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Search results 1 to 100 out of 115 for Arhgef6

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Type Details Score
Gene
9459 | ARHGEF6
Type: gene
Organism: human
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Gene
473803 | ARHGEF6
Type: gene
Organism: chimpanzee
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Gene
533823 | ARHGEF6
Type: gene
Organism: cattle
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Gene
422247 | ARHGEF6
Type: gene
Organism: chicken
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Gene
558288 | arhgef6
Type: gene
Organism: zebrafish
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Gene
693976 | ARHGEF6
Type: gene
Organism: macaque, rhesus
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Gene
100489192 | arhgef6
Type: gene
Organism: frog, western clawed
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Gene
363509 | Arhgef6
Type: gene
Organism: rat
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Gene
610290 | ARHGEF6
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1920591 | Arhgef6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12063400 | J:78158
First Author: Kutsche K
Year: 2001
Journal: Cytogenet Cell Genet
Title: The mouse Arhgef6 gene: cDNA sequence, expression analysis, and chromosome assignment.
Volume: 95
Issue: 3-4
Pages: 196-201
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Publication
25639612 | J:224019
First Author: Hemmesi K
Year: 2015
Journal: Stem Cells
Title: miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression.
Volume: 33
Issue: 5
Pages: 1377-89
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Publication
30333726 | J:280168
 
First Author: Zhu C
Year: 2018
Journal: Front Mol Neurosci
Title: Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice.
Volume: 11
Pages: 362
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Publication
21989057 | J:179026
First Author: Ramakers GJ
Year: 2012
Journal: Hum Mol Genet
Title: Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
Volume: 21
Issue: 2
Pages: 268-86
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Publication
29273735 | J:260061
First Author: Tedford K
Year: 2017
Journal: Nat Commun
Title: The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling.
Volume: 8
Issue: 1
Pages: 2261
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Protein Coding Gene
MGP_CAROLIEiJ_G0033097 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035650 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1920591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036246 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034712 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035394 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035548 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035534 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034408 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031640 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034252 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3028570
Assay Type: Northern blot
Annotation Date: 2004-02-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3028572
Age: embryonic day 13.0
Specimen Label: E13
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3028570
Assay Type: Northern blot
Annotation Date: 2004-02-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:3028572
Age: embryonic day 17.0
Specimen Label: E17
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3028570
Assay Type: Northern blot
Annotation Date: 2004-02-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028572
Age: postnatal day 7
Specimen Label: P7
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3028570
Assay Type: Northern blot
Annotation Date: 2004-02-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028572
Age: postnatal adult
Specimen Label: adult
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
       
Probe: MGI:3028570
Assay Type: Northern blot
Annotation Date: 2004-02-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3028572
Age: postnatal adult
Specimen Label: L
Specimen Num: 5
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GXD Expression
GXD Expression
       
Probe: MGI:3028570
Assay Type: Northern blot
Annotation Date: 2004-02-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3028572
Age: postnatal adult
Specimen Label: T
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6382111
Assay Type: RT-PCR
Annotation Date: 2019-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116915
Stage: TS15
Assay Id: MGI:6382143
Age: embryonic day 9.5
Image: 2
Specimen Label: Paraxis +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6382111
Assay Type: RT-PCR
Annotation Date: 2019-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3705415
Stage: TS15
Assay Id: MGI:6382143
Age: embryonic day 9.5
Image: 2
Specimen Label: Paraxis +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6382111
Assay Type: RT-PCR
Annotation Date: 2019-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116915
Stage: TS15
Assay Id: MGI:6382143
Age: embryonic day 9.5
Image: 2
Specimen Label: Paraxis -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6382111
Assay Type: RT-PCR
Annotation Date: 2019-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3705415
Stage: TS15
Assay Id: MGI:6382143
Age: embryonic day 9.5
Image: 2
Specimen Label: Paraxis -/-
Detected: true
Specimen Num: 2
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Publication
24591366 | J:209876
First Author: Korthals M
Year: 2014
Journal: J Immunol
Title: αPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes.
Volume: 192
Issue: 7
Pages: 3228-38
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Publication
18378701 | J:137269
First Author: Missy K
Year: 2008
Journal: Mol Cell Biol
Title: AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling.
Volume: 28
Issue: 11
Pages: 3776-89
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Publication
18325335 | J:189982
First Author: Matsuda C
Year: 2008
Journal: FEBS Lett
Title: Affixin activates Rac1 via betaPIX in C2C12 myoblast.
Volume: 582
Issue: 8
Pages: 1189-96
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Publication
12799088 | J:84356
First Author: Yoshizawa M
Year: 2003
Journal: Gene Expr Patterns
Title: Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.
Volume: 3
Issue: 3
Pages: 375-81
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Publication
24038871 | J:202837
First Author: Rowton M
Year: 2013
Journal: Dev Dyn
Title: Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis.
Volume: 242
Issue: 11
Pages: 1332-44
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Publication
25139745 | J:230220
First Author: Boczonadi V
Year: 2014
Journal: Cardiovasc Res
Title: Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium.
Volume: 104
Issue: 1
Pages: 103-15
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Publication
18329113 | J:136723
First Author: Vaillend C
Year: 2008
Journal: Behav Brain Res
Title: Genes, plasticity and mental retardation.
Volume: 192
Issue: 1
Pages: 88-105
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Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Strain
MGI:5576461 | B6;129-Arhgef6<tm1Kkut>/Biat
Attribute String: mutant stock, targeted mutation
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Publication
17105769 | -
First Author: Nodé-Langlois R
Year: 2006
Journal: J Cell Sci
Title: Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis.
Volume: 119
Issue: Pt 23
Pages: 4986-93
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Allele
Arhgef6<em1Smoc> | MGI:7288339
Name: Rac/Cdc42 guanine nucleotide exchange factor 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Tg(Arhgef6-cre)NL189Gsat | MGI:5051784
Name: transgene insertion NL189, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Arhgef6-EGFP)HG42Gsat | MGI:4846858
Name: transgene insertion HG42, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5524099 | STOCK Tg(Arhgef6-cre)NL189Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
33031743 | J:299111
First Author: Botta P
Year: 2020
Journal: Cell
Title: An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration.
Volume: 183
Issue: 3
Pages: 605-619.e22
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Strain
MGI:5003682 | STOCK Tg(Arhgef6-EGFP)HG42Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Arhgef6-cre)NL189Gsat/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
11017088 | -
First Author: Kutsche K
Year: 2000
Journal: Nat Genet
Title: Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation.
Volume: 26
Issue: 2
Pages: 247-50
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Protein Domain
IPR035788 | AlphaPIX_SH3
Type: Domain
Description: Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6) or Cool (Cloned out of Library)-2, activates small GTPases by exchanging bound GDP for free GTP []. It acts as a GEF for both Cdc42 and Rac1, and is localized in dendritic spines where it regulates spine morphogenesis []. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans [, ]. PIX proteins contain an N-terminal SH3 domain followed by RhoGEF (also called Dbl-homologous or DH) and Pleckstrin Homology (PH) domains, and a C-terminal leucine-zipper domain for dimerization. This entry represents the SH3 domain of alpha-PIX.
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Publication
16472649 | -
 
First Author: Baird D
Year: 2006
Journal: Methods Enzymol
Title: Biochemical characterization of the Cool (Cloned-out-of-Library)/Pix (Pak-interactive exchange factor) proteins.
Volume: 406
Pages: 58-69
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Publication
32780989 | -
First Author: Zhu J
Year: 2020
Journal: Mol Cell
Title: GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Volume: 79
Issue: 5
Pages: 782-796.e6
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Publication
10461188 | -
First Author: Bagrodia S
Year: 1999
Journal: Trends Cell Biol
Title: Pak to the future.
Volume: 9
Issue: 9
Pages: 350-5
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Publication
12935897 | -
First Author: Flanders JA
Year: 2003
Journal: FEBS Lett
Title: The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
Volume: 550
Issue: 1-3
Pages: 119-23
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Publication
11741931 | -
First Author: Feng Q
Year: 2002
Journal: J Biol Chem
Title: Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
Volume: 277
Issue: 7
Pages: 5644-50
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Publication
19969308 | -
First Author: Eriguchi M
Year: 2010
Journal: J Neurol Sci
Title: alpha Pix enhances mutant huntingtin aggregation.
Volume: 290
Issue: 1-2
Pages: 80-5
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Protein Domain
IPR046376 | PH_Cool_Pix
Type: Domain
Description: There are two forms of Pix proteins: alpha Pix (also called Rho guanine nucleotide exchange factor (GEF) 6, 90Cool-2 or ARHGEF6) and beta Pix (GEF7, p85Cool-1 or ARHGEF7), which activate small GTPases by exchanging bound GDP for free GTP. betaPix contains an N-terminal SH3 domain, a RhoGEF/DH domain, a PH domain, a GIT1 binding domain (GBD), and a C-terminal coiled-coil (CC) domain []. It acts as a GEF for both Cdc42 and Rac1 [], and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion [, , , ]. alphaPix differs in that it contains a calponin homology (CH) domain, which interacts with beta-parvin, N-terminal to the SH3 domain. alphaPix is an exchange factor for Rac1 and Cdc42 and mediates Pak activation on cell adhesion to fibronectin. Mutations in alphaPix can cause X-linked mental retardation. alphaPix also interacts with Huntington's disease protein (htt), and enhances the aggregation of mutant htt (muthtt) by facilitating SDS-soluble muthtt-muthtt interactions. The DH-PH domain of a Pix was required for its binding to htt. In the majority of Rho GEF proteins, the DH-PH domain is responsible for the exchange activity [, , , , ].This entry represents the PH domain of ARHGEF6 and ARHGEF7.
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