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Search results 1 to 100 out of 3652 for Apc

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Drosophila melanogaster
Protein Domain
Type: Family
Description: Adenomatous polyposis coli (APC) is a tumor suppressor protein that induces thedegradation of oncogenic beta-catenin and negatively regulates Wnt signalling []. It has roles in regulating cell migration, DNA replication/repair, mitosis and apoptosis [, ]. APC regulates cell-cell adhesion and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (GEF; Asef) [, ]. It acts as a mediator of ERBB2-dependent stabilisation of microtubules at the cell cortex []. It is required for the localisation of MACF1/ACF7 to the cell membrane and this localisation of MACF1/ACF7 is critical for its function in microtubule stabilisation []. APC mutations are particularly prevalent in colorectal cancer [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 2845  
Fragment?: false
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Powell SM
Year: 1992
Journal: Nature
Title: APC mutations occur early during colorectal tumorigenesis.
Volume: 359
Issue: 6392
Pages: 235-7
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Kawasaki Y
Year: 2000
Journal: Science
Title: Asef, a link between the tumor suppressor APC and G-protein signaling.
Volume: 289
Issue: 5482
Pages: 1194-7
Publication
First Author: Lui C
Year: 2012
Journal: IUBMB Life
Title: APC as a mobile scaffold: regulation and function at the nucleus, centrosomes, and mitochondria.
Volume: 64
Issue: 3
Pages: 209-14
Publication
First Author: Aoki K
Year: 2007
Journal: J Cell Sci
Title: Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.
Volume: 120
Issue: Pt 19
Pages: 3327-35
Publication
First Author: Daly CS
Year: 2017
Journal: Oncogene
Title: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.
Volume: 36
Issue: 13
Pages: 1793-1803
Publication
First Author: MacDonald BT
Year: 2009
Journal: Dev Cell
Title: Wnt/beta-catenin signaling: components, mechanisms, and diseases.
Volume: 17
Issue: 1
Pages: 9-26
Publication
First Author: Zhang Z
Year: 2012
Journal: Cell Res
Title: Structural basis for the recognition of Asef by adenomatous polyposis coli.
Volume: 22
Issue: 2
Pages: 372-86
Publication
First Author: Zaoui K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Volume: 107
Issue: 43
Pages: 18517-22
Protein
Organism: Mus musculus
Length: 344  
Fragment?: true
Protein
Organism: Mus musculus
Length: 146  
Fragment?: true
Protein
Organism: Mus musculus
Length: 324  
Fragment?: false
Protein
Organism: Mus musculus
Length: 51  
Fragment?: true
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 2842  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2808  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1133  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1056  
Fragment?: true
Protein
Organism: Mus musculus
Length: 489  
Fragment?: false
Protein
Organism: Mus musculus
Length: 672  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1132  
Fragment?: false
Protein
Organism: Mus musculus
Length: 780  
Fragment?: false
Protein
Organism: Mus musculus
Length: 217  
Fragment?: true
Protein
Organism: Mus musculus
Length: 509  
Fragment?: false
Protein
Organism: Mus musculus
Length: 635  
Fragment?: false
Protein
Organism: Mus musculus
Length: 391  
Fragment?: false
Protein
Organism: Mus musculus
Length: 146  
Fragment?: false
Protein
Organism: Mus musculus
Length: 96  
Fragment?: false
Publication
First Author: McCart AE
Year: 2008
Journal: Pathol Res Pract
Title: Apc mice: models, modifiers and mutants.
Volume: 204
Issue: 7
Pages: 479-90
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Zeineldin M
Year: 2013
Journal: Cancer Res
Title: Understanding phenotypic variation in rodent models with germline Apc mutations.
Volume: 73
Issue: 8
Pages: 2389-99
Protein
Organism: Mus musculus
Length: 25  
Fragment?: true
Publication      
First Author: Jacks T
Year: 2010
Journal: MGI Direct Data Submission
Title: Generation of a conditional Apc allele
Publication
First Author: Sansom OJ
Year: 2005
Journal: Oncogene
Title: Apc deficiency predisposes to renal carcinoma in the mouse.
Volume: 24
Issue: 55
Pages: 8205-10
Publication
First Author: Fischer JM
Year: 2012
Journal: Oncogene
Title: Different phenotypic consequences of simultaneous versus stepwise Apc loss.
Volume: 31
Issue: 16
Pages: 2028-38
Publication
First Author: Sansom OJ
Year: 2007
Journal: Nature
Title: Myc deletion rescues Apc deficiency in the small intestine.
Volume: 446
Issue: 7136
Pages: 676-9
Publication
First Author: Wasan HS
Year: 1998
Journal: J Pathol
Title: APC in the regulation of intestinal crypt fission.
Volume: 185
Issue: 3
Pages: 246-55
Publication
First Author: Roose J
Year: 1999
Journal: Science
Title: Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
Volume: 285
Issue: 5435
Pages: 1923-6
Publication
First Author: Levy DB
Year: 1994
Journal: Cancer Res
Title: Inactivation of both APC alleles in human and mouse tumors.
Volume: 54
Issue: 22
Pages: 5953-8
Publication
First Author: Benhamouche S
Year: 2006
Journal: Dev Cell
Title: Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.
Volume: 10
Issue: 6
Pages: 759-70
Publication
First Author: Bruxvoort KJ
Year: 2007
Journal: Cancer Res
Title: Inactivation of Apc in the mouse prostate causes prostate carcinoma.
Volume: 67
Issue: 6
Pages: 2490-6
Publication
First Author: Méniel V
Year: 2005
Journal: Cancer Res
Title: Mutations in Apc and p53 synergize to promote mammary neoplasia.
Volume: 65
Issue: 2
Pages: 410-6
Publication
First Author: Cheung AF
Year: 2010
Journal: Oncogene
Title: Complete deletion of Apc results in severe polyposis in mice.
Volume: 29
Issue: 12
Pages: 1857-64
Publication
First Author: Liu S
Year: 2017
Journal: Oncogene
Title: Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis.
Volume: 36
Issue: 10
Pages: 1374-1383
Publication
First Author: He Z
Year: 2017
Journal: Sci Rep
Title: Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice.
Volume: 7
Issue: 1
Pages: 5520
Publication
First Author: Crist RC
Year: 2010
Journal: Mamm Genome
Title: The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.
Volume: 21
Issue: 9-10
Pages: 450-7
Publication
First Author: Lapierre M
Year: 2014
Journal: J Clin Invest
Title: RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis.
Volume: 124
Issue: 5
Pages: 1899-913
Publication  
First Author: Pirone A
Year: 2017
Journal: Neurobiol Dis
Title: APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures.
Volume: 98
Pages: 149-157
Publication
First Author: Prescott SM
Year: 1996
Journal: Cell
Title: Self-promotion? Intimate connections between APC and prostaglandin H synthase-2.
Volume: 87
Issue: 5
Pages: 783-6
Publication
First Author: Gaspar C
Year: 2009
Journal: PLoS Genet
Title: A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
Volume: 5
Issue: 7
Pages: e1000547
Publication
First Author: Sansom OJ
Year: 2004
Journal: Genes Dev
Title: Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.
Volume: 18
Issue: 12
Pages: 1385-90
Publication
First Author: Shibata H
Year: 1997
Journal: Science
Title: Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.
Volume: 278
Issue: 5335
Pages: 120-3
Publication
First Author: Athineos D
Year: 2010
Journal: Oncogene
Title: Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.
Volume: 29
Issue: 17
Pages: 2585-90
Publication
First Author: Radulescu S
Year: 2012
Journal: Cell Rep
Title: Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.
Volume: 2
Issue: 2
Pages: 270-82
Publication
First Author: Li W
Year: 2013
Journal: Blood
Title: Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.
Volume: 121
Issue: 20
Pages: 4063-72
Publication
First Author: Song JH
Year: 2014
Journal: Cell Rep
Title: The APC network regulates the removal of mutated cells from colonic crypts.
Volume: 7
Issue: 1
Pages: 94-103
Publication
First Author: Lewis A
Year: 2012
Journal: J Pathol
Title: The C-terminus of Apc does not influence intestinal adenoma development or progression.
Volume: 226
Issue: 1
Pages: 73-83
Publication
First Author: Bjerknes M
Year: 1997
Journal: Am J Pathol
Title: APC mutation and the crypt cycle in murine and human intestine.
Volume: 150
Issue: 3
Pages: 833-9
Publication
First Author: Tao Y
Year: 2016
Journal: Carcinogenesis
Title: Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Volume: 37
Issue: 7
Pages: 731-739
Publication
First Author: Abal M
Year: 2007
Journal: Gastroenterology
Title: APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.
Volume: 132
Issue: 7
Pages: 2448-58
Publication
First Author: Pollard P
Year: 2009
Journal: Gastroenterology
Title: The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
Volume: 136
Issue: 7
Pages: 2204-2213.e1-13
Publication
First Author: Dow LE
Year: 2015
Journal: Cell
Title: Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.
Volume: 161
Issue: 7
Pages: 1539-1552
Publication
First Author: Deming DA
Year: 2014
Journal: Oncogene
Title: PIK3CA and APC mutations are synergistic in the development of intestinal cancers.
Volume: 33
Issue: 17
Pages: 2245-54
Publication
First Author: Hinoi T
Year: 2007
Journal: Cancer Res
Title: Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.
Volume: 67
Issue: 20
Pages: 9721-30
Publication
First Author: Moser AR
Year: 1995
Journal: Dev Dyn
Title: Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation.
Volume: 203
Issue: 4
Pages: 422-33
Publication
First Author: Cai J
Year: 2015
Journal: Genes Dev
Title: β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis.
Volume: 29
Issue: 14
Pages: 1493-506
Publication
First Author: Sohn KJ
Year: 2003
Journal: Carcinogenesis
Title: Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.
Volume: 24
Issue: 2
Pages: 217-24
Publication
First Author: Luo F
Year: 2011
Journal: Oncol Rep
Title: Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
Volume: 26
Issue: 1
Pages: 125-33
Publication
First Author: Brandt M
Year: 2018
Journal: Cell Metab
Title: mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.
Volume: 27
Issue: 1
Pages: 118-135.e8
Publication
First Author: Wilkins JA
Year: 2008
Journal: Cancer Res
Title: C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine.
Volume: 68
Issue: 13
Pages: 4963-6
Publication
First Author: Bjerke GA
Year: 2014
Journal: PLoS One
Title: Prostate cancer induced by loss of Apc is restrained by TGFβ signaling.
Volume: 9
Issue: 3
Pages: e92800
Publication
First Author: Méniel V
Year: 2015
Journal: Oncogene
Title: Apc and p53 interaction in DNA damage and genomic instability in hepatocytes.
Volume: 34
Issue: 31
Pages: 4118-29
Publication
First Author: Hasegawa S
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene.
Volume: 99
Issue: 1
Pages: 297-302
Publication
First Author: Fodde R
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.
Volume: 91
Issue: 19
Pages: 8969-73
Publication
First Author: Bellis J
Year: 2012
Journal: J Cell Biol
Title: The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.
Volume: 198
Issue: 3
Pages: 331-41
Publication  
First Author: Zhang L
Year: 2017
Journal: J Natl Cancer Inst
Title: Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.
Volume: 109
Issue: 8
Publication
First Author: Mahmoud NN
Year: 1997
Journal: Cancer Res
Title: Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration.
Volume: 57
Issue: 22
Pages: 5045-50
Publication
First Author: Møllersen L
Year: 2004
Journal: Anticancer Res
Title: Loss of heterozygosity and nonsense mutation in Apc in azoxymethane-induced colonic tumours in min mice.
Volume: 24
Issue: 5A
Pages: 2595-9
Publication
First Author: Marsh V
Year: 2008
Journal: Nat Genet
Title: Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.
Volume: 40
Issue: 12
Pages: 1436-44
Publication
First Author: Parisi A
Year: 2015
Journal: J Cell Biol
Title: APC is required for muscle stem cell proliferation and skeletal muscle tissue repair.
Volume: 210
Issue: 5
Pages: 717-26
Publication
First Author: Oshima M
Year: 1996
Journal: Cell
Title: Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
Volume: 87
Issue: 5
Pages: 803-9
Publication
First Author: Chazaud C
Year: 2006
Journal: Development
Title: Disruption of early proximodistal patterning and AVE formation in Apc mutants.
Volume: 133
Issue: 17
Pages: 3379-87
Publication
First Author: Oshima M
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
Volume: 92
Issue: 10
Pages: 4482-6
Publication
First Author: Senda T
Year: 1996
Journal: Biochem Biophys Res Commun
Title: The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells.
Volume: 223
Issue: 2
Pages: 329-34