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Search results 1 to 80 out of 80 for Alpk1

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Type Details Score
Gene
80216 | ALPK1
Type: gene
Organism: human
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Protein
I3PQW7
Organism: Mus musculus/domesticus
Length: 1224  
Fragment?: false
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Gene
524375 | ALPK1
Type: gene
Organism: cattle
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Gene
100858173 | ALPK1
Type: gene
Organism: chicken
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Gene
100333928 | alpk1
Type: gene
Organism: zebrafish
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Gene
700993 | ALPK1
Type: gene
Organism: macaque, rhesus
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Gene
100036729 | alpk1
Type: gene
Organism: frog, western clawed
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Gene
310879 | Alpk1
Type: gene
Organism: rat
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Gene
487906 | ALPK1
Type: gene
Organism: dog, domestic
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Gene
471280 | ALPK1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1918731 | Alpk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR043529 | ALPK1
Type: Family
Description: This entry includes the alpha-protein kinase 1, a serine/threonine-protein kinase that has no homology to conventional protein kinases and phosphorylate amino acids located within α-helices []. The N-terminal region had several conserved secondary α-helix structures with amphipathic properties []. The structure contains 18 helices (α1 to α18), forming seven antiparallel pairs. The one-by-one-packed seven helix pairs form a right-hand solenoid, similar to the tetratricopeptide repeat (TPR) domain structure [].This kinase detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognises and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose binds to a narrow pocket of the concave side of the alpha-protein kinase 1 N-terminal which stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signalling [, ]. In addition, alpha-protein kinase 1 may play a role in regulating intracellular trafficking processes through the phosphorylation of myosin MYO1A []. It has been shown that this kinase is also involved in monosodium urate monohydrate (MSU)-induced inflammation and gout by phosphorylation of myosin motor protein which enable the vesicle transport of of certain cytokines (like TNF-alpha) to the plasma membrane [].
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Publication
30111836 | J:264436
First Author: Zhou P
Year: 2018
Journal: Nature
Title: Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
Volume: 561
Issue: 7721
Pages: 122-126
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Publication
26275947 | J:279142
 
First Author: Kuo TM
Year: 2015
Journal: J Steroid Biochem Mol Biol
Title: ALPK1 affects testosterone mediated regulation of proinflammatory cytokines production.
Volume: 154
Pages: 150-8
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Publication
- | J:324324
     
First Author: Birling M-C
Year: 2021
Journal: Direct Data Submission
Title: Direct Data Submission for Alpk1 and Iscu alleles.
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Publication
21208416 | J:329824
 
First Author: Chen M
Year: 2011
Journal: BMC Neurosci
Title: Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon.
Volume: 12
Pages: 1
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Publication
30967659 | J:306639
First Author: Williams LB
Year: 2019
Journal: Genet Med
Title: ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.
Volume: 21
Issue: 9
Pages: 2103-2115
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Publication
27169898 | -
 
First Author: Lee CP
Year: 2016
Journal: Sci Rep
Title: ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares.
Volume: 6
Pages: 25740
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Publication
28222186 | -
First Author: Milivojevic M
Year: 2017
Journal: PLoS Pathog
Title: ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria.
Volume: 13
Issue: 2
Pages: e1006224
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Publication
35868845 | J:344848
First Author: Kozycki CT
Year: 2022
Journal: Ann Rheum Dis
Title: Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome.
Volume: 81
Issue: 10
Pages: 1453-1464
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Protein
Q9CXB8
Organism: Mus musculus/domesticus
Length: 1231  
Fragment?: false
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Protein
F6V0L2
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
E9QNX4
Organism: Mus musculus/domesticus
Length: 1231  
Fragment?: false
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Publication
15883161 | -
First Author: Heine M
Year: 2005
Journal: J Biol Chem
Title: Alpha-kinase 1, a new component in apical protein transport.
Volume: 280
Issue: 27
Pages: 25637-43
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Publication
30228258 | J:267912
First Author: Ryzhakov G
Year: 2018
Journal: Nat Commun
Title: Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
Volume: 9
Issue: 1
Pages: 3797
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Protein Coding Gene
MGP_CAROLIEiJ_G0025617 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027864 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027822 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027835 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027564 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918731 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028279 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027681 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027648 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027790 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027679 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028336 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026745 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027100 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027064 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026570 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
37625369 | J:340603
First Author: Liu X
Year: 2023
Journal: Int Immunopharmacol
Title: Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling.
Volume: 124
Issue: Pt A
Pages: 110781
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Publication
23012479 | J:190322
First Author: Archambaud C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of lactobacilli on orally acquired listeriosis.
Volume: 109
Issue: 41
Pages: 16684-9
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
31557402 | J:294675
First Author: Lee CP
Year: 2019
Journal: J Cell Mol Med
Title: ALPK1 regulates streptozotocin-induced nephropathy through CCL2 and CCL5 expressions.
Volume: 23
Issue: 11
Pages: 7699-7708
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Publication
22734048 | J:189190
First Author: Boulard O
Year: 2012
Journal: J Exp Med
Title: Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.
Volume: 209
Issue: 7
Pages: 1309-24
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Publication
36098982 | J:332171
First Author: Snelling T
Year: 2022
Journal: Biochem J
Title: Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.
Volume: 479
Issue: 20
Pages: 2195-2216
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Publication
19856416 | J:171733
First Author: Bleich A
Year: 2010
Journal: Inflamm Bowel Dis
Title: Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity.
Volume: 16
Issue: 5
Pages: 765-75
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Publication
27542954 | J:256383
First Author: Kuo TM
Year: 2016
Journal: Biochim Biophys Acta
Title: Enhanced alpha-kinase 1 accelerates multiple early nephropathies in streptozotocin-induced hyperglycemic mice.
Volume: 1862
Issue: 11
Pages: 2034-2042
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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