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Search results 1 to 100 out of 140 for Arf5

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
381 | ARF5
Type: gene
Organism: human
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Gene
79117 | Arf5
Type: gene
Organism: rat
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Gene
475206 | ARF5
Type: gene
Organism: dog, domestic
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Gene
463698 | ARF5
Type: gene
Organism: chimpanzee
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Gene
511918 | ARF5
Type: gene
Organism: cattle
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Gene
396265 | ARF5
Type: gene
Organism: chicken
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Gene
378724 | arf5
Type: gene
Organism: zebrafish
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Gene
699426 | ARF5
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:99434 | Arf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22111578 | J:194029
First Author: Sadakata T
Year: 2012
Journal: FEBS J
Title: Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.
Volume: 279
Issue: 3
Pages: 384-94
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Publication
31201232 | J:279779
First Author: Hosoi N
Year: 2019
Journal: J Neurosci
Title: Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.
Volume: 39
Issue: 32
Pages: 6339-6353
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Protein Coding Gene
MGP_CAROLIEiJ_G0028156 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030481 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030408 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030491 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030204 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99434 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029606 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030182 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030280 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030316 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029682 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021914 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029156 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1B
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1D1
Note: Expression is in cell bodies and proximal processes of postmigratory neurons.
Specimen Label: 1D1
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1B
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1H1
Note: Expression is in migrating neurons.
Specimen Label: 1H1
Detected: true
Specimen Num: 4
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•
•
GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1F1
Note: Expression was very strong in the axon bundle corresponding to developing fibers projecting to subcortical regions.
Specimen Label: 1F1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1B
Specimen Label: 1B
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
Probe: MGI:7704154
Assay Type: Immunohistochemistry
Annotation Date: 2024-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270725
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:7705298
Age: embryonic day 17.0
Image: 1J1
Note: Expression is in radial glia.
Specimen Label: 1J1
Detected: true
Specimen Num: 5
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Publication
8947846 | J:42235
First Author: Hosaka M
Year: 1996
Journal: J Biochem
Title: Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).
Volume: 120
Issue: 4
Pages: 813-9
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Publication
8195219 | J:18483
First Author: Schürmann A
Year: 1994
Journal: J Biol Chem
Title: Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.
Volume: 269
Issue: 22
Pages: 15683-8
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Publication
37848288 | J:342331
 
First Author: Hara Y
Year: 2023
Journal: eNeuro
Title: ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development.
Volume: 10
Issue: 11
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Publication
16707424 | J:109061
First Author: Fenske TS
Year: 2006
Journal: Cancer Res
Title: Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.
Volume: 66
Issue: 10
Pages: 5029-38
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
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Title: MGI-UniGene Interconnection Effort
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First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
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Title: Annotation inferences using phylogenetic trees
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First Author: Mouse Genome Database and National Center for Biotechnology Information
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Journal: Database Release
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First Author: Allen Institute for Brain Science
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
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First Author: Mouse Genome Informatics Group
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Journal: Database Procedure
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First Author: Bairoch A
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Journal: Database Release
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Title: GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.
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Journal: Genes Cells
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Pages: 8271-83
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Year: 2003
Journal: J Biol Chem
Title: CrkL directs ASAP1 to peripheral focal adhesions.
Volume: 278
Issue: 8
Pages: 6456-60
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Protein Domain
IPR037928 | ASAP1_BAR
Type: Domain
Description: ASAP1 is an Arf GTPase activating protein (GAP) with activity towards Arf1 and Arf5 but not Arf6 However, it has been shown to bind GTP-Arf6 stably without GAP activity []. It has been implicated in cell growth, migration, and survival, as well as in tumor invasion and malignancy. It binds paxillin and cortactin, two components of invadopodia which are essential for tumor invasiveness. It also binds focal adhesion kinase (FAK) and the SH2/SH3 adaptor CrkL [, ]. ASAP1 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, ankyrin (ANK) repeats, and a C-terminal SH3 domain [].This entry represents the BAR domain of ASAP1. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of ASAP1 mediates membrane bending, is essential for function, and autoinhibits GAP activity by interacting with the PH and/or Arf GAP domains [].
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21686261 | -
First Author: Shoubridge C
Year: 2010
Journal: Small GTPases
Title: Subtle functional defects in the Arf-specific guanine nucleotide exchange factor IQSEC2 cause non-syndromic X-linked intellectual disability.
Volume: 1
Issue: 2
Pages: 98-103
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Publication
22886754 | J:263581
First Author: Sakagami H
Year: 2013
Journal: J Comp Neurol
Title: Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina.
Volume: 521
Issue: 4
Pages: 860-76
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21198641 | J:170549
First Author: Fukaya M
Year: 2011
Journal: J Neurochem
Title: SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses.
Volume: 116
Issue: 6
Pages: 1122-37
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24058294 | -
First Author: Aizel K
Year: 2013
Journal: PLoS Biol
Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.
Volume: 11
Issue: 9
Pages: e1001652
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