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Search results 1 to 100 out of 947 for Apobec1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: hamster, golden
Gene
Type: gene
Organism: rabbit, European
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: This entry includes APOBEC1 from animals. APOBEC1 is a catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Snyder EM
Year: 2017
Journal: RNA
Title: APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.
Volume: 23
Issue: 4
Pages: 457-465
GXD Expression      
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 26
Specimen Num: 1
GXD Expression      
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 29
Specimen Num: 2
GXD Expression      
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 32
Specimen Num: 3
GXD Expression    
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 26
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 29
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 32
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 23
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 26
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 29
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 32
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:3662879
Assay Type: RT-PCR
Annotation Date: 2006-10-05
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3662892
Age: postnatal
Image: 3
Specimen Label: Apobec1 40
Detected: true
Specimen Num: 21
Publication
First Author: Mukhopadhyay D
Year: 2002
Journal: Am J Hum Genet
Title: C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.
Volume: 70
Issue: 1
Pages: 38-50
Publication
First Author: Fossat N
Year: 2014
Journal: EMBO Rep
Title: C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.
Volume: 15
Issue: 8
Pages: 903-10
Publication
First Author: Ikeda T
Year: 2008
Journal: Nucleic Acids Res
Title: The antiretroviral potency of APOBEC1 deaminase from small animal species.
Volume: 36
Issue: 21
Pages: 6859-71
Publication
First Author: Caval V
Year: 2019
Journal: BMC Genomics
Title: Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.
Volume: 20
Issue: 1
Pages: 858
Publication  
First Author: Barrett BS
Year: 2014
Journal: Virology
Title: Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.
Volume: 468-470
Pages: 601-8
Publication
First Author: Hassan MA
Year: 2014
Journal: Genome Res
Title: The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages.
Volume: 24
Issue: 3
Pages: 377-89
Publication
First Author: Cole DC
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology.
Volume: 114
Issue: 50
Pages: 13272-13277
Protein
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
Publication
First Author: Petit V
Year: 2009
Journal: J Mol Biol
Title: Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.
Volume: 385
Issue: 1
Pages: 65-78
Publication
First Author: Smallwood TL
Year: 2014
Journal: G3 (Bethesda)
Title: High-resolution genetic mapping in the diversity outbred mouse population identifies Apobec1 as a candidate gene for atherosclerosis.
Volume: 4
Issue: 12
Pages: 2353-63
Publication
First Author: Ikeda T
Year: 2011
Journal: Nucleic Acids Res
Title: Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.
Volume: 39
Issue: 13
Pages: 5538-54
Publication
First Author: Nelson VR
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
Volume: 109
Issue: 41
Pages: E2766-73
Publication
First Author: Harkins S
Year: 2016
Journal: Transgenic Res
Title: Chromosomal mapping of the αMHC-MerCreMer transgene in mice reveals a large genomic deletion.
Volume: 25
Issue: 5
Pages: 639-48
Publication
First Author: Nakamuta M
Year: 1995
Journal: J Biol Chem
Title: Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases.
Volume: 270
Issue: 22
Pages: 13042-56
Publication
First Author: Carouge D
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.
Volume: 113
Issue: 37
Pages: E5425-33
Publication
First Author: Hirose N
Year: 2022
Journal: Sci Rep
Title: Genetically-biased fertilization in APOBEC1 complementation factor (A1cf) mutant mice.
Volume: 12
Issue: 1
Pages: 13599
Publication
First Author: Blanc V
Year: 2012
Journal: J Lipid Res
Title: Intestine-specific expression of Apobec-1 rescues apolipoprotein B RNA editing and alters chylomicron production in Apobec1 -/- mice.
Volume: 53
Issue: 12
Pages: 2643-55
Publication
First Author: Wolfe AD
Year: 2019
Journal: J Mol Biol
Title: Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells.
Volume: 431
Issue: 7
Pages: 1506-1517
Publication
First Author: Guo JU
Year: 2011
Journal: Cell
Title: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.
Volume: 145
Issue: 3
Pages: 423-34
Publication
First Author: Blanc V
Year: 2005
Journal: Mol Cell Biol
Title: Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality.
Volume: 25
Issue: 16
Pages: 7260-9
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Publication
First Author: Blanc V
Year: 2001
Journal: J Biol Chem
Title: Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing.
Volume: 276
Issue: 13
Pages: 10272-83
Protein
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
Publication
First Author: Nabel CS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase.
Volume: 110
Issue: 35
Pages: 14225-30
Publication
First Author: Wedekind JE
Year: 2003
Journal: Trends Genet
Title: Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.
Volume: 19
Issue: 4
Pages: 207-16
Publication
First Author: Morgan HD
Year: 2004
Journal: J Biol Chem
Title: Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.
Volume: 279
Issue: 50
Pages: 52353-60
Publication
First Author: Kassim SH
Year: 2010
Journal: PLoS One
Title: Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis.
Volume: 5
Issue: 10
Pages: e13424
Publication
First Author: Nadeau JH
Year: 2017
Journal: Genetics
Title: Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization.
Volume: 207
Issue: 2
Pages: 369-387
Publication
First Author: Chen Z
Year: 2008
Journal: J Lipid Res
Title: ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice.
Volume: 49
Issue: 9
Pages: 2013-22
Protein Domain
Type: Family
Description: APOBEC1 complementation factor (A1CF or ACF) and APOBEC1 (an RNA-binding cytidine deaminase) form the apolipoprotein B (apoB) mRNA editing enzyme complex, which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in apoB mRNA [, ]. APOBEC1 alone induces nonsense-mediated decay (NMD), while the APOBEC1-ACF complex edits and remains associated with the edited RNA to protect it from NMD []. ACF has been shown to bind with high affinity to single-stranded but not double-stranded apoB mRNA [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Reyes-Soffer G
Year: 2016
Journal: Sci Transl Med
Title: Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans.
Volume: 8
Issue: 323
Pages: 323ra12
Publication
First Author: Sparks JD
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Acute suppression of apo B secretion by insulin occurs independently of MTP.
Volume: 406
Issue: 2
Pages: 252-6
Publication
First Author: Conlon DM
Year: 2016
Journal: J Clin Invest
Title: Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis.
Volume: 126
Issue: 10
Pages: 3852-3867
Publication
First Author: Nakamuta M
Year: 1996
Journal: J Biol Chem
Title: Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1.
Volume: 271
Issue: 42
Pages: 25981-8
Publication
First Author: Morrison JR
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism.
Volume: 93
Issue: 14
Pages: 7154-9
Publication
First Author: Kendrick JS
Year: 2001
Journal: Biochem J
Title: Superior role of apolipoprotein B48 over apolipoprotein B100 in chylomicron assembly and fat absorption: an investigation of apobec-1 knock-out and wild-type mice.
Volume: 356
Issue: Pt 3
Pages: 821-7
Publication
First Author: Hersberger M
Year: 1999
Journal: J Biol Chem
Title: Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3' efficiency element.
Volume: 274
Issue: 49
Pages: 34590-7
Publication
First Author: Reaves SK
Year: 2000
Journal: J Nutr
Title: Regulation of intestinal apolipoprotein B mRNA editing levels by a zinc-deficient diet and cDNA cloning of editing protein in hamsters.
Volume: 130
Issue: 9
Pages: 2166-73
Publication
First Author: Innerarity TL
Year: 1996
Journal: J Biol Chem
Title: Biosynthesis of apolipoprotein B48-containing lipoproteins. Regulation by novel post-transcriptional mechanisms.
Volume: 271
Issue: 5
Pages: 2353-6
Publication
First Author: Oka K
Year: 1997
Journal: J Biol Chem
Title: Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice.
Volume: 272
Issue: 3
Pages: 1456-60
Publication
First Author: Hirano K
Year: 1997
Journal: J Lipid Res
Title: Cloning and characterization of the rat apobec-1 gene: a comparative analysis of gene structure and promoter usage in rat and mouse.
Volume: 38
Issue: 6
Pages: 1103-19
Publication
First Author: Eto T
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells.
Volume: 100
Issue: 22
Pages: 12895-8
GXD Expression    
Probe: MGI:6159572
Assay Type: RT-PCR
Annotation Date: 2018-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6159602
Age: embryonic day 0.5
Image: S1
Specimen Label: Z-I
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6159572
Assay Type: RT-PCR
Annotation Date: 2018-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6159602
Age: embryonic day 0.5
Image: S1
Specimen Label: Z-M
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6159572
Assay Type: RT-PCR
Annotation Date: 2018-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6159602
Age: embryonic day 1.0
Image: S1
Specimen Label: 2-cell-I
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6159572
Assay Type: RT-PCR
Annotation Date: 2018-06-05
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:6159602
Age: postnatal adult
Image: S1
Specimen Label: MII
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6159572
Assay Type: RT-PCR
Annotation Date: 2018-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:6159602
Age: embryonic day 2.0
Image: S1
Specimen Label: 4-cell
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6159572
Assay Type: RT-PCR
Annotation Date: 2018-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:6159602
Age: embryonic day 2.5
Image: S1
Specimen Label: 8-cell
Detected: true
Specimen Num: 9