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Search results 1 to 100 out of 162 for Arl2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
402 | ARL2
Type: gene
Organism: human
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Gene
394753 | arl2
Type: gene
Organism: frog, western clawed
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Gene
65142 | Arl2
Type: gene
Organism: rat
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Gene
483753 | ARL2
Type: gene
Organism: dog, domestic
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Gene
511349 | ARL2
Type: gene
Organism: cattle
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Gene
101056982 | ARL2
Type: gene
Organism: chimpanzee
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Gene
769546 | ARL2
Type: gene
Organism: chicken
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Gene
449774 | arl2
Type: gene
Organism: zebrafish
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Gene
722013 | ARL2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR045873 | Arl2
Type: Family
Description: Arl2 (Arf-like 2) GTPases are members of the Arf family that bind GDP and GTP with very low affinity. Unlike most Arf family proteins, Arl2 is not myristoylated at its N-terminal helix. The protein PDE-delta, first identified in photoreceptor rod cells, binds specifically to Arl2 and is structurally very similar to RhoGDI. Despite the high structural similarity between Arl2 and Rho proteins and between PDE-delta and RhoGDI, the interactions between the GTPases and their effectors are very different. In its GTP bound form, Arl2 interacts with the protein Binder of Arl2 (BART), and thecomplex is believed to play a role in mitochondrial adenine nucleotide transport []. In its GDP bound form, Arl2 interacts with tubulin- folding Cofactor D; this interaction is believed to play a role in regulation of microtubule dynamics that impact the cytoskeleton, cell division, and cytokinesis [].This entry also includes Alp41 from fission yeasts which is essential for the cofactor-dependent biogenesis of microtubules [].
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Protein Coding Gene
MGI:1928393 | Arl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11809823 | J:168212
First Author: Sharer JD
Year: 2002
Journal: Mol Biol Cell
Title: ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter.
Volume: 13
Issue: 1
Pages: 71-83
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Publication
30945270 | J:281417
First Author: Cai XB
Year: 2019
Journal: Clin Genet
Title: Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.
Volume: 96
Issue: 1
Pages: 61-71
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Publication
10683446 | -
First Author: Radcliffe PA
Year: 2000
Journal: FEBS Lett
Title: A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast.
Volume: 468
Issue: 1
Pages: 84-8
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Publication
10831612 | -
First Author: Bhamidipati A
Year: 2000
Journal: J Cell Biol
Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.
Volume: 149
Issue: 5
Pages: 1087-96
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Protein
Q9D0J4
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
36611941 | J:332516
 
First Author: Gerstner CD
Year: 2022
Journal: Cells
Title: Arf-like Protein 2 (ARL2) Controls Microtubule Neogenesis during Early Postnatal Photoreceptor Development.
Volume: 12
Issue: 1
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Publication
26455799 | J:247391
First Author: Lokaj M
Year: 2015
Journal: Structure
Title: The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Volume: 23
Issue: 11
Pages: 2122-32
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Publication
11980706 | J:116350
First Author: Hanzal-Bayer M
Year: 2002
Journal: EMBO J
Title: The complex of Arl2-GTP and PDE delta: from structure to function.
Volume: 21
Issue: 9
Pages: 2095-106
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Publication
22960633 | J:200475
First Author: Ismail SA
Year: 2012
Journal: EMBO J
Title: Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Volume: 31
Issue: 20
Pages: 4085-94
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Publication
15979089 | J:99978
First Author: Hanzal-Bayer M
Year: 2005
Journal: J Mol Biol
Title: Properties of the interaction of Arf-like protein 2 with PDEdelta.
Volume: 350
Issue: 5
Pages: 1074-82
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Publication
18234692 | J:131811
First Author: Muromoto R
Year: 2008
Journal: Int Immunol
Title: BART is essential for nuclear retention of STAT3.
Volume: 20
Issue: 3
Pages: 395-403
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Publication
23849777 | J:206686
First Author: Davidson AE
Year: 2013
Journal: Am J Hum Genet
Title: Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa.
Volume: 93
Issue: 2
Pages: 321-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0022597 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024751 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024690 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024485 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1928393 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025163 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024457 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024584 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024550 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024670 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024579 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025211 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024019 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014091 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023508 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
- | J:66358
   
First Author: Linari M
Year: 1999
Journal: GenBank Submission
Title: Mus musculus arf-like protein 2 (ARL2) mRNA, complete cds
Pages: AF143680
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Publication
23559067 | J:200445
First Author: Wätzlich D
Year: 2013
Journal: EMBO Rep
Title: The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Volume: 14
Issue: 5
Pages: 465-72
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Publication
27063844 | J:236897
 
First Author: Fansa EK
Year: 2016
Journal: Nat Commun
Title: PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.
Volume: 7
Pages: 11366
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Publication
33147210 | J:297431
First Author: Dewhurst MR
Year: 2020
Journal: PLoS Genet
Title: Loss of hepatocyte cell division leads to liver inflammation and fibrosis.
Volume: 16
Issue: 11
Pages: e1009084
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
24911211 | -
First Author: Newman LE
Year: 2014
Journal: PLoS One
Title: The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.
Volume: 9
Issue: 6
Pages: e99270
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Publication
26208336 | -
   
First Author: Nithianantham S
Year: 2015
Journal: Elife
Title: Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics.
Volume: 4
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Publication
24039609 | -
First Author: Jaworek TJ
Year: 2013
Journal: PLoS Genet
Title: An alteration in ELMOD3, an Arl2 GTPase-activating protein, is associated with hearing impairment in humans.
Volume: 9
Issue: 9
Pages: e1003774
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Interaction Experiment
Sharer JD (2002)
Description: ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter.
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Publication
17452337 | -
First Author: Bowzard JB
Year: 2007
Journal: J Biol Chem
Title: ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.
Volume: 282
Issue: 24
Pages: 17568-80
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Publication
12527357 | -
First Author: Kobayashi A
Year: 2003
Journal: FEBS Lett
Title: Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain.
Volume: 534
Issue: 1-3
Pages: 26-32
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Publication
10488091 | J:57774
First Author: Sharer JD
Year: 1999
Journal: J Biol Chem
Title: The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization.
Volume: 274
Issue: 39
Pages: 27553-61
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Publication
27806215 | -
First Author: Fansa EK
Year: 2016
Journal: Small GTPases
Title: Sorting of lipidated cargo by the Arl2/Arl3 system.
Volume: 7
Issue: 4
Pages: 222-230
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Protein Domain
IPR044612 | ARL2/3
Type: Family
Description: This entry represents a group of Arf-like small GTP-binding proteins, including ARL2/3 from animals, Cin4 from budding yeasts, Alp41 from fission yeasts and ARL2 from Arabidopsis. They are involved in microtubule-dependent processes []. Despite the structural similarity of ARL2 and ARL3, they have different biochemical properties and biological functions []. ARL2 plays roles in both the regulation of tubulin folding and microtubule destruction. It is also essential to a number of mitochondrial functions, including mitochondrial morphology, motility, and maintenance of ATP levels []. ARL3 is required for normal cytokinesis and cilia signaling []. Alp41 is essential for the cofactor-dependent biogenesis of microtubules [].
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Publication
22085962 | -
First Author: Wright KJ
Year: 2011
Journal: Genes Dev
Title: An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
Volume: 25
Issue: 22
Pages: 2347-60
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Publication
19368893 | -
First Author: Zhang T
Year: 2009
Journal: Structure
Title: Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.
Volume: 17
Issue: 4
Pages: 602-10
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Protein Domain
IPR012945 | Tubulin-bd_cofactor_C_dom
Type: Domain
Description: This domain is found in tubulin-binding cofactor C (or tubulin-specific chaperone C) (TBCC) and in protein XRP2. TBCC is a folding cofactor that participates in tubulin biogenesis along with the other tubulin folding cofactors A (TBCA), B (TBCB), E (TBCE) and D (TBCD), as well as the GTP-binding protein Arl2 [, ]. XRP2 is a GTPase-activating protein (GAP) involved in intracellular trafficking [].
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Protein
Q9D385
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Protein
A0A1D5RMA5
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Publication
17184771 | -
First Author: Kortazar D
Year: 2007
Journal: Exp Cell Res
Title: Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation.
Volume: 313
Issue: 3
Pages: 425-36
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Protein Domain
IPR042541 | BART_sf
Type: Homologous_superfamily
Description: This domain superfamily is found in ADP-ribosylation factor-like 2 (ARF2) binding protein, also known as BART. BART binds specifically to ARF2.GTP with a high affinity. However, it does not bind to ARF2.GDP. It is thought that this specific interaction is due to BART being the first identified ARF2-specific effector. The function is not completely characterised []. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 [].The interactions between ARL2 and BART involve a conserved N-terminal LLxIL motif of ARL2 []. This domain is also found in CFAP36/CCDC104, a protein renamed as BARTL1. The BART-like domain of CCDC104/BARTL1 recognizes an LLxILxxL motif at the N-terminal amphipathic helix of ARL3 [].
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Protein Domain
IPR023379 | BART_dom
Type: Domain
Description: This domain is found in ADP-ribosylation factor-like 2 (ARF2) binding protein, also known as BART. BART binds specifically to ARF2.GTP with a high affinity. However, it does not bind to ARF2.GDP. It is thought that this specific interaction is due to BART being the first identified ARF2-specific effector. The function is not completely characterised []. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 [].The interactions between ARL2 and BART involve a conserved N-terminal LLxIL motif of ARL2 []. This domain is also found in CFAP36/CCDC104, a protein renamed as BARTL1. The BART-like domain of CCDC104/BARTL1 recognizes an LLxILxxL motif at the N-terminal amphipathic helix of ARL3 [].
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Protein
Q8C6E0
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Publication
9990021 | J:168215
First Author: Linari M
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase.
Volume: 96
Issue: 4
Pages: 1315-20
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Protein
Q5SNY8
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
Q99JR9
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Publication
10452952 | -
First Author: Wang W
Year: 1999
Journal: Gene
Title: Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D).
Volume: 236
Issue: 2
Pages: 325-32
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Publication
14561760 | J:87331
First Author: Zhang H
Year: 2004
Journal: J Biol Chem
Title: Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.
Volume: 279
Issue: 1
Pages: 407-13
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Publication
18503409 | -
First Author: Day JP
Year: 2008
Journal: Biochem J
Title: Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein.
Volume: 414
Issue: 3
Pages: 363-74
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Protein Domain
IPR038849 | ARL2BP
Type: Family
Description: Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation and survival in immune responses. ADP-ribosylation factor-like protein 2-binding protein, also known as BART, plays an essential role in the nuclear retention of STAT3 through interaction with GTPase ARL2 (ARF-like 2) []. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 and may have a role in mitochondria transport and/or apoptosis [].
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Protein Domain
IPR017287 | Rhodop-sen_GMP-Pdiesterase_dsu
Type: Family
Description: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase () is an oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and a delta chain. This protein interacts with RPGR (retinitis pigmentosa GTPase regulator) [], ARL2 (Arf-like-2) and ARL3. This entry represents the delta subunit [], which is thought to act as a prenyl-binding protein []and participates in the transport of PDE6 catalytic alpha/beta subunits [].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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