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Search results 1 to 100 out of 161 for Arl2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Arl2 (Arf-like 2) GTPases are members of the Arf family that bind GDP and GTP with very low affinity. Unlike most Arf family proteins, Arl2 is not myristoylated at its N-terminal helix. The protein PDE-delta, first identified in photoreceptor rod cells, binds specifically to Arl2 and is structurally very similar to RhoGDI. Despite the high structural similarity between Arl2 and Rho proteins and between PDE-delta and RhoGDI, the interactions between the GTPases and their effectors are very different. In its GTP bound form, Arl2 interacts with the protein Binder of Arl2 (BART), and thecomplex is believed to play a role in mitochondrial adenine nucleotide transport []. In its GDP bound form, Arl2 interacts with tubulin- folding Cofactor D; this interaction is believed to play a role in regulation of microtubule dynamics that impact the cytoskeleton, cell division, and cytokinesis [].This entry also includes Alp41 from fission yeasts which is essential for the cofactor-dependent biogenesis of microtubules [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sharer JD
Year: 2002
Journal: Mol Biol Cell
Title: ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter.
Volume: 13
Issue: 1
Pages: 71-83
Publication
First Author: Cai XB
Year: 2019
Journal: Clin Genet
Title: Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.
Volume: 96
Issue: 1
Pages: 61-71
Publication
First Author: Radcliffe PA
Year: 2000
Journal: FEBS Lett
Title: A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast.
Volume: 468
Issue: 1
Pages: 84-8
Publication
First Author: Bhamidipati A
Year: 2000
Journal: J Cell Biol
Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.
Volume: 149
Issue: 5
Pages: 1087-96
Protein
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
Publication  
First Author: Gerstner CD
Year: 2022
Journal: Cells
Title: Arf-like Protein 2 (ARL2) Controls Microtubule Neogenesis during Early Postnatal Photoreceptor Development.
Volume: 12
Issue: 1
Publication
First Author: Lokaj M
Year: 2015
Journal: Structure
Title: The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Volume: 23
Issue: 11
Pages: 2122-32
Publication
First Author: Hanzal-Bayer M
Year: 2002
Journal: EMBO J
Title: The complex of Arl2-GTP and PDE delta: from structure to function.
Volume: 21
Issue: 9
Pages: 2095-106
Publication
First Author: Ismail SA
Year: 2012
Journal: EMBO J
Title: Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Volume: 31
Issue: 20
Pages: 4085-94
Publication
First Author: Hanzal-Bayer M
Year: 2005
Journal: J Mol Biol
Title: Properties of the interaction of Arf-like protein 2 with PDEdelta.
Volume: 350
Issue: 5
Pages: 1074-82
Publication
First Author: Muromoto R
Year: 2008
Journal: Int Immunol
Title: BART is essential for nuclear retention of STAT3.
Volume: 20
Issue: 3
Pages: 395-403
Publication
First Author: Davidson AE
Year: 2013
Journal: Am J Hum Genet
Title: Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa.
Volume: 93
Issue: 2
Pages: 321-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication    
First Author: Linari M
Year: 1999
Journal: GenBank Submission
Title: Mus musculus arf-like protein 2 (ARL2) mRNA, complete cds
Pages: AF143680
Publication
First Author: Wätzlich D
Year: 2013
Journal: EMBO Rep
Title: The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Volume: 14
Issue: 5
Pages: 465-72
Publication  
First Author: Fansa EK
Year: 2016
Journal: Nat Commun
Title: PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.
Volume: 7
Pages: 11366
Publication
First Author: Dewhurst MR
Year: 2020
Journal: PLoS Genet
Title: Loss of hepatocyte cell division leads to liver inflammation and fibrosis.
Volume: 16
Issue: 11
Pages: e1009084
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication
First Author: Newman LE
Year: 2014
Journal: PLoS One
Title: The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.
Volume: 9
Issue: 6
Pages: e99270
Publication    
First Author: Nithianantham S
Year: 2015
Journal: Elife
Title: Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics.
Volume: 4
Publication
First Author: Jaworek TJ
Year: 2013
Journal: PLoS Genet
Title: An alteration in ELMOD3, an Arl2 GTPase-activating protein, is associated with hearing impairment in humans.
Volume: 9
Issue: 9
Pages: e1003774
Interaction Experiment
Description: ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter.
Publication
First Author: Bowzard JB
Year: 2007
Journal: J Biol Chem
Title: ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.
Volume: 282
Issue: 24
Pages: 17568-80
Publication
First Author: Kobayashi A
Year: 2003
Journal: FEBS Lett
Title: Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain.
Volume: 534
Issue: 1-3
Pages: 26-32
Publication
First Author: Sharer JD
Year: 1999
Journal: J Biol Chem
Title: The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization.
Volume: 274
Issue: 39
Pages: 27553-61
Publication
First Author: Fansa EK
Year: 2016
Journal: Small GTPases
Title: Sorting of lipidated cargo by the Arl2/Arl3 system.
Volume: 7
Issue: 4
Pages: 222-230
Protein Domain
Type: Family
Description: This entry represents a group of Arf-like small GTP-binding proteins, including ARL2/3 from animals, Cin4 from budding yeasts, Alp41 from fission yeasts and ARL2 from Arabidopsis. They are involved in microtubule-dependent processes []. Despite the structural similarity of ARL2 and ARL3, they have different biochemical properties and biological functions []. ARL2 plays roles in both the regulation of tubulin folding and microtubule destruction. It is also essential to a number of mitochondrial functions, including mitochondrial morphology, motility, and maintenance of ATP levels []. ARL3 is required for normal cytokinesis and cilia signaling []. Alp41 is essential for the cofactor-dependent biogenesis of microtubules [].
Publication
First Author: Wright KJ
Year: 2011
Journal: Genes Dev
Title: An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
Volume: 25
Issue: 22
Pages: 2347-60
Publication
First Author: Zhang T
Year: 2009
Journal: Structure
Title: Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.
Volume: 17
Issue: 4
Pages: 602-10
Protein Domain
Type: Domain
Description: This domain is found in tubulin-binding cofactor C (or tubulin-specific chaperone C) (TBCC) and in protein XRP2. TBCC is a folding cofactor that participates in tubulin biogenesis along with the other tubulin folding cofactors A (TBCA), B (TBCB), E (TBCE) and D (TBCD), as well as the GTP-binding protein Arl2 [, ]. XRP2 is a GTPase-activating protein (GAP) involved in intracellular trafficking [].
Protein
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
Publication
First Author: Kortazar D
Year: 2007
Journal: Exp Cell Res
Title: Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation.
Volume: 313
Issue: 3
Pages: 425-36
Protein Domain
Type: Homologous_superfamily
Description: This domain superfamily is found in ADP-ribosylation factor-like 2 (ARF2) binding protein, also known as BART. BART binds specifically to ARF2.GTP with a high affinity. However, it does not bind to ARF2.GDP. It is thought that this specific interaction is due to BART being the first identified ARF2-specific effector. The function is not completely characterised []. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 [].The interactions between ARL2 and BART involve a conserved N-terminal LLxIL motif of ARL2 []. This domain is also found in CFAP36/CCDC104, a protein renamed as BARTL1. The BART-like domain of CCDC104/BARTL1 recognizes an LLxILxxL motif at the N-terminal amphipathic helix of ARL3 [].
Protein Domain
Type: Domain
Description: This domain is found in ADP-ribosylation factor-like 2 (ARF2) binding protein, also known as BART. BART binds specifically to ARF2.GTP with a high affinity. However, it does not bind to ARF2.GDP. It is thought that this specific interaction is due to BART being the first identified ARF2-specific effector. The function is not completely characterised []. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 [].The interactions between ARL2 and BART involve a conserved N-terminal LLxIL motif of ARL2 []. This domain is also found in CFAP36/CCDC104, a protein renamed as BARTL1. The BART-like domain of CCDC104/BARTL1 recognizes an LLxILxxL motif at the N-terminal amphipathic helix of ARL3 [].
Protein
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
Publication
First Author: Linari M
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase.
Volume: 96
Issue: 4
Pages: 1315-20
Protein
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
Publication
First Author: Wang W
Year: 1999
Journal: Gene
Title: Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D).
Volume: 236
Issue: 2
Pages: 325-32
Publication
First Author: Zhang H
Year: 2004
Journal: J Biol Chem
Title: Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.
Volume: 279
Issue: 1
Pages: 407-13
Publication
First Author: Day JP
Year: 2008
Journal: Biochem J
Title: Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein.
Volume: 414
Issue: 3
Pages: 363-74
Protein Domain
Type: Family
Description: Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation and survival in immune responses. ADP-ribosylation factor-like protein 2-binding protein, also known as BART, plays an essential role in the nuclear retention of STAT3 through interaction with GTPase ARL2 (ARF-like 2) []. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 and may have a role in mitochondria transport and/or apoptosis [].
Protein Domain
Type: Family
Description: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase () is an oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and a delta chain. This protein interacts with RPGR (retinitis pigmentosa GTPase regulator) [], ARL2 (Arf-like-2) and ARL3. This entry represents the delta subunit [], which is thought to act as a prenyl-binding protein []and participates in the transport of PDE6 catalytic alpha/beta subunits [].
Publication
First Author: Veltel S
Year: 2008
Journal: FEBS Lett
Title: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.
Volume: 582
Issue: 17
Pages: 2501-7