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Search results 1 to 100 out of 7122 for App

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
351 | APP
Type: gene
Organism: human
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Gene
448208 | app
Type: gene
Organism: frog, western clawed
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Gene
280722 | APP
Type: gene
Organism: cattle
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Gene
key_79359 | APP
Type: gene
Organism: goat
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Gene
54226 | App
Type: gene
Organism: rat
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Gene
403407 | APP
Type: gene
Organism: dog, domestic
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Gene
473931 | APP
Type: gene
Organism: chimpanzee
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Gene
374198 | APP
Type: gene
Organism: chicken
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Gene
100427716 | APP
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028866 | APP
Type: Family
Description: Amyloid-beta precursor protein, also known as amyloid beta A4 protein (APP or A4), consists of a large N-terminal extracellular region containing heparin-binding and copper-binding sites, Kunitz domain, E2 domain, a short hydrophobic transmembrane domain, and a short C-terminal intracellular domain. The N-terminal region is similar in structure to cysteine-rich growth factors and appears to function as a cell surface receptor, contributing to neurite growth, neuronal adhesion, axonogenesis and cell mobility []. There are several alternative splicing isoforms of APP in humans. Two of the main isoforms, amyloid-β40 (Abeta40) and amyloid-β42 (Abeta42), are found predominantly in the extracellular brain deposits associated with Alzheimer's disease (AD) []. The ratio of Abeta42 to Abeta40 affects the pathogenesis of AD []. The Abeta peptide is mostly unstructured, and through molecular dynamics simulations, confirmed by amyloid-oligomer-specific antibodies, was revealed that Abeta monomer acquires the atypical alpha-sheet secondary structure that adopts an alpha-strand structure which proceeds to an alpha-sheet between adjacent alpha-strands in oligomers with opposite charges on both edges, inducing self-assembly/aggregation to form soluble oligomeric amyloid protofibrils and finally, insoluble highly ordered amyloid fibrils with a cross β-sheet structure [, , ].APP can be processed by different sets of enzymes:In the non-amyloidogenic (non-plaque-forming) pathway, APP is cleaved by alpha-secretase to yield a soluble N-terminal sAPP-alpha (neuroprotective) and a membrane-bound CTF-alpha. CTF-alpha is broken-down by presenilin-containing gamma-secretase to yield soluble p3 and membrane-bound AICD (nuclear signalling). In the amyloidogenic pathway (plaque-forming), APP is broken down by beta-secretase to yield soluble sAPP-beta and membrane-bound CTF-beta. CTF-beta is broken down by gamma-secretase to yield soluble amyloid-beta and membrane-bound AICD. Amyloid-beta is required for neuronal function, but can aggregate to form amyloid plaques that seem to disrupt brain cells by clogging points of cell-cell contact.
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Protein Coding Gene
MGI:88059 | App
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
118568803 | APP-DT
Type: gene
Organism: human
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666515
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1619817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1619822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1640515
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1697422
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1721322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1665922
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1706822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1727022
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1674822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674815
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654215
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624015
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1609615
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3275715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1778722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3598822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1853522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3596122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1842622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1684622
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1624717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1624722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624715
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1718522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1636715
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1759722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1775122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1797222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1776322
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1609215
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1611715
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1620122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1617715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1608915
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640522
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619315
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2666206
Age: embryonic day 10.5
Image: App 10.5dpc
Specimen Label: App 10.5dpc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1733122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1672822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604215
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2673348
Assay Type: RNA in situ
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1620115
Stage: TS15
Assay Id: MGI:2674691
Age: embryonic day 9.5
Image: App 9.5dpc
Specimen Label: App 9.5dpc
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2663079
Assay Type: RNA in situ
Annotation Date: 2003-07-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1796222
Pattern: Uniform
Stage: TS22
Assay Id: MGI:2666206
Age: embryonic day 14.5
Image: App 14.5dpc
Specimen Label: App 14.5dpc
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
20097169 | J:158017
First Author: Jin S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Evidence for dimeric BACE-mediated APP processing.
Volume: 393
Issue: 1
Pages: 21-7
•
•
•
•
•
Publication
21812781 | J:176601
First Author: Rabe S
Year: 2011
Journal: J Neurochem
Title: The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Volume: 119
Issue: 1
Pages: 231-9
•
•
•
•
•
Protein
P12023
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: false
•
•
•
•
•
Publication
19683527 | J:152969
First Author: Philipson O
Year: 2009
Journal: FEBS Lett
Title: Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
Volume: 583
Issue: 18
Pages: 3021-6
•
•
•
•
•
Publication
26642089 | J:234437
First Author: Das U
Year: 2016
Journal: Nat Neurosci
Title: Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.
Volume: 19
Issue: 1
Pages: 55-64
•
•
•
•
•
Publication
22912719 | J:189875
First Author: Koike MA
Year: 2012
Journal: PLoS One
Title: APP knockout mice experience acute mortality as the result of ischemia.
Volume: 7
Issue: 8
Pages: e42665
•
•
•
•
•
Publication
31004062 | J:274676
First Author: Shea D
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease.
Volume: 116
Issue: 18
Pages: 8895-8900
•
•
•
•
•
Publication
16406235 | -
First Author: Chen Y
Year: 2006
Journal: Biochem Biophys Res Commun
Title: The amyloid precursor protein and postnatal neurogenesis/neuroregeneration.
Volume: 341
Issue: 1
Pages: 1-5
•
•
•
•
•
Protein
Q6GR78
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
•
•
•
•
•
Protein
A0A2I3BQZ9
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
•
•
•
•
•
Protein
Q53ZT3
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: false
•
•
•
•
•
Protein
Q3TXI9
Organism: Mus musculus/domesticus
Length: 752  
Fragment?: false
•
•
•
•
•
Protein
A0A2I3BPT1
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
•
•
•
•
•
Protein
Q3TWF3
Organism: Mus musculus/domesticus
Length: 752  
Fragment?: false
•
•
•
•
•
Protein
Q8BPV5
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
•
•
•
•
•
Protein
Q8BPC7
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: true
•
•
•
•
•
Protein
A0A2I3BR03
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
•
•
•
•
•
Protein
Q3TVS1
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
•
•
•
•
•
Publication
26091071 | J:348415
 
First Author: Li S
Year: 2015
Journal: Sci Rep
Title: Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
Volume: 5
Pages: 11322
•
•
•
•
•
Publication
24312636 | -
First Author: Chang CC
Year: 2013
Journal: PLoS One
Title: Synergistic interactions between Alzheimer's Aβ40 and Aβ42 on the surface of primary neurons revealed by single molecule microscopy.
Volume: 8
Issue: 12
Pages: e82139
•
•
•
•
•
Publication
23442968 | -
First Author: Johnson RD
Year: 2013
Journal: Biophys J
Title: Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes.
Volume: 104
Issue: 4
Pages: 894-903
•
•
•
•
•
Publication
31967790 | -
First Author: Li D
Year: 2020
Journal: Biochemistry
Title: Structural Diversity of Amyloid Fibrils and Advances in Their Structure Determination.
Volume: 59
Issue: 5
Pages: 639-646
•
•
•
•
•
Publication
32046006 | -
 
First Author: Balupuri A
Year: 2020
Journal: Int J Mol Sci
Title: Aggregation Mechanism of Alzheimer's Amyloid β-Peptide Mediated by α-Strand/α-Sheet Structure.
Volume: 21
Issue: 3
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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