| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Angiopoietin-like protein 8 (ANGPTL8), also known as betatrophin or lipasin, is a regulator of lipid metabolism [, , ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ren G |
| Year: |
2012 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. |
| Volume: |
303 |
| Issue: |
3 |
| Pages: |
E334-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang R |
| Year: |
2012 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. |
| Volume: |
424 |
| Issue: |
4 |
| Pages: |
786-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen S |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
Angptl8 mediates food-driven resetting of hepatic circadian clock in mice. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
3518 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu L |
| Year: |
2022 |
| Journal: |
Cell Death Dis |
| Title: |
ANGPTL8 is a negative regulator in pathological cardiac hypertrophy. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
621 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oldoni F |
| Year: |
2020 |
| Journal: |
JCI Insight |
| Title: |
ANGPTL8 has both endocrine and autocrine effects on substrate utilization. |
| Volume: |
5 |
| Issue: |
17 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gusarova V |
| Year: |
2017 |
| Journal: |
Endocrinology |
| Title: |
ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice. |
| Volume: |
158 |
| Issue: |
5 |
| Pages: |
1252-1259 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. |
| Volume: |
110 |
| Issue: |
40 |
| Pages: |
16109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haller JF |
| Year: |
2017 |
| Journal: |
J Lipid Res |
| Title: |
ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance. |
| Volume: |
58 |
| Issue: |
6 |
| Pages: |
1166-1173 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chi X |
| Year: |
2017 |
| Journal: |
Mol Metab |
| Title: |
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. |
| Volume: |
6 |
| Issue: |
10 |
| Pages: |
1137-1149 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang J |
| Year: |
2022 |
| Journal: |
Front Endocrinol (Lausanne) |
| Title: |
ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition. |
| Volume: |
13 |
|
| Pages: |
927763 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meng M |
| Year: |
2024 |
| Journal: |
Metabolism |
| Title: |
Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner. |
| Volume: |
152 |
|
| Pages: |
155784 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang L |
| Year: |
2020 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Regulation of ANGPTL8 in liver and adipose tissue by nutritional and hormonal signals and its effect on glucose homeostasis in mice. |
| Volume: |
318 |
| Issue: |
5 |
| Pages: |
E613-E624 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fu Z |
| Year: |
2013 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. |
| Volume: |
430 |
| Issue: |
3 |
| Pages: |
1126-31 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
198
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
198
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
187
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
183
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gusarova V |
| Year: |
2014 |
| Journal: |
Cell |
| Title: |
ANGPTL8/betatrophin does not control pancreatic beta cell expansion. |
| Volume: |
159 |
| Issue: |
3 |
| Pages: |
691-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang YY |
| Year: |
2023 |
| Journal: |
Biochim Biophys Acta Mol Basis Dis |
| Title: |
Angiopoietin-like protein 8 deficiency attenuates thoracic aortic aneurysm/dissection development in β-aminopropionitrile monofumarate-induced model mice. |
| Volume: |
1869 |
| Issue: |
2 |
| Pages: |
166619 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang YY |
| Year: |
2021 |
| Journal: |
Biochem Pharmacol |
| Title: |
Angiopoietin-like proteins 8 knockout reduces intermittent hypoxia-induced vascular remodeling in a murine model of obstructive sleep apnea. |
| Volume: |
186 |
|
| Pages: |
114502 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2016 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase. |
| Volume: |
1861 |
| Issue: |
2 |
| Pages: |
130-137 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Quagliarini F |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Atypical angiopoietin-like protein that regulates ANGPTL3. |
| Volume: |
109 |
| Issue: |
48 |
| Pages: |
19751-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang JW |
| Year: |
2019 |
| Journal: |
Int J Mol Sci |
| Title: |
Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice. |
| Volume: |
20 |
| Issue: |
17 |
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiao Y |
| Year: |
2014 |
| Journal: |
Diabetes |
| Title: |
Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting. |
| Volume: |
63 |
| Issue: |
4 |
| Pages: |
1283-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yi P |
| Year: |
2013 |
| Journal: |
Cell |
| Title: |
Betatrophin: a hormone that controls pancreatic β cell proliferation. |
| Volume: |
153 |
| Issue: |
4 |
| Pages: |
747-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fu Z |
| Year: |
2015 |
| Journal: |
Sci Rep |
| Title: |
A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase. |
| Volume: |
5 |
|
| Pages: |
18502 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2015 |
| Journal: |
J Lipid Res |
| Title: |
Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. |
| Volume: |
56 |
| Issue: |
7 |
| Pages: |
1296-307 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saul MC |
| Year: |
2018 |
| Journal: |
PLoS One |
| Title: |
Genomic variants in an inbred mouse model predict mania-like behaviors. |
| Volume: |
13 |
| Issue: |
5 |
| Pages: |
e0197624 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang T |
| Year: |
2010 |
| Journal: |
Nat Biotechnol |
| Title: |
A mouse knockout library for secreted and transmembrane proteins. |
| Volume: |
28 |
| Issue: |
7 |
| Pages: |
749-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lexicon Genetics, Inc |
| Year: |
2011 |
| Journal: |
Database Download |
| Title: |
MGI download of Lexicon knockout data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2016 |
|
| Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Watanabe T |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
9999 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
ANGPTL8 negatively regulates NF-B activation by facilitating selective autophagic degradation of IKK. |
|
•
•
•
•
•
|
| Allele |
| Name: |
angiopoietin-like 8; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
2164 |
|
•
•
•
•
•
|
| Allele |
| Name: |
angiopoietin-like 8; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|