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Search results 1 to 100 out of 406 for Angptl4

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0.044s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Angiopoietin-related protein 4 (ANGPTL4, also known as HFARP) functions as an antiangiogenic modulatory factor that is involved in various neoplastic diseases []. It acts as an apoptosis survival factor for vascular endothelial cells, and may have a protective function on endothelial cells through an endocrine action in liver [].
Publication  
First Author: Kim I
Year: 2000
Journal: Biochem J
Title: Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis.
Volume: 346 Pt 3
Pages: 603-10
Publication
First Author: Mattijssen F
Year: 2014
Journal: Mol Metab
Title: Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion.
Volume: 3
Issue: 2
Pages: 135-44
Publication
First Author: Köster A
Year: 2005
Journal: Endocrinology
Title: Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.
Volume: 146
Issue: 11
Pages: 4943-50
Publication
First Author: Spitler KM
Year: 2021
Journal: Sci Rep
Title: Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice.
Volume: 11
Issue: 1
Pages: 7873
Publication
First Author: Catoire M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise.
Volume: 111
Issue: 11
Pages: E1043-52
Publication  
First Author: Aryal B
Year: 2018
Journal: JCI Insight
Title: Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis.
Volume: 3
Issue: 6
Publication  
First Author: Aryal B
Year: 2016
Journal: Nat Commun
Title: ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
Volume: 7
Pages: 12313
Publication
First Author: Zhu H
Year: 2002
Journal: Zhonghua Yi Xue Za Zhi
Title: [Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis].
Volume: 82
Issue: 2
Pages: 94-9
Publication
First Author: Gusarova V
Year: 2018
Journal: Nat Commun
Title: Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.
Volume: 9
Issue: 1
Pages: 2252
Publication    
First Author: Dijk W
Year: 2015
Journal: Elife
Title: ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure.
Volume: 4
Publication
First Author: Okamoto H
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition.
Volume: 114
Issue: 10
Pages: 2747-2752
Publication      
First Author: Singh AK
Year: 2018
Journal: Mol Metab
Title: Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis.
Publication
First Author: Oteng AB
Year: 2019
Journal: J Lipid Res
Title: Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice.
Volume: 60
Issue: 10
Pages: 1741-1754
Publication  
First Author: Singh AK
Year: 2021
Journal: J Clin Invest
Title: Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice.
Volume: 131
Issue: 17
Publication
First Author: Yu X
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart.
Volume: 102
Issue: 5
Pages: 1767-72
Publication
First Author: Lichtenstein L
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake.
Volume: 27
Issue: 11
Pages: 2420-7
Publication
First Author: Spitler KM
Year: 2021
Journal: Am J Physiol Endocrinol Metab
Title: Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice.
Volume: 321
Issue: 4
Pages: E464-E478
Publication
First Author: Ben-Zvi D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.
Volume: 112
Issue: 50
Pages: 15498-503
Publication
First Author: Wang CY
Year: 2015
Journal: Sci Signal
Title: Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism.
Volume: 8
Issue: 407
Pages: ra127
Publication
First Author: Adachi H
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice.
Volume: 409
Issue: 2
Pages: 177-80
Publication  
First Author: Qin Y
Year: 2022
Journal: JCI Insight
Title: ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization.
Volume: 7
Issue: 13
Publication
First Author: Gealekman O
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production.
Volume: 295
Issue: 5
Pages: E1056-64
Publication
First Author: Janssen AWF
Year: 2017
Journal: Biochim Biophys Acta
Title: ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.
Volume: 1862
Issue: 10 Pt A
Pages: 1056-1067
Publication
First Author: Lichtenstein L
Year: 2010
Journal: Cell Metab
Title: Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages.
Volume: 12
Issue: 6
Pages: 580-92
GXD Expression    
Probe: MGI:6167381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189780
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Angptl4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6167381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189780
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Angptl4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6167381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189780
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Angptl4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6167381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189780
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Angptl4
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6167381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189780
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Angptl4
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6167381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189780
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Angptl4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6167381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189780
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Angptl4
Detected: true
Specimen Num: 7
Publication
First Author: Ito Y
Year: 2003
Journal: Cancer Res
Title: Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.
Volume: 63
Issue: 20
Pages: 6651-7
Protein
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: true
Publication
First Author: Georgiadi A
Year: 2010
Journal: Circ Res
Title: Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress.
Volume: 106
Issue: 11
Pages: 1712-21
Publication
First Author: Dijk W
Year: 2016
Journal: J Lipid Res
Title: Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes.
Volume: 57
Issue: 9
Pages: 1670-83
Publication
First Author: Yoshida K
Year: 2002
Journal: J Lipid Res
Title: Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase.
Volume: 43
Issue: 11
Pages: 1770-2
Publication
First Author: Desai U
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.
Volume: 104
Issue: 28
Pages: 11766-71
Publication  
First Author: Hübers C
Year: 2023
Journal: J Exp Med
Title: Primary tumor-derived systemic nANGPTL4 inhibits metastasis.
Volume: 220
Issue: 1
Publication      
First Author: Li L
Year: 2015
Journal: Cell Rep
Title: Angiopoietin-like 4 Increases Pulmonary Tissue Leakiness and Damage during Influenza Pneumonia.
Publication
First Author: Cazes A
Year: 2006
Journal: Circ Res
Title: Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton.
Volume: 99
Issue: 11
Pages: 1207-15
Publication
First Author: Perdiguero EG
Year: 2011
Journal: J Biol Chem
Title: Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.
Volume: 286
Issue: 42
Pages: 36841-51
Publication
First Author: Gomez Perdiguero E
Year: 2016
Journal: J Pathol
Title: ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.
Volume: 240
Issue: 4
Pages: 461-471
Publication
First Author: Kim HK
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Angiopoietin-like peptide 4 regulates insulin secretion and islet morphology.
Volume: 485
Issue: 1
Pages: 113-118
Publication
First Author: Oteng AB
Year: 2017
Journal: J Lipid Res
Title: Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites.
Volume: 58
Issue: 6
Pages: 1100-1113
Publication
First Author: Galaup A
Year: 2012
Journal: Circulation
Title: Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.
Volume: 125
Issue: 1
Pages: 140-9
Publication
First Author: Chen TC
Year: 2019
Journal: J Biol Chem
Title: An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice.
Volume: 294
Issue: 23
Pages: 9213-9224
Publication
First Author: Nyrén R
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Lipoprotein lipase in mouse kidney: effects of nutritional status and high-fat diet.
Volume: 316
Issue: 3
Pages: F558-F571
Publication
First Author: Clement LC
Year: 2011
Journal: Nat Med
Title: Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome.
Volume: 17
Issue: 1
Pages: 117-22
Publication
First Author: Pal M
Year: 2011
Journal: PLoS One
Title: Angiopoietin-like 4 regulates epidermal differentiation.
Volume: 6
Issue: 9
Pages: e25377
Publication
First Author: Mousavizadeh R
Year: 2016
Journal: J Physiol
Title: Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts.
Volume: 594
Issue: 11
Pages: 2971-83
Publication
First Author: Ding S
Year: 2020
Journal: Am J Cancer Res
Title: Angiopoietin-like 4 deficiency upregulates macrophage function through the dysregulation of cell-intrinsic fatty acid metabolism.
Volume: 10
Issue: 2
Pages: 595-609
Publication  
First Author: Phua T
Year: 2017
Journal: Sci Rep
Title: Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin.
Volume: 7
Pages: 44351
Publication
First Author: Janssen AWF
Year: 2018
Journal: Diabetologia
Title: Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota.
Volume: 61
Issue: 6
Pages: 1447-1458
Publication
First Author: Dijk W
Year: 2018
Journal: J Biol Chem
Title: Angiopoietin-like 4 promotes the intracellular cleavage of lipoprotein lipase by PCSK3/furin in adipocytes.
Volume: 293
Issue: 36
Pages: 14134-14145
Publication
First Author: Cushing EM
Year: 2017
Journal: Mol Metab
Title: Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting.
Volume: 6
Issue: 8
Pages: 809-818
Publication  
First Author: Chen TC
Year: 2017
Journal: Sci Signal
Title: The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ.
Volume: 10
Issue: 489
Publication
First Author: Gray NE
Year: 2012
Journal: J Biol Chem
Title: Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.
Volume: 287
Issue: 11
Pages: 8444-56
Publication
First Author: Varela L
Year: 2021
Journal: Sci Adv
Title: Astrocytic lipid metabolism determines susceptibility to diet-induced obesity.
Volume: 7
Issue: 50
Pages: eabj2814
Publication
First Author: Goh YY
Year: 2010
Journal: J Biol Chem
Title: Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing.
Volume: 285
Issue: 43
Pages: 32999-3009
Publication
First Author: Makoveichuk E
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Inactivation of lipoprotein lipase in 3T3-L1 adipocytes by angiopoietin-like protein 4 requires that both proteins have reached the cell surface.
Volume: 441
Issue: 4
Pages: 941-6
Publication
First Author: Xu A
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.
Volume: 102
Issue: 17
Pages: 6086-91
Publication
First Author: Sonnenburg WK
Year: 2009
Journal: J Lipid Res
Title: GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4.
Volume: 50
Issue: 12
Pages: 2421-9
Publication
First Author: Vienberg SG
Year: 2015
Journal: Mol Metab
Title: Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity.
Volume: 4
Issue: 2
Pages: 144-50
Publication
First Author: Teo Z
Year: 2017
Journal: Sci Rep
Title: Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression.
Volume: 7
Issue: 1
Pages: 6303
Publication  
First Author: Li Y
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal injury by down-regulating the expression of ACTN4.
Volume: 595
Pages: 69-75
Publication
First Author: Kolb R
Year: 2019
Journal: Oncogene
Title: Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4.
Volume: 38
Issue: 13
Pages: 2351-2363
Publication
First Author: Goh YY
Year: 2010
Journal: Am J Pathol
Title: Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration.
Volume: 177
Issue: 6
Pages: 2791-803
Publication
First Author: Xin X
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.
Volume: 110
Issue: 36
Pages: E3425-34
Publication
First Author: Kim HK
Year: 2010
Journal: Diabetes
Title: Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight.
Volume: 59
Issue: 11
Pages: 2772-80
Publication
First Author: Yang YH
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.
Volume: 28
Issue: 5
Pages: 835-40
Publication
First Author: Makoveichuk E
Year: 2017
Journal: Biochim Biophys Acta
Title: TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4.
Volume: 1862
Issue: 5
Pages: 533-540
Publication
First Author: Lee EC
Year: 2009
Journal: J Biol Chem
Title: Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).
Volume: 284
Issue: 20
Pages: 13735-45
Publication
First Author: Scott CA
Year: 2012
Journal: Cell Tissue Res
Title: Angiopoietin-like gene expression in the mouse uterus during implantation and in response to steroids.
Volume: 348
Issue: 1
Pages: 199-211
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory