 2015
Journal: J Mol Cell Biol
Title: Non-homologous functions of the AlkB homologs.
Volume: 7
Issue: 6
Pages: 494-504
Protein
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true