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Search results 1 to 83 out of 83 for Alpk1

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Hits by Strain

Type Details Score
Gene
80216 | ALPK1
Type: gene
Organism: human
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Protein
I3PQW7
Organism: Mus musculus/domesticus
Length: 1224  
Fragment?: false
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Gene
100036729 | alpk1
Type: gene
Organism: frog, western clawed
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Gene
310879 | Alpk1
Type: gene
Organism: rat
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Gene
487906 | ALPK1
Type: gene
Organism: dog, domestic
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Gene
471280 | ALPK1
Type: gene
Organism: chimpanzee
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Gene
524375 | ALPK1
Type: gene
Organism: cattle
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Gene
100858173 | ALPK1
Type: gene
Organism: chicken
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Gene
100333928 | alpk1
Type: gene
Organism: zebrafish
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Gene
700993 | ALPK1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1918731 | Alpk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR043529 | ALPK1
Type: Family
Description: This entry includes the alpha-protein kinase 1, a serine/threonine-protein kinase that has no homology to conventional protein kinases and phosphorylate amino acids located within α-helices []. The N-terminal region had several conserved secondary α-helix structures with amphipathic properties []. The structure contains 18 helices (α1 to α18), forming seven antiparallel pairs. The one-by-one-packed seven helix pairs form a right-hand solenoid, similar to the tetratricopeptide repeat (TPR) domain structure [].This kinase detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognises and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose binds to a narrow pocket of the concave side of the alpha-protein kinase 1 N-terminal which stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signalling [, ]. In addition, alpha-protein kinase 1 may play a role in regulating intracellular trafficking processes through the phosphorylation of myosin MYO1A []. It has been shown that this kinase is also involved in monosodium urate monohydrate (MSU)-induced inflammation and gout by phosphorylation of myosin motor protein which enable the vesicle transport of of certain cytokines (like TNF-alpha) to the plasma membrane [].
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Publication
30111836 | J:264436
First Author: Zhou P
Year: 2018
Journal: Nature
Title: Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
Volume: 561
Issue: 7721
Pages: 122-126
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Publication
26275947 | J:279142
 
First Author: Kuo TM
Year: 2015
Journal: J Steroid Biochem Mol Biol
Title: ALPK1 affects testosterone mediated regulation of proinflammatory cytokines production.
Volume: 154
Pages: 150-8
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Publication
- | J:324324
     
First Author: Birling M-C
Year: 2021
Journal: Direct Data Submission
Title: Direct Data Submission for Alpk1 and Iscu alleles.
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Publication
21208416 | J:329824
 
First Author: Chen M
Year: 2011
Journal: BMC Neurosci
Title: Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon.
Volume: 12
Pages: 1
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Publication
30967659 | J:306639
First Author: Williams LB
Year: 2019
Journal: Genet Med
Title: ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.
Volume: 21
Issue: 9
Pages: 2103-2115
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Publication
27169898 | -
 
First Author: Lee CP
Year: 2016
Journal: Sci Rep
Title: ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares.
Volume: 6
Pages: 25740
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Publication
28222186 | -
First Author: Milivojevic M
Year: 2017
Journal: PLoS Pathog
Title: ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria.
Volume: 13
Issue: 2
Pages: e1006224
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Publication
35868845 | J:344848
First Author: Kozycki CT
Year: 2022
Journal: Ann Rheum Dis
Title: Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome.
Volume: 81
Issue: 10
Pages: 1453-1464
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Protein
Q9CXB8
Organism: Mus musculus/domesticus
Length: 1231  
Fragment?: false
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Protein
F6V0L2
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
E9QNX4
Organism: Mus musculus/domesticus
Length: 1231  
Fragment?: false
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Publication
15883161 | -
First Author: Heine M
Year: 2005
Journal: J Biol Chem
Title: Alpha-kinase 1, a new component in apical protein transport.
Volume: 280
Issue: 27
Pages: 25637-43
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Publication
30228258 | J:267912
First Author: Ryzhakov G
Year: 2018
Journal: Nat Commun
Title: Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
Volume: 9
Issue: 1
Pages: 3797
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Protein Coding Gene
MGP_CAROLIEiJ_G0025617 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027864 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027822 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027835 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027564 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918731 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028279 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027681 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027648 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027790 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027679 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028336 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026745 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027100 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027064 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026570 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
37625369 | J:340603
First Author: Liu X
Year: 2023
Journal: Int Immunopharmacol
Title: Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling.
Volume: 124
Issue: Pt A
Pages: 110781
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Publication
37967175 | J:358221
First Author: He J
Year: 2023
Journal: Sci Adv
Title: Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells.
Volume: 9
Issue: 46
Pages: eadh0322
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Publication
23012479 | J:190322
First Author: Archambaud C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Impact of lactobacilli on orally acquired listeriosis.
Volume: 109
Issue: 41
Pages: 16684-9
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
31557402 | J:294675
First Author: Lee CP
Year: 2019
Journal: J Cell Mol Med
Title: ALPK1 regulates streptozotocin-induced nephropathy through CCL2 and CCL5 expressions.
Volume: 23
Issue: 11
Pages: 7699-7708
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Publication
22734048 | J:189190
First Author: Boulard O
Year: 2012
Journal: J Exp Med
Title: Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.
Volume: 209
Issue: 7
Pages: 1309-24
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Publication
36098982 | J:332171
First Author: Snelling T
Year: 2022
Journal: Biochem J
Title: Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.
Volume: 479
Issue: 20
Pages: 2195-2216
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Publication
19856416 | J:171733
First Author: Bleich A
Year: 2010
Journal: Inflamm Bowel Dis
Title: Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity.
Volume: 16
Issue: 5
Pages: 765-75
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Publication
27542954 | J:256383
First Author: Kuo TM
Year: 2016
Journal: Biochim Biophys Acta
Title: Enhanced alpha-kinase 1 accelerates multiple early nephropathies in streptozotocin-induced hyperglycemic mice.
Volume: 1862
Issue: 11
Pages: 2034-2042
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