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Search results 1 to 100 out of 653 for Alx4

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0.046s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Homeobox protein aristaless-like 4 (ALX4) is involved in limb development []. It also plays a critical role both in craniofacial development as in skin and hair follicle development in human [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kuijper S
Year: 2005
Journal: Dev Biol
Title: Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh.
Volume: 285
Issue: 2
Pages: 533-44
GXD Expression  
Probe: MGI:7610229
Assay Type: RNA in situ
Annotation Date: 2024-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7610249
Age: embryonic day 10.5
Image: 4F Alx4 CTRL
Specimen Label: 4F Alx4 CTRL
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7610229
Assay Type: RNA in situ
Annotation Date: 2024-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7610249
Age: embryonic day 10.5
Image: 4F Alx4 Tfap delta/NCKO
Note: Expression reduced compared to controls.
Specimen Label: 4F Alx4 Tfap delta/NCKO
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7576832
Assay Type: RNA in situ
Annotation Date: 2024-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640616
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:7576860
Age: embryonic day 10.0
Image: 6D Alx4 WT
Specimen Label: 6D Alx4 WT
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7576832
Assay Type: RNA in situ
Annotation Date: 2024-01-26
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640616
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:7576860
Age: embryonic day 10.0
Image: 6D Alx4 delta/deltac
Note: Expression reduced and altered compared to control.
Specimen Label: 6D Alx4 delta/deltac
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7576832
Assay Type: RNA in situ
Annotation Date: 2024-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7576860
Age: embryonic day 10.5
Image: S5B Alx4 E10.5 WT
Specimen Label: S5B Alx4 E10.5 WT
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7576832
Assay Type: RNA in situ
Annotation Date: 2024-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7576860
Age: embryonic day 10.5
Image: S5B Alx4 E10.5 delta/deltac
Note: Authors report differential expression compared to control.
Specimen Label: S5B Alx4 E10.5 delta/deltac
Detected: true
Specimen Num: 4
Publication
First Author: Kayserili H
Year: 2009
Journal: Hum Mol Genet
Title: ALX4 dysfunction disrupts craniofacial and epidermal development.
Volume: 18
Issue: 22
Pages: 4357-66
Publication
First Author: Boras K
Year: 2002
Journal: J Biol Chem
Title: Alx4 binding to LEF-1 regulates N-CAM promoter activity.
Volume: 277
Issue: 2
Pages: 1120-7
Publication
First Author: Panman L
Year: 2005
Journal: Int J Dev Biol
Title: Genetic interaction of Gli3 and Alx4 during limb development.
Volume: 49
Issue: 4
Pages: 443-8
Publication
First Author: Garg A
Year: 2017
Journal: PLoS Genet
Title: Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.
Volume: 13
Issue: 10
Pages: e1007047
Publication
First Author: Qu S
Year: 1999
Journal: Development
Title: Physical and genetic interactions between Alx4 and Cart1.
Volume: 126
Issue: 2
Pages: 359-69
Publication
First Author: Chen B
Year: 2013
Journal: Genet Mol Res
Title: Multiple abnormalities due to a nonsense mutation in the Alx4 gene.
Volume: 12
Issue: 3
Pages: 2771-8
Protein
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
Publication
First Author: Wu YQ
Year: 2000
Journal: Am J Hum Genet
Title: Haploinsufficiency of ALX4 as a potential cause of parietal foramina in the 11p11.2 contiguous gene-deletion syndrome.
Volume: 67
Issue: 5
Pages: 1327-32
GXD Expression  
Probe: MGI:5811013
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823571
Age: embryonic day 11.5
Note: Domains of staining are similar to those seen at E10.5.
Specimen Label: Supplemental Data - Alx4
Detected: true
Specimen Num: 2
Publication
First Author: Boras-Granic K
Year: 2006
Journal: Int J Dev Biol
Title: Genetic interaction between Lef1 and Alx4 is required for early embryonic development.
Volume: 50
Issue: 7
Pages: 601-10
Publication
First Author: Antonopoulou I
Year: 2004
Journal: J Anat
Title: Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation.
Volume: 204
Issue: 6
Pages: 487-99
Publication      
First Author: Du X
Year: 2008
Journal: MGI Direct Data Submission
Title: Goofy, a mouse Alx4 mutant with anomalies of craniofacial and digit development and hair growth
Publication
First Author: Matsumaru D
Year: 2014
Journal: Eur J Hum Genet
Title: Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation.
Volume: 22
Issue: 3
Pages: 350-7
Publication
First Author: Curtain M
Year: 2015
Journal: Mamm Genome
Title: A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice.
Volume: 26
Issue: 3-4
Pages: 173-80
GXD Expression  
Probe: MGI:5811013
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823571
Age: embryonic day 10.5
Note: Staining is observed in the proximal-anterior limb bud.
Specimen Label: Supplemental Table 1 - Alx4
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6167323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189769
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Alx4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6167323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189769
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Alx4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6167323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189769
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Alx4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6167323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189769
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Alx4
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6167323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6189769
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Alx4
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6167323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189769
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Alx4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6167323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189769
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Alx4
Detected: true
Specimen Num: 7
GXD Expression
Probe: MGI:2152048
Assay Type: RNA in situ
Annotation Date: 2001-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2152081
Age: embryonic day 9.5
Image: 2D
Note: Expression in facial primordia. There is an overlap in the expression domain with Alx3 (see assay MGI:2152057) while the Alx4 expression domain extends more laterally.
Specimen Label: 2D
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:2152048
Assay Type: RNA in situ
Annotation Date: 2001-10-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2152081
Age: embryonic day 10.5
Image: 2H
Note: Expression in facial primordia. There is an overlap in the expression domain with Alx3 (see assay MGI:2152057) while the Alx4 expression domain extends more laterally.
Specimen Label: 2H
Detected: true
Specimen Num: 2
Publication
First Author: Rockwell DM
Year: 2022
Journal: Dev Dyn
Title: A transgenic Alx4-CreER mouse to analyze anterior limb and nephric duct development.
Volume: 251
Issue: 9
Pages: 1524-1534
Publication
First Author: te Welscher P
Year: 2002
Journal: Genes Dev
Title: Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling.
Volume: 16
Issue: 4
Pages: 421-6
Publication
First Author: Qu S
Year: 1998
Journal: Development
Title: Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly.
Volume: 125
Issue: 14
Pages: 2711-21
Publication
First Author: Joshi PA
Year: 2006
Journal: Dev Biol
Title: Loss of Alx4, a stromally-restricted homeodomain protein, impairs mammary epithelial morphogenesis.
Volume: 297
Issue: 1
Pages: 284-94
Publication
First Author: Rice R
Year: 2003
Journal: Dev Biol
Title: Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4.
Volume: 262
Issue: 1
Pages: 75-87
Publication
First Author: Loebel DA
Year: 2002
Journal: Genesis
Title: Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.
Volume: 33
Issue: 3
Pages: 103-13
Publication
First Author: Zhang D
Year: 2020
Journal: Adv Sci (Weinh)
Title: Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.
Volume: 7
Issue: 23
Pages: 2002117
Publication
First Author: Manley NR
Year: 2001
Journal: Dev Biol
Title: Hoxb2 and hoxb4 act together to specify ventral body wall formation.
Volume: 237
Issue: 1
Pages: 130-44
Publication  
First Author: Nguyen TT
Year: 2024
Journal: Development
Title: TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway.
Volume: 151
Issue: 1
Publication
First Author: Beverdam A
Year: 2001
Journal: Development
Title: Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice.
Volume: 128
Issue: 20
Pages: 3975-86
Publication
First Author: Kuijper S
Year: 2005
Journal: Development
Title: Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes.
Volume: 132
Issue: 7
Pages: 1601-10
Publication
First Author: Yada Y
Year: 2002
Journal: Int J Dev Biol
Title: The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud.
Volume: 46
Issue: 7
Pages: 975-82
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Qu S
Year: 1997
Journal: Gene
Title: Alx-4: cDNA cloning and characterization of a novel paired-type homeodomain protein.
Volume: 203
Issue: 2
Pages: 217-23
Publication
First Author: Strong LC
Year: 1956
Journal: J Hered
Title: A new Luxoid mutant in mice.
Volume: 47
Issue: 6
Pages: 277-84
Publication
First Author: Forsthoefel PF
Year: 1968
Journal: Teratology
Title: Responses to selection for plus and minus modifiers of some effects of Strong's luxoid gene on the mouse skeleton.
Volume: 1
Issue: 3
Pages: 339-51
Publication  
First Author: FORSTHOEFEL PF
Year: 1963
Journal: J Morphol
Title: THE EMBRYOLOGICAL DEVELOPMENT OF THE EFFECTS OF STRONG'S LUXOID GENE IN THE MOUSE.
Volume: 113
Pages: 427-51
Publication  
First Author: FORSTHOEFEL PF
Year: 1962
Journal: J Morphol
Title: Genetics and manifold effects of Strong's luxoid gene in the mouse, including its interactions with Green's luxoid and Carter's luxate genes.
Volume: 110
Pages: 391-420
Publication
First Author: Strong LC
Year: 1961
Journal: J Hered
Title: The Springville mouse, further observations on a new "Luxoid" mouse.
Volume: 52
Issue: 3
Pages: 122-124
Publication
First Author: Forsthoefel PF
Year: 1975
Journal: Teratology
Title: The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Volume: 11
Issue: 1
Pages: 1-13
GXD Expression    
Probe: MGI:3842552
Assay Type: RT-PCR
Annotation Date: 2009-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3842731
Age: embryonic day 10.5
Image: 1
Specimen Label: Wild-type forelimb 1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3842552
Assay Type: RT-PCR
Annotation Date: 2009-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3842731
Age: embryonic day 10.5
Image: 1
Specimen Label: Wild-type forelimb 1:10
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3842552
Assay Type: RT-PCR
Annotation Date: 2009-05-04
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3842731
Age: embryonic day 10.5
Image: 1
Specimen Label: Wild-type forelimb 1:100
Specimen Num: 4
GXD Expression    
Probe: MGI:3842552
Assay Type: RT-PCR
Annotation Date: 2009-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3842731
Age: embryonic day 10.5
Image: 1
Specimen Label: Mutant forelimb 1
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3842552
Assay Type: RT-PCR
Annotation Date: 2009-05-04
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3842731
Age: embryonic day 10.5
Image: 1
Specimen Label: Mutant forelimb 1:10
Specimen Num: 6
GXD Expression      
Probe: MGI:3842552
Assay Type: RT-PCR
Annotation Date: 2009-05-04
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3842731
Age: embryonic day 10.5
Image: 1
Specimen Label: Mutant forelimb 1:100
Specimen Num: 7
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5305117
Age: embryonic day 9.5
Specimen Label: 9.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5305117
Age: embryonic day 11.5
Specimen Label: 11.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:5305117
Age: embryonic day 13.5
Specimen Label: 13.5
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:5305117
Age: embryonic day 16.5
Specimen Label: 16.5
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5305117
Age: postnatal adult
Specimen Label: brain
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5305117
Age: postnatal adult
Specimen Label: heart
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:5305117
Age: postnatal adult
Specimen Label: intestine
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5305117
Age: postnatal adult
Specimen Label: kidney
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5305117
Age: postnatal adult
Specimen Label: liver
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:5305117
Age: postnatal adult
Specimen Label: muscle
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5305117
Age: postnatal adult
Specimen Label: spleen
Detected: false
Specimen Num: 11
GXD Expression      
Probe: MGI:5305114
Assay Type: Northern blot
Annotation Date: 2012-02-08
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5305117
Age: postnatal adult
Specimen Label: testis
Detected: false
Specimen Num: 12
GXD Expression      
Probe: MGI:5305116
Assay Type: Western blot
Annotation Date: 2012-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5305118
Age: embryonic day 10.5
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7610234
Assay Type: RT-PCR
Annotation Date: 2024-03-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1680517
Stage: TS17
Assay Id: MGI:7610255
Age: embryonic day 10.5
Image: 4
Specimen Label: CTRL
Detected: true
Specimen Num: 1