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Search results 1 to 100 out of 1881 for Arc

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Data Source  
Strain
Attribute String: strain family, outbred stock
Protein Domain
Type: Family
Description: The Activity-Regulated Cytoskeleton-associated protein (Arc), also referred to as Arg3.1 (Activity-Regulated Gene), is an immediate-early gene predominantly found in mammals that has been related to synaptic plasticity, learning and memory processes [, , , , ]. It has been shown that Arc/Arg3.1 expression increases with strong synaptic activation []. Its mRNA is transported to activated dendritic regions, conferring on the protein-distribution temporal correlation with the inducing stimulus and spatial specificity [, ].Via interactions with dynamin and endophilin isoforms, the Arc/Arg3.1 protein enhances receptor endocytosis []. Specifically, it modulates trafficking of neuronal AMPA-type glutamate receptors (AMPARs) by accelerating endocytosis and reducing surface expression []. In particular, Arc/Arg3.1 has been shown to reduce the number of GluR2/3 receptors, leading to a decrease in AMPAR-mediated synaptic currents []. These observations are consistent with a role in homeostatic regulation of synaptic strength [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zhang W
Year: 2019
Journal: Mol Cell
Title: Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation.
Volume: 75
Issue: 1
Pages: 13-25.e5
GXD Expression  
Probe: MGI:1380553
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2622022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825926
Age: embryonic day 14.5
Image: Additional file 4 Arc
Specimen Label: Additional file 4 Arc
Detected: true
Specimen Num: 1
Publication
First Author: Greer PL
Year: 2010
Journal: Cell
Title: The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.
Volume: 140
Issue: 5
Pages: 704-16
Publication
First Author: Shepherd JD
Year: 2006
Journal: Neuron
Title: Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors.
Volume: 52
Issue: 3
Pages: 475-84
Publication
First Author: Chowdhury S
Year: 2006
Journal: Neuron
Title: Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.
Volume: 52
Issue: 3
Pages: 445-59
Publication
First Author: de la Peña JB
Year: 2021
Journal: J Neurosci
Title: Intercellular Arc Signaling Regulates Vasodilation.
Volume: 41
Issue: 37
Pages: 7712-7726
Publication  
First Author: Epstein I
Year: 2018
Journal: Semin Cell Dev Biol
Title: The Arc of cognition: Signaling cascades regulating Arc and implications for cognitive function and disease.
Volume: 77
Pages: 63-72
Publication
First Author: Wall MJ
Year: 2018
Journal: Neuron
Title: The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.
Volume: 98
Issue: 6
Pages: 1124-1132.e7
Publication
First Author: Ren M
Year: 2014
Journal: J Neurosci
Title: Arc regulates experience-dependent persistent firing patterns in frontal cortex.
Volume: 34
Issue: 19
Pages: 6583-95
Publication
First Author: Peebles CL
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Arc regulates spine morphology and maintains network stability in vivo.
Volume: 107
Issue: 42
Pages: 18173-8
Publication
First Author: Jenks KR
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Arc restores juvenile plasticity in adult mouse visual cortex.
Volume: 114
Issue: 34
Pages: 9182-9187
Publication    
First Author: Chowhury S
Year: 1999
Journal: GenBank Submission
Title: Mus musculus growth factor ARC (Arc) mRNA, complete cds
Pages: AF162777
Publication
First Author: Korb E
Year: 2013
Journal: Nat Neurosci
Title: Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
Volume: 16
Issue: 7
Pages: 874-83
Publication
First Author: Lalonde J
Year: 2017
Journal: Nat Commun
Title: Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability.
Volume: 8
Issue: 1
Pages: 1659
Publication
First Author: Kyrke-Smith M
Year: 2021
Journal: J Neurosci
Title: The Immediate Early Gene Arc Is Not Required for Hippocampal Long-Term Potentiation.
Volume: 41
Issue: 19
Pages: 4202-4211
Publication
First Author: McCurry CL
Year: 2010
Journal: Nat Neurosci
Title: Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation.
Volume: 13
Issue: 4
Pages: 450-7
Publication
First Author: Rudinskiy N
Year: 2012
Journal: Nat Neurosci
Title: Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease.
Volume: 15
Issue: 10
Pages: 1422-9
Publication
First Author: Wang KH
Year: 2006
Journal: Cell
Title: In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex.
Volume: 126
Issue: 2
Pages: 389-402
Publication
First Author: Pastuzyn ED
Year: 2018
Journal: Cell
Title: The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer.
Volume: 172
Issue: 1-2
Pages: 275-288.e18
Publication
First Author: Ravens A
Year: 2023
Journal: iScience
Title: Arc regulates a second-guessing cognitive bias during naturalistic foraging through effects on discrete behavior modules.
Volume: 26
Issue: 5
Pages: 106761
Protein
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
Publication
First Author: Fernández E
Year: 2017
Journal: Cell Rep
Title: Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence.
Volume: 21
Issue: 3
Pages: 679-691
Publication
First Author: Li L
Year: 2005
Journal: Mol Cell Biol
Title: The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors.
Volume: 25
Issue: 23
Pages: 10286-300
Publication
First Author: Maier B
Year: 2003
Journal: Biol Reprod
Title: Developmental association of the synaptic activity-regulated protein arc with the mouse acrosomal organelle and the sperm tail.
Volume: 68
Issue: 1
Pages: 67-76
Publication
First Author: McKimpson WM
Year: 2021
Journal: Dev Cell
Title: Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes.
Volume: 56
Issue: 6
Pages: 747-760.e6
Publication
First Author: Mandel-Brehm C
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression.
Volume: 112
Issue: 16
Pages: 5129-34
Publication
First Author: Pyo JO
Year: 2008
Journal: J Biol Chem
Title: Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice.
Volume: 283
Issue: 45
Pages: 30707-14
Publication
First Author: McKimpson WM
Year: 2017
Journal: Sci Rep
Title: ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes.
Volume: 7
Issue: 1
Pages: 7019
Publication
First Author: Smith-Hicks C
Year: 2010
Journal: Nat Neurosci
Title: SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells.
Volume: 13
Issue: 9
Pages: 1082-9
GXD Expression    
Probe: MGI:6167624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189801
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Arc
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6167624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189801
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Arc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6167624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189801
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Arc
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6167624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189801
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Arc
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6167624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189801
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Arc
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6167624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189801
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Arc
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6167624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189801
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Arc
Detected: true
Specimen Num: 7
Publication
First Author: Niere F
Year: 2012
Journal: J Neurosci
Title: Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.
Volume: 32
Issue: 17
Pages: 5924-36
Publication
First Author: Itoh M
Year: 2019
Journal: Neuropsychopharmacol Rep
Title: Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation-deficient mice.
Volume: 39
Issue: 1
Pages: 61-66
Publication
First Author: Xie L
Year: 2013
Journal: J Neurochem
Title: Early life stress-induced histone acetylations correlate with activation of the synaptic plasticity genes Arc and Egr1 in the mouse hippocampus.
Volume: 125
Issue: 3
Pages: 457-64
Publication
First Author: Rial Verde EM
Year: 2006
Journal: Neuron
Title: Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission.
Volume: 52
Issue: 3
Pages: 461-74
Publication
First Author: Bock J
Year: 2005
Journal: Neuroscience
Title: Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick.
Volume: 133
Issue: 3
Pages: 625-33
Publication  
First Author: Pastuzyn ED
Year: 2017
Journal: Front Mol Neurosci
Title: Activity-Dependent Arc Expression and Homeostatic Synaptic Plasticity Are Altered in Neurons from a Mouse Model of Angelman Syndrome.
Volume: 10
Pages: 234
Publication
First Author: Wang H
Year: 2016
Journal: J Neurosci
Title: Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus.
Volume: 36
Issue: 5
Pages: 1723-9
GXD Expression      
Probe: MGI:6766425
Assay Type: RT-PCR
Annotation Date: 2021-10-12
Strength: Present
Sex: Male
Emaps: EMAPS:3514228
Stage: TS28
Assay Id: MGI:6766558
Age: postnatal week 12
Specimen Label: ARC
Detected: true
Specimen Num: 1
Publication
First Author: Suzuki A
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice.
Volume: 117
Issue: 19
Pages: 10547-10553
Publication
First Author: Okuno H
Year: 2012
Journal: Cell
Title: Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ.
Volume: 149
Issue: 4
Pages: 886-98
Allele  
Name: arco piccolo
Allele Type: Chemically induced (ENU)
Allele
Name: VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog; targeted mutation 1c, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Conditional ready
Allele
Name: vacuolar protein sorting 33B; targeted mutation 1.1, TaconicArtemis
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
GO Term
Publication
First Author: Zuk KE
Year: 2023
Journal: J Neurosci
Title: Arc-Expressing Accessory Olfactory Bulb Interneurons Support Chemosensory Social Behavioral Plasticity.
Volume: 43
Issue: 7
Pages: 1178-1190
Publication
First Author: Cho HY
Year: 2021
Journal: Curr Biol
Title: Turnover of fear engram cells by repeated experience.
Volume: 31
Issue: 24
Pages: 5450-5461.e4
Publication
First Author: Guenthner CJ
Year: 2013
Journal: Neuron
Title: Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations.
Volume: 78
Issue: 5
Pages: 773-84
Publication
First Author: Castello-Waldow TP
Year: 2020
Journal: PLoS Biol
Title: Hippocampal neurons with stable excitatory connectivity become part of neuronal representations.
Volume: 18
Issue: 11
Pages: e3000928
Publication  
First Author: Tanaka DH
Year: 2019
Journal: Neuroscience
Title: Genetic Access to Gustatory Disgust-Associated Neurons in the Interstitial Nucleus of the Posterior Limb of the Anterior Commissure in Male Mice.
Volume: 413
Pages: 45-63
Publication
First Author: Mikuni T
Year: 2013
Journal: Neuron
Title: Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.
Volume: 78
Issue: 6
Pages: 1024-35
Publication
First Author: Managò F
Year: 2016
Journal: Cell Rep
Title: Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia.
Volume: 16
Issue: 8
Pages: 2116-2128
Publication
First Author: Jenks KR
Year: 2020
Journal: Cell Rep
Title: Experience-Dependent Development and Maintenance of Binocular Neurons in the Mouse Visual Cortex.
Volume: 30
Issue: 6
Pages: 1982-1994.e4
Publication
First Author: Cao VY
Year: 2015
Journal: Neuron
Title: Motor Learning Consolidates Arc-Expressing Neuronal Ensembles in Secondary Motor Cortex.
Volume: 86
Issue: 6
Pages: 1385-92
Publication
First Author: Nakayama D
Year: 2015
Journal: J Neurosci
Title: Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory.
Volume: 35
Issue: 2
Pages: 819-30
Publication
First Author: Guskjolen A
Year: 2018
Journal: Curr Biol
Title: Recovery of "Lost" Infant Memories in Mice.
Volume: 28
Issue: 14
Pages: 2283-2290.e3
Publication  
First Author: Epp JR
Year: 2015
Journal: eNeuro
Title: Optimization of CLARITY for Clearing Whole-Brain and Other Intact Organs(1,2,3).
Volume: 2
Issue: 3
Publication
First Author: Barylko B
Year: 2018
Journal: Biochemistry
Title: Palmitoylation and Membrane Binding of Arc/Arg3.1: A Potential Role in Synaptic Depression.
Volume: 57
Issue: 5
Pages: 520-524
Publication
First Author: Penrod RD
Year: 2019
Journal: Genes Brain Behav
Title: Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) regulates anxiety- and novelty-related behaviors.
Volume: 18
Issue: 7
Pages: e12561
Publication
First Author: Gao M
Year: 2010
Journal: J Neurosci
Title: A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex.
Volume: 30
Issue: 21
Pages: 7168-78
Publication
First Author: Wegenast-Braun BM
Year: 2009
Journal: Am J Pathol
Title: Independent effects of intra- and extracellular Abeta on learning-related gene expression.
Volume: 175
Issue: 1
Pages: 271-82
Publication
First Author: Templin AT
Year: 2017
Journal: Diabetes
Title: Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation.
Volume: 66
Issue: 10
Pages: 2636-2645
Publication
First Author: Byers CE
Year: 2015
Journal: Biochim Biophys Acta
Title: Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1.
Volume: 1850
Issue: 6
Pages: 1310-8
Publication
First Author: Perusini JN
Year: 2017
Journal: Hippocampus
Title: Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice.
Volume: 27
Issue: 10
Pages: 1110-1122
Publication
First Author: Hunsberger HC
Year: 2020
Journal: Sci Rep
Title: Divergence in the metabolome between natural aging and Alzheimer's disease.
Volume: 10
Issue: 1
Pages: 12171
Publication
First Author: Zhang MD
Year: 2018
Journal: J Clin Invest
Title: Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity.
Volume: 128
Issue: 9
Pages: 3757-3768
Publication
First Author: Liu D
Year: 2000
Journal: Mech Dev
Title: Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis.
Volume: 92
Issue: 2
Pages: 207-15
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Chen JY
Year: 2018
Journal: Neuron
Title: Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories.
Volume: 100
Issue: 4
Pages: 891-899.e5
Publication    
First Author: Chang CW
Year: 2017
Journal: Elife
Title: Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D.
Volume: 6
Publication
First Author: Mabb AM
Year: 2014
Journal: Neuron
Title: Triad3A regulates synaptic strength by ubiquitination of Arc.
Volume: 82
Issue: 6
Pages: 1299-316
Publication
First Author: Ishii KK
Year: 2017
Journal: Neuron
Title: A Labeled-Line Neural Circuit for Pheromone-Mediated Sexual Behaviors in Mice.
Volume: 95
Issue: 1
Pages: 123-137.e8
Publication
First Author: Hagihara KM
Year: 2021
Journal: Nature
Title: Intercalated amygdala clusters orchestrate a switch in fear state.
Volume: 594
Issue: 7863
Pages: 403-407
Publication
First Author: Wu J
Year: 2011
Journal: Cell
Title: Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.
Volume: 147
Issue: 3
Pages: 615-28
Publication
First Author: Sams DS
Year: 2016
Journal: Cell Rep
Title: Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc.
Volume: 17
Issue: 9
Pages: 2418-2430
Publication
First Author: Cansler HL
Year: 2017
Journal: J Neurosci
Title: Experience-Dependent Plasticity in Accessory Olfactory Bulb Interneurons following Male-Male Social Interaction.
Volume: 37
Issue: 30
Pages: 7240-7252
Publication    
First Author: Xing L
Year: 2016
Journal: Elife
Title: Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex.
Volume: 5
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory