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Search results 1 to 100 out of 396 for Alox5

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
240 | ALOX5
Type: gene
Organism: human
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Gene
100036609 | alox5
Type: gene
Organism: frog, western clawed
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Gene
key_37736 | ALOX5
Type: gene
Organism: hamster, golden
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Gene
25290 | Alox5
Type: gene
Organism: rat
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Gene
477753 | ALOX5
Type: gene
Organism: dog, domestic
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Gene
450428 | ALOX5
Type: gene
Organism: chimpanzee
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Gene
404074 | ALOX5
Type: gene
Organism: cattle
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Gene
423769 | ALOX5
Type: gene
Organism: chicken
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Gene
707926 | ALOX5
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:87999 | Alox5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27784744 | J:238005
First Author: Chen Y
Year: 2017
Journal: Cancer Res
Title: Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice.
Volume: 77
Issue: 1
Pages: 164-174
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Publication
22128029 | J:181771
First Author: Le P
Year: 2012
Journal: Endocrinology
Title: A high-fat diet induces bone loss in mice lacking the Alox5 gene.
Volume: 153
Issue: 1
Pages: 6-16
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Publication
19503090 | J:151419
First Author: Chen Y
Year: 2009
Journal: Nat Genet
Title: Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Volume: 41
Issue: 7
Pages: 783-92
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Publication
18421434 | J:137920
First Author: Mehrabian M
Year: 2008
Journal: Diabetologia
Title: Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Volume: 51
Issue: 6
Pages: 978-88
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Publication
28334897 | J:242323
First Author: Li JG
Year: 2017
Journal: Hum Mol Genet
Title: Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.
Volume: 26
Issue: 10
Pages: 1855-1862
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Publication
24130502 | J:202929
First Author: DeKelver RC
Year: 2013
Journal: PLoS Genet
Title: Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.
Volume: 9
Issue: 10
Pages: e1003765
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Publication
24906289 | J:285027
First Author: Wu Y
Year: 2014
Journal: Cell Tissue Res
Title: Deletion of Alox5 gene decreases osteogenic differentiation but increases adipogenic differentiation of mouse induced pluripotent stem cells.
Volume: 358
Issue: 1
Pages: 135-47
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Publication
23246375 | J:206711
First Author: Hofheinz K
Year: 2013
Journal: Arch Biochem Biophys
Title: Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.
Volume: 530
Issue: 1
Pages: 40-7
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Publication
31642348 | J:284993
First Author: Marbach-Breitrück E
Year: 2020
Journal: Antioxid Redox Signal
Title: Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.
Volume: 32
Issue: 1
Pages: 1-17
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Publication
25025884 | J:218489
First Author: Adel S
Year: 2014
Journal: Biochim Biophys Acta
Title: Phosphorylation mimicking mutations of ALOX5 orthologs of different vertebrates do not alter reaction specificities of the enzymes.
Volume: 1842
Issue: 10
Pages: 1460-6
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Publication
25122659 | J:216418
First Author: Joshi YB
Year: 2014
Journal: Hum Mol Genet
Title: Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
Volume: 23
Issue: 25
Pages: 6894-902
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Publication
21224059 | J:168089
First Author: Nagashima T
Year: 2011
Journal: Am J Pathol
Title: Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
Volume: 178
Issue: 1
Pages: 222-32
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Publication
35461365 | J:328747
First Author: Stranahan AW
Year: 2022
Journal: Leukemia
Title: Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia.
Volume: 36
Issue: 6
Pages: 1575-1584
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Publication
29247243 | J:286946
First Author: Prado MKB
Year: 2017
Journal: Sci Rep
Title: Leukotriene B4 is essential for lung host defence and alpha-defensin-1 production during Achromobacter xylosoxidans infection.
Volume: 7
Issue: 1
Pages: 17658
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Publication
31057373 | J:276315
 
First Author: Locachevic GA
Year: 2019
Journal: Front Behav Neurosci
Title: Paradoxical Effect of LTB4 on the Regulation of Stress-Induced Corticosterone Production.
Volume: 13
Pages: 73
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Publication
21596859 | J:174876
First Author: Chen Y
Year: 2011
Journal: Blood
Title: A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia.
Volume: 118
Issue: 2
Pages: 390-400
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Publication
36921996 | J:341099
First Author: Song S
Year: 2023
Journal: Genes Dev
Title: ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease.
Volume: 37
Issue: 5-6
Pages: 204-217
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Protein
Q810M3
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
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Publication
22675576 | J:187845
First Author: Peng C
Year: 2012
Journal: PLoS One
Title: LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells.
Volume: 7
Issue: 6
Pages: e38614
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Publication
7969451 | J:21372
First Author: Chen XS
Year: 1994
Journal: Nature
Title: Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.
Volume: 372
Issue: 6502
Pages: 179-82
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Publication
28965882 | J:284986
 
First Author: Guimarães FR
Year: 2018
Journal: Clin Immunol
Title: The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing.
Volume: 190
Pages: 74-83
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Publication
25270168 | J:218037
 
First Author: Moura AP
Year: 2014
Journal: Bone
Title: The relevance of leukotrienes for bone resorption induced by mechanical loading.
Volume: 69
Pages: 133-8
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Publication
18403121 | J:136638
First Author: Uz T
Year: 2008
Journal: Neurosci Lett
Title: Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice.
Volume: 436
Issue: 2
Pages: 269-72
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Publication
34599216 | J:313702
First Author: Mahmoud RH
Year: 2021
Journal: Sci Rep
Title: Alveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid.
Volume: 11
Issue: 1
Pages: 19535
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Publication
12941149 | J:113639
First Author: Cuzzocrea S
Year: 2003
Journal: Immunology
Title: 5-lipoxygenase knockout mice exhibit a resistance to acute pancreatitis induced by cerulein.
Volume: 110
Issue: 1
Pages: 120-30
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Publication
11790660 | J:103107
First Author: Peters-Golden M
Year: 2002
Journal: Am J Respir Crit Care Med
Title: Protection from pulmonary fibrosis in leukotriene-deficient mice.
Volume: 165
Issue: 2
Pages: 229-35
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Publication
16046553 | J:101535
First Author: Rossi A
Year: 2005
Journal: J Leukoc Biol
Title: Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}.
Volume: 78
Issue: 4
Pages: 985-91
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Publication
16006535 | J:101536
First Author: Serezani CH
Year: 2005
Journal: J Leukoc Biol
Title: Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils.
Volume: 78
Issue: 4
Pages: 976-84
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Publication
11325876 | J:115401
First Author: Ichinose F
Year: 2001
Journal: Circ Res
Title: Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice.
Volume: 88
Issue: 8
Pages: 832-8
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Publication
25302946 | J:223455
First Author: Landgraf SS
Year: 2014
Journal: PLoS One
Title: 5-Lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice.
Volume: 9
Issue: 10
Pages: e107549
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Publication
27630217 | J:243514
First Author: Singh A
Year: 2017
Journal: J Leukoc Biol
Title: Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia.
Volume: 101
Issue: 2
Pages: 531-542
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Publication
20231413 | J:159878
First Author: Mancuso P
Year: 2010
Journal: Infect Immun
Title: Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia.
Volume: 78
Issue: 5
Pages: 2264-71
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Publication
19050273 | J:142061
First Author: Medeiros AI
Year: 2008
Journal: J Immunol
Title: Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells.
Volume: 181
Issue: 12
Pages: 8544-51
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Publication
23947598 | J:231874
First Author: Monteiro AP
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Pivotal role of the 5-lipoxygenase pathway in lung injury after experimental sepsis.
Volume: 50
Issue: 1
Pages: 87-95
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Publication
16920959 | J:139527
First Author: Serezani CH
Year: 2006
Journal: J Immunol
Title: Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility.
Volume: 177
Issue: 5
Pages: 3201-8
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Publication
17586489 | J:136740
First Author: Adamek A
Year: 2007
Journal: Eur J Pharmacol
Title: Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice.
Volume: 571
Issue: 1
Pages: 51-4
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Publication
16148135 | J:116694
First Author: Machado ER
Year: 2005
Journal: J Immunol
Title: Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis.
Volume: 175
Issue: 6
Pages: 3892-9
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Publication
23325886 | J:193406
First Author: Soares EM
Year: 2013
Journal: J Immunol
Title: Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes.
Volume: 190
Issue: 4
Pages: 1614-22
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Publication
24076233 | J:210050
First Author: Kennedy-Feitosa E
Year: 2014
Journal: Biochim Biophys Acta
Title: The influence of 5-lipoxygenase on cigarette smoke-induced emphysema in mice.
Volume: 1840
Issue: 1
Pages: 199-208
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Publication
22688342 | J:208532
First Author: Mothe-Satney I
Year: 2012
Journal: Diabetes
Title: Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice.
Volume: 61
Issue: 9
Pages: 2311-9
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Publication
15033436 | J:89268
First Author: Kitagawa K
Year: 2004
Journal: Brain Res
Title: Cerebral ischemia in 5-lipoxygenase knockout mice.
Volume: 1004
Issue: 1-2
Pages: 198-202
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Publication
24288682 | J:311779
 
First Author: Hohmann MS
Year: 2013
Journal: Biomed Res Int
Title: 5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality.
Volume: 2013
Pages: 627046
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Publication
21270404 | J:169390
First Author: Blaho VA
Year: 2011
Journal: J Immunol
Title: 5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis.
Volume: 186
Issue: 5
Pages: 3076-84
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Publication
22448213 | J:187034
First Author: Secatto A
Year: 2012
Journal: PLoS One
Title: 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.
Volume: 7
Issue: 3
Pages: e31701
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Publication
31167124 | J:277812
First Author: Chen JX
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: 5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling.
Volume: 1865
Issue: 9
Pages: 2379-2392
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Publication
30242286 | J:278144
First Author: Ramalho T
Year: 2018
Journal: Sci Rep
Title: Impaired wound healing in type 1 diabetes is dependent on 5-lipoxygenase products.
Volume: 8
Issue: 1
Pages: 14164
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Publication
15328337 | J:93517
First Author: Collin M
Year: 2004
Journal: J Leukoc Biol
Title: Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Volume: 76
Issue: 5
Pages: 961-70
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Publication
15661924 | J:96404
First Author: Benjamim CF
Year: 2005
Journal: J Immunol
Title: Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis.
Volume: 174
Issue: 3
Pages: 1616-20
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Publication
28645655 | J:254015
First Author: Baek SE
Year: 2017
Journal: Biochim Biophys Acta
Title: 5-Lipoxygenase in monocytes emerges as a therapeutic target for intimal hyperplasia in a murine wire-injured femoral artery.
Volume: 1863
Issue: 9
Pages: 2210-2219
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Publication
8955165 | J:110715
First Author: Bailie MB
Year: 1996
Journal: J Immunol
Title: Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities.
Volume: 157
Issue: 12
Pages: 5221-4
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Publication
20817008 | J:170218
First Author: Paiva LA
Year: 2010
Journal: Biochim Biophys Acta
Title: Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas.
Volume: 1801
Issue: 12
Pages: 1341-8
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Publication
25324573 | J:230458
First Author: Bhamidipati CM
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: 5-Lipoxygenase pathway in experimental abdominal aortic aneurysms.
Volume: 34
Issue: 12
Pages: 2669-78
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Publication
25870230 | J:229695
First Author: Lasky CE
Year: 2015
Journal: Infect Immun
Title: Macrophage Polarization during Murine Lyme Borreliosis.
Volume: 83
Issue: 7
Pages: 2627-35
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Publication
17894798 | J:134808
First Author: DiMeo D
Year: 2008
Journal: Immunology
Title: Increased interleukin-10 production and Th2 skewing in the absence of 5-lipoxygenase.
Volume: 123
Issue: 2
Pages: 250-62
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Publication
18025235 | J:154902
First Author: Vannella KM
Year: 2007
Journal: J Immunol
Title: Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function.
Volume: 179
Issue: 11
Pages: 7883-90
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Publication
15931391 | J:99199
First Author: Bafica A
Year: 2005
Journal: J Clin Invest
Title: Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production.
Volume: 115
Issue: 6
Pages: 1601-6
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Publication
16574771 | J:109680
First Author: Canetti C
Year: 2006
Journal: J Leukoc Biol
Title: Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages.
Volume: 79
Issue: 6
Pages: 1234-41
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Publication
32849277 | J:329577
 
First Author: Biguetti CC
Year: 2020
Journal: Front Endocrinol (Lausanne)
Title: New Surgical Model for Bone-Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse.
Volume: 11
Pages: 484
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Publication
31666208 | J:283519
First Author: Sorgi CA
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Eicosanoid pathway on host resistance and inflammation during Mycobacterium tuberculosis infection is comprised by LTB4 reduction but not PGE2 increment.
Volume: 1866
Issue: 3
Pages: 165574
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Publication
9227503 | J:113047
First Author: Irvin CG
Year: 1997
Journal: Am J Physiol
Title: 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice.
Volume: 272
Issue: 6 Pt 1
Pages: L1053-8
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Publication
12773506 | J:120440
First Author: Cuzzocrea S
Year: 2003
Journal: J Leukoc Biol
Title: 5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan.
Volume: 73
Issue: 6
Pages: 739-46
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Publication
16019083 | J:106400
First Author: Genovese T
Year: 2005
Journal: J Neuroimmunol
Title: Involvement of 5-lipoxygenase in spinal cord injury.
Volume: 166
Issue: 1-2
Pages: 55-64
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Publication
23613965 | J:200108
First Author: Shryock N
Year: 2013
Journal: PLoS One
Title: Lipoxin A₄ and 15-epi-lipoxin A₄ protect against experimental cerebral malaria by inhibiting IL-12/IFN-γ in the brain.
Volume: 8
Issue: 4
Pages: e61882
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Publication
20724598 | J:163914
First Author: Obrosova IG
Year: 2010
Journal: Am J Pathol
Title: Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.
Volume: 177
Issue: 3
Pages: 1436-47
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Publication
17913976 | J:130113
First Author: Guerrero AT
Year: 2008
Journal: J Leukoc Biol
Title: Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2.
Volume: 83
Issue: 1
Pages: 122-30
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Publication
17998412 | J:134897
First Author: Firuzi O
Year: 2008
Journal: FASEB J
Title: 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease.
Volume: 22
Issue: 4
Pages: 1169-78
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Publication
23720274 | J:219262
First Author: Lee SJ
Year: 2013
Journal: Cardiovasc Res
Title: 5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1.
Volume: 99
Issue: 4
Pages: 724-33
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Publication
24226420 | J:208193
First Author: Brogliato AR
Year: 2014
Journal: J Invest Dermatol
Title: Critical role of 5-lipoxygenase and heme oxygenase-1 in wound healing.
Volume: 134
Issue: 5
Pages: 1436-1445
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Publication
21536805 | J:173172
First Author: Monteiro AP
Year: 2011
Journal: J Immunol
Title: Leukotriene B4 mediates neutrophil migration induced by heme.
Volume: 186
Issue: 11
Pages: 6562-7
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Publication
32690653 | J:300616
First Author: Zhou W
Year: 2020
Journal: J Immunol
Title: COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice.
Volume: 205
Issue: 4
Pages: 1157-1166
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Publication
29610142 | J:261605
First Author: Hegde B
Year: 2018
Journal: J Immunol
Title: Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica-Induced Sterile Inflammation.
Volume: 200
Issue: 10
Pages: 3556-3567
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Publication
16200066 | J:104825
First Author: Mehrabian M
Year: 2005
Journal: Nat Genet
Title: Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits.
Volume: 37
Issue: 11
Pages: 1224-33
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Publication
18346986 | J:136092
First Author: Gubitosi-Klug RA
Year: 2008
Journal: Diabetes
Title: 5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.
Volume: 57
Issue: 5
Pages: 1387-93
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Publication
16339565 | J:122257
First Author: Peebles RS Jr
Year: 2005
Journal: J Immunol
Title: Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent.
Volume: 175
Issue: 12
Pages: 8253-9
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Publication
30188757 | J:284833
First Author: Fettel J
Year: 2019
Journal: FASEB J
Title: Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.
Volume: 33
Issue: 2
Pages: 1711-1726
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Publication
16565390 | J:108446
First Author: Liao T
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis.
Volume: 47
Issue: 4
Pages: 1543-9
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Publication
18276782 | J:132275
First Author: Jiang W
Year: 2008
Journal: Am J Pathol
Title: Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury.
Volume: 172
Issue: 3
Pages: 592-602
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Publication
36267914 | J:336984
First Author: Hopke A
Year: 2022
Journal: iScience
Title: Transcellular biosynthesis of leukotriene B(4) orchestrates neutrophil swarming to fungi.
Volume: 25
Issue: 10
Pages: 105226
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Publication
20696828 | J:164236
First Author: Zhu L
Year: 2010
Journal: Infect Immun
Title: Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier.
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