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Search results 1 to 100 out of 120 for Alkbh5

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
54890 | ALKBH5
Type: gene
Organism: human
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Gene
533303 | ALKBH5
Type: gene
Organism: cattle
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Gene
770703 | ALKBH5
Type: gene
Organism: chicken
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Gene
570158 | alkbh5
Type: gene
Organism: zebrafish
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Gene
700205 | ALKBH5
Type: gene
Organism: macaque, rhesus
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Gene
493400 | alkbh5
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR032860 | ALKBH5
Type: Family
Description: Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [, ].ALKBH5 is an dioxygenase that has been shown to specifically demethylate m(6)A in single-stranded RNA [, , ]. Reversible m(6)A modification is one of the most abundant RNA modifications, and is probably involved in broad and fundamental functions in mammalian cells []. ALKBH5 may have a role in the regulation of cellular responses to hypoxia [].
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Gene
303193 | Alkbh5
Type: gene
Organism: rat
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Gene
609383 | ALKBH5
Type: gene
Organism: dog, domestic
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Gene
743473 | ALKBH5
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2144489 | Alkbh5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23177736 | J:194218
First Author: Zheng G
Year: 2013
Journal: Mol Cell
Title: ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Volume: 49
Issue: 1
Pages: 18-29
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Protein
Q3TSG4
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Publication
24778178 | -
First Author: Xu C
Year: 2014
Journal: J Biol Chem
Title: Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Volume: 289
Issue: 25
Pages: 17299-311
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Publication
24489119 | -
First Author: Aik W
Year: 2014
Journal: Nucleic Acids Res
Title: Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
Volume: 42
Issue: 7
Pages: 4741-54
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Publication
21264265 | -
First Author: Thalhammer A
Year: 2011
Journal: PLoS One
Title: Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).
Volume: 6
Issue: 1
Pages: e16210
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Publication
29279410 | J:258382
First Author: Tang C
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.
Volume: 115
Issue: 2
Pages: E325-E333
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Publication
37848452 | J:341728
First Author: Bai L
Year: 2023
Journal: Nat Commun
Title: ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N (6)-methyladenosine methylation.
Volume: 14
Issue: 1
Pages: 6532
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Publication
32402250 | J:342104
First Author: Shen C
Year: 2020
Journal: Cell Stem Cell
Title: RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Volume: 27
Issue: 1
Pages: 64-80.e9
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Publication
34134995 | J:338683
 
First Author: Zhou J
Year: 2021
Journal: Sci Adv
Title: m(6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity.
Volume: 7
Issue: 25
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Publication
37742191 | J:342103
First Author: Gao Y
Year: 2023
Journal: Cell Rep
Title: ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m(6)A modification-mediated RNA stability control.
Volume: 42
Issue: 10
Pages: 113163
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Publication
36859428 | J:340651
First Author: Chen J
Year: 2023
Journal: Nat Commun
Title: Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment.
Volume: 14
Issue: 1
Pages: 1161
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Publication
35939687 | J:340652
First Author: Ding C
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: RNA m(6)A demethylase ALKBH5 regulates the development of γδ T cells.
Volume: 119
Issue: 33
Pages: e2203318119
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Publication
34088896 | J:340511
First Author: Li Z
Year: 2021
Journal: Cell Death Dis
Title: The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6.
Volume: 12
Issue: 6
Pages: 578
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Publication
37524872 | J:340510
First Author: Ye G
Year: 2023
Journal: Exp Mol Med
Title: ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression.
Volume: 55
Issue: 8
Pages: 1743-1756
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Publication
26003568 | -
First Author: Ougland R
Year: 2015
Journal: J Mol Cell Biol
Title: Non-homologous functions of the AlkB homologs.
Volume: 7
Issue: 6
Pages: 494-504
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Publication
37169182 | J:339252
First Author: Zhai J
Year: 2023
Journal: Gastroenterology
Title: ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy.
Volume: 165
Issue: 2
Pages: 445-462
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Publication
26152727 | -
First Author: Fedeles BI
Year: 2015
Journal: J Biol Chem
Title: The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.
Volume: 290
Issue: 34
Pages: 20734-42
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Publication
32402251 | J:305976
First Author: Wang J
Year: 2020
Journal: Cell Stem Cell
Title: Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.
Volume: 27
Issue: 1
Pages: 81-97.e8
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Publication
35784864 | J:342106
 
First Author: Tian C
Year: 2022
Journal: Front Physiol
Title: Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.
Volume: 13
Pages: 923185
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Publication
38443404 | J:346173
First Author: Zhuang T
Year: 2024
Journal: Nat Commun
Title: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.
Volume: 15
Issue: 1
Pages: 1995
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Protein Coding Gene
MGP_CAROLIEiJ_G0016458 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018420 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018389 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018359 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2144489 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018812 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018147 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018256 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018247 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018329 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017501 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017781 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017588 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017293 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6276184
Assay Type: RT-PCR
Annotation Date: 2019-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6276186
Age: postnatal adult
Image: S10
Specimen Label: Auts2 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6276184
Assay Type: RT-PCR
Annotation Date: 2019-02-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6276186
Age: postnatal adult
Image: S10
Specimen Label: Auts2 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7433103
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434138
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433103
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434139
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434158
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434158
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434158
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434162
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434162
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434162
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7433103
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434181
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433103
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434192
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434201
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434201
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434201
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434202
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434202
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7433125
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434202
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7433103
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7434249
Age: embryonic day 18.0
Image: S5
Specimen Label: CONV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433103
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7434283
Age: embryonic day 18.0
Image: S1
Specimen Label: SPF
Detected: true
Specimen Num: 1
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Publication
10552926 | J:58614
First Author: Liang Y
Year: 1999
Journal: Genomics
Title: Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2.
Volume: 61
Issue: 3
Pages: 243-58
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Publication
35098923 | J:343961
   
First Author: Wang A
Year: 2022
Journal: Elife
Title: m6A modifications regulate intestinal immunity and rotavirus infection.
Volume: 11
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Publication
16174769 | J:104108
First Author: Lee DH
Year: 2005
Journal: J Biol Chem
Title: Repair of methylation damage in DNA and RNA by mammalian AlkB homologues.
Volume: 280
Issue: 47
Pages: 39448-59
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Publication
16818490 | J:116945
First Author: Simon GM
Year: 2006
Journal: J Biol Chem
Title: Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.
Volume: 281
Issue: 36
Pages: 26465-72
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Publication
25519132 | J:217675
First Author: Gao Z
Year: 2014
Journal: Nature
Title: An AUTS2-Polycomb complex activates gene expression in the CNS.
Volume: 516
Issue: 7531
Pages: 349-54
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Publication
17273973 | J:125240
First Author: Yan J
Year: 2007
Journal: Am J Hum Genet
Title: Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.
Volume: 80
Issue: 3
Pages: 518-25
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Publication
35874829 | J:327184
 
First Author: Xiao Z
Year: 2022
Journal: Front Cell Dev Biol
Title: The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.
Volume: 10
Pages: 882994
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Publication
37269288 | J:337931
First Author: Li L
Year: 2023
Journal: Cell Rep
Title: Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
Volume: 42
Issue: 6
Pages: 112596
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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