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Search results 1 to 100 out of 107 for Arf5

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Type Details Score
Gene
381 | ARF5
Type: gene
Organism: human
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Gene
463698 | ARF5
Type: gene
Organism: chimpanzee
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Gene
511918 | ARF5
Type: gene
Organism: cattle
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Gene
396265 | ARF5
Type: gene
Organism: chicken
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Gene
378724 | arf5
Type: gene
Organism: zebrafish
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Gene
699426 | ARF5
Type: gene
Organism: macaque, rhesus
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Gene
79117 | Arf5
Type: gene
Organism: rat
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Gene
475206 | ARF5
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:99434 | Arf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22111578 | J:194029
First Author: Sadakata T
Year: 2012
Journal: FEBS J
Title: Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.
Volume: 279
Issue: 3
Pages: 384-94
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Publication
31201232 | J:279779
First Author: Hosoi N
Year: 2019
Journal: J Neurosci
Title: Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.
Volume: 39
Issue: 32
Pages: 6339-6353
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Protein Coding Gene
MGP_CAROLIEiJ_G0028156 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030481 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030408 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030491 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030204 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99434 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029606 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030182 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030280 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030316 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029682 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021914 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029156 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8947846 | J:42235
First Author: Hosaka M
Year: 1996
Journal: J Biochem
Title: Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).
Volume: 120
Issue: 4
Pages: 813-9
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Publication
8195219 | J:18483
First Author: Schürmann A
Year: 1994
Journal: J Biol Chem
Title: Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.
Volume: 269
Issue: 22
Pages: 15683-8
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Publication
37848288 | J:342331
 
First Author: Hara Y
Year: 2023
Journal: eNeuro
Title: ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development.
Volume: 10
Issue: 11
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Publication
16707424 | J:109061
First Author: Fenske TS
Year: 2006
Journal: Cancer Res
Title: Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.
Volume: 66
Issue: 10
Pages: 5029-38
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
26000619 | -
First Author: Egerer J
Year: 2015
Journal: J Invest Dermatol
Title: GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.
Volume: 135
Issue: 10
Pages: 2368-2376
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Publication
27582038 | J:329074
First Author: Nakamura H
Year: 2016
Journal: Genes Cells
Title: Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice.
Volume: 21
Issue: 10
Pages: 1059-1079
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Publication
19017632 | -
First Author: Jian X
Year: 2009
Journal: J Biol Chem
Title: Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1.
Volume: 284
Issue: 3
Pages: 1652-63
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Publication
17893324 | J:129034
First Author: Bharti S
Year: 2007
Journal: Mol Cell Biol
Title: Src-dependent phosphorylation of ASAP1 regulates podosomes.
Volume: 27
Issue: 23
Pages: 8271-83
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Publication
12522101 | -
First Author: Oda A
Year: 2003
Journal: J Biol Chem
Title: CrkL directs ASAP1 to peripheral focal adhesions.
Volume: 278
Issue: 8
Pages: 6456-60
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Protein Domain
IPR037928 | ASAP1_BAR
Type: Domain
Description: ASAP1 is an Arf GTPase activating protein (GAP) with activity towards Arf1 and Arf5 but not Arf6 However, it has been shown to bind GTP-Arf6 stably without GAP activity []. It has been implicated in cell growth, migration, and survival, as well as in tumor invasion and malignancy. It binds paxillin and cortactin, two components of invadopodia which are essential for tumor invasiveness. It also binds focal adhesion kinase (FAK) and the SH2/SH3 adaptor CrkL [, ]. ASAP1 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, ankyrin (ANK) repeats, and a C-terminal SH3 domain [].This entry represents the BAR domain of ASAP1. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of ASAP1 mediates membrane bending, is essential for function, and autoinhibits GAP activity by interacting with the PH and/or Arf GAP domains [].
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Publication
21686261 | -
First Author: Shoubridge C
Year: 2010
Journal: Small GTPases
Title: Subtle functional defects in the Arf-specific guanine nucleotide exchange factor IQSEC2 cause non-syndromic X-linked intellectual disability.
Volume: 1
Issue: 2
Pages: 98-103
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Publication
22886754 | J:263581
First Author: Sakagami H
Year: 2013
Journal: J Comp Neurol
Title: Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina.
Volume: 521
Issue: 4
Pages: 860-76
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Publication
21198641 | J:170549
First Author: Fukaya M
Year: 2011
Journal: J Neurochem
Title: SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses.
Volume: 116
Issue: 6
Pages: 1122-37
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Publication
24058294 | -
First Author: Aizel K
Year: 2013
Journal: PLoS Biol
Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.
Volume: 11
Issue: 9
Pages: e1001652
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Publication
12058076 | -
First Author: Liu Y
Year: 2002
Journal: Mol Biol Cell
Title: The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.
Volume: 13
Issue: 6
Pages: 2147-56
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Publication
11062263 | -
First Author: Jackson TR
Year: 2000
Journal: J Cell Biol
Title: ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.
Volume: 151
Issue: 3
Pages: 627-38
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Protein Domain
IPR033742 | IQSEC_PH
Type: Domain
Description: The IQSEC (IQ motif and SEC7 domain-containing protein), also called BRAG (Brefeldin A-resistant Arf-gunanine nucleotide exchange factor) family are a subset of Arf GEFs that have been shown to activate Arf6, which acts in the endocytic pathway to control the trafficking of a subset of cargo proteins including integrins. IQSEC family also have key roles in the function and organization of distinct excitatory and inhibitory synapses in the retina [, ]. The family consists of 3 members: IQSEC1 (also called BRAG2/GEP100), IQSEC2 (also called BRAG1), and IQSEC3 (also called SynArfGEF, BRAG3, or KIAA1110). IQSEC1 interacts with clathrin and modulates cell adhesion by regulating integrin surface expression and in addition to Arf6, it also activates the class II Arfs, Arf4 and Arf5 []. Mutations in IQSEC2 cause non-syndromic X-linked intellectual disability as well as reduced activation of Arf substrates (Arf1, Arf6) []. IQSEC3 regulates Arf6 at inhibitory synapses and associates with the dystrophin-associated glycoprotein complex and S-SCAM [].These IQSEC family members contain a IQ domain that may bind calmodulin, a PH domain that is thought to mediate membrane localization, and a SEC7 domain that can promote GEF activity on ARF []. The PH domain of BRAG2 has been shown to potentiate nucleotide exchange by binding to polyanionic membranes without marked phosphoinositides preference [].
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Publication
11950392 | -
First Author: Takatsu H
Year: 2002
Journal: Biochem J
Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
Volume: 365
Issue: Pt 2
Pages: 369-78
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Publication
16461286 | -
First Author: Dunphy JL
Year: 2006
Journal: Curr Biol
Title: The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins.
Volume: 16
Issue: 3
Pages: 315-20
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Publication
22815487 | -
First Author: Moravec R
Year: 2012
Journal: J Biol Chem
Title: BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
Volume: 287
Issue: 37
Pages: 31138-47
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Publication
17850229 | -
First Author: Casanova JE
Year: 2007
Journal: Traffic
Title: Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.
Volume: 8
Issue: 11
Pages: 1476-85
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Publication
15979507 | -
First Author: Donaldson JG
Year: 2005
Journal: Biochim Biophys Acta
Title: Multiple activities for Arf1 at the Golgi complex.
Volume: 1744
Issue: 3
Pages: 364-73
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Publication
15728366 | -
First Author: Deretic D
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4).
Volume: 102
Issue: 9
Pages: 3301-6
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Publication
16030262 | -
First Author: Volpicelli-Daley LA
Year: 2005
Journal: Mol Biol Cell
Title: Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic.
Volume: 16
Issue: 10
Pages: 4495-508
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Publication
12446727 | -
First Author: Kim SW
Year: 2003
Journal: J Biol Chem
Title: ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation.
Volume: 278
Issue: 4
Pages: 2661-8
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Protein Domain
IPR045872 | Arf1-5-like
Type: Family
Description: Arf GTPases are involved in the formation of coated carrier vesicles by recruiting coat proteins. This entry includes Arf1, Arf2, Arf3, Arf4, Arf5, and related proteins. Each contains an N-terminal myristoylated amphipathic helix that is folded into the protein in the GDP-bound state. GDP/GTP exchange exposes the helix, which anchors to the membrane. Following GTP hydrolysis, the helix dissociates from the membrane and folds back into the protein. A general feature of Arf1-5 signaling may be the cooperation of two Arfs at the same site. Arfs1-5 are generally considered to be interchangeable in function and location, but some specific functions have been assigned []. Arf1 localizes to the early/cis-Golgi, where it is activated by GBF1 and recruits the coat protein COPI. It also localizes to the trans-Golgi network (TGN), where it is activated by BIG1/BIG2 and recruits the AP1, AP3, AP4, and GGA proteins []. Humans, but not rodents and other lower eukaryotes, lack Arf2. Human Arf3 shares 96% sequence identity with Arf1 and is believed to generally function interchangeably with Arf1. Human Arf4 in the activated (GTP-bound) state has been shown to interact with the cytoplasmic domain of epidermal growth factor receptor (EGFR) and mediate the EGF-dependent activation of phospholipase D2 (PLD2), leading to activation of the activator protein 1 (AP-1) transcription factor []. Arf4 has also been shown to recognise the C-terminal sorting signal of rhodopsin and regulate its incorporation into specialised post-Golgi rhodopsin transport carriers (RTCs) []. There is some evidence that Arf5 functions at the early-Golgi and the trans-Golgi to affect Golgi-associated alpha-adaptin homology Arf-binding proteins (GGAs) [].
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Protein
Q3TES0
Organism: Mus musculus/domesticus
Length: 1195  
Fragment?: false
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Protein
Q8R0S2
Organism: Mus musculus/domesticus
Length: 961  
Fragment?: false
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Protein
A4GZ26
Organism: Mus musculus/domesticus
Length: 1479  
Fragment?: false
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Protein
E9PUA3
Organism: Mus musculus/domesticus
Length: 1099  
Fragment?: false
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Protein
A0A1D5RM83
Organism: Mus musculus/domesticus
Length: 1051  
Fragment?: false
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Protein
Q3UHJ6
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
A0A5F8MPT9
Organism: Mus musculus/domesticus
Length: 788  
Fragment?: true
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Protein
Q5DU25
Organism: Mus musculus/domesticus
Length: 1478  
Fragment?: false
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Protein
D3Z6V7
Organism: Mus musculus/domesticus
Length: 949  
Fragment?: false
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Protein
D3Z5I6
Organism: Mus musculus/domesticus
Length: 1154  
Fragment?: false
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Protein
E9QAD8
Organism: Mus musculus/domesticus
Length: 1488  
Fragment?: false
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Protein
P61750
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
P84084
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
Q8BSL7
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
P61205
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
P84078
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
Q9DD04
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
Q3U344
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
Q14BR4
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
Q9QWY8
Organism: Mus musculus/domesticus
Length: 1147  
Fragment?: false
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Protein
Q3UJA5
Organism: Mus musculus/domesticus
Length: 1087  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom