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Search results 1 to 100 out of 5405 for App

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Amyloid-beta precursor protein, also known as amyloid beta A4 protein (APP or A4), consists of a large N-terminal extracellular region containing heparin-binding and copper-binding sites, a short hydrophobic transmembrane domain, and a short C-terminal intracellular domain. The N-terminal region is similar in structure to cysteine-rich growth factors and appears to function as a cell surface receptor, contributing to neurite growth, neuronal adhesion, axonogenesis and cell mobility []. There are several alternative splicing isoforms of APP in humans. Two of the main isoforms, amyloid-beta40 (Abeta40) and amyloid-beta42 (Abeta42), are found prominently in the extracellular brain deposits associated with Alzheimer's disease (AD) []. The ratio of Abeta42 to Abeta40 affects the pathogenesis of AD []. APP can be processed by different sets of enzymes:In the non-amyloidogenic (non-plaque-forming) pathway, APP is cleaved by alpha-secretase to yield a soluble N-terminal sAPP-alpha (neuroprotective) and a membrane-bound CTF-alpha. CTF-alpha is broken-down by presenilin-containing gamma-secretase to yield soluble p3 and membrane-bound AICD (nuclear signalling). In the amyloidogenic pathway (plaque-forming), APP is broken down by beta-secretase to yield soluble sAPP-beta and membrane-bound CTF-beta. CTF-beta is broken down by gamma-secretase to yield soluble amyloid-beta and membrane-bound AICD. Amyloid-beta is required for neuronal function, but can aggregate to form amyloid plaques that seem to disrupt brain cells by clogging points of cell-cell contact.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Jin S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Evidence for dimeric BACE-mediated APP processing.
Volume: 393
Issue: 1
Pages: 21-7
Publication
First Author: Rabe S
Year: 2011
Journal: J Neurochem
Title: The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Volume: 119
Issue: 1
Pages: 231-9
Protein
Organism: Mus musculus
Length: 770  
Fragment?: false
Publication
First Author: Philipson O
Year: 2009
Journal: FEBS Lett
Title: Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
Volume: 583
Issue: 18
Pages: 3021-6
Publication
First Author: Das U
Year: 2016
Journal: Nat Neurosci
Title: Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.
Volume: 19
Issue: 1
Pages: 55-64
Publication
First Author: Koike MA
Year: 2012
Journal: PLoS One
Title: APP knockout mice experience acute mortality as the result of ischemia.
Volume: 7
Issue: 8
Pages: e42665
Publication
First Author: Chen Y
Year: 2006
Journal: Biochem Biophys Res Commun
Title: The amyloid precursor protein and postnatal neurogenesis/neuroregeneration.
Volume: 341
Issue: 1
Pages: 1-5
Protein
Organism: Mus musculus
Length: 582  
Fragment?: false
Protein
Organism: Mus musculus
Length: 582  
Fragment?: false
Protein
Organism: Mus musculus
Length: 751  
Fragment?: false
Protein
Organism: Mus musculus
Length: 752  
Fragment?: false
Protein
Organism: Mus musculus
Length: 752  
Fragment?: false
Protein
Organism: Mus musculus
Length: 695  
Fragment?: false
Protein
Organism: Mus musculus
Length: 733  
Fragment?: false
Protein
Organism: Mus musculus
Length: 770  
Fragment?: false
Protein
Organism: Mus musculus
Length: 218  
Fragment?: true
Protein
Organism: Mus musculus
Length: 384  
Fragment?: true
Publication
First Author: Chang CC
Year: 2013
Journal: PLoS One
Title: Synergistic interactions between Alzheimer's Aβ40 and Aβ42 on the surface of primary neurons revealed by single molecule microscopy.
Volume: 8
Issue: 12
Pages: e82139
Publication
First Author: Johnson RD
Year: 2013
Journal: Biophys J
Title: Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes.
Volume: 104
Issue: 4
Pages: 894-903
Publication
First Author: Lincoln S
Year: 2013
Journal: PLoS One
Title: LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
Volume: 8
Issue: 6
Pages: e64164
Publication
First Author: Das U
Year: 2013
Journal: Neuron
Title: Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
Volume: 79
Issue: 3
Pages: 447-60
Publication
First Author: Meakin PJ
Year: 2020
Journal: J Clin Invest
Title: Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
Volume: 130
Issue: 8
Pages: 4104-4117
Publication
First Author: Rodrigues EM
Year: 2012
Journal: Hum Mol Genet
Title: Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.
Volume: 21
Issue: 21
Pages: 4587-601
Publication
First Author: Sadleir KR
Year: 2018
Journal: J Biol Chem
Title: ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
Volume: 293
Issue: 48
Pages: 18434-18443
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666515
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1619817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1640515
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1721322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1665922
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1706822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1727022
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1674822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674815
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654215
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619315
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624015
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1609615
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1733122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3275715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1672822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3598822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1853522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3596122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1842622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604215
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1624717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1624722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624715
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1718522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1636715
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1759722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1775122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1797222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1776322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1609215
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1611715
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1620122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1620115
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1617715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1608915
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1796222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Detected: true
Specimen Num: 2
Publication
First Author: Devi L
Year: 2010
Journal: Eur J Neurosci
Title: Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.
Volume: 31
Issue: 1
Pages: 110-8
Publication
First Author: Ghosal K
Year: 2010
Journal: PLoS One
Title: APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation.
Volume: 5
Issue: 7
Pages: e11866
Publication
First Author: Maesako M
Year: 2015
Journal: PLoS One
Title: High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.
Volume: 10
Issue: 9
Pages: e0131199
Publication
First Author: Salehi A
Year: 2006
Journal: Neuron
Title: Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Volume: 51
Issue: 1
Pages: 29-42
Publication
First Author: Almeida CG
Year: 2005
Journal: Neurobiol Dis
Title: Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.
Volume: 20
Issue: 2
Pages: 187-98