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Search results 1 to 100 out of 378 for Alox15

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0.128s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rabbit, European
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zhang W
Year: 2017
Journal: Sci Rep
Title: Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.
Volume: 7
Issue: 1
Pages: 8976
Publication
First Author: Klein RF
Year: 2004
Journal: Science
Title: Regulation of bone mass in mice by the lipoxygenase gene Alox15.
Volume: 303
Issue: 5655
Pages: 229-32
Publication
First Author: Sun D
Year: 1996
Journal: J Biol Chem
Title: Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein.
Volume: 271
Issue: 39
Pages: 24055-62
Publication
First Author: Huang JT
Year: 1999
Journal: Nature
Title: Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.
Volume: 400
Issue: 6742
Pages: 378-82
Publication
First Author: Miller YI
Year: 2001
Journal: J Biol Chem
Title: 12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells.
Volume: 276
Issue: 22
Pages: 19431-9
Publication
First Author: Kroschwald S
Year: 2018
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function.
Volume: 1863
Issue: 8
Pages: 866-880
Publication
First Author: Gronert K
Year: 2005
Journal: J Biol Chem
Title: A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense.
Volume: 280
Issue: 15
Pages: 15267-78
Publication
First Author: Uderhardt S
Year: 2012
Journal: Immunity
Title: 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance.
Volume: 36
Issue: 5
Pages: 834-46
Publication
First Author: Caravaca AS
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit.
Volume: 119
Issue: 22
Pages: e2023285119
Publication
First Author: Brütsch SH
Year: 2016
Journal: J Biol Chem
Title: Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene.
Volume: 291
Issue: 45
Pages: 23578-23588
Publication
First Author: Freire-Moar J
Year: 1995
Journal: Biochim Biophys Acta
Title: Cloning and characterization of a murine macrophage lipoxygenase.
Volume: 1254
Issue: 1
Pages: 112-6
Publication
First Author: Brütsch SH
Year: 2015
Journal: Antioxid Redox Signal
Title: Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice.
Volume: 22
Issue: 4
Pages: 281-93
Publication
First Author: Cole BK
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: 12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.
Volume: 302
Issue: 6
Pages: E654-65
Publication
First Author: Chen XS
Year: 1994
Journal: J Biol Chem
Title: cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases.
Volume: 269
Issue: 19
Pages: 13979-87
Publication
First Author: Jang I
Year: 2014
Journal: Exp Cell Res
Title: Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Volume: 321
Issue: 2
Pages: 276-87
Publication
First Author: Kayama Y
Year: 2009
Journal: J Exp Med
Title: Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure.
Volume: 206
Issue: 7
Pages: 1565-74
Publication  
First Author: Jackson CD
Year: 2023
Journal: Front Immunol
Title: 12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis.
Volume: 14
Pages: 1144172
Publication
First Author: Middleton MK
Year: 2006
Journal: J Immunol
Title: Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase.
Volume: 176
Issue: 1
Pages: 265-74
Publication
First Author: Rademacher M
Year: 2020
Journal: FASEB J
Title: Systemic deficiency of mouse arachidonate 15-lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype.
Volume: 34
Issue: 11
Pages: 14318-14335
Publication
First Author: Middleton MK
Year: 2006
Journal: J Exp Med
Title: Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease.
Volume: 203
Issue: 11
Pages: 2529-40
Publication
First Author: Kriska T
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension.
Volume: 302
Issue: 11
Pages: H2428-38
Publication
First Author: Makullah M
Year: 2023
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma.
Volume: 325
Issue: 2
Pages: L104-L113
Publication
First Author: Piñeros AR
Year: 2022
Journal: Cell Rep
Title: Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes.
Volume: 39
Issue: 13
Pages: 111011
Gene
Type: gene
Organism: chimpanzee
Publication
First Author: Kinder M
Year: 2010
Journal: Exp Hematol
Title: Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling.
Volume: 38
Issue: 11
Pages: 1036-1046.e1-4
Publication
First Author: Conteh AM
Year: 2019
Journal: J Biol Chem
Title: Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.
Volume: 294
Issue: 16
Pages: 6612-6620
Publication
First Author: Kim SN
Year: 2018
Journal: Sci Rep
Title: Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice.
Volume: 8
Issue: 1
Pages: 8856
Publication
First Author: Green-Mitchell SM
Year: 2013
Journal: PLoS One
Title: Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.
Volume: 8
Issue: 2
Pages: e56763
Publication
First Author: Chen Y
Year: 2014
Journal: J Clin Invest
Title: Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival.
Volume: 124
Issue: 9
Pages: 3847-62
Publication  
First Author: Soria-Tiedemann M
Year: 2022
Journal: Int J Mol Sci
Title: Unbalanced Expression of Glutathione Peroxidase 4 and Arachidonate 15-Lipoxygenase Affects Acrosome Reaction and In Vitro Fertilization.
Volume: 23
Issue: 17
Publication
First Author: Morita M
Year: 2013
Journal: Cell
Title: The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza.
Volume: 153
Issue: 1
Pages: 112-25
Publication  
First Author: Shichiri M
Year: 2021
Journal: Free Radic Biol Med
Title: Stress-activated leukocyte 12/15-lipoxygenase metabolite enhances struggle behaviour and tocotrienols relieve stress-induced behaviour alteration.
Volume: 175
Pages: 171-183
Publication
First Author: Kundumani-Sridharan V
Year: 2013
Journal: J Biol Chem
Title: 12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.
Volume: 288
Issue: 22
Pages: 15830-42
Publication  
First Author: Bhattacharya A
Year: 2014
Journal: Free Radic Biol Med
Title: Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy.
Volume: 67
Pages: 30-40
Publication
First Author: McDuffie M
Year: 2008
Journal: Diabetes
Title: Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.
Volume: 57
Issue: 1
Pages: 199-208
Publication
First Author: Kinder M
Year: 2010
Journal: Blood
Title: Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism.
Volume: 115
Issue: 24
Pages: 5012-22
Publication
First Author: Kain V
Year: 2021
Journal: Theranostics
Title: Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice.
Volume: 11
Issue: 6
Pages: 2742-2754
Publication
First Author: Khanna S
Year: 2013
Journal: J Cereb Blood Flow Metab
Title: Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size.
Volume: 33
Issue: 8
Pages: 1197-206
Publication
First Author: Al-Shabrawey M
Year: 2011
Journal: Diabetes
Title: Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization.
Volume: 60
Issue: 2
Pages: 614-24
Publication
First Author: Anning PB
Year: 2005
Journal: Am J Pathol
Title: Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
Volume: 166
Issue: 3
Pages: 653-62
Publication
First Author: Habouri L
Year: 2017
Journal: Osteoarthritis Cartilage
Title: Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis.
Volume: 25
Issue: 10
Pages: 1719-1728
Publication
First Author: DeCostanzo AJ
Year: 2010
Journal: J Neurosci
Title: 12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels.
Volume: 30
Issue: 5
Pages: 1822-31
Publication
First Author: Feinmark SJ
Year: 2003
Journal: J Neurosci
Title: 12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses.
Volume: 23
Issue: 36
Pages: 11427-35
Publication
First Author: Chiang N
Year: 2013
Journal: J Immunol
Title: Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits.
Volume: 190
Issue: 12
Pages: 6378-88
Publication  
First Author: Wang D
Year: 2017
Journal: Sci Rep
Title: Key role of 15-LO/15-HETE in angiogenesis and functional recovery in later stages of post-stroke mice.
Volume: 7
Pages: 46698
Publication  
First Author: He Y
Year: 2017
Journal: Neurosci Lett
Title: Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity.
Volume: 643
Pages: 65-69
Publication
First Author: van Leyen K
Year: 2006
Journal: Stroke
Title: Baicalein and 12/15-lipoxygenase in the ischemic brain.
Volume: 37
Issue: 12
Pages: 3014-8
Publication
First Author: Chinnici CM
Year: 2005
Journal: Am J Pathol
Title: Absence of 12/15 lipoxygenase reduces brain oxidative stress in apolipoprotein E-deficient mice.
Volume: 167
Issue: 5
Pages: 1371-7
Publication
First Author: Halade GV
Year: 2017
Journal: Am J Physiol Heart Circ Physiol
Title: Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing.
Volume: 313
Issue: 1
Pages: H89-H102
Publication
First Author: Carion TW
Year: 2018
Journal: FASEB J
Title: Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.
Volume: 32
Issue: 9
Pages: 5026-5038
Publication
First Author: Isobe Y
Year: 2012
Journal: J Biol Chem
Title: Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid.
Volume: 287
Issue: 13
Pages: 10525-34
Publication
First Author: Reddy MA
Year: 2003
Journal: Hypertension
Title: Reduced growth factor responses in vascular smooth muscle cells derived from 12/15-lipoxygenase-deficient mice.
Volume: 41
Issue: 6
Pages: 1294-300
Publication
First Author: Dioszeghy V
Year: 2008
Journal: J Immunol
Title: 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo.
Volume: 181
Issue: 9
Pages: 6514-24
Publication
First Author: Taylor PR
Year: 2012
Journal: Blood
Title: Development of myeloproliferative disease in 12/15-lipoxygenase deficiency.
Volume: 119
Issue: 25
Pages: 6173-4; author reply 6174-5
Publication
First Author: Walters CL
Year: 2003
Journal: Psychopharmacology (Berl)
Title: Augmented responses to morphine and cocaine in mice with a 12-lipoxygenase gene disruption.
Volume: 170
Issue: 2
Pages: 124-31
Publication
First Author: Ibrahim AS
Year: 2017
Journal: Biochim Biophys Acta
Title: Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis.
Volume: 1862
Issue: 6
Pages: 636-645
Publication
First Author: Bhowmick R
Year: 2013
Journal: J Immunol
Title: Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation.
Volume: 191
Issue: 10
Pages: 5115-23
Publication
First Author: Andersson CK
Year: 2008
Journal: Am J Respir Cell Mol Biol
Title: Mice lacking 12/15-lipoxygenase have attenuated airway allergic inflammation and remodeling.
Volume: 39
Issue: 6
Pages: 648-56
Publication
First Author: Warner DR
Year: 2017
Journal: Am J Pathol
Title: Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice.
Volume: 187
Issue: 10
Pages: 2232-2245
Publication
First Author: Kang KH
Year: 2013
Journal: Eur J Cancer
Title: Enhancement role of host 12/15-lipoxygenase in melanoma progression.
Volume: 49
Issue: 12
Pages: 2747-59
Publication
First Author: Krönke G
Year: 2009
Journal: J Immunol
Title: 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.
Volume: 183
Issue: 5
Pages: 3383-9
Publication
First Author: Suzuki H
Year: 2015
Journal: Diabetes
Title: Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Volume: 64
Issue: 2
Pages: 618-30
Publication
First Author: Park HA
Year: 2009
Journal: Cell Death Differ
Title: Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway.
Volume: 16
Issue: 8
Pages: 1167-79
Publication
First Author: Yang H
Year: 2010
Journal: Biol Psychiatry
Title: Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
Volume: 68
Issue: 10
Pages: 922-9
Publication
First Author: Tomio K
Year: 2013
Journal: PLoS One
Title: Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models.
Volume: 8
Issue: 9
Pages: e73085
Publication
First Author: Zarbock A
Year: 2009
Journal: J Immunol
Title: Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).
Volume: 183
Issue: 7
Pages: 4715-22
Publication
First Author: Vahsen S
Year: 2006
Journal: Horm Metab Res
Title: Altered GLUT4 translocation in skeletal muscle of 12/15-lipoxygenase knockout mice.
Volume: 38
Issue: 6
Pages: 391-6
Publication
First Author: Middleton MK
Year: 2009
Journal: Infect Immun
Title: 12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.
Volume: 77
Issue: 12
Pages: 5690-700
Publication
First Author: Singh NK
Year: 2011
Journal: Blood
Title: 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation.
Volume: 118
Issue: 20
Pages: 5701-12
Publication
First Author: Wen Y
Year: 2008
Journal: Am J Physiol Heart Circ Physiol
Title: Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.
Volume: 294
Issue: 4
Pages: H1933-8
Publication  
First Author: Lauder SN
Year: 2017
Journal: Sci Signal
Title: Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.
Volume: 10
Issue: 507
Publication
First Author: Kenchegowda S
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.
Volume: 52
Issue: 5
Pages: 2240-9
Publication
First Author: Paintlia AS
Year: 2006
Journal: J Immunol
Title: IL-4-induced peroxisome proliferator-activated receptor gamma activation inhibits NF-kappaB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases.
Volume: 176
Issue: 7
Pages: 4385-98
Publication
First Author: Kotla S
Year: 2017
Journal: J Biol Chem
Title: Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.
Volume: 292
Issue: 36
Pages: 14885-14901
Publication
First Author: Elmasry K
Year: 2018
Journal: Diabetologia
Title: Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy.
Volume: 61
Issue: 5
Pages: 1220-1232
Publication
First Author: Kriska T
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: Role of macrophage PPARγ in experimental hypertension.
Volume: 306
Issue: 1
Pages: H26-32
Publication
First Author: Bromfield EG
Year: 2017
Journal: Biol Reprod
Title: Inhibition of arachidonate 15-lipoxygenase prevents 4-hydroxynonenal-induced protein damage in male germ cells.
Volume: 96
Issue: 3
Pages: 598-609
Publication
First Author: Gaberel T
Year: 2019
Journal: Stroke
Title: Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Volume: 50
Issue: 2
Pages: 520-523
Publication
First Author: Allen-Redpath K
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity.
Volume: 116
Issue: 16
Pages: 8038-8047
Publication
First Author: Leedom AJ
Year: 2010
Journal: Am J Pathol
Title: Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury.
Volume: 176
Issue: 1
Pages: 74-84
Publication  
First Author: Kulkarni A
Year: 2021
Journal: JCI Insight
Title: 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
Volume: 6
Issue: 14
Publication
First Author: Taylor AM
Year: 2005
Journal: Arterioscler Thromb Vasc Biol
Title: The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth.
Volume: 25
Issue: 10
Pages: 2069-74
Publication
First Author: George J
Year: 2001
Journal: Circulation
Title: 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice.
Volume: 104
Issue: 14
Pages: 1646-50
Publication  
First Author: Chou VP
Year: 2013
Journal: Neuroscience
Title: Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.
Volume: 228
Pages: 73-82
Publication
First Author: Emerson MR
Year: 2004
Journal: Brain Res
Title: Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.
Volume: 1021
Issue: 1
Pages: 140-5
Publication
First Author: Liu S
Year: 2012
Journal: J Biol Chem
Title: Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formation.
Volume: 287
Issue: 29
Pages: 24739-53
Publication
First Author: Liu Y
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.
Volume: 310
Issue: 9
Pages: E762-73
Publication
First Author: Rothe T
Year: 2015
Journal: J Clin Invest
Title: 12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.
Volume: 125
Issue: 5
Pages: 1944-54
Publication
First Author: Zhao L
Year: 2005
Journal: Prostaglandins Other Lipid Mediat
Title: 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway.
Volume: 78
Issue: 1-4
Pages: 185-93
Publication
First Author: Cyrus T
Year: 1999
Journal: J Clin Invest
Title: Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.
Volume: 103
Issue: 11
Pages: 1597-604
Publication
First Author: Cyrus T
Year: 2001
Journal: Circulation
Title: Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice.
Volume: 103
Issue: 18
Pages: 2277-82
Publication
First Author: Yotsumoto S
Year: 2017
Journal: Sci Rep
Title: Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation.
Volume: 7
Issue: 1
Pages: 16026