Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Airik M |
Year: |
2020 |
Journal: |
Hum Mol Genet |
Title: |
Loss of Anks6 leads to YAP deficiency and liver abnormalities. |
Volume: |
29 |
Issue: |
18 |
Pages: |
3064-3080 |
|
•
•
•
•
•
|
Publication |
First Author: |
Czarnecki PG |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. |
Volume: |
6 |
|
Pages: |
6023 |
|
•
•
•
•
•
|
Publication |
First Author: |
Delestré L |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice. |
Volume: |
10 |
Issue: |
9 |
Pages: |
e0136781 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stagner EE |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The polycystic kidney disease-related proteins Bicc1 and SamCystin interact. |
Volume: |
383 |
Issue: |
1 |
Pages: |
16-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Airik M |
Year: |
2022 |
Journal: |
FASEB J |
Title: |
Mitigation of portal fibrosis and cholestatic liver disease in ANKS6-deficient livers by macrophage depletion. |
Volume: |
36 |
Issue: |
2 |
Pages: |
e22157 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakajima Y |
Year: |
2018 |
Journal: |
Kidney Int |
Title: |
The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6. |
Volume: |
93 |
Issue: |
5 |
Pages: |
1108-1117 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1720326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7333225 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
4B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1720327 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
4C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1720328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 21 |
|
|
Specimen Label: |
4D |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1720328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 50 |
|
|
Specimen Label: |
4E |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684623 |
Pattern: |
Uniform |
Stage: |
TS23 |
Assay Id: |
MGI:7333225 |
Age: |
embryonic day 15.5 |
|
Note: |
Uniform expression throughout liver. |
Specimen Label: |
4A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684626 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7333225 |
Age: |
embryonic day 18.5 |
|
Note: |
Expression in periportal mesenchyme. |
Specimen Label: |
4B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684627 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 0 |
|
Note: |
Expression in periportal mesenchyme. |
Specimen Label: |
4C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 21 |
|
Note: |
Expression in mesenchyme surrounding biliary epithelium. |
Specimen Label: |
4D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 50 |
|
Note: |
Expression in mesenchyme surrounding biliary epithelium. |
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333186 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3684026 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7333222 |
Age: |
embryonic day 18.5 |
|
Note: |
Expression localized to cilia. |
Specimen Label: |
6C,C" |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333186 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-09-02 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3684026 |
|
Stage: |
TS26 |
Assay Id: |
MGI:7333222 |
Age: |
embryonic day 18.5 |
|
Note: |
Expression absent from mutant cilia. |
Specimen Label: |
6D,D" |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3684026 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7333225 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
4B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3684027 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
4C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3684028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 21 |
|
|
Specimen Label: |
4D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7333178 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-09-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3684028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7333225 |
Age: |
postnatal day 50 |
|
|
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beier DR |
Year: |
2016 |
Journal: |
Mamm Genome |
Title: |
High-resolution genetic localization of a modifying locus affecting disease severity in the juvenile cystic kidneys (jck) mouse model of polycystic kidney disease. |
Volume: |
27 |
Issue: |
5-6 |
Pages: |
191-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson R |
Year: |
2016 |
Journal: |
Wellcome Open Res |
Title: |
Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. |
Volume: |
1 |
|
Pages: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
San Agustin JT |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Genetic link between renal birth defects and congenital heart disease. |
Volume: |
7 |
|
Pages: |
11103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geyer SH |
Year: |
2017 |
Journal: |
J Anat |
Title: |
A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5). |
Volume: |
230 |
Issue: |
5 |
Pages: |
710-719 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Consortium: Deciphering the Mechanisms of Developmental Disorders (DMDD) |
Year: |
2017 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from Deciphering the Mechanisms of Developmental Disorders (DMDD) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Perez-Garcia V |
Year: |
2018 |
Journal: |
Nature |
Title: |
Placentation defects are highly prevalent in embryonic lethal mouse mutants. |
Volume: |
555 |
Issue: |
7697 |
Pages: |
463-468 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2015 |
Journal: |
Nature |
Title: |
Global genetic analysis in mice unveils central role for cilia in congenital heart disease. |
Volume: |
521 |
Issue: |
7553 |
Pages: |
520-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lo C |
Year: |
2011 |
Journal: |
MGI Direct Data Submission (B2B/CvDC) |
Title: |
Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
Pages: |
508-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Hoff S |
Year: |
2013 |
Journal: |
Nat Genet |
Title: |
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. |
Volume: |
45 |
Issue: |
8 |
Pages: |
951-6 |
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DO Term |
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Publication |
First Author: |
Maisonneuve C |
Year: |
2009 |
Journal: |
Development |
Title: |
Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow. |
Volume: |
136 |
Issue: |
17 |
Pages: |
3019-30 |
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Publication |
First Author: |
Saffman EE |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C. |
Volume: |
18 |
Issue: |
8 |
Pages: |
4855-62 |
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Publication |
First Author: |
Park S |
Year: |
2016 |
Journal: |
Development |
Title: |
A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators. |
Volume: |
143 |
Issue: |
5 |
Pages: |
864-71 |
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Protein Domain |
Type: |
Domain |
Description: |
Bicaudal-C (BICC, BICC1 in vertebrates) is an RNA-binding protein with translational repression function []. It is involved in the regulation of embryonic differentiation and plays a role in the regulation of Dvl (Dishevelled) signaling, particularly in the correct cilia orientation and nodal flow generation []. In Drosophila, disruption of BICC can disturb the normal migration direction of the anterior follicle cell of oocytes []. In mammals, mutations in this gene are associated with polycystic kidney disease and it was suggested that the BICC1 protein can indirectly interact with ANKS6 protein (ANKS6 is also associated with polycystic kidney disease) through some protein and RNA intermediates [].BICC1 contains N-terminal K homology RNA-binding vigilin-like repeats and a C-terminal SAM domain. This entry represents the SAM (sterile alpha motif) domain, which is a protein-protein interaction domain []. |
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Publication |
First Author: |
Ramachandran H |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Anks3 alters the sub-cellular localization of the Nek7 kinase. |
Volume: |
464 |
Issue: |
3 |
Pages: |
901-7 |
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Publication |
First Author: |
Qiao F |
Year: |
2005 |
Journal: |
Sci STKE |
Title: |
The many faces of SAM. |
Volume: |
2005 |
Issue: |
286 |
Pages: |
re7 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
977
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
951
 |
Fragment?: |
false |
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